Caenorhabditis elegans

127 known processes

sma-3 (CELE_R13F6.9)

Protein SMA-3

sma-3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development GO:0009790 3052 0.788
multicellular organismal reproductive process GO:0048609 815 0.737
Worm
developmental process involved in reproduction GO:0003006 1165 0.644
multicellular organism reproduction GO:0032504 819 0.589
Worm
positive regulation of transcription dna templated GO:0045893 102 0.470
embryo development ending in birth or egg hatching GO:0009792 2992 0.455
organ development GO:0048513 1102 0.417
Worm
gamete generation GO:0007276 461 0.410
positive regulation of cellular metabolic process GO:0031325 178 0.387
positive regulation of nucleic acid templated transcription GO:1903508 102 0.386
positive regulation of rna metabolic process GO:0051254 103 0.378
single organism reproductive process GO:0044702 1196 0.368
sexual reproduction GO:0019953 546 0.303
positive regulation of rna biosynthetic process GO:1902680 102 0.297
post embryonic development GO:0009791 2152 0.284
regulation of macromolecule metabolic process GO:0060255 421 0.276
positive regulation of macromolecule metabolic process GO:0010604 149 0.263
germ cell development GO:0007281 351 0.263
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.259
growth GO:0040007 562 0.258
sex differentiation GO:0007548 909 0.224
biosynthetic process GO:0009058 323 0.221
cell development GO:0048468 696 0.216
locomotion GO:0040011 1634 0.215
Worm
cellular biosynthetic process GO:0044249 315 0.211
cellular response to organic substance GO:0071310 119 0.210
hermaphrodite genitalia development GO:0040035 734 0.205
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.204
development of primary sexual characteristics GO:0045137 840 0.196
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.194
establishment of localization GO:0051234 1171 0.193
regulation of cellular metabolic process GO:0031323 305 0.192
reproductive structure development GO:0048608 850 0.189
positive regulation of gene expression GO:0010628 112 0.187
genitalia development GO:0048806 741 0.181
multicellular organismal aging GO:0010259 812 0.175
transport GO:0006810 1093 0.164
determination of adult lifespan GO:0008340 812 0.164
cell cycle GO:0007049 526 0.158
Worm
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.156
positive regulation of biosynthetic process GO:0009891 109 0.155
body morphogenesis GO:0010171 620 0.154
Worm
transcription from rna polymerase ii promoter GO:0006366 149 0.154
transcription dna templated GO:0006351 168 0.150
response to organic substance GO:0010033 131 0.149
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.145
macromolecule localization GO:0033036 771 0.140
regulation of biosynthetic process GO:0009889 189 0.138
single organism transport GO:0044765 447 0.137
regulation of nitrogen compound metabolic process GO:0051171 222 0.135
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.132
regulation of gene expression GO:0010468 366 0.129
cellular localization GO:0051641 360 0.129
negative regulation of biological process GO:0048519 567 0.125
Worm
organic substance biosynthetic process GO:1901576 323 0.123
regulation of metabolic process GO:0019222 478 0.122
regulation of macromolecule biosynthetic process GO:0010556 189 0.121
gonad development GO:0008406 840 0.120
single organism localization GO:1902578 518 0.119
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.119
organelle organization GO:0006996 783 0.117
death GO:0016265 547 0.115
oogenesis GO:0048477 229 0.114
cell morphogenesis GO:0000902 163 0.113
reproductive system development GO:0061458 850 0.110
phosphorus metabolic process GO:0006793 232 0.109
response to chemical GO:0042221 356 0.109
nucleic acid templated transcription GO:0097659 169 0.108
positive regulation of metabolic process GO:0009893 187 0.107
aging GO:0007568 812 0.106
female gamete generation GO:0007292 254 0.105
regulation of rna metabolic process GO:0051252 173 0.104
regulation of nucleic acid templated transcription GO:1903506 165 0.103
positive regulation of organ growth GO:0046622 4 0.103
positive regulation of epithelial cell proliferation GO:0050679 1 0.101
cell fate commitment GO:0045165 139 0.101
meiotic cell cycle GO:0051321 335 0.099
Worm
neurogenesis GO:0022008 236 0.099
regulation of cell cycle GO:0051726 194 0.098
Worm
organic cyclic compound biosynthetic process GO:1901362 195 0.098
developmental growth GO:0048589 412 0.093
gene expression GO:0010467 412 0.089
macromolecular complex subunit organization GO:0043933 320 0.087
lipid localization GO:0010876 573 0.087
regulation of biological quality GO:0065008 741 0.087
multi organism reproductive process GO:0044703 867 0.086
Worm
muscle structure development GO:0061061 191 0.085
lipid storage GO:0019915 565 0.084
neuron projection development GO:0031175 187 0.081
establishment of localization in cell GO:0051649 318 0.080
cellular macromolecule biosynthetic process GO:0034645 247 0.079
negative regulation of biosynthetic process GO:0009890 65 0.079
Worm
cellular nitrogen compound biosynthetic process GO:0044271 192 0.078
positive regulation of multicellular organism growth GO:0040018 352 0.078
maintenance of location GO:0051235 580 0.077
vulval development GO:0040025 333 0.076
Worm
positive regulation of developmental growth GO:0048639 354 0.076
nucleobase containing compound metabolic process GO:0006139 406 0.076
multicellular organismal reproductive behavior GO:0033057 384 0.075
Worm
regulation of developmental process GO:0050793 684 0.073
positive regulation of cellular biosynthetic process GO:0031328 109 0.072
negative regulation of cellular protein metabolic process GO:0032269 27 0.072
organic substance catabolic process GO:1901575 294 0.072
Worm
intraspecies interaction between organisms GO:0051703 3 0.070
Worm
regulation of primary metabolic process GO:0080090 292 0.070
anatomical structure formation involved in morphogenesis GO:0048646 250 0.066
aromatic compound biosynthetic process GO:0019438 192 0.066
regulation of multicellular organismal process GO:0051239 726 0.065
multicellular organism growth GO:0035264 385 0.065
single organism signaling GO:0044700 401 0.064
membrane organization GO:0061024 135 0.064
single organism biosynthetic process GO:0044711 91 0.064
regulation of developmental growth GO:0048638 389 0.062
signal transduction GO:0007165 317 0.062
signaling GO:0023052 401 0.061
cellular nitrogen compound catabolic process GO:0044270 119 0.061
regulation of organ morphogenesis GO:2000027 4 0.061
oxoacid metabolic process GO:0043436 47 0.061
cellular response to chemical stimulus GO:0070887 129 0.059
nucleobase containing compound biosynthetic process GO:0034654 184 0.059
small molecule metabolic process GO:0044281 186 0.059
regulation of rna biosynthetic process GO:2001141 165 0.058
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.058
heterocycle biosynthetic process GO:0018130 187 0.058
regulation of cellular biosynthetic process GO:0031326 189 0.058
positive regulation of growth GO:0045927 369 0.057
regulation of mitotic cell cycle GO:0007346 76 0.056
Worm
endocytosis GO:0006897 819 0.056
cellular component morphogenesis GO:0032989 318 0.055
stress activated mapk cascade GO:0051403 10 0.055
positive regulation of cellular process GO:0048522 332 0.054
regulation of multicellular organism growth GO:0040014 373 0.054
organic acid metabolic process GO:0006082 47 0.053
nematode male tail tip morphogenesis GO:0045138 77 0.053
innate immune response GO:0045087 190 0.052
vesicle mediated transport GO:0016192 852 0.051
response to endogenous stimulus GO:0009719 33 0.050
nucleic acid metabolic process GO:0090304 299 0.050
defense response GO:0006952 296 0.049
regulation of transcription dna templated GO:0006355 164 0.049
cytoskeleton organization GO:0007010 339 0.048
negative regulation of cellular process GO:0048523 239 0.048
Worm
negative regulation of nucleic acid templated transcription GO:1903507 53 0.045
Worm
cellular component assembly GO:0022607 293 0.044
cell death GO:0008219 547 0.044
immune response GO:0006955 192 0.043
catabolic process GO:0009056 318 0.043
Worm
cellular component movement GO:0006928 388 0.042
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.041
Worm
negative regulation of cellular biosynthetic process GO:0031327 65 0.041
Worm
cell division GO:0051301 262 0.041
negative regulation of gene expression GO:0010629 217 0.041
Worm
negative regulation of metabolic process GO:0009892 240 0.041
Worm
purine nucleotide catabolic process GO:0006195 75 0.040
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.039
Worm
digestive system development GO:0055123 122 0.039
protein complex biogenesis GO:0070271 186 0.039
stress activated protein kinase signaling cascade GO:0031098 10 0.038
positive regulation of phosphorus metabolic process GO:0010562 56 0.038
regulation of signaling GO:0023051 172 0.038
nervous system development GO:0007399 253 0.037
positive regulation of developmental process GO:0051094 408 0.037
regulation of multicellular organismal development GO:2000026 317 0.037
Worm
epithelial cell proliferation GO:0050673 1 0.036
skeletal muscle organ development GO:0060538 3 0.036
apoptotic process GO:0006915 478 0.036
cellular component biogenesis GO:0044085 297 0.036
cellular response to growth factor stimulus GO:0071363 18 0.035
reproductive behavior GO:0019098 387 0.035
Worm
response to other organism GO:0051707 101 0.034
cell cycle process GO:0022402 482 0.034
Worm
protein phosphorylation GO:0006468 85 0.034
cell migration GO:0016477 306 0.033
intracellular transport GO:0046907 77 0.032
rna biosynthetic process GO:0032774 169 0.032
macromolecule biosynthetic process GO:0009059 250 0.032
multi multicellular organism process GO:0044706 390 0.032
Worm
generation of neurons GO:0048699 235 0.032
positive regulation of cell cycle GO:0045787 55 0.031
Worm
mapk cascade GO:0000165 31 0.031
receptor mediated endocytosis GO:0006898 715 0.031
phagocytosis GO:0006909 115 0.031
digestive tract morphogenesis GO:0048546 76 0.031
cell motility GO:0048870 313 0.031
hatching GO:0035188 48 0.030
muscle cell differentiation GO:0042692 171 0.029
microtubule based process GO:0007017 182 0.029
regulation of epithelial cell proliferation GO:0050678 1 0.028
positive regulation of transcription from rna polymerase ii promoter involved in defense response to gram negative bacterium GO:1902097 4 0.027
protein localization GO:0008104 205 0.027
secretion GO:0046903 147 0.027
single organism organelle organization GO:1902589 501 0.027
phosphate containing compound metabolic process GO:0006796 232 0.027
nucleoside phosphate metabolic process GO:0006753 108 0.027
macromolecular complex assembly GO:0065003 193 0.026
secretion by cell GO:0032940 138 0.026
response to osmotic stress GO:0006970 29 0.026
response to external stimulus GO:0009605 289 0.026
ras protein signal transduction GO:0007265 31 0.026
rna metabolic process GO:0016070 228 0.025
dna metabolic process GO:0006259 74 0.025
head development GO:0060322 1 0.025
programmed cell death GO:0012501 500 0.025
regulation of cellular ketone metabolic process GO:0010565 3 0.025
regulation of cellular protein metabolic process GO:0032268 75 0.024
response to bacterium GO:0009617 86 0.024
Worm
defense response to gram negative bacterium GO:0050829 64 0.024
Worm
single organism catabolic process GO:0044712 129 0.024
regulation of response to stimulus GO:0048583 243 0.024
Worm
purine ribonucleotide metabolic process GO:0009150 95 0.024
regulation of cell communication GO:0010646 176 0.023
carboxylic acid metabolic process GO:0019752 34 0.023
cell surface receptor signaling pathway GO:0007166 149 0.023
cellular response to endogenous stimulus GO:0071495 32 0.023
multi organism reproductive behavior GO:0044705 387 0.023
Worm
regulation of anatomical structure size GO:0090066 46 0.023
regulation of localization GO:0032879 194 0.023
lipid metabolic process GO:0006629 77 0.023
neuron development GO:0048666 199 0.023
regulation of signal transduction GO:0009966 135 0.022
regulation of growth GO:0040008 409 0.022
cell fate commitment involved in formation of primary germ layer GO:0060795 33 0.022
cellular lipid metabolic process GO:0044255 40 0.022
tissue development GO:0009888 112 0.022
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 2 0.022
molting cycle GO:0042303 281 0.022
cellular protein metabolic process GO:0044267 279 0.021
organonitrogen compound metabolic process GO:1901564 151 0.021
regulation of cell differentiation GO:0045595 81 0.021
tissue morphogenesis GO:0048729 65 0.021
regulation of catabolic process GO:0009894 57 0.021
Worm
cell projection organization GO:0030030 231 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.021
Worm
organelle assembly GO:0070925 214 0.021
protein catabolic process GO:0030163 162 0.021
Worm
cell growth GO:0016049 44 0.021
muscle tissue development GO:0060537 1 0.021
tube development GO:0035295 126 0.020
regulation of protein metabolic process GO:0051246 81 0.020
Worm
negative regulation of cell cycle GO:0045786 53 0.020
Worm
regulation of post embryonic development GO:0048580 260 0.020
Worm
male sex differentiation GO:0046661 86 0.020
cell type specific apoptotic process GO:0097285 4 0.020
synaptic growth at neuromuscular junction GO:0051124 1 0.020
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 2 0.019
phosphorylation GO:0016310 116 0.019
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.019
cellular response to inorganic substance GO:0071241 3 0.019
amine metabolic process GO:0009308 15 0.019
response to growth factor GO:0070848 18 0.019
sensory organ morphogenesis GO:0090596 2 0.018
regulation of cell proliferation GO:0042127 105 0.018
small gtpase mediated signal transduction GO:0007264 32 0.018
regulation of cell morphogenesis GO:0022604 40 0.018
positive regulation of multicellular organismal process GO:0051240 417 0.018
regulation of cell cycle process GO:0010564 145 0.018
cellular ketone metabolic process GO:0042180 14 0.018
chromosome segregation GO:0007059 180 0.018
cellular macromolecular complex assembly GO:0034622 184 0.017
nucleoside triphosphate metabolic process GO:0009141 87 0.017
ribonucleotide metabolic process GO:0009259 99 0.017
positive regulation of protein metabolic process GO:0051247 45 0.017
Worm
cellular response to abiotic stimulus GO:0071214 4 0.017
feeding behavior GO:0007631 70 0.017
Worm
cellular catabolic process GO:0044248 199 0.017
negative regulation of protein metabolic process GO:0051248 27 0.017
neuron differentiation GO:0030182 217 0.016
response to acid chemical GO:0001101 4 0.016
regulation of mesoderm development GO:2000380 2 0.016
intracellular protein transmembrane transport GO:0065002 4 0.016
ectoderm development GO:0007398 3 0.016
positive regulation of synapse assembly GO:0051965 1 0.016
protein complex subunit organization GO:0071822 280 0.016
purine nucleotide metabolic process GO:0006163 95 0.016
purine nucleoside catabolic process GO:0006152 75 0.016
mesoderm development GO:0007498 27 0.016
cellular amine metabolic process GO:0044106 15 0.016
negative regulation of cellular metabolic process GO:0031324 95 0.016
Worm
positive regulation of bmp signaling pathway GO:0030513 2 0.015
male anatomical structure morphogenesis GO:0090598 78 0.015
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.015
Worm
fatty acid metabolic process GO:0006631 16 0.015
negative regulation of macromolecule metabolic process GO:0010605 229 0.015
Worm
negative regulation of developmental process GO:0051093 227 0.015
Worm
gastrulation GO:0007369 58 0.015
gene silencing by rna GO:0031047 143 0.015
negative regulation of multicellular organismal process GO:0051241 236 0.015
Worm
purine ribonucleoside metabolic process GO:0046128 92 0.015
organelle fission GO:0048285 363 0.015
organ morphogenesis GO:0009887 67 0.014
regulation of cell size GO:0008361 30 0.014
positive regulation of neurogenesis GO:0050769 4 0.014
localization of cell GO:0051674 313 0.014
organism emergence from protective structure GO:0071684 48 0.014
chemical homeostasis GO:0048878 29 0.014
nucleotide metabolic process GO:0009117 108 0.014
regulation of vulval development GO:0040028 248 0.014
Worm
regionalization GO:0003002 31 0.014
aromatic compound catabolic process GO:0019439 116 0.014
nucleobase containing small molecule metabolic process GO:0055086 115 0.014
digestive tract development GO:0048565 122 0.014
cuticle development GO:0042335 100 0.014
cell proliferation GO:0008283 116 0.014
hormone metabolic process GO:0042445 3 0.014
positive regulation of stem cell differentiation GO:2000738 1 0.014
regulation of gastrulation GO:0010470 4 0.014
response to external biotic stimulus GO:0043207 101 0.014
cellular response to metal ion GO:0071248 3 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.013
response to salt stress GO:0009651 1 0.013
glycosyl compound catabolic process GO:1901658 79 0.013
posttranscriptional regulation of gene expression GO:0010608 166 0.013
dauer larval development GO:0040024 92 0.013
Worm
regulation of lipid metabolic process GO:0019216 4 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
purine containing compound metabolic process GO:0072521 95 0.013
axon development GO:0061564 163 0.013
neuromuscular junction development GO:0007528 2 0.013
single organism intracellular transport GO:1902582 70 0.013
regulation of nuclear division GO:0051783 115 0.013
heterocycle catabolic process GO:0046700 119 0.013
intracellular signal transduction GO:0035556 96 0.013
cellular protein localization GO:0034613 75 0.013
cellular component assembly involved in morphogenesis GO:0010927 183 0.013
regulation of organelle organization GO:0033043 164 0.013
regulation of striated muscle contraction GO:0006942 4 0.012
enzyme linked receptor protein signaling pathway GO:0007167 50 0.012
mesoderm morphogenesis GO:0048332 24 0.012
regulation of reproductive process GO:2000241 66 0.012
regulation of protein targeting GO:1903533 3 0.012
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.012
nucleobase containing compound catabolic process GO:0034655 114 0.012
actin filament based process GO:0030029 191 0.012
cellular macromolecule localization GO:0070727 75 0.012
regulation of intracellular signal transduction GO:1902531 77 0.012
modification dependent protein catabolic process GO:0019941 32 0.012
cellular protein complex assembly GO:0043623 178 0.012
positive regulation of protein catabolic process GO:0045732 6 0.012
Worm
ribonucleoside triphosphate metabolic process GO:0009199 87 0.012
negative regulation of cell communication GO:0010648 61 0.012
positive regulation of catabolic process GO:0009896 38 0.012
Worm
regulation of dna templated transcription in response to stress GO:0043620 3 0.012
cell part morphogenesis GO:0032990 152 0.012
gtp metabolic process GO:0046039 46 0.012
protein metabolic process GO:0019538 422 0.012
Worm
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.012
Worm
regulation of cellular component organization GO:0051128 248 0.012
positive regulation of cellular catabolic process GO:0031331 35 0.012
regulation of cell division GO:0051302 142 0.012
negative regulation of vulval development GO:0040027 206 0.011
Worm
negative regulation of nematode larval development GO:0061064 208 0.011
Worm
cell cycle switching mitotic to meiotic cell cycle GO:0051728 35 0.011
Worm
regulation of small gtpase mediated signal transduction GO:0051056 41 0.011
regulation of mitosis GO:0007088 18 0.011
positive regulation of response to stimulus GO:0048584 55 0.011
protein modification process GO:0036211 207 0.011
cell cycle g1 s phase transition GO:0044843 2 0.011
cell projection morphogenesis GO:0048858 148 0.011
jnk cascade GO:0007254 8 0.011
mitotic cell cycle process GO:1903047 194 0.011
posttranscriptional gene silencing GO:0016441 143 0.011
behavior GO:0007610 527 0.011
Worm
response to oxygen containing compound GO:1901700 44 0.011
protein localization to organelle GO:0033365 37 0.011
nucleoside triphosphate catabolic process GO:0009143 72 0.011
regulation of cell death GO:0010941 65 0.011
lipid biosynthetic process GO:0008610 28 0.011
proteolysis GO:0006508 61 0.011
negative regulation of mitotic cell cycle GO:0045930 42 0.011
Worm
macromolecule catabolic process GO:0009057 202 0.011
Worm
response to transition metal nanoparticle GO:1990267 18 0.011
posttranscriptional gene silencing by rna GO:0035194 143 0.011
gtp catabolic process GO:0006184 46 0.011
polarity specification of proximal distal axis GO:0010085 6 0.011
regulation of catalytic activity GO:0050790 78 0.010
defense response to bacterium GO:0042742 86 0.010
Worm
response to metal ion GO:0010038 33 0.010
response to nutrient levels GO:0031667 35 0.010
protein transmembrane transport GO:0071806 4 0.010
organic acid catabolic process GO:0016054 3 0.010
peptide hormone processing GO:0016486 2 0.010

sma-3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.029
disease of cellular proliferation DOID:14566 0 0.021
cancer DOID:162 0 0.015
organ system cancer DOID:0050686 0 0.015
reproductive organ cancer DOID:193 0 0.013
ovarian cancer DOID:2394 0 0.013
female reproductive organ cancer DOID:120 0 0.013