Caenorhabditis elegans

131 known processes

lin-1 (CELE_C37F5.1)

Protein LIN-1

lin-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cellular process GO:0048522 332 0.439
Human Mouse
positive regulation of nucleic acid templated transcription GO:1903508 102 0.381
Human Mouse
organic cyclic compound biosynthetic process GO:1901362 195 0.378
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.356
positive regulation of cellular metabolic process GO:0031325 178 0.344
Human Mouse
rna biosynthetic process GO:0032774 169 0.341
regulation of primary metabolic process GO:0080090 292 0.340
cell fate commitment GO:0045165 139 0.339
organ development GO:0048513 1102 0.335
positive regulation of metabolic process GO:0009893 187 0.326
Human Mouse
regulation of cellular metabolic process GO:0031323 305 0.322
regulation of macromolecule metabolic process GO:0060255 421 0.316
positive regulation of macromolecule metabolic process GO:0010604 149 0.309
Human Mouse
post embryonic development GO:0009791 2152 0.295
cellular biosynthetic process GO:0044249 315 0.277
hermaphrodite genitalia development GO:0040035 734 0.276
regulation of cellular biosynthetic process GO:0031326 189 0.268
positive regulation of transcription dna templated GO:0045893 102 0.264
Human Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.251
Human Mouse
positive regulation of cellular biosynthetic process GO:0031328 109 0.251
Human Mouse
single organism signaling GO:0044700 401 0.239
regulation of metabolic process GO:0019222 478 0.233
reproductive structure development GO:0048608 850 0.230
regulation of biosynthetic process GO:0009889 189 0.227
cellular response to organic substance GO:0071310 119 0.219
endocytosis GO:0006897 819 0.215
embryo development GO:0009790 3052 0.207
positive regulation of gene expression GO:0010628 112 0.207
Human Mouse
cellular macromolecule biosynthetic process GO:0034645 247 0.205
multicellular organismal aging GO:0010259 812 0.205
positive regulation of growth GO:0045927 369 0.203
single organism reproductive process GO:0044702 1196 0.200
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.196
cell cycle GO:0007049 526 0.196
establishment of localization GO:0051234 1171 0.192
nucleobase containing compound metabolic process GO:0006139 406 0.182
cell proliferation GO:0008283 116 0.180
signaling GO:0023052 401 0.176
positive regulation of developmental process GO:0051094 408 0.176
gene expression GO:0010467 412 0.176
vesicle mediated transport GO:0016192 852 0.170
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.168
Human Mouse
negative regulation of gene expression GO:0010629 217 0.167
protein metabolic process GO:0019538 422 0.164
macromolecule localization GO:0033036 771 0.164
rna metabolic process GO:0016070 228 0.162
cellular nitrogen compound biosynthetic process GO:0044271 192 0.159
determination of adult lifespan GO:0008340 812 0.156
regulation of biological quality GO:0065008 741 0.155
regulation of transcription dna templated GO:0006355 164 0.154
development of primary sexual characteristics GO:0045137 840 0.153
nucleobase containing compound biosynthetic process GO:0034654 184 0.150
organic substance biosynthetic process GO:1901576 323 0.149
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.149
Human
regulation of nitrogen compound metabolic process GO:0051171 222 0.148
sex differentiation GO:0007548 909 0.148
locomotion GO:0040011 1634 0.143
signal transduction GO:0007165 317 0.142
positive regulation of biosynthetic process GO:0009891 109 0.137
Human Mouse
nucleic acid metabolic process GO:0090304 299 0.135
regulation of rna metabolic process GO:0051252 173 0.134
regulation of gene expression GO:0010468 366 0.130
biosynthetic process GO:0009058 323 0.128
intracellular signal transduction GO:0035556 96 0.127
cell morphogenesis GO:0000902 163 0.126
transcription from rna polymerase ii promoter GO:0006366 149 0.124
aging GO:0007568 812 0.123
positive regulation of developmental growth GO:0048639 354 0.118
regulation of multicellular organismal process GO:0051239 726 0.118
transport GO:0006810 1093 0.116
positive regulation of rna biosynthetic process GO:1902680 102 0.116
Human Mouse
regulation of macromolecule biosynthetic process GO:0010556 189 0.114
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.113
response to transforming growth factor beta GO:0071559 13 0.110
regulation of developmental process GO:0050793 684 0.110
negative regulation of cellular process GO:0048523 239 0.109
multicellular organism growth GO:0035264 385 0.108
transcription dna templated GO:0006351 168 0.108
negative regulation of metabolic process GO:0009892 240 0.107
regulation of cell communication GO:0010646 176 0.107
negative regulation of biological process GO:0048519 567 0.100
body morphogenesis GO:0010171 620 0.100
multicellular organismal reproductive process GO:0048609 815 0.100
microtubule based process GO:0007017 182 0.097
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.095
Human Mouse
genitalia development GO:0048806 741 0.095
protein localization GO:0008104 205 0.092
reproductive system development GO:0061458 850 0.091
apoptotic process GO:0006915 478 0.090
heterocycle biosynthetic process GO:0018130 187 0.090
positive regulation of multicellular organismal process GO:0051240 417 0.088
regulation of signal transduction GO:0009966 135 0.086
negative regulation of rna metabolic process GO:0051253 53 0.085
developmental growth GO:0048589 412 0.084
growth GO:0040007 562 0.083
single organism localization GO:1902578 518 0.082
cellular response to chemical stimulus GO:0070887 129 0.082
cell surface receptor signaling pathway GO:0007166 149 0.080
neuron differentiation GO:0030182 217 0.080
catabolic process GO:0009056 318 0.079
gamete generation GO:0007276 461 0.078
embryo development ending in birth or egg hatching GO:0009792 2992 0.077
cell cycle process GO:0022402 482 0.074
protein complex subunit organization GO:0071822 280 0.073
organ morphogenesis GO:0009887 67 0.073
sexual reproduction GO:0019953 546 0.073
multi organism reproductive process GO:0044703 867 0.072
phosphate containing compound metabolic process GO:0006796 232 0.071
regulation of response to stimulus GO:0048583 243 0.071
regulation of rna biosynthetic process GO:2001141 165 0.071
defense response GO:0006952 296 0.071
regulation of multicellular organism growth GO:0040014 373 0.070
regulation of signaling GO:0023051 172 0.070
aromatic compound biosynthetic process GO:0019438 192 0.068
phosphorus metabolic process GO:0006793 232 0.068
cell death GO:0008219 547 0.067
establishment of localization in cell GO:0051649 318 0.067
maintenance of location GO:0051235 580 0.066
positive regulation of cell communication GO:0010647 69 0.066
lipid localization GO:0010876 573 0.066
cellular component biogenesis GO:0044085 297 0.065
single organism organelle organization GO:1902589 501 0.064
tissue morphogenesis GO:0048729 65 0.064
developmental process involved in reproduction GO:0003006 1165 0.063
programmed cell death GO:0012501 500 0.063
enzyme linked receptor protein signaling pathway GO:0007167 50 0.063
lipid storage GO:0019915 565 0.062
regulation of nucleic acid templated transcription GO:1903506 165 0.061
protein complex assembly GO:0006461 186 0.060
establishment of spindle localization GO:0051293 51 0.060
small gtpase mediated signal transduction GO:0007264 32 0.060
regulation of cellular component organization GO:0051128 248 0.060
lipid metabolic process GO:0006629 77 0.060
cell development GO:0048468 696 0.059
nervous system development GO:0007399 253 0.059
cellular response to growth factor stimulus GO:0071363 18 0.057
single organism behavior GO:0044708 83 0.057
organic substance catabolic process GO:1901575 294 0.056
cellular component assembly GO:0022607 293 0.055
regulation of apoptotic process GO:0042981 36 0.055
negative regulation of cellular metabolic process GO:0031324 95 0.053
single organism transport GO:0044765 447 0.053
negative regulation of nematode larval development GO:0061064 208 0.052
death GO:0016265 547 0.052
regulation of cell differentiation GO:0045595 81 0.052
cellular localization GO:0051641 360 0.051
positive regulation of multicellular organism growth GO:0040018 352 0.051
regulation of growth GO:0040008 409 0.050
macromolecular complex subunit organization GO:0043933 320 0.049
response to chemical GO:0042221 356 0.048
positive regulation of rna metabolic process GO:0051254 103 0.048
Human Mouse
regulation of epithelial cell proliferation GO:0050678 1 0.047
negative regulation of response to stimulus GO:0048585 73 0.047
cell projection morphogenesis GO:0048858 148 0.046
organonitrogen compound metabolic process GO:1901564 151 0.046
response to external stimulus GO:0009605 289 0.045
response to organic substance GO:0010033 131 0.045
digestive tract development GO:0048565 122 0.044
macromolecule biosynthetic process GO:0009059 250 0.044
germ cell development GO:0007281 351 0.043
organelle organization GO:0006996 783 0.042
organic substance transport GO:0071702 113 0.042
negative regulation of rna biosynthetic process GO:1902679 53 0.042
anatomical structure formation involved in morphogenesis GO:0048646 250 0.041
Mouse
negative regulation of macromolecule metabolic process GO:0010605 229 0.041
regulation of multicellular organismal development GO:2000026 317 0.041
gastrulation GO:0007369 58 0.041
asymmetric protein localization GO:0008105 35 0.041
regulation of intracellular signal transduction GO:1902531 77 0.041
receptor mediated endocytosis GO:0006898 715 0.040
cellular response to transforming growth factor beta stimulus GO:0071560 13 0.040
regulation of catalytic activity GO:0050790 78 0.040
cell division GO:0051301 262 0.040
regulation of cell proliferation GO:0042127 105 0.040
cytoskeleton organization GO:0007010 339 0.040
nucleic acid templated transcription GO:0097659 169 0.039
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.039
adult locomotory behavior GO:0008344 1 0.039
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 2 0.039
mitotic cell cycle process GO:1903047 194 0.038
regulation of anatomical structure morphogenesis GO:0022603 51 0.037
sensory organ morphogenesis GO:0090596 2 0.037
macromolecular complex assembly GO:0065003 193 0.037
molting cycle GO:0042303 281 0.037
tube morphogenesis GO:0035239 79 0.036
negative regulation of developmental process GO:0051093 227 0.036
behavior GO:0007610 527 0.036
protein targeting to membrane GO:0006612 1 0.036
regulation of developmental growth GO:0048638 389 0.036
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.035
apical junction assembly GO:0043297 1 0.035
transforming growth factor beta receptor signaling pathway GO:0007179 13 0.034
dauer larval development GO:0040024 92 0.034
regulation of gene expression epigenetic GO:0040029 163 0.033
cell type specific apoptotic process GO:0097285 4 0.033
gene silencing GO:0016458 143 0.033
immune response GO:0006955 192 0.032
cellular component morphogenesis GO:0032989 318 0.032
response to biotic stimulus GO:0009607 101 0.032
protein complex biogenesis GO:0070271 186 0.032
establishment or maintenance of cell polarity GO:0007163 63 0.032
regulation of cellular protein metabolic process GO:0032268 75 0.032
regulation of cell cycle GO:0051726 194 0.031
negative regulation of cell communication GO:0010648 61 0.031
gonad development GO:0008406 840 0.031
vulval development GO:0040025 333 0.030
developmental growth involved in morphogenesis GO:0060560 37 0.030
organelle localization GO:0051640 127 0.030
epithelial tube morphogenesis GO:0060562 1 0.030
digestive tract morphogenesis GO:0048546 76 0.029
regulation of protein metabolic process GO:0051246 81 0.029
positive regulation of epithelial cell proliferation GO:0050679 1 0.028
multicellular organism reproduction GO:0032504 819 0.028
membrane depolarization GO:0051899 1 0.028
protein modification process GO:0036211 207 0.028
neuron projection morphogenesis GO:0048812 114 0.027
tissue development GO:0009888 112 0.027
positive regulation of stem cell differentiation GO:2000738 1 0.027
response to abiotic stimulus GO:0009628 152 0.026
establishment of cell polarity GO:0030010 46 0.026
post embryonic organ development GO:0048569 336 0.026
cell migration GO:0016477 306 0.026
neurogenesis GO:0022008 236 0.026
cellular protein metabolic process GO:0044267 279 0.026
response to growth factor GO:0070848 18 0.026
cell cell signaling GO:0007267 118 0.026
generation of neurons GO:0048699 235 0.026
regulation of phosphate metabolic process GO:0019220 81 0.026
localization of cell GO:0051674 313 0.026
regulation of organelle organization GO:0033043 164 0.025
regulation of organ morphogenesis GO:2000027 4 0.025
response to wounding GO:0009611 4 0.025
Mouse
neuron development GO:0048666 199 0.025
regulation of cell morphogenesis GO:0022604 40 0.024
head development GO:0060322 1 0.024
canonical wnt signaling pathway GO:0060070 3 0.024
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.024
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.024
secretion by cell GO:0032940 138 0.023
membrane organization GO:0061024 135 0.023
cellular response to stress GO:0033554 162 0.023
cellular component movement GO:0006928 388 0.023
neuromuscular junction development GO:0007528 2 0.023
cell adhesion GO:0007155 21 0.022
female gamete generation GO:0007292 254 0.022
negative regulation of signal transduction GO:0009968 60 0.022
protein phosphorylation GO:0006468 85 0.022
intracellular receptor signaling pathway GO:0030522 2 0.022
negative regulation of cellular biosynthetic process GO:0031327 65 0.021
adult behavior GO:0030534 3 0.021
response to external biotic stimulus GO:0043207 101 0.021
synaptic growth at neuromuscular junction GO:0051124 1 0.020
establishment of mitotic spindle localization GO:0040001 41 0.020
microtubule based transport GO:0010970 19 0.020
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.020
macromolecule catabolic process GO:0009057 202 0.020
neuron projection development GO:0031175 187 0.019
regulation of mitotic cell cycle GO:0007346 76 0.019
digestive system development GO:0055123 122 0.019
negative regulation of signaling GO:0023057 61 0.019
ribosome biogenesis GO:0042254 4 0.019
multi organism reproductive behavior GO:0044705 387 0.018
cellular response to endogenous stimulus GO:0071495 32 0.018
ras protein signal transduction GO:0007265 31 0.018
positive regulation of phosphate metabolic process GO:0045937 56 0.018
regulation of cell fate specification GO:0042659 22 0.018
axon development GO:0061564 163 0.018
establishment of organelle localization GO:0051656 123 0.018
regulation of cell cycle process GO:0010564 145 0.018
reproductive behavior GO:0019098 387 0.018
negative regulation of nucleic acid templated transcription GO:1903507 53 0.018
defense response to bacterium GO:0042742 86 0.018
establishment of protein localization to membrane GO:0090150 3 0.018
axonogenesis GO:0007409 102 0.017
spindle localization GO:0051653 51 0.017
intraspecies interaction between organisms GO:0051703 3 0.017
regulation of nuclear division GO:0051783 115 0.017
regulation of bmp signaling pathway GO:0030510 3 0.017
secretion GO:0046903 147 0.017
epidermal cell fate specification GO:0009957 5 0.017
regulation of post embryonic development GO:0048580 260 0.017
negative regulation of post embryonic development GO:0048581 208 0.017
cellular catabolic process GO:0044248 199 0.017
organelle fission GO:0048285 363 0.016
nucleobase containing compound catabolic process GO:0034655 114 0.016
mitotic spindle organization GO:0007052 81 0.016
endoderm development GO:0007492 20 0.016
aromatic compound catabolic process GO:0019439 116 0.016
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.016
peptide hormone processing GO:0016486 2 0.015
regulation of phosphorylation GO:0042325 45 0.015
positive regulation of signaling GO:0023056 66 0.015
organic cyclic compound catabolic process GO:1901361 119 0.015
cell motility GO:0048870 313 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.015
regulation of molecular function GO:0065009 89 0.015
heterocycle catabolic process GO:0046700 119 0.015
cell morphogenesis involved in differentiation GO:0000904 112 0.015
posttranscriptional gene silencing GO:0016441 143 0.015
biological adhesion GO:0022610 21 0.015
positive regulation of protein transport GO:0051222 4 0.014
pigmentation GO:0043473 2 0.014
wnt signaling pathway GO:0016055 27 0.014
regulation of phosphorus metabolic process GO:0051174 81 0.014
positive regulation of catalytic activity GO:0043085 59 0.014
positive regulation of synapse assembly GO:0051965 1 0.014
posttranscriptional gene silencing by rna GO:0035194 143 0.014
negative regulation of biosynthetic process GO:0009890 65 0.014
memory GO:0007613 3 0.014
defense response to other organism GO:0098542 100 0.014
regulation of cell death GO:0010941 65 0.014
regulation of epithelial cell differentiation GO:0030856 4 0.014
regulation of cytoskeleton organization GO:0051493 41 0.014
rna processing GO:0006396 34 0.014
stress activated mapk cascade GO:0051403 10 0.014
regulation of apoptotic signaling pathway GO:2001233 1 0.013
macromolecule modification GO:0043412 218 0.013
gene silencing by rna GO:0031047 143 0.013
regulation of cell division GO:0051302 142 0.013
tube development GO:0035295 126 0.013
chromosome organization GO:0051276 104 0.013
cuticle development GO:0042335 100 0.013
phosphorylation GO:0016310 116 0.013
positive regulation of catabolic process GO:0009896 38 0.013
positive regulation of cell projection organization GO:0031346 4 0.013
positive regulation of cell cycle GO:0045787 55 0.013
cell projection organization GO:0030030 231 0.013
oviposition GO:0018991 364 0.013
regulation of protein modification process GO:0031399 46 0.013
cellular macromolecular complex assembly GO:0034622 184 0.013
neuron apoptotic process GO:0051402 4 0.012
positive regulation of transferase activity GO:0051347 21 0.012
organism emergence from protective structure GO:0071684 48 0.012
inductive cell migration GO:0040039 145 0.012
mapk cascade GO:0000165 31 0.012
cell part morphogenesis GO:0032990 152 0.012
asymmetric protein localization involved in cell fate determination GO:0045167 18 0.012
carbohydrate derivative metabolic process GO:1901135 141 0.012
regulation of lipid metabolic process GO:0019216 4 0.012
phagocytosis GO:0006909 115 0.012
regulation of gastrulation GO:0010470 4 0.012
small molecule metabolic process GO:0044281 186 0.012
regulation of nervous system development GO:0051960 41 0.012
regulation of programmed cell death GO:0043067 50 0.012
axon guidance GO:0007411 82 0.012
regulation of dna templated transcription in response to stress GO:0043620 3 0.012
multi organism behavior GO:0051705 389 0.012
cellular protein modification process GO:0006464 207 0.012
regulation of synapse assembly GO:0051963 2 0.011
negative regulation of vulval development GO:0040027 206 0.011
synaptic transmission GO:0007268 106 0.011
insulin metabolic process GO:1901142 2 0.011
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 2 0.011
mesoderm morphogenesis GO:0048332 24 0.011
regulation of cellular response to growth factor stimulus GO:0090287 11 0.011
membrane invagination GO:0010324 98 0.011
social behavior GO:0035176 3 0.011
glycosyl compound metabolic process GO:1901657 100 0.011
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.011
collagen and cuticulin based cuticle development GO:0040002 99 0.011
negative regulation of multicellular organismal process GO:0051241 236 0.011
single organism membrane organization GO:0044802 35 0.011
male sex differentiation GO:0046661 86 0.011
cellular nitrogen compound catabolic process GO:0044270 119 0.011
embryonic morphogenesis GO:0048598 152 0.011
positive regulation of protein metabolic process GO:0051247 45 0.011
establishment of protein localization GO:0045184 50 0.011
response to other organism GO:0051707 101 0.011
glycosyl compound catabolic process GO:1901658 79 0.011
response to bacterium GO:0009617 86 0.011
cytokinesis GO:0000910 80 0.011
purine nucleotide metabolic process GO:0006163 95 0.011
response to endogenous stimulus GO:0009719 33 0.010
cellular amide metabolic process GO:0043603 11 0.010
cellular response to nitrogen compound GO:1901699 24 0.010
oogenesis GO:0048477 229 0.010
rna interference GO:0016246 137 0.010
regulation of cell projection organization GO:0031344 38 0.010
male anatomical structure morphogenesis GO:0090598 78 0.010
positive regulation of cell differentiation GO:0045597 8 0.010
innate immune response GO:0045087 190 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.010

lin-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
disease of cellular proliferation DOID:14566 0 0.020
musculoskeletal system disease DOID:17 0 0.014
cancer DOID:162 0 0.013
organ system cancer DOID:0050686 0 0.013
cardiovascular system disease DOID:1287 0 0.012