Caenorhabditis elegans

45 known processes

die-1 (CELE_C18D1.1)

Protein DIE-1

die-1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2152 0.463
embryo development GO:0009790 3052 0.325
locomotion GO:0040011 1634 0.301
sex differentiation GO:0007548 909 0.291
cell motility GO:0048870 313 0.291
reproductive structure development GO:0048608 850 0.266
gonad development GO:0008406 840 0.253
regulation of multicellular organismal process GO:0051239 726 0.240
hermaphrodite genitalia development GO:0040035 734 0.236
genitalia development GO:0048806 741 0.233
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.218
regulation of primary metabolic process GO:0080090 292 0.190
regulation of metabolic process GO:0019222 478 0.166
positive regulation of growth GO:0045927 369 0.160
growth GO:0040007 562 0.144
organelle organization GO:0006996 783 0.143
regulation of macromolecule biosynthetic process GO:0010556 189 0.134
generation of neurons GO:0048699 235 0.129
protein metabolic process GO:0019538 422 0.129
embryo development ending in birth or egg hatching GO:0009792 2992 0.123
rna biosynthetic process GO:0032774 169 0.121
cellular protein metabolic process GO:0044267 279 0.120
programmed cell death GO:0012501 500 0.119
regulation of developmental growth GO:0048638 389 0.119
regulation of cellular protein metabolic process GO:0032268 75 0.115
cellular biosynthetic process GO:0044249 315 0.110
response to external stimulus GO:0009605 289 0.107
nucleic acid metabolic process GO:0090304 299 0.106
macromolecule localization GO:0033036 771 0.105
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.105
reproductive system development GO:0061458 850 0.104
neuron projection development GO:0031175 187 0.102
regulation of cellular biosynthetic process GO:0031326 189 0.100
regulation of transcription dna templated GO:0006355 164 0.097
regulation of cellular component organization GO:0051128 248 0.095
regulation of gene expression GO:0010468 366 0.095
body morphogenesis GO:0010171 620 0.093
developmental process involved in reproduction GO:0003006 1165 0.093
establishment of localization GO:0051234 1171 0.092
posttranscriptional regulation of gene expression GO:0010608 166 0.087
cellular macromolecule biosynthetic process GO:0034645 247 0.087
neuron differentiation GO:0030182 217 0.087
organic substance catabolic process GO:1901575 294 0.086
single organism organelle organization GO:1902589 501 0.085
development of primary sexual characteristics GO:0045137 840 0.085
protein localization GO:0008104 205 0.084
cell cycle GO:0007049 526 0.082
cellular component movement GO:0006928 388 0.082
cell migration GO:0016477 306 0.081
regulation of developmental process GO:0050793 684 0.081
ribonucleoprotein complex assembly GO:0022618 4 0.078
cell death GO:0008219 547 0.077
cell cycle process GO:0022402 482 0.077
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.077
transcription dna templated GO:0006351 168 0.076
cell development GO:0048468 696 0.076
multicellular organismal aging GO:0010259 812 0.076
positive regulation of multicellular organismal process GO:0051240 417 0.075
protein modification process GO:0036211 207 0.074
cellular protein modification process GO:0006464 207 0.074
death GO:0016265 547 0.073
taxis GO:0042330 128 0.073
regulation of biological quality GO:0065008 741 0.073
aging GO:0007568 812 0.071
behavior GO:0007610 527 0.071
negative regulation of gene expression GO:0010629 217 0.069
regulation of multicellular organism growth GO:0040014 373 0.069
aromatic compound biosynthetic process GO:0019438 192 0.068
nervous system development GO:0007399 253 0.068
organ development GO:0048513 1102 0.068
head development GO:0060322 1 0.067
regulation of rna metabolic process GO:0051252 173 0.067
muscle structure development GO:0061061 191 0.067
mitotic nuclear division GO:0007067 89 0.065
transport GO:0006810 1093 0.065
sensory organ morphogenesis GO:0090596 2 0.064
transcription from rna polymerase ii promoter GO:0006366 149 0.064
heterocycle biosynthetic process GO:0018130 187 0.064
sexual reproduction GO:0019953 546 0.064
gene silencing GO:0016458 143 0.063
negative regulation of macromolecule metabolic process GO:0010605 229 0.063
rna metabolic process GO:0016070 228 0.063
positive regulation of multicellular organism growth GO:0040018 352 0.062
neuron development GO:0048666 199 0.062
maintenance of location GO:0051235 580 0.061
biosynthetic process GO:0009058 323 0.061
gene expression GO:0010467 412 0.060
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.060
establishment of spindle localization GO:0051293 51 0.059
establishment of localization in cell GO:0051649 318 0.058
lipid storage GO:0019915 565 0.058
regulation of growth GO:0040008 409 0.058
neurogenesis GO:0022008 236 0.058
catabolic process GO:0009056 318 0.057
organic cyclic compound biosynthetic process GO:1901362 195 0.057
regulation of neuron projection development GO:0010975 31 0.056
regulation of cellular metabolic process GO:0031323 305 0.056
lipid localization GO:0010876 573 0.056
developmental growth GO:0048589 412 0.055
apoptotic process GO:0006915 478 0.054
digestive system development GO:0055123 122 0.054
nucleobase containing compound biosynthetic process GO:0034654 184 0.053
positive regulation of developmental growth GO:0048639 354 0.052
multi organism reproductive process GO:0044703 867 0.052
intracellular receptor signaling pathway GO:0030522 2 0.052
response to chemical GO:0042221 356 0.052
asymmetric protein localization GO:0008105 35 0.052
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.051
regulation of biosynthetic process GO:0009889 189 0.051
cell projection organization GO:0030030 231 0.050
positive regulation of cellular process GO:0048522 332 0.050
regulation of gene expression epigenetic GO:0040029 163 0.049
regulation of nucleic acid templated transcription GO:1903506 165 0.049
cell division GO:0051301 262 0.049
macromolecule biosynthetic process GO:0009059 250 0.048
posttranscriptional gene silencing by rna GO:0035194 143 0.048
gamete generation GO:0007276 461 0.047
macromolecular complex subunit organization GO:0043933 320 0.047
single organism reproductive process GO:0044702 1196 0.047
negative regulation of gene expression epigenetic GO:0045814 2 0.047
localization of cell GO:0051674 313 0.047
striated muscle cell differentiation GO:0051146 158 0.046
multicellular organism growth GO:0035264 385 0.046
chemotaxis GO:0006935 120 0.046
determination of adult lifespan GO:0008340 812 0.045
signaling GO:0023052 401 0.045
cellular localization GO:0051641 360 0.045
digestive tract development GO:0048565 122 0.045
regulation of organelle organization GO:0033043 164 0.044
multicellular organismal reproductive process GO:0048609 815 0.044
vesicle mediated transport GO:0016192 852 0.043
chromosome organization GO:0051276 104 0.043
single organism transport GO:0044765 447 0.042
nucleic acid templated transcription GO:0097659 169 0.042
cellular catabolic process GO:0044248 199 0.042
muscle cell differentiation GO:0042692 171 0.042
negative regulation of metabolic process GO:0009892 240 0.042
regulation of nematode larval development GO:0061062 260 0.041
single organism localization GO:1902578 518 0.041
neuron recognition GO:0008038 83 0.041
posttranscriptional gene silencing GO:0016441 143 0.041
multicellular organism reproduction GO:0032504 819 0.041
positive regulation of macromolecule metabolic process GO:0010604 149 0.040
cellular component assembly GO:0022607 293 0.040
positive regulation of developmental process GO:0051094 408 0.039
axonogenesis GO:0007409 102 0.039
establishment of organelle localization GO:0051656 123 0.038
regulation of cell differentiation GO:0045595 81 0.038
regulation of protein metabolic process GO:0051246 81 0.037
protein complex subunit organization GO:0071822 280 0.037
protein phosphorylation GO:0006468 85 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.036
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.036
negative regulation of cellular biosynthetic process GO:0031327 65 0.035
negative regulation of biological process GO:0048519 567 0.035
axon guidance GO:0007411 82 0.034
nucleobase containing compound metabolic process GO:0006139 406 0.034
negative regulation of biosynthetic process GO:0009890 65 0.034
regulation of macromolecule metabolic process GO:0060255 421 0.033
regulation of rna biosynthetic process GO:2001141 165 0.033
molting cycle GO:0042303 281 0.033
endocytosis GO:0006897 819 0.033
axon development GO:0061564 163 0.032
negative regulation of cellular metabolic process GO:0031324 95 0.031
negative regulation of rna biosynthetic process GO:1902679 53 0.031
positive regulation of cellular metabolic process GO:0031325 178 0.031
ribose phosphate metabolic process GO:0019693 99 0.031
cell fate commitment GO:0045165 139 0.031
response to biotic stimulus GO:0009607 101 0.031
rho protein signal transduction GO:0007266 2 0.031
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.030
negative regulation of cellular process GO:0048523 239 0.030
adult behavior GO:0030534 3 0.030
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.029
rna interference GO:0016246 137 0.029
regulation of cell communication GO:0010646 176 0.029
cellular component biogenesis GO:0044085 297 0.029
organic substance biosynthetic process GO:1901576 323 0.029
positive regulation of phosphorus metabolic process GO:0010562 56 0.029
aromatic compound catabolic process GO:0019439 116 0.028
carboxylic acid metabolic process GO:0019752 34 0.028
regulation of post embryonic development GO:0048580 260 0.027
signal transduction GO:0007165 317 0.027
olfactory behavior GO:0042048 27 0.027
purine ribonucleoside catabolic process GO:0046130 75 0.027
regulation of multicellular organismal development GO:2000026 317 0.027
cellular nitrogen compound biosynthetic process GO:0044271 192 0.026
positive regulation of metabolic process GO:0009893 187 0.026
single organism signaling GO:0044700 401 0.026
positive regulation of rna biosynthetic process GO:1902680 102 0.026
purine ribonucleotide catabolic process GO:0009154 75 0.026
negative regulation of nucleic acid templated transcription GO:1903507 53 0.025
organelle assembly GO:0070925 214 0.025
cell proliferation GO:0008283 116 0.025
organic cyclic compound catabolic process GO:1901361 119 0.025
multi organism behavior GO:0051705 389 0.025
muscle cell development GO:0055001 158 0.024
cell growth GO:0016049 44 0.024
cell morphogenesis involved in differentiation GO:0000904 112 0.024
multi organism reproductive behavior GO:0044705 387 0.024
regulation of mitotic cell cycle GO:0007346 76 0.024
positive regulation of cell communication GO:0010647 69 0.024
mrna metabolic process GO:0016071 31 0.024
mitotic cell cycle process GO:1903047 194 0.024
negative regulation of transcription dna templated GO:0045892 53 0.023
cytoskeleton organization GO:0007010 339 0.023
reproductive behavior GO:0019098 387 0.023
positive regulation of axonogenesis GO:0050772 4 0.023
negative regulation of developmental process GO:0051093 227 0.023
macromolecular complex assembly GO:0065003 193 0.023
purine nucleoside triphosphate catabolic process GO:0009146 72 0.023
negative regulation of rna metabolic process GO:0051253 53 0.023
carbohydrate derivative metabolic process GO:1901135 141 0.022
embryonic morphogenesis GO:0048598 152 0.022
spindle localization GO:0051653 51 0.022
regulation of nitrogen compound metabolic process GO:0051171 222 0.022
secretion by cell GO:0032940 138 0.021
single organism catabolic process GO:0044712 129 0.021
organelle localization GO:0051640 127 0.021
organelle fission GO:0048285 363 0.021
positive regulation of phosphate metabolic process GO:0045937 56 0.021
dosage compensation by hypoactivation of x chromosome GO:0042464 11 0.021
striated muscle cell development GO:0055002 157 0.021
positive regulation of transcription dna templated GO:0045893 102 0.021
muscle tissue development GO:0060537 1 0.021
guanosine containing compound metabolic process GO:1901068 49 0.021
single organism behavior GO:0044708 83 0.021
positive regulation of neuron projection development GO:0010976 4 0.021
ras protein signal transduction GO:0007265 31 0.020
cell recognition GO:0008037 85 0.020
cell part morphogenesis GO:0032990 152 0.020
phosphate containing compound metabolic process GO:0006796 232 0.020
cellular macromolecular complex assembly GO:0034622 184 0.020
negative regulation of multicellular organismal process GO:0051241 236 0.020
negative regulation of vulval development GO:0040027 206 0.020
regulation of neurogenesis GO:0050767 40 0.019
oxoacid metabolic process GO:0043436 47 0.019
negative regulation of locomotion GO:0040013 21 0.019
multi multicellular organism process GO:0044706 390 0.019
regulation of cellular component movement GO:0051270 62 0.018
cell morphogenesis GO:0000902 163 0.018
mapk cascade GO:0000165 31 0.018
regulation of cell cycle GO:0051726 194 0.018
cellular component morphogenesis GO:0032989 318 0.018
neuron projection guidance GO:0097485 82 0.018
defense response to other organism GO:0098542 100 0.018
axonal fasciculation GO:0007413 79 0.018
macromolecule catabolic process GO:0009057 202 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.017
meiotic cell cycle GO:0051321 335 0.017
regulation of cell cycle process GO:0010564 145 0.017
gastrulation GO:0007369 58 0.017
phagocytosis GO:0006909 115 0.017
cellular amino acid metabolic process GO:0006520 15 0.017
purine nucleotide metabolic process GO:0006163 95 0.017
oogenesis GO:0048477 229 0.017
immune response GO:0006955 192 0.017
heterocycle catabolic process GO:0046700 119 0.016
response to wounding GO:0009611 4 0.016
membrane organization GO:0061024 135 0.016
cellular macromolecule catabolic process GO:0044265 73 0.016
germ cell development GO:0007281 351 0.016
ribonucleotide catabolic process GO:0009261 75 0.016
multicellular organismal reproductive behavior GO:0033057 384 0.016
tube morphogenesis GO:0035239 79 0.016
cellular nitrogen compound catabolic process GO:0044270 119 0.016
oviposition GO:0018991 364 0.016
organic acid metabolic process GO:0006082 47 0.016
regulation of localization GO:0032879 194 0.016
cuticle development GO:0042335 100 0.015
microtubule based process GO:0007017 182 0.015
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 8 0.015
mrna processing GO:0006397 13 0.015
regulation of cytoplasmic mrna processing body assembly GO:0010603 1 0.015
response to bacterium GO:0009617 86 0.015
regulation of epithelial cell differentiation GO:0030856 4 0.015
cellular ketone metabolic process GO:0042180 14 0.015
modification dependent protein catabolic process GO:0019941 32 0.015
negative regulation of neurogenesis GO:0050768 4 0.014
guanosine containing compound catabolic process GO:1901069 48 0.014
canonical wnt signaling pathway GO:0060070 3 0.014
carbohydrate derivative catabolic process GO:1901136 82 0.014
positive regulation of catalytic activity GO:0043085 59 0.014
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.014
hormone transport GO:0009914 2 0.014
nucleoside triphosphate catabolic process GO:0009143 72 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
intracellular signal transduction GO:0035556 96 0.014
defense response GO:0006952 296 0.014
small molecule metabolic process GO:0044281 186 0.014
regulation of intracellular signal transduction GO:1902531 77 0.014
gene silencing by rna GO:0031047 143 0.014
regulation of jun kinase activity GO:0043506 3 0.014
ribonucleoside catabolic process GO:0042454 77 0.014
regulation of cellular catabolic process GO:0031329 51 0.014
regulation of signaling GO:0023051 172 0.014
rna splicing via transesterification reactions GO:0000375 8 0.014
positive regulation of cell cycle GO:0045787 55 0.013
cellular response to stress GO:0033554 162 0.013
tube development GO:0035295 126 0.013
purine containing compound metabolic process GO:0072521 95 0.013
epithelium development GO:0060429 68 0.013
ribonucleoside triphosphate catabolic process GO:0009203 72 0.013
digestive tract morphogenesis GO:0048546 76 0.013
myosin filament organization GO:0031033 138 0.013
macromolecule modification GO:0043412 218 0.013
anatomical structure formation involved in morphogenesis GO:0048646 250 0.013
vulval development GO:0040025 333 0.013
regulation of cell motility GO:2000145 57 0.013
collagen and cuticulin based cuticle development GO:0040002 99 0.013
cellular protein catabolic process GO:0044257 37 0.013
regulation of phosphate metabolic process GO:0019220 81 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.013
response to external biotic stimulus GO:0043207 101 0.013
proteolysis GO:0006508 61 0.012
protein complex assembly GO:0006461 186 0.012
cell type specific apoptotic process GO:0097285 4 0.012
regulation of apoptotic signaling pathway GO:2001233 1 0.012
nucleobase containing compound catabolic process GO:0034655 114 0.012
regulation of catalytic activity GO:0050790 78 0.012
phosphorylation GO:0016310 116 0.012
mrna catabolic process GO:0006402 16 0.012
organonitrogen compound metabolic process GO:1901564 151 0.012
neuron projection morphogenesis GO:0048812 114 0.012
regulation of response to stimulus GO:0048583 243 0.012
sex determination GO:0007530 60 0.012
locomotory behavior GO:0007626 40 0.012
negative regulation of signal transduction GO:0009968 60 0.012
cellular component assembly involved in morphogenesis GO:0010927 183 0.012
positive regulation of neurogenesis GO:0050769 4 0.012
striated muscle myosin thick filament assembly GO:0071688 138 0.012
post embryonic organ development GO:0048569 336 0.012
cellular response to unfolded protein GO:0034620 71 0.012
positive regulation of neuron differentiation GO:0045666 4 0.012
positive regulation of response to stimulus GO:0048584 55 0.012
receptor mediated endocytosis GO:0006898 715 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.012
nucleoside triphosphate metabolic process GO:0009141 87 0.011
purine ribonucleotide metabolic process GO:0009150 95 0.011
inductive cell migration GO:0040039 145 0.011
purine containing compound catabolic process GO:0072523 75 0.011
purine nucleoside catabolic process GO:0006152 75 0.011
spindle organization GO:0007051 92 0.011
chemosensory behavior GO:0007635 33 0.011
cellular amine metabolic process GO:0044106 15 0.011
pre mirna processing GO:0031054 3 0.011
organ morphogenesis GO:0009887 67 0.011
meiotic nuclear division GO:0007126 300 0.011
rna localization GO:0006403 3 0.011
positive regulation of chromosome organization GO:2001252 2 0.011
positive regulation of protein modification process GO:0031401 29 0.011
regulation of vulval development GO:0040028 248 0.011
enzyme linked receptor protein signaling pathway GO:0007167 50 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
nucleoside catabolic process GO:0009164 78 0.010
gtp catabolic process GO:0006184 46 0.010
regulation of purine nucleotide catabolic process GO:0033121 35 0.010
ribonucleotide metabolic process GO:0009259 99 0.010
apoptotic cell clearance GO:0043277 111 0.010
regulation of transcription from rna polymerase ii promoter in response to salt stress GO:0061416 1 0.010
muscle fiber development GO:0048747 2 0.010
response to abiotic stimulus GO:0009628 152 0.010
glycosyl compound catabolic process GO:1901658 79 0.010
meiotic chromosome segregation GO:0045132 139 0.010

die-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.010
nervous system disease DOID:863 0 0.010