Caenorhabditis elegans

45 known processes

mec-8 (CELE_F46A9.6)

Protein MEC-8

mec-8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell projection organization GO:0030030 231 0.544
Zebrafish
embryo development GO:0009790 3052 0.422
embryo development ending in birth or egg hatching GO:0009792 2992 0.409
cell part morphogenesis GO:0032990 152 0.388
Zebrafish
multicellular organism reproduction GO:0032504 819 0.383
cell projection morphogenesis GO:0048858 148 0.298
Zebrafish
regulation of multicellular organismal process GO:0051239 726 0.286
Fly
multi organism behavior GO:0051705 389 0.255
nervous system development GO:0007399 253 0.235
cellular component morphogenesis GO:0032989 318 0.233
Zebrafish
post embryonic development GO:0009791 2152 0.233
gene expression GO:0010467 412 0.230
neuron differentiation GO:0030182 217 0.228
cell morphogenesis involved in differentiation GO:0000904 112 0.223
Zebrafish
neuron projection development GO:0031175 187 0.215
Zebrafish
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.208
Zebrafish
multi organism reproductive process GO:0044703 867 0.207
cell development GO:0048468 696 0.205
nucleic acid metabolic process GO:0090304 299 0.205
regulation of multicellular organismal development GO:2000026 317 0.193
genitalia development GO:0048806 741 0.182
positive regulation of macromolecule metabolic process GO:0010604 149 0.170
Human
cell motility GO:0048870 313 0.163
locomotion GO:0040011 1634 0.162
rna metabolic process GO:0016070 228 0.161
sex differentiation GO:0007548 909 0.155
sexual reproduction GO:0019953 546 0.153
neuron projection guidance GO:0097485 82 0.141
nucleobase containing compound metabolic process GO:0006139 406 0.139
regulation of gene expression GO:0010468 366 0.138
single organism reproductive process GO:0044702 1196 0.138
neuron development GO:0048666 199 0.138
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.137
regulation of developmental process GO:0050793 684 0.135
Fly
negative regulation of biological process GO:0048519 567 0.129
regulation of nematode larval development GO:0061062 260 0.128
negative regulation of post embryonic development GO:0048581 208 0.128
reproductive behavior GO:0019098 387 0.123
multi multicellular organism process GO:0044706 390 0.117
establishment of localization GO:0051234 1171 0.115
Human
transport GO:0006810 1093 0.114
Human
organ development GO:0048513 1102 0.114
cellular biosynthetic process GO:0044249 315 0.111
positive regulation of multicellular organismal process GO:0051240 417 0.111
behavior GO:0007610 527 0.105
localization of cell GO:0051674 313 0.104
macromolecule localization GO:0033036 771 0.104
Human
signaling GO:0023052 401 0.102
Human Fly
multicellular organismal reproductive behavior GO:0033057 384 0.101
regulation of cellular biosynthetic process GO:0031326 189 0.100
Human
macromolecule biosynthetic process GO:0009059 250 0.099
organic substance biosynthetic process GO:1901576 323 0.099
multi organism reproductive behavior GO:0044705 387 0.097
endocytosis GO:0006897 819 0.092
regulation of biological quality GO:0065008 741 0.092
cell cycle process GO:0022402 482 0.092
cellular component movement GO:0006928 388 0.089
cellular macromolecule biosynthetic process GO:0034645 247 0.084
hermaphrodite genitalia development GO:0040035 734 0.083
cell migration GO:0016477 306 0.083
developmental process involved in reproduction GO:0003006 1165 0.082
positive regulation of gene expression GO:0010628 112 0.082
axonogenesis GO:0007409 102 0.078
regulation of macromolecule biosynthetic process GO:0010556 189 0.077
Human
single organism signaling GO:0044700 401 0.077
Human Fly
regulation of post embryonic development GO:0048580 260 0.077
positive regulation of developmental process GO:0051094 408 0.077
regulation of nitrogen compound metabolic process GO:0051171 222 0.076
Human
regulation of macromolecule metabolic process GO:0060255 421 0.076
Human
negative regulation of vulval development GO:0040027 206 0.076
vesicle mediated transport GO:0016192 852 0.075
regulation of signaling GO:0023051 172 0.075
Human
digestive system development GO:0055123 122 0.074
reproductive structure development GO:0048608 850 0.072
chemotaxis GO:0006935 120 0.071
regulation of cell communication GO:0010646 176 0.069
Human
neurogenesis GO:0022008 236 0.069
multicellular organismal reproductive process GO:0048609 815 0.068
lipid storage GO:0019915 565 0.068
negative regulation of multicellular organismal process GO:0051241 236 0.068
organelle organization GO:0006996 783 0.066
cell division GO:0051301 262 0.066
response to unfolded protein GO:0006986 71 0.066
maintenance of location GO:0051235 580 0.065
negative regulation of cellular process GO:0048523 239 0.063
negative regulation of developmental process GO:0051093 227 0.062
regulation of signal transduction GO:0009966 135 0.062
Human
mating behavior GO:0007617 32 0.061
body morphogenesis GO:0010171 620 0.061
developmental growth GO:0048589 412 0.060
gamete generation GO:0007276 461 0.059
heterocycle biosynthetic process GO:0018130 187 0.058
regulation of vulval development GO:0040028 248 0.058
cell morphogenesis GO:0000902 163 0.057
Zebrafish
determination of adult lifespan GO:0008340 812 0.056
positive regulation of developmental growth GO:0048639 354 0.055
vulval development GO:0040025 333 0.055
positive regulation of multicellular organism growth GO:0040018 352 0.054
regulation of multicellular organism growth GO:0040014 373 0.054
lipid localization GO:0010876 573 0.053
regulation of primary metabolic process GO:0080090 292 0.053
Human
protein localization GO:0008104 205 0.053
Human
multicellular organismal aging GO:0010259 812 0.053
development of primary sexual characteristics GO:0045137 840 0.052
cellular nitrogen compound biosynthetic process GO:0044271 192 0.052
regulation of epithelial cell proliferation GO:0050678 1 0.052
receptor mediated endocytosis GO:0006898 715 0.051
regulation of cell cycle GO:0051726 194 0.051
positive regulation of biosynthetic process GO:0009891 109 0.050
protein metabolic process GO:0019538 422 0.050
Human
positive regulation of cell cycle GO:0045787 55 0.050
positive regulation of transcription dna templated GO:0045893 102 0.050
regulation of biosynthetic process GO:0009889 189 0.049
Human
cell cycle GO:0007049 526 0.049
gonad development GO:0008406 840 0.049
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.048
single organism localization GO:1902578 518 0.048
Human
transcription from rna polymerase ii promoter GO:0006366 149 0.048
rna biosynthetic process GO:0032774 169 0.048
sensory organ morphogenesis GO:0090596 2 0.048
response to topologically incorrect protein GO:0035966 82 0.047
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.047
negative regulation of nematode larval development GO:0061064 208 0.046
positive regulation of cellular process GO:0048522 332 0.046
Human
response to endoplasmic reticulum stress GO:0034976 71 0.043
positive regulation of cellular biosynthetic process GO:0031328 109 0.043
transcription dna templated GO:0006351 168 0.043
regulation of developmental growth GO:0048638 389 0.042
nucleobase containing compound biosynthetic process GO:0034654 184 0.042
positive regulation of rna metabolic process GO:0051254 103 0.041
post embryonic organ development GO:0048569 336 0.040
biosynthetic process GO:0009058 323 0.040
regulation of cell cycle process GO:0010564 145 0.039
cell death GO:0008219 547 0.039
regulation of response to stimulus GO:0048583 243 0.039
Human
regulation of cellular component organization GO:0051128 248 0.039
cellular component biogenesis GO:0044085 297 0.038
embryonic morphogenesis GO:0048598 152 0.038
negative regulation of macromolecule metabolic process GO:0010605 229 0.038
aging GO:0007568 812 0.038
positive regulation of growth GO:0045927 369 0.037
nucleic acid templated transcription GO:0097659 169 0.037
cell proliferation GO:0008283 116 0.037
Fly
regulation of rna metabolic process GO:0051252 173 0.036
Human
tube development GO:0035295 126 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.035
regulation of nucleic acid templated transcription GO:1903506 165 0.035
Human
catabolic process GO:0009056 318 0.034
negative regulation of cellular biosynthetic process GO:0031327 65 0.034
regulation of cell differentiation GO:0045595 81 0.033
generation of neurons GO:0048699 235 0.033
organelle fission GO:0048285 363 0.033
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.032
Human
cellular component assembly GO:0022607 293 0.032
single organism organelle organization GO:1902589 501 0.032
organelle assembly GO:0070925 214 0.031
oogenesis GO:0048477 229 0.031
head development GO:0060322 1 0.031
regulation of cell proliferation GO:0042127 105 0.031
Fly
negative regulation of metabolic process GO:0009892 240 0.030
growth GO:0040007 562 0.030
death GO:0016265 547 0.030
negative regulation of gene expression GO:0010629 217 0.030
negative regulation of biosynthetic process GO:0009890 65 0.029
regulation of protein metabolic process GO:0051246 81 0.029
Human
molting cycle GO:0042303 281 0.029
digestive tract development GO:0048565 122 0.029
programmed cell death GO:0012501 500 0.029
positive regulation of neuron projection development GO:0010976 4 0.029
multicellular organism growth GO:0035264 385 0.028
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.028
germ cell development GO:0007281 351 0.027
reproductive system development GO:0061458 850 0.027
regulation of growth GO:0040008 409 0.027
regulation of rna biosynthetic process GO:2001141 165 0.027
Human
inductive cell migration GO:0040039 145 0.027
muscle structure development GO:0061061 191 0.027
regulation of locomotion GO:0040012 161 0.027
regulation of cellular metabolic process GO:0031323 305 0.027
Human
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.026
negative regulation of response to stimulus GO:0048585 73 0.026
macromolecular complex assembly GO:0065003 193 0.026
synaptic vesicle recycling GO:0036465 3 0.026
macromolecular complex subunit organization GO:0043933 320 0.026
positive regulation of metabolic process GO:0009893 187 0.025
Human
regulation of apoptotic signaling pathway GO:2001233 1 0.025
response to organic substance GO:0010033 131 0.025
axon development GO:0061564 163 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.024
single organism cellular localization GO:1902580 72 0.024
Human
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.023
mating GO:0007618 34 0.023
oocyte axis specification GO:0007309 2 0.023
single organism transport GO:0044765 447 0.023
Human
organic cyclic compound biosynthetic process GO:1901362 195 0.023
regulation of cytoplasmic transport GO:1903649 3 0.022
Human
neuron recognition GO:0008038 83 0.022
aromatic compound biosynthetic process GO:0019438 192 0.022
positive regulation of neuron differentiation GO:0045666 4 0.022
canonical wnt signaling pathway GO:0060070 3 0.021
microtubule based process GO:0007017 182 0.021
intracellular transport GO:0046907 77 0.020
Human
cellular response to unfolded protein GO:0034620 71 0.020
signal transduction GO:0007165 317 0.020
Human
regulation of transcription dna templated GO:0006355 164 0.020
muscle tissue development GO:0060537 1 0.020
positive regulation of cell projection organization GO:0031346 4 0.020
epithelial cell proliferation GO:0050673 1 0.020
mrna metabolic process GO:0016071 31 0.020
female gamete generation GO:0007292 254 0.020
mesodermal cell migration GO:0008078 9 0.020
regulation of cell death GO:0010941 65 0.019
ras protein signal transduction GO:0007265 31 0.019
small molecule metabolic process GO:0044281 186 0.019
positive regulation of cellular metabolic process GO:0031325 178 0.019
Human
anatomical structure formation involved in morphogenesis GO:0048646 250 0.018
positive regulation of response to stimulus GO:0048584 55 0.018
Human
neuron projection morphogenesis GO:0048812 114 0.018
Zebrafish
positive regulation of rna biosynthetic process GO:1902680 102 0.018
positive regulation of signaling GO:0023056 66 0.018
Human
single organism intracellular transport GO:1902582 70 0.018
Human
vesicle localization GO:0051648 24 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.018
regulation of mitotic cell cycle GO:0007346 76 0.018
regulation of metabolic process GO:0019222 478 0.018
Human
synaptic vesicle endocytosis GO:0048488 3 0.018
response to external stimulus GO:0009605 289 0.017
epithelium development GO:0060429 68 0.017
myofibril assembly GO:0030239 154 0.017
cell cycle switching mitotic to meiotic cell cycle GO:0051728 35 0.017
ribonucleoprotein complex assembly GO:0022618 4 0.017
cytoskeleton organization GO:0007010 339 0.017
oocyte development GO:0048599 44 0.016
axon guidance GO:0007411 82 0.016
cellular macromolecule catabolic process GO:0044265 73 0.016
muscle cell differentiation GO:0042692 171 0.016
regulation of neuron differentiation GO:0045664 40 0.016
oocyte construction GO:0007308 2 0.016
positive regulation of nucleic acid templated transcription GO:1903508 102 0.016
taxis GO:0042330 128 0.016
oviposition GO:0018991 364 0.016
cell recognition GO:0008037 85 0.016
intracellular receptor signaling pathway GO:0030522 2 0.016
synaptic vesicle localization GO:0097479 22 0.015
cellular response to topologically incorrect protein GO:0035967 76 0.015
positive regulation of neurogenesis GO:0050769 4 0.015
oocyte differentiation GO:0009994 45 0.015
neurological system process GO:0050877 53 0.015
negative regulation of translation GO:0017148 10 0.015
protein modification process GO:0036211 207 0.015
Human
skeletal muscle organ development GO:0060538 3 0.015
developmental maturation GO:0021700 26 0.015
negative regulation of cell cycle GO:0045786 53 0.015
regulation of organelle organization GO:0033043 164 0.014
regulation of cell development GO:0060284 49 0.014
negative regulation of neurogenesis GO:0050768 4 0.014
regulation of transport GO:0051049 91 0.014
Human
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.014
cellular localization GO:0051641 360 0.014
Human
mitotic cell cycle process GO:1903047 194 0.014
response to abiotic stimulus GO:0009628 152 0.014
er nucleus signaling pathway GO:0006984 66 0.014
asymmetric cell division GO:0008356 36 0.013
establishment of localization in cell GO:0051649 318 0.013
Human
positive regulation of cell morphogenesis involved in differentiation GO:0010770 4 0.013
cellular protein localization GO:0034613 75 0.013
Human
actomyosin structure organization GO:0031032 154 0.013
organic cyclic compound catabolic process GO:1901361 119 0.013
positive regulation of jnk cascade GO:0046330 3 0.013
organ morphogenesis GO:0009887 67 0.013
regulation of neurogenesis GO:0050767 40 0.013
regulation of cell projection organization GO:0031344 38 0.013
tissue development GO:0009888 112 0.013
mitotic nuclear division GO:0007067 89 0.013
epithelial tube morphogenesis GO:0060562 1 0.013
regulation of cellular component movement GO:0051270 62 0.013
regulation of stem cell differentiation GO:2000736 1 0.013
negative regulation of signal transduction GO:0009968 60 0.013
organic substance transport GO:0071702 113 0.013
Human
intraspecies interaction between organisms GO:0051703 3 0.013
regulation of intracellular signal transduction GO:1902531 77 0.013
dendrite development GO:0016358 42 0.013
Zebrafish
endoplasmic reticulum unfolded protein response GO:0030968 66 0.012
innate immune response GO:0045087 190 0.012
regulation of cell division GO:0051302 142 0.012
organic substance catabolic process GO:1901575 294 0.012
cellular response to abiotic stimulus GO:0071214 4 0.012
translation GO:0006412 37 0.012
dauer larval development GO:0040024 92 0.012
cellular component assembly involved in morphogenesis GO:0010927 183 0.012
regulation of nucleocytoplasmic transport GO:0046822 3 0.012
Human
male sex differentiation GO:0046661 86 0.012
male mating behavior GO:0060179 26 0.012
neuromuscular junction development GO:0007528 2 0.012
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.012
positive regulation of signal transduction GO:0009967 40 0.012
Human
cellular macromolecular complex assembly GO:0034622 184 0.012
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 5 0.012
necrotic cell death GO:0070265 29 0.012
macromolecule catabolic process GO:0009057 202 0.011
tube morphogenesis GO:0035239 79 0.011
negative regulation of cell communication GO:0010648 61 0.011
negative regulation of nucleic acid templated transcription GO:1903507 53 0.011
negative regulation of wnt signaling pathway GO:0030178 6 0.011
pattern specification process GO:0007389 59 0.011
rna splicing via transesterification reactions GO:0000375 8 0.011
myosin filament organization GO:0031033 138 0.011
spindle organization GO:0007051 92 0.011
muscle cell development GO:0055001 158 0.011
neuromuscular process GO:0050905 1 0.011
negative regulation of cellular metabolic process GO:0031324 95 0.011
cellular protein complex assembly GO:0043623 178 0.011
regulation of small gtpase mediated signal transduction GO:0051056 41 0.011
collagen and cuticulin based cuticle development GO:0040002 99 0.011
defense response GO:0006952 296 0.010
regulation of cellular protein metabolic process GO:0032268 75 0.010
Human
striated muscle cell development GO:0055002 157 0.010
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.010
cellular response to stress GO:0033554 162 0.010
regulation of nervous system development GO:0051960 41 0.010
regulation of meiotic cell cycle GO:0051445 136 0.010

mec-8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011