Caenorhabditis elegans

64 known processes

him-10 (CELE_R12B2.4)

Protein HIM-10

him-10 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic cell cycle process GO:1903047 194 0.882
mitotic sister chromatid segregation GO:0000070 38 0.831
cell cycle GO:0007049 526 0.710
single organism reproductive process GO:0044702 1196 0.669
development of primary sexual characteristics GO:0045137 840 0.633
attachment of spindle microtubules to kinetochore GO:0008608 8 0.606
microtubule based process GO:0007017 182 0.572
mitotic spindle organization GO:0007052 81 0.571
hermaphrodite genitalia development GO:0040035 734 0.570
developmental process involved in reproduction GO:0003006 1165 0.556
embryo development ending in birth or egg hatching GO:0009792 2992 0.555
sex differentiation GO:0007548 909 0.551
sexual reproduction GO:0019953 546 0.526
nucleic acid metabolic process GO:0090304 299 0.515
multicellular organism reproduction GO:0032504 819 0.511
reproductive system development GO:0061458 850 0.509
multi organism reproductive process GO:0044703 867 0.509
cell cycle process GO:0022402 482 0.487
meiotic chromosome segregation GO:0045132 139 0.473
cellular localization GO:0051641 360 0.459
gonad development GO:0008406 840 0.457
sister chromatid segregation GO:0000819 46 0.457
cell morphogenesis GO:0000902 163 0.436
nucleobase containing compound metabolic process GO:0006139 406 0.413
multicellular organismal reproductive process GO:0048609 815 0.411
dna metabolic process GO:0006259 74 0.379
microtubule cytoskeleton organization involved in mitosis GO:1902850 12 0.378
gene expression GO:0010467 412 0.376
reproductive structure development GO:0048608 850 0.372
embryo development GO:0009790 3052 0.370
meiotic cell cycle GO:0051321 335 0.362
single organism organelle organization GO:1902589 501 0.327
organ development GO:0048513 1102 0.313
establishment of localization GO:0051234 1171 0.306
gamete generation GO:0007276 461 0.293
spindle organization GO:0007051 92 0.285
chromosome segregation GO:0007059 180 0.283
organelle organization GO:0006996 783 0.276
cellular macromolecule biosynthetic process GO:0034645 247 0.269
oviposition GO:0018991 364 0.266
negative regulation of biological process GO:0048519 567 0.261
cell projection morphogenesis GO:0048858 148 0.248
maintenance of location in cell GO:0051651 12 0.242
mitotic nuclear division GO:0007067 89 0.239
locomotion GO:0040011 1634 0.238
maintenance of protein location in cell GO:0032507 12 0.236
organelle fission GO:0048285 363 0.231
neuron projection development GO:0031175 187 0.228
neurogenesis GO:0022008 236 0.222
regulation of cell cycle GO:0051726 194 0.221
cellular component morphogenesis GO:0032989 318 0.207
cytoskeleton organization GO:0007010 339 0.206
germ cell development GO:0007281 351 0.196
genitalia development GO:0048806 741 0.193
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.188
multi organism reproductive behavior GO:0044705 387 0.180
establishment of localization in cell GO:0051649 318 0.180
establishment of organelle localization GO:0051656 123 0.176
rna biosynthetic process GO:0032774 169 0.175
microtubule polymerization or depolymerization GO:0031109 22 0.168
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.166
protein complex subunit organization GO:0071822 280 0.165
centromere complex assembly GO:0034508 5 0.165
reproductive behavior GO:0019098 387 0.163
cell part morphogenesis GO:0032990 152 0.160
neuron differentiation GO:0030182 217 0.160
post embryonic development GO:0009791 2152 0.156
cell projection organization GO:0030030 231 0.155
generation of neurons GO:0048699 235 0.154
cellular component movement GO:0006928 388 0.152
aromatic compound biosynthetic process GO:0019438 192 0.149
positive regulation of cellular process GO:0048522 332 0.140
regulation of primary metabolic process GO:0080090 292 0.139
transcription dna templated GO:0006351 168 0.137
regulation of rna biosynthetic process GO:2001141 165 0.133
cell development GO:0048468 696 0.132
regulation of transcription dna templated GO:0006355 164 0.129
regulation of gene expression GO:0010468 366 0.129
receptor mediated endocytosis GO:0006898 715 0.128
regulation of macromolecule biosynthetic process GO:0010556 189 0.128
transcription from rna polymerase ii promoter GO:0006366 149 0.123
organelle localization GO:0051640 127 0.122
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.119
multicellular organismal reproductive behavior GO:0033057 384 0.118
phosphate containing compound metabolic process GO:0006796 232 0.117
organic substance biosynthetic process GO:1901576 323 0.116
macromolecular complex subunit organization GO:0043933 320 0.112
multi multicellular organism process GO:0044706 390 0.111
neuron projection morphogenesis GO:0048812 114 0.111
macromolecule biosynthetic process GO:0009059 250 0.108
regulation of rna metabolic process GO:0051252 173 0.107
regulation of biological quality GO:0065008 741 0.106
single organism localization GO:1902578 518 0.103
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.101
regulation of mitotic cell cycle GO:0007346 76 0.101
biosynthetic process GO:0009058 323 0.100
response to chemical GO:0042221 356 0.100
catabolic process GO:0009056 318 0.099
spindle assembly GO:0051225 8 0.099
cellular nitrogen compound biosynthetic process GO:0044271 192 0.099
cell migration GO:0016477 306 0.099
cellular biosynthetic process GO:0044249 315 0.095
meiotic nuclear division GO:0007126 300 0.093
microtubule anchoring GO:0034453 8 0.093
negative regulation of cellular process GO:0048523 239 0.092
regulation of cellular component organization GO:0051128 248 0.092
aging GO:0007568 812 0.091
determination of adult lifespan GO:0008340 812 0.089
cellular component biogenesis GO:0044085 297 0.089
organic substance catabolic process GO:1901575 294 0.087
nucleic acid templated transcription GO:0097659 169 0.082
meiotic cell cycle process GO:1903046 170 0.080
cellular response to dna damage stimulus GO:0006974 41 0.079
regulation of macromolecule metabolic process GO:0060255 421 0.079
negative regulation of gene expression GO:0010629 217 0.078
negative regulation of developmental process GO:0051093 227 0.075
macromolecule catabolic process GO:0009057 202 0.074
axon development GO:0061564 163 0.074
regulation of cell division GO:0051302 142 0.073
body morphogenesis GO:0010171 620 0.073
multicellular organismal aging GO:0010259 812 0.073
cell motility GO:0048870 313 0.073
regulation of nucleic acid templated transcription GO:1903506 165 0.070
cellular macromolecular complex assembly GO:0034622 184 0.070
fertilization GO:0009566 63 0.070
nervous system development GO:0007399 253 0.068
cell cycle phase transition GO:0044770 19 0.067
regulation of cellular biosynthetic process GO:0031326 189 0.067
protein metabolic process GO:0019538 422 0.067
growth GO:0040007 562 0.066
regulation of microtubule cytoskeleton organization GO:0070507 21 0.066
behavior GO:0007610 527 0.065
gene silencing by rna GO:0031047 143 0.065
rna metabolic process GO:0016070 228 0.064
developmental growth GO:0048589 412 0.064
organic cyclic compound biosynthetic process GO:1901362 195 0.064
negative regulation of cell cycle GO:0045786 53 0.064
positive regulation of developmental process GO:0051094 408 0.063
negative regulation of vulval development GO:0040027 206 0.061
regulation of multicellular organismal process GO:0051239 726 0.061
regulation of meiosis GO:0040020 94 0.061
phosphorus metabolic process GO:0006793 232 0.060
regulation of gene expression epigenetic GO:0040029 163 0.060
kinetochore assembly GO:0051382 5 0.060
macromolecule localization GO:0033036 771 0.059
localization of cell GO:0051674 313 0.058
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.058
cellular nitrogen compound catabolic process GO:0044270 119 0.058
polar body extrusion after meiotic divisions GO:0040038 14 0.056
single fertilization GO:0007338 61 0.056
kinetochore organization GO:0051383 7 0.055
regulation of meiotic cell cycle GO:0051445 136 0.054
maintenance of location GO:0051235 580 0.054
ribose phosphate metabolic process GO:0019693 99 0.053
cellular macromolecule catabolic process GO:0044265 73 0.052
cell proliferation GO:0008283 116 0.052
maintenance of protein location GO:0045185 15 0.052
multi organism behavior GO:0051705 389 0.051
oogenesis GO:0048477 229 0.051
cellular component assembly GO:0022607 293 0.050
cell division GO:0051301 262 0.050
positive regulation of nematode larval development GO:0061063 54 0.050
female meiotic division GO:0007143 17 0.049
positive regulation of transcription dna templated GO:0045893 102 0.049
organelle assembly GO:0070925 214 0.049
regulation of cell cycle process GO:0010564 145 0.048
posttranscriptional gene silencing by rna GO:0035194 143 0.047
organonitrogen compound metabolic process GO:1901564 151 0.046
attachment of mitotic spindle microtubules to kinetochore GO:0051315 6 0.046
protein complex biogenesis GO:0070271 186 0.045
regulation of developmental process GO:0050793 684 0.045
chromosome organization involved in meiosis GO:0070192 25 0.045
neuron projection guidance GO:0097485 82 0.044
macromolecular complex assembly GO:0065003 193 0.044
regulation of cellular ketone metabolic process GO:0010565 3 0.044
dendrite development GO:0016358 42 0.044
aromatic compound catabolic process GO:0019439 116 0.043
nucleobase containing compound biosynthetic process GO:0034654 184 0.043
metaphase anaphase transition of cell cycle GO:0044784 15 0.042
regulation of cellular metabolic process GO:0031323 305 0.041
chromosome organization GO:0051276 104 0.041
pronuclear migration GO:0035046 51 0.040
purine nucleotide metabolic process GO:0006163 95 0.040
gene silencing GO:0016458 143 0.040
positive regulation of multicellular organismal process GO:0051240 417 0.040
cell morphogenesis involved in differentiation GO:0000904 112 0.039
regulation of microtubule based process GO:0032886 21 0.039
male sex differentiation GO:0046661 86 0.038
nucleotide metabolic process GO:0009117 108 0.038
dna repair GO:0006281 23 0.038
lipid storage GO:0019915 565 0.038
cellular protein modification process GO:0006464 207 0.038
regulation of nitrogen compound metabolic process GO:0051171 222 0.037
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.037
neuron development GO:0048666 199 0.037
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.037
cellular catabolic process GO:0044248 199 0.036
macromolecule modification GO:0043412 218 0.035
single organism catabolic process GO:0044712 129 0.035
lipid localization GO:0010876 573 0.035
regulation of organelle organization GO:0033043 164 0.034
homeostatic process GO:0042592 51 0.034
negative regulation of gene expression epigenetic GO:0045814 2 0.034
regulation of metabolic process GO:0019222 478 0.033
establishment of spindle localization GO:0051293 51 0.033
nucleoside phosphate metabolic process GO:0006753 108 0.033
cellular protein metabolic process GO:0044267 279 0.033
positive regulation of post embryonic development GO:0048582 54 0.032
carbohydrate derivative metabolic process GO:1901135 141 0.032
positive regulation of cellular metabolic process GO:0031325 178 0.031
single organism signaling GO:0044700 401 0.031
posttranscriptional gene silencing GO:0016441 143 0.031
dna duplex unwinding GO:0032508 3 0.031
protein localization GO:0008104 205 0.031
cytokinesis GO:0000910 80 0.031
negative regulation of metabolic process GO:0009892 240 0.031
negative regulation of nucleic acid templated transcription GO:1903507 53 0.030
negative regulation of multicellular organismal process GO:0051241 236 0.030
rna interference GO:0016246 137 0.030
protein catabolic process GO:0030163 162 0.030
endocytosis GO:0006897 819 0.030
positive regulation of gene expression GO:0010628 112 0.029
multicellular organism growth GO:0035264 385 0.029
response to oxygen containing compound GO:1901700 44 0.029
chemotaxis GO:0006935 120 0.029
molting cycle GO:0042303 281 0.028
organic cyclic compound catabolic process GO:1901361 119 0.028
cytokinesis completion of separation GO:0007109 4 0.028
cell fate commitment GO:0045165 139 0.027
mitotic sister chromatid separation GO:0051306 13 0.027
dna templated transcription elongation GO:0006354 1 0.027
regulation of growth GO:0040008 409 0.027
purine nucleoside metabolic process GO:0042278 92 0.027
cellular protein complex assembly GO:0043623 178 0.027
negative regulation of mitotic cell cycle GO:0045930 42 0.026
nucleobase containing compound catabolic process GO:0034655 114 0.026
regulation of vulval development GO:0040028 248 0.026
small molecule metabolic process GO:0044281 186 0.026
regulation of chromosome segregation GO:0051983 20 0.026
negative regulation of rna biosynthetic process GO:1902679 53 0.025
negative regulation of macromolecule metabolic process GO:0010605 229 0.025
ubiquitin dependent protein catabolic process GO:0006511 32 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.025
cellular amine metabolic process GO:0044106 15 0.025
mitotic g2 m transition checkpoint GO:0044818 1 0.024
peptidyl amino acid modification GO:0018193 58 0.024
heterocycle biosynthetic process GO:0018130 187 0.024
cellular ketone metabolic process GO:0042180 14 0.024
regulation of nuclear division GO:0051783 115 0.024
regulation of mitotic metaphase anaphase transition GO:0030071 5 0.024
cellular protein localization GO:0034613 75 0.024
organonitrogen compound catabolic process GO:1901565 90 0.024
vesicle mediated transport GO:0016192 852 0.023
meiotic cytokinesis GO:0033206 15 0.023
modification dependent protein catabolic process GO:0019941 32 0.023
cellular response to stress GO:0033554 162 0.023
nucleoside monophosphate metabolic process GO:0009123 46 0.023
regulation of response to stimulus GO:0048583 243 0.022
regulation of nematode larval development GO:0061062 260 0.022
establishment of cell polarity GO:0030010 46 0.022
axonogenesis GO:0007409 102 0.022
amine metabolic process GO:0009308 15 0.022
actin filament based process GO:0030029 191 0.022
death GO:0016265 547 0.022
positive regulation of multicellular organism growth GO:0040018 352 0.022
protein complex assembly GO:0006461 186 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.022
spindle assembly involved in mitosis GO:0090307 6 0.022
internal peptidyl lysine acetylation GO:0018393 3 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.022
response to organic substance GO:0010033 131 0.022
meiosis i GO:0007127 19 0.021
head development GO:0060322 1 0.021
regulation of localization GO:0032879 194 0.021
negative regulation of cellular biosynthetic process GO:0031327 65 0.021
regulation of cellular amine metabolic process GO:0033238 0 0.021
nuclear migration GO:0007097 54 0.021
regulation of post embryonic development GO:0048580 260 0.021
dna recombination GO:0006310 19 0.021
negative regulation of post embryonic development GO:0048581 208 0.021
positive regulation of vulval development GO:0040026 52 0.021
muscle structure development GO:0061061 191 0.020
regulation of locomotion GO:0040012 161 0.020
glycosyl compound metabolic process GO:1901657 100 0.020
axon guidance GO:0007411 82 0.020
positive regulation of growth GO:0045927 369 0.020
ribonucleoside triphosphate metabolic process GO:0009199 87 0.020
post embryonic organ development GO:0048569 336 0.020
inductive cell migration GO:0040039 145 0.020
proteasomal protein catabolic process GO:0010498 20 0.020
posttranscriptional regulation of gene expression GO:0010608 166 0.019
regulation of multicellular organism growth GO:0040014 373 0.019
establishment of nucleus localization GO:0040023 55 0.019
regulation of cell differentiation GO:0045595 81 0.019
regulation of attachment of spindle microtubules to kinetochore GO:0051988 2 0.019
protein modification process GO:0036211 207 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
vulval development GO:0040025 333 0.019
organic acid metabolic process GO:0006082 47 0.018
protein phosphorylation GO:0006468 85 0.018
transport GO:0006810 1093 0.018
female gamete generation GO:0007292 254 0.018
regulation of biosynthetic process GO:0009889 189 0.018
regulation of cell motility GO:2000145 57 0.018
cell death GO:0008219 547 0.018
carbohydrate derivative catabolic process GO:1901136 82 0.018
organophosphate metabolic process GO:0019637 125 0.018
regulation of mitotic sister chromatid segregation GO:0033047 16 0.018
striated muscle cell differentiation GO:0051146 158 0.018
positive regulation of nucleic acid templated transcription GO:1903508 102 0.018
purine containing compound metabolic process GO:0072521 95 0.017
ribonucleoside catabolic process GO:0042454 77 0.017
regulation of cell proliferation GO:0042127 105 0.017
dna replication GO:0006260 15 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.017
actomyosin structure organization GO:0031032 154 0.017
cuticle development GO:0042335 100 0.017
negative regulation of organelle organization GO:0010639 20 0.017
dna conformation change GO:0071103 11 0.017
ribonucleoside monophosphate metabolic process GO:0009161 45 0.017
ribonucleotide metabolic process GO:0009259 99 0.016
regulation of cellular component movement GO:0051270 62 0.016
purine nucleoside catabolic process GO:0006152 75 0.016
cellular amino acid metabolic process GO:0006520 15 0.016
protein modification by small protein conjugation or removal GO:0070647 40 0.016
oxoacid metabolic process GO:0043436 47 0.016
actin cytoskeleton organization GO:0030036 184 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.016
negative regulation of chromosome segregation GO:0051985 4 0.016
regulation of cytoskeleton organization GO:0051493 41 0.015
establishment of mitotic spindle orientation GO:0000132 28 0.015
nucleobase containing small molecule metabolic process GO:0055086 115 0.015
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.015
neuromuscular junction development GO:0007528 2 0.015
cellular macromolecule localization GO:0070727 75 0.015
regulation of cell cycle phase transition GO:1901987 13 0.015
positive regulation of rna biosynthetic process GO:1902680 102 0.015
collagen and cuticulin based cuticle development GO:0040002 99 0.015
positive regulation of developmental growth GO:0048639 354 0.015
mitotic cell cycle phase transition GO:0044772 13 0.015
negative regulation of cellular protein catabolic process GO:1903363 4 0.014
purine ribonucleotide metabolic process GO:0009150 95 0.014
protein polymerization GO:0051258 26 0.014
nucleoside phosphate catabolic process GO:1901292 77 0.014
dna geometric change GO:0032392 3 0.014
programmed cell death GO:0012501 500 0.014
positive regulation of macromolecule metabolic process GO:0010604 149 0.014
purine ribonucleoside catabolic process GO:0046130 75 0.014
mitotic cell cycle checkpoint GO:0007093 5 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 20 0.014
regulation of multicellular organismal development GO:2000026 317 0.014
metaphase anaphase transition of mitotic cell cycle GO:0007091 10 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 65 0.014
epithelial tube morphogenesis GO:0060562 1 0.013
positive regulation of cellular biosynthetic process GO:0031328 109 0.013
nucleoside metabolic process GO:0009116 99 0.013
positive regulation of chromosome organization GO:2001252 2 0.013
positive regulation of stem cell differentiation GO:2000738 1 0.013
meiosis ii GO:0007135 16 0.013
taxis GO:0042330 128 0.013
microtubule based movement GO:0007018 33 0.013
tube development GO:0035295 126 0.013
dna packaging GO:0006323 7 0.013
g1 s transition of mitotic cell cycle GO:0000082 2 0.013
response to external stimulus GO:0009605 289 0.013
positive regulation of rna metabolic process GO:0051254 103 0.013
cellular component assembly involved in morphogenesis GO:0010927 183 0.013
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 4 0.013
defense response GO:0006952 296 0.012
spindle localization GO:0051653 51 0.012
positive regulation of cell cycle GO:0045787 55 0.012
protein dna complex assembly GO:0065004 7 0.012
cytoskeleton dependent cytokinesis GO:0061640 35 0.012
atp metabolic process GO:0046034 42 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.012
regulation of protein localization GO:0032880 50 0.012
positive regulation of chromosome segregation GO:0051984 1 0.012
glycosyl compound catabolic process GO:1901658 79 0.012
signal transduction GO:0007165 317 0.012
chromatin assembly GO:0031497 1 0.012
proteolysis GO:0006508 61 0.012
negative regulation of nematode larval development GO:0061064 208 0.012
positive regulation of neurogenesis GO:0050769 4 0.012
peptidyl lysine acetylation GO:0018394 3 0.012
protein dna complex subunit organization GO:0071824 7 0.011
regulation of mitosis GO:0007088 18 0.011
establishment of mitotic spindle localization GO:0040001 41 0.011
purine nucleoside triphosphate catabolic process GO:0009146 72 0.011
regulation of developmental growth GO:0048638 389 0.011
regulation of apoptotic signaling pathway GO:2001233 1 0.011
regulation of mitotic spindle organization GO:0060236 3 0.011
centrosome cycle GO:0007098 13 0.011
spindle checkpoint GO:0031577 4 0.011
cellular response to organic substance GO:0071310 119 0.011
nucleoside triphosphate metabolic process GO:0009141 87 0.011
positive regulation of intracellular transport GO:0032388 2 0.011
phosphorylation GO:0016310 116 0.011
ribonucleoside triphosphate catabolic process GO:0009203 72 0.011
negative regulation of mitotic sister chromatid segregation GO:0033048 4 0.011
regulation of epithelial cell differentiation GO:0030856 4 0.011
negative regulation of transcription dna templated GO:0045892 53 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 28 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.011
microtubule depolymerization GO:0007019 10 0.011
protein localization to organelle GO:0033365 37 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 43 0.010
organ morphogenesis GO:0009887 67 0.010
nucleus localization GO:0051647 55 0.010
chromatin remodeling GO:0006338 2 0.010
mitotic spindle stabilization GO:0043148 2 0.010
positive regulation of biosynthetic process GO:0009891 109 0.010
regulation of nucleocytoplasmic transport GO:0046822 3 0.010
signaling GO:0023052 401 0.010
regulation of cellular catabolic process GO:0031329 51 0.010
purine nucleoside triphosphate metabolic process GO:0009144 87 0.010
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.010

him-10 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.033
cancer DOID:162 0 0.022
disease of anatomical entity DOID:7 0 0.021
organ system cancer DOID:0050686 0 0.019
gastrointestinal system cancer DOID:3119 0 0.017
intestinal cancer DOID:10155 0 0.015
large intestine cancer DOID:5672 0 0.015