Caenorhabditis elegans

159 known processes

mdf-2 (CELE_Y69A2AR.30)

Protein MDF-2

mdf-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
developmental process involved in reproduction GO:0003006 1165 0.935
gene expression GO:0010467 412 0.843
regulation of macromolecule metabolic process GO:0060255 421 0.832
single organism reproductive process GO:0044702 1196 0.790
embryo development ending in birth or egg hatching GO:0009792 2992 0.768
mitotic sister chromatid segregation GO:0000070 38 0.745
regulation of gene expression GO:0010468 366 0.710
sexual reproduction GO:0019953 546 0.681
reproductive structure development GO:0048608 850 0.675
gamete generation GO:0007276 461 0.666
regulation of metabolic process GO:0019222 478 0.655
development of primary sexual characteristics GO:0045137 840 0.585
regulation of primary metabolic process GO:0080090 292 0.570
reproductive system development GO:0061458 850 0.568
rna metabolic process GO:0016070 228 0.539
negative regulation of macromolecule metabolic process GO:0010605 229 0.539
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.535
gonad development GO:0008406 840 0.523
cell division GO:0051301 262 0.419
regulation of cellular biosynthetic process GO:0031326 189 0.407
embryo development GO:0009790 3052 0.405
post embryonic development GO:0009791 2152 0.403
cell cycle GO:0007049 526 0.396
regulation of developmental process GO:0050793 684 0.361
positive regulation of biosynthetic process GO:0009891 109 0.358
regulation of rna biosynthetic process GO:2001141 165 0.351
nucleic acid templated transcription GO:0097659 169 0.348
macromolecule modification GO:0043412 218 0.342
Human
regulation of gene expression epigenetic GO:0040029 163 0.339
regulation of macromolecule biosynthetic process GO:0010556 189 0.335
negative regulation of biological process GO:0048519 567 0.329
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.306
negative regulation of metabolic process GO:0009892 240 0.289
heterocycle biosynthetic process GO:0018130 187 0.284
organ development GO:0048513 1102 0.270
locomotion GO:0040011 1634 0.268
establishment of localization GO:0051234 1171 0.263
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.262
organelle organization GO:0006996 783 0.262
organic cyclic compound biosynthetic process GO:1901362 195 0.261
biosynthetic process GO:0009058 323 0.259
nucleic acid metabolic process GO:0090304 299 0.256
nucleobase containing compound biosynthetic process GO:0034654 184 0.254
multicellular organismal reproductive process GO:0048609 815 0.251
regulation of multicellular organismal process GO:0051239 726 0.250
endocytosis GO:0006897 819 0.242
localization of cell GO:0051674 313 0.241
germ cell development GO:0007281 351 0.240
sex differentiation GO:0007548 909 0.238
female gamete generation GO:0007292 254 0.228
aromatic compound biosynthetic process GO:0019438 192 0.215
genitalia development GO:0048806 741 0.210
positive regulation of macromolecule metabolic process GO:0010604 149 0.206
positive regulation of cellular process GO:0048522 332 0.204
Human Mouse
cellular nitrogen compound biosynthetic process GO:0044271 192 0.203
positive regulation of gene expression GO:0010628 112 0.202
receptor mediated endocytosis GO:0006898 715 0.200
regulation of protein metabolic process GO:0051246 81 0.193
multicellular organism reproduction GO:0032504 819 0.191
negative regulation of gene expression GO:0010629 217 0.186
cellular protein catabolic process GO:0044257 37 0.180
cell cycle process GO:0022402 482 0.177
positive regulation of cellular metabolic process GO:0031325 178 0.176
mitotic nuclear division GO:0007067 89 0.174
modification dependent macromolecule catabolic process GO:0043632 32 0.169
regulation of post embryonic development GO:0048580 260 0.167
regulation of biosynthetic process GO:0009889 189 0.161
positive regulation of nucleic acid templated transcription GO:1903508 102 0.157
cellular biosynthetic process GO:0044249 315 0.157
transcription from rna polymerase ii promoter GO:0006366 149 0.157
protein modification process GO:0036211 207 0.156
Human
regulation of nucleic acid templated transcription GO:1903506 165 0.155
regulation of cell cycle GO:0051726 194 0.154
cytokinesis GO:0000910 80 0.154
protein catabolic process GO:0030163 162 0.153
transcription dna templated GO:0006351 168 0.152
positive regulation of metabolic process GO:0009893 187 0.149
cellular protein modification process GO:0006464 207 0.148
Human
positive regulation of rna biosynthetic process GO:1902680 102 0.143
modification dependent protein catabolic process GO:0019941 32 0.140
single organism organelle organization GO:1902589 501 0.138
macromolecular complex subunit organization GO:0043933 320 0.136
gene silencing GO:0016458 143 0.135
meiotic cell cycle process GO:1903046 170 0.130
hermaphrodite genitalia development GO:0040035 734 0.127
vesicle mediated transport GO:0016192 852 0.126
positive regulation of cellular biosynthetic process GO:0031328 109 0.125
post embryonic organ development GO:0048569 336 0.120
single organism localization GO:1902578 518 0.118
multicellular organism growth GO:0035264 385 0.118
regulation of cellular metabolic process GO:0031323 305 0.117
regulation of transcription dna templated GO:0006355 164 0.116
secretion GO:0046903 147 0.116
negative regulation of vulval development GO:0040027 206 0.114
macromolecule catabolic process GO:0009057 202 0.114
vulval development GO:0040025 333 0.114
macromolecule localization GO:0033036 771 0.110
cellular localization GO:0051641 360 0.108
protein phosphorylation GO:0006468 85 0.106
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 20 0.106
cellular macromolecule biosynthetic process GO:0034645 247 0.101
posttranscriptional regulation of gene expression GO:0010608 166 0.100
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.100
transport GO:0006810 1093 0.098
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 5 0.098
sister chromatid segregation GO:0000819 46 0.097
regulation of rna metabolic process GO:0051252 173 0.093
protein metabolic process GO:0019538 422 0.092
secretion by cell GO:0032940 138 0.090
negative regulation of cellular process GO:0048523 239 0.090
regulation of cell cycle process GO:0010564 145 0.088
organelle fission GO:0048285 363 0.086
regulation of biological quality GO:0065008 741 0.085
death GO:0016265 547 0.085
Human Mouse
macromolecular complex assembly GO:0065003 193 0.084
regulation of growth GO:0040008 409 0.083
oviposition GO:0018991 364 0.083
cell death GO:0008219 547 0.083
Human Mouse
organic substance biosynthetic process GO:1901576 323 0.082
negative regulation of biosynthetic process GO:0009890 65 0.081
positive regulation of nematode larval development GO:0061063 54 0.080
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.080
phosphorylation GO:0016310 116 0.078
rna biosynthetic process GO:0032774 169 0.077
positive regulation of transcription dna templated GO:0045893 102 0.072
spindle organization GO:0007051 92 0.071
multicellular organismal aging GO:0010259 812 0.069
cellular macromolecular complex assembly GO:0034622 184 0.069
regulation of cellular protein metabolic process GO:0032268 75 0.068
maintenance of location GO:0051235 580 0.068
nucleobase containing compound metabolic process GO:0006139 406 0.068
determination of adult lifespan GO:0008340 812 0.067
cellular component assembly GO:0022607 293 0.066
meiotic cell cycle GO:0051321 335 0.064
lipid storage GO:0019915 565 0.063
negative regulation of multicellular organismal process GO:0051241 236 0.062
regulation of nuclear division GO:0051783 115 0.062
posttranscriptional gene silencing by rna GO:0035194 143 0.060
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.057
cellular component biogenesis GO:0044085 297 0.056
meiotic nuclear division GO:0007126 300 0.054
regulation of phosphorus metabolic process GO:0051174 81 0.053
posttranscriptional gene silencing GO:0016441 143 0.053
macromolecule biosynthetic process GO:0009059 250 0.052
cytoskeleton dependent cytokinesis GO:0061640 35 0.052
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.052
protein complex subunit organization GO:0071822 280 0.052
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.051
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.050
positive regulation of multicellular organismal process GO:0051240 417 0.050
regulation of vulval development GO:0040028 248 0.050
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.049
microtubule cytoskeleton organization involved in mitosis GO:1902850 12 0.049
phosphate containing compound metabolic process GO:0006796 232 0.049
tissue development GO:0009888 112 0.049
dna metabolic process GO:0006259 74 0.048
lipid localization GO:0010876 573 0.048
multi organism reproductive process GO:0044703 867 0.048
establishment of localization in cell GO:0051649 318 0.047
regulation of multicellular organism growth GO:0040014 373 0.046
cell migration GO:0016477 306 0.046
negative regulation of post embryonic development GO:0048581 208 0.044
proteolysis GO:0006508 61 0.044
response to external stimulus GO:0009605 289 0.043
positive regulation of rna metabolic process GO:0051254 103 0.043
mitotic spindle organization GO:0007052 81 0.043
organic substance catabolic process GO:1901575 294 0.043
cell development GO:0048468 696 0.042
regulation of developmental growth GO:0048638 389 0.042
organelle assembly GO:0070925 214 0.042
regulation of nematode larval development GO:0061062 260 0.041
proteolysis involved in cellular protein catabolic process GO:0051603 32 0.041
cellular component morphogenesis GO:0032989 318 0.040
aging GO:0007568 812 0.040
system process GO:0003008 136 0.039
rna interference GO:0016246 137 0.039
transcription initiation from rna polymerase ii promoter GO:0006367 2 0.039
cellular protein metabolic process GO:0044267 279 0.039
regulation of nitrogen compound metabolic process GO:0051171 222 0.039
proteasomal protein catabolic process GO:0010498 20 0.038
body morphogenesis GO:0010171 620 0.037
mitotic cell cycle process GO:1903047 194 0.037
cellular component movement GO:0006928 388 0.036
cellular response to stress GO:0033554 162 0.036
neuron projection development GO:0031175 187 0.036
cytoskeleton organization GO:0007010 339 0.035
cell motility GO:0048870 313 0.034
multicellular organismal reproductive behavior GO:0033057 384 0.034
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.034
anatomical structure formation involved in morphogenesis GO:0048646 250 0.033
oogenesis GO:0048477 229 0.033
gene silencing by rna GO:0031047 143 0.033
multi organism behavior GO:0051705 389 0.032
negative regulation of nucleic acid templated transcription GO:1903507 53 0.031
chromosome organization GO:0051276 104 0.031
phosphorus metabolic process GO:0006793 232 0.031
nervous system development GO:0007399 253 0.031
negative regulation of cellular biosynthetic process GO:0031327 65 0.030
regulation of multicellular organismal development GO:2000026 317 0.030
ubiquitin dependent protein catabolic process GO:0006511 32 0.030
single organism cellular localization GO:1902580 72 0.030
microtubule based process GO:0007017 182 0.030
behavior GO:0007610 527 0.030
pattern specification process GO:0007389 59 0.029
programmed cell death GO:0012501 500 0.029
Human Mouse
internal peptidyl lysine acetylation GO:0018393 3 0.028
negative regulation of cellular metabolic process GO:0031324 95 0.028
positive regulation of multicellular organism growth GO:0040018 352 0.027
embryonic morphogenesis GO:0048598 152 0.027
negative regulation of developmental process GO:0051093 227 0.027
dna templated transcription elongation GO:0006354 1 0.027
dna templated transcription initiation GO:0006352 3 0.027
cell morphogenesis GO:0000902 163 0.026
nucleus organization GO:0006997 38 0.026
single organism transport GO:0044765 447 0.026
regulation of cell division GO:0051302 142 0.026
muscle structure development GO:0061061 191 0.026
multi organism reproductive behavior GO:0044705 387 0.025
negative regulation of transcription dna templated GO:0045892 53 0.025
positive regulation of developmental process GO:0051094 408 0.025
dna conformation change GO:0071103 11 0.025
positive regulation of growth GO:0045927 369 0.024
axon development GO:0061564 163 0.024
membrane organization GO:0061024 135 0.024
multi multicellular organism process GO:0044706 390 0.024
developmental growth GO:0048589 412 0.024
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.023
protein complex assembly GO:0006461 186 0.023
regulation of meiosis GO:0040020 94 0.023
apoptotic cell clearance GO:0043277 111 0.023
histone modification GO:0016570 30 0.022
positive regulation of chromosome segregation GO:0051984 1 0.022
positive regulation of cellular protein catabolic process GO:1903364 3 0.022
regulation of cellular component organization GO:0051128 248 0.021
cellular protein complex assembly GO:0043623 178 0.021
oocyte differentiation GO:0009994 45 0.021
regulation of mitotic cell cycle GO:0007346 76 0.021
negative regulation of nematode larval development GO:0061064 208 0.021
cell projection organization GO:0030030 231 0.021
molting cycle GO:0042303 281 0.021
peptidyl amino acid modification GO:0018193 58 0.020
peptidyl lysine acetylation GO:0018394 3 0.020
positive regulation of developmental growth GO:0048639 354 0.019
mitotic cell cycle phase transition GO:0044772 13 0.019
cellular macromolecule catabolic process GO:0044265 73 0.019
negative regulation of response to stimulus GO:0048585 73 0.018
cell cell signaling GO:0007267 118 0.018
actin filament based process GO:0030029 191 0.018
apoptotic process GO:0006915 478 0.018
Human Mouse
generation of neurons GO:0048699 235 0.018
cell cycle phase transition GO:0044770 19 0.018
cellular catabolic process GO:0044248 199 0.017
striated muscle myosin thick filament assembly GO:0071688 138 0.017
neurogenesis GO:0022008 236 0.017
protein localization GO:0008104 205 0.017
positive regulation of vulval development GO:0040026 52 0.016
protein dna complex assembly GO:0065004 7 0.016
chromatin organization GO:0006325 32 0.016
pronuclear migration GO:0035046 51 0.016
regulation of intracellular signal transduction GO:1902531 77 0.016
tube morphogenesis GO:0035239 79 0.016
regulation of canonical wnt signaling pathway GO:0060828 1 0.015
negative regulation of signal transduction GO:0009968 60 0.015
positive regulation of proteasomal protein catabolic process GO:1901800 1 0.015
metaphase anaphase transition of mitotic cell cycle GO:0007091 10 0.015
covalent chromatin modification GO:0016569 30 0.015
reproductive behavior GO:0019098 387 0.015
regulation of cell differentiation GO:0045595 81 0.014
regulation of protein stability GO:0031647 3 0.014
regulation of organelle organization GO:0033043 164 0.014
protein complex biogenesis GO:0070271 186 0.014
hatching GO:0035188 48 0.014
regulation of meiotic cell cycle GO:0051445 136 0.014
positive regulation of post embryonic development GO:0048582 54 0.013
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 2 0.013
g1 s transition of mitotic cell cycle GO:0000082 2 0.013
chemotaxis GO:0006935 120 0.013
negative regulation of cell communication GO:0010648 61 0.013
cell fate commitment GO:0045165 139 0.013
fertilization GO:0009566 63 0.013
internal protein amino acid acetylation GO:0006475 3 0.013
growth GO:0040007 562 0.013
neuron differentiation GO:0030182 217 0.012
response to wounding GO:0009611 4 0.012
response to chemical GO:0042221 356 0.012
spindle checkpoint GO:0031577 4 0.012
spermatogenesis GO:0007283 41 0.012
cell cycle g1 s phase transition GO:0044843 2 0.012
positive regulation of chromosome organization GO:2001252 2 0.012
cell maturation GO:0048469 26 0.012
lateral inhibition GO:0046331 3 0.011
regulation of chromosome segregation GO:0051983 20 0.011
adult behavior GO:0030534 3 0.011
negative regulation of signaling GO:0023057 61 0.011
cellular component assembly involved in morphogenesis GO:0010927 183 0.011
single organism biosynthetic process GO:0044711 91 0.011
nematode male tail tip morphogenesis GO:0045138 77 0.011
meiosis i GO:0007127 19 0.011
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.011
chromosome separation GO:0051304 19 0.011
regulation of multi organism process GO:0043900 69 0.011
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 1 0.011
negative regulation of rna biosynthetic process GO:1902679 53 0.010
regulation of signal transduction GO:0009966 135 0.010
oocyte development GO:0048599 44 0.010

mdf-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
gastrointestinal system cancer DOID:3119 0 0.020
cancer DOID:162 0 0.020
disease of cellular proliferation DOID:14566 0 0.020
organ system cancer DOID:0050686 0 0.020
disease of anatomical entity DOID:7 0 0.010