Caenorhabditis elegans

129 known processes

tph-1 (CELE_ZK1290.2)

Protein TPH-1

tph-1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
establishment of localization GO:0051234 1171 0.283
embryo development ending in birth or egg hatching GO:0009792 2992 0.280
embryo development GO:0009790 3052 0.279
behavior GO:0007610 527 0.212
transport GO:0006810 1093 0.180
multicellular organism reproduction GO:0032504 819 0.175
regulation of developmental process GO:0050793 684 0.148
Mouse
multicellular organismal reproductive process GO:0048609 815 0.144
growth GO:0040007 562 0.129
response to wounding GO:0009611 4 0.127
regulation of multicellular organismal process GO:0051239 726 0.126
reproductive behavior GO:0019098 387 0.121
response to chemical GO:0042221 356 0.120
multi organism behavior GO:0051705 389 0.117
localization of cell GO:0051674 313 0.116
vesicle mediated transport GO:0016192 852 0.113
aging GO:0007568 812 0.108
cellular component movement GO:0006928 388 0.107
multicellular organismal aging GO:0010259 812 0.096
single organism localization GO:1902578 518 0.096
post embryonic development GO:0009791 2152 0.095
multi organism reproductive behavior GO:0044705 387 0.091
single organism reproductive process GO:0044702 1196 0.090
positive regulation of multicellular organismal process GO:0051240 417 0.089
regulation of biological quality GO:0065008 741 0.087
determination of adult lifespan GO:0008340 812 0.083
locomotion GO:0040011 1634 0.082
Worm
cellular localization GO:0051641 360 0.077
acetylcholine catabolic process GO:0006581 4 0.074
defense response GO:0006952 296 0.074
single organism signaling GO:0044700 401 0.073
regulation of cellular component organization GO:0051128 248 0.073
multi organism reproductive process GO:0044703 867 0.073
organ development GO:0048513 1102 0.069
Mouse
lipid localization GO:0010876 573 0.068
secretion by cell GO:0032940 138 0.068
multi multicellular organism process GO:0044706 390 0.068
developmental process involved in reproduction GO:0003006 1165 0.068
multicellular organismal reproductive behavior GO:0033057 384 0.066
regulation of pharyngeal pumping GO:0043051 36 0.066
synaptic transmission GO:0007268 106 0.065
response to organic substance GO:0010033 131 0.065
lipid storage GO:0019915 565 0.063
secretion GO:0046903 147 0.062
endocytosis GO:0006897 819 0.060
gamete generation GO:0007276 461 0.060
regulation of multicellular organism growth GO:0040014 373 0.059
cell migration GO:0016477 306 0.059
memory GO:0007613 3 0.058
macromolecule localization GO:0033036 771 0.057
maintenance of location GO:0051235 580 0.056
cell development GO:0048468 696 0.055
reproductive structure development GO:0048608 850 0.055
organic substance catabolic process GO:1901575 294 0.055
Worm
reproductive system development GO:0061458 850 0.054
cell death GO:0008219 547 0.054
g protein coupled receptor signaling pathway GO:0007186 46 0.054
receptor mediated endocytosis GO:0006898 715 0.053
organelle organization GO:0006996 783 0.052
development of primary sexual characteristics GO:0045137 840 0.051
death GO:0016265 547 0.050
cell motility GO:0048870 313 0.049
oviposition GO:0018991 364 0.049
hermaphrodite genitalia development GO:0040035 734 0.049
sex differentiation GO:0007548 909 0.049
body morphogenesis GO:0010171 620 0.048
biosynthetic process GO:0009058 323 0.048
head development GO:0060322 1 0.047
protein metabolic process GO:0019538 422 0.046
regulation of oviposition GO:0046662 43 0.046
phosphorus metabolic process GO:0006793 232 0.045
regulation of response to wounding GO:1903034 1 0.045
gonad development GO:0008406 840 0.045
negative regulation of biological process GO:0048519 567 0.044
signaling GO:0023052 401 0.043
regulation of cellular metabolic process GO:0031323 305 0.042
regulation of metabolic process GO:0019222 478 0.041
regulation of multicellular organismal development GO:2000026 317 0.041
positive regulation of developmental growth GO:0048639 354 0.040
neurogenesis GO:0022008 236 0.040
multicellular organism growth GO:0035264 385 0.039
programmed cell death GO:0012501 500 0.039
regulation of response to stimulus GO:0048583 243 0.039
establishment of localization in cell GO:0051649 318 0.038
positive regulation of multicellular organism growth GO:0040018 352 0.038
regulation of growth GO:0040008 409 0.037
regulation of developmental growth GO:0048638 389 0.037
cellular biosynthetic process GO:0044249 315 0.036
nucleobase containing compound metabolic process GO:0006139 406 0.036
regulation of macromolecule metabolic process GO:0060255 421 0.036
protein catabolic process GO:0030163 162 0.036
single organism transport GO:0044765 447 0.035
nucleic acid metabolic process GO:0090304 299 0.035
neuron projection development GO:0031175 187 0.035
apoptotic process GO:0006915 478 0.035
regulation of cell cycle GO:0051726 194 0.034
cytoskeleton organization GO:0007010 339 0.034
developmental growth GO:0048589 412 0.033
excretion GO:0007588 49 0.033
cellular component assembly GO:0022607 293 0.033
pharyngeal pumping GO:0043050 58 0.032
eating behavior GO:0042755 59 0.032
positive regulation of developmental process GO:0051094 408 0.032
Mouse
response to abiotic stimulus GO:0009628 152 0.032
Worm
cell cell signaling GO:0007267 118 0.032
sexual reproduction GO:0019953 546 0.032
Worm
cellular protein modification process GO:0006464 207 0.032
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.030
organelle fission GO:0048285 363 0.030
cellular protein metabolic process GO:0044267 279 0.030
acetate ester metabolic process GO:1900619 4 0.029
small molecule metabolic process GO:0044281 186 0.029
cellular macromolecule biosynthetic process GO:0034645 247 0.029
sensory organ morphogenesis GO:0090596 2 0.029
macromolecular complex subunit organization GO:0043933 320 0.029
cell projection organization GO:0030030 231 0.029
neurotransmitter catabolic process GO:0042135 4 0.029
response to external stimulus GO:0009605 289 0.029
Worm
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.028
cell cycle GO:0007049 526 0.028
cation transport GO:0006812 78 0.028
regulation of cellular localization GO:0060341 42 0.028
cell surface receptor signaling pathway GO:0007166 149 0.028
positive regulation of striated muscle contraction GO:0045989 2 0.028
gene expression GO:0010467 412 0.027
nervous system development GO:0007399 253 0.027
learning or memory GO:0007611 27 0.027
Worm
organonitrogen compound metabolic process GO:1901564 151 0.027
single organism organelle organization GO:1902589 501 0.027
organic substance biosynthetic process GO:1901576 323 0.027
axon development GO:0061564 163 0.027
nitrogen compound transport GO:0071705 49 0.027
molting cycle GO:0042303 281 0.027
cell type specific apoptotic process GO:0097285 4 0.026
germ cell development GO:0007281 351 0.026
positive regulation of growth GO:0045927 369 0.026
skeletal muscle organ development GO:0060538 3 0.026
cell cycle process GO:0022402 482 0.026
catabolic process GO:0009056 318 0.026
Worm
tube development GO:0035295 126 0.025
regulation of cell division GO:0051302 142 0.025
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.025
macromolecule modification GO:0043412 218 0.025
positive regulation of cellular process GO:0048522 332 0.025
generation of neurons GO:0048699 235 0.025
regulation of gene expression GO:0010468 366 0.025
negative regulation of response to stimulus GO:0048585 73 0.025
negative regulation of macromolecule metabolic process GO:0010605 229 0.025
organic cyclic compound biosynthetic process GO:1901362 195 0.024
neuron projection guidance GO:0097485 82 0.024
regulation of reproductive process GO:2000241 66 0.024
cell projection morphogenesis GO:0048858 148 0.024
adult behavior GO:0030534 3 0.024
negative regulation of multicellular organismal process GO:0051241 236 0.024
regulation of striated muscle contraction GO:0006942 4 0.024
signal transduction GO:0007165 317 0.024
cell part morphogenesis GO:0032990 152 0.024
regulation of behavior GO:0050795 97 0.024
neuron projection morphogenesis GO:0048812 114 0.023
regulation of nuclear division GO:0051783 115 0.023
protein modification process GO:0036211 207 0.023
aromatic compound biosynthetic process GO:0019438 192 0.023
muscle structure development GO:0061061 191 0.023
positive regulation of cellular metabolic process GO:0031325 178 0.023
negative regulation of gene expression GO:0010629 217 0.023
regulation of biosynthetic process GO:0009889 189 0.023
cation transmembrane transport GO:0098655 59 0.023
regulation of cellular biosynthetic process GO:0031326 189 0.023
actin cytoskeleton organization GO:0030036 184 0.023
genitalia development GO:0048806 741 0.023
regulation of cell cycle process GO:0010564 145 0.023
cellular component morphogenesis GO:0032989 318 0.023
female gamete generation GO:0007292 254 0.022
nucleic acid templated transcription GO:0097659 169 0.022
phosphate containing compound metabolic process GO:0006796 232 0.022
regulation of primary metabolic process GO:0080090 292 0.022
carbohydrate derivative metabolic process GO:1901135 141 0.022
dauer larval development GO:0040024 92 0.021
regulation of muscle contraction GO:0006937 20 0.021
negative regulation of developmental process GO:0051093 227 0.021
macromolecule catabolic process GO:0009057 202 0.021
regulation of signal transduction GO:0009966 135 0.021
muscle contraction GO:0006936 43 0.021
actin filament based process GO:0030029 191 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.021
muscle tissue development GO:0060537 1 0.021
acetylcholine metabolic process GO:0008291 4 0.021
negative regulation of metabolic process GO:0009892 240 0.021
taxis GO:0042330 128 0.021
regulation of nitrogen compound metabolic process GO:0051171 222 0.021
regulation of macromolecule biosynthetic process GO:0010556 189 0.020
response to extracellular stimulus GO:0009991 38 0.020
Worm
response to endogenous stimulus GO:0009719 33 0.020
regulation of nematode larval development GO:0061062 260 0.020
regulation of rna metabolic process GO:0051252 173 0.020
macromolecule biosynthetic process GO:0009059 250 0.020
regulation of post embryonic development GO:0048580 260 0.020
neuron differentiation GO:0030182 217 0.020
neurological system process GO:0050877 53 0.020
Worm
oogenesis GO:0048477 229 0.020
regulation of signaling GO:0023051 172 0.020
rna metabolic process GO:0016070 228 0.020
cellular component biogenesis GO:0044085 297 0.020
negative regulation of cellular process GO:0048523 239 0.019
heterocycle biosynthetic process GO:0018130 187 0.019
cyclic nucleotide biosynthetic process GO:0009190 2 0.019
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.019
vulval development GO:0040025 333 0.019
regulation of cell communication GO:0010646 176 0.019
regulation of localization GO:0032879 194 0.019
regulation of phosphorus metabolic process GO:0051174 81 0.019
collagen and cuticulin based cuticle development GO:0040002 99 0.019
Worm
digestive system development GO:0055123 122 0.019
organelle assembly GO:0070925 214 0.019
meiotic nuclear division GO:0007126 300 0.019
cell division GO:0051301 262 0.018
feeding behavior GO:0007631 70 0.018
regeneration GO:0031099 4 0.018
inductive cell migration GO:0040039 145 0.018
cellular catabolic process GO:0044248 199 0.018
Worm
cellular response to abiotic stimulus GO:0071214 4 0.018
post embryonic organ development GO:0048569 336 0.017
negative regulation of transporter activity GO:0032410 3 0.017
meiotic cell cycle GO:0051321 335 0.017
canonical wnt signaling pathway GO:0060070 3 0.017
oxoacid metabolic process GO:0043436 47 0.017
protein complex subunit organization GO:0071822 280 0.017
epithelial tube morphogenesis GO:0060562 1 0.017
negative regulation of post embryonic development GO:0048581 208 0.017
organic acid metabolic process GO:0006082 47 0.017
rna biosynthetic process GO:0032774 169 0.017
positive regulation of metabolic process GO:0009893 187 0.017
regulation of neurotransmitter levels GO:0001505 36 0.017
single organism carbohydrate metabolic process GO:0044723 29 0.017
protein complex assembly GO:0006461 186 0.017
neuron development GO:0048666 199 0.017
positive regulation of neuron differentiation GO:0045666 4 0.016
organic substance transport GO:0071702 113 0.016
regulation of nucleocytoplasmic transport GO:0046822 3 0.016
response to nutrient levels GO:0031667 35 0.016
Worm
negative regulation of neurogenesis GO:0050768 4 0.016
nucleobase containing compound biosynthetic process GO:0034654 184 0.016
cellular component assembly involved in morphogenesis GO:0010927 183 0.016
anatomical structure formation involved in morphogenesis GO:0048646 250 0.016
protein localization GO:0008104 205 0.016
cellular macromolecular complex assembly GO:0034622 184 0.016
regulation of locomotion GO:0040012 161 0.016
Worm
cellular response to chemical stimulus GO:0070887 129 0.016
digestive tract development GO:0048565 122 0.015
chemotaxis GO:0006935 120 0.015
transmembrane transport GO:0055085 110 0.015
regulation of synaptic transmission dopaminergic GO:0032225 1 0.015
membrane organization GO:0061024 135 0.015
regulation of cytoplasmic transport GO:1903649 3 0.015
ion transport GO:0006811 113 0.015
cuticle development GO:0042335 100 0.015
Worm
system process GO:0003008 136 0.015
Worm
regulation of catalytic activity GO:0050790 78 0.015
response to organonitrogen compound GO:0010243 15 0.015
regulation of lipid metabolic process GO:0019216 4 0.015
neuromuscular junction development GO:0007528 2 0.015
negative regulation of nematode larval development GO:0061064 208 0.015
developmental cell growth GO:0048588 39 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.015
macromolecular complex assembly GO:0065003 193 0.015
mating behavior GO:0007617 32 0.014
Worm
nucleoside phosphate metabolic process GO:0006753 108 0.014
cellular protein complex assembly GO:0043623 178 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.014
regulation of apoptotic signaling pathway GO:2001233 1 0.014
ion transmembrane transport GO:0034220 91 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
muscle cell development GO:0055001 158 0.014
regulation of rna biosynthetic process GO:2001141 165 0.014
regulation of cell migration GO:0030334 55 0.014
protein complex biogenesis GO:0070271 186 0.014
cellular response to stress GO:0033554 162 0.014
myosin filament organization GO:0031033 138 0.014
intracellular signal transduction GO:0035556 96 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.014
organophosphate metabolic process GO:0019637 125 0.014
regulation of organelle organization GO:0033043 164 0.014
regulation of nucleic acid templated transcription GO:1903506 165 0.014
phosphorylation GO:0016310 116 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
axonogenesis GO:0007409 102 0.013
rhythmic process GO:0048511 8 0.013
Fly
amine metabolic process GO:0009308 15 0.013
myofibril assembly GO:0030239 154 0.013
positive regulation of cell migration GO:0030335 3 0.013
myosin filament assembly GO:0031034 138 0.013
apoptotic cell clearance GO:0043277 111 0.013
posttranscriptional regulation of gene expression GO:0010608 166 0.013
regulation of organ morphogenesis GO:2000027 4 0.013
regulation of meiotic cell cycle GO:0051445 136 0.013
regulation of stem cell differentiation GO:2000736 1 0.013
positive regulation of molecular function GO:0044093 61 0.013
tube morphogenesis GO:0035239 79 0.013
regulation of transcription dna templated GO:0006355 164 0.013
immune response GO:0006955 192 0.013
striated muscle myosin thick filament assembly GO:0071688 138 0.013
nucleobase containing small molecule metabolic process GO:0055086 115 0.013
cellular amine metabolic process GO:0044106 15 0.013
cyclic purine nucleotide metabolic process GO:0052652 2 0.013
rna interference GO:0016246 137 0.013
response to external biotic stimulus GO:0043207 101 0.013
negative regulation of response to external stimulus GO:0032102 3 0.013
nucleotide metabolic process GO:0009117 108 0.013
negative regulation of vulval development GO:0040027 206 0.013
mitotic cell cycle process GO:1903047 194 0.013
regulation of protein targeting GO:1903533 3 0.013
gene silencing by rna GO:0031047 143 0.012
posttranscriptional gene silencing by rna GO:0035194 143 0.012
carboxylic acid metabolic process GO:0019752 34 0.012
positive regulation of neurogenesis GO:0050769 4 0.012
rna localization GO:0006403 3 0.012
positive regulation of organ growth GO:0046622 4 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
epithelial cell proliferation GO:0050673 1 0.012
response to ketone GO:1901654 1 0.012
hormone metabolic process GO:0042445 3 0.012
cellular nitrogen compound biosynthetic process GO:0044271 192 0.012
positive regulation of intracellular transport GO:0032388 2 0.012
regulation of cellular catabolic process GO:0031329 51 0.012
regulation of epithelial cell proliferation GO:0050678 1 0.012
response to heat GO:0009408 50 0.012
locomotory behavior GO:0007626 40 0.012
Worm
actomyosin structure organization GO:0031032 154 0.012
positive regulation of protein transport GO:0051222 4 0.012
regulation of protein metabolic process GO:0051246 81 0.012
regulation of phosphate metabolic process GO:0019220 81 0.012
regulation of meiosis GO:0040020 94 0.012
striated muscle cell development GO:0055002 157 0.012
protein oligomerization GO:0051259 4 0.012
establishment of cell polarity GO:0030010 46 0.012
regulation of cellular component size GO:0032535 40 0.012
phagocytosis engulfment GO:0006911 98 0.012
embryonic morphogenesis GO:0048598 152 0.011
sleep GO:0030431 4 0.011
Fly
regulation of gene expression epigenetic GO:0040029 163 0.011
regulation of vulval development GO:0040028 248 0.011
striated muscle cell differentiation GO:0051146 158 0.011
regulation of protein import into nucleus GO:0042306 3 0.011
response to organic cyclic compound GO:0014070 10 0.011
cell fate commitment GO:0045165 139 0.011
glycoprotein metabolic process GO:0009100 29 0.011
positive regulation of response to stimulus GO:0048584 55 0.011
organonitrogen compound biosynthetic process GO:1901566 44 0.011
positive regulation of catabolic process GO:0009896 38 0.011
single organism catabolic process GO:0044712 129 0.011
Worm
single organism biosynthetic process GO:0044711 91 0.011
peptidyl tyrosine phosphorylation GO:0018108 2 0.011
positive regulation of biosynthetic process GO:0009891 109 0.011
posttranscriptional gene silencing GO:0016441 143 0.011
response to food GO:0032094 9 0.011
Worm
monosaccharide metabolic process GO:0005996 2 0.011
cellular amino acid metabolic process GO:0006520 15 0.011
actin cytoskeleton reorganization GO:0031532 4 0.011
tissue development GO:0009888 112 0.011
small gtpase mediated signal transduction GO:0007264 32 0.011
negative regulation of signal transduction GO:0009968 60 0.011
oxidation reduction process GO:0055114 59 0.011
Mouse Worm Fly
neuron neuron synaptic transmission GO:0007270 22 0.011
detection of external stimulus GO:0009581 4 0.011
regulation of intracellular signal transduction GO:1902531 77 0.011
single organism behavior GO:0044708 83 0.011
Worm Fly
muscle fiber development GO:0048747 2 0.011
lipid metabolic process GO:0006629 77 0.011
cytokinesis GO:0000910 80 0.011
cell morphogenesis GO:0000902 163 0.011
axonal fasciculation GO:0007413 79 0.011
purine containing compound metabolic process GO:0072521 95 0.011
cell proliferation GO:0008283 116 0.011
cell morphogenesis involved in differentiation GO:0000904 112 0.011
ribonucleoprotein complex assembly GO:0022618 4 0.011
tissue morphogenesis GO:0048729 65 0.011
transcription dna templated GO:0006351 168 0.010
peptidyl tyrosine modification GO:0018212 3 0.010
regulation of cell proliferation GO:0042127 105 0.010
adult locomotory behavior GO:0008344 1 0.010
ras protein signal transduction GO:0007265 31 0.010
chromosome segregation GO:0007059 180 0.010
response to biotic stimulus GO:0009607 101 0.010
cell recognition GO:0008037 85 0.010
positive regulation of cellular catabolic process GO:0031331 35 0.010
defense response to other organism GO:0098542 100 0.010
phagocytosis GO:0006909 115 0.010
enzyme linked receptor protein signaling pathway GO:0007167 50 0.010
muscle organ morphogenesis GO:0048644 4 0.010
regulation of cellular component movement GO:0051270 62 0.010
regulation of catabolic process GO:0009894 57 0.010
engulfment of apoptotic cell GO:0043652 94 0.010

tph-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
disease of metabolism DOID:0014667 0 0.016
nervous system disease DOID:863 0 0.010
inherited metabolic disorder DOID:655 0 0.010