Caenorhabditis elegans

8 known processes

clp-2 (CELE_T04A8.16)

Protein CLP-2

clp-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
developmental process involved in reproduction GO:0003006 1165 0.745
embryo development ending in birth or egg hatching GO:0009792 2992 0.724
development of primary sexual characteristics GO:0045137 840 0.632
embryo development GO:0009790 3052 0.578
organ development GO:0048513 1102 0.533
reproductive system development GO:0061458 850 0.468
chromosome segregation GO:0007059 180 0.434
sister chromatid segregation GO:0000819 46 0.369
regulation of developmental process GO:0050793 684 0.357
gonad development GO:0008406 840 0.351
sex differentiation GO:0007548 909 0.348
locomotion GO:0040011 1634 0.345
Human
determination of adult lifespan GO:0008340 812 0.337
hermaphrodite genitalia development GO:0040035 734 0.335
reproductive structure development GO:0048608 850 0.328
cell death GO:0008219 547 0.323
multicellular organismal aging GO:0010259 812 0.301
single organism reproductive process GO:0044702 1196 0.293
aging GO:0007568 812 0.291
regulation of multicellular organismal process GO:0051239 726 0.283
Human
establishment of localization GO:0051234 1171 0.272
nervous system development GO:0007399 253 0.267
post embryonic development GO:0009791 2152 0.264
genitalia development GO:0048806 741 0.260
transport GO:0006810 1093 0.252
single organism organelle organization GO:1902589 501 0.210
response to external stimulus GO:0009605 289 0.188
positive regulation of developmental process GO:0051094 408 0.187
growth GO:0040007 562 0.168
endocytosis GO:0006897 819 0.166
gamete generation GO:0007276 461 0.160
post embryonic organ development GO:0048569 336 0.159
multicellular organismal reproductive process GO:0048609 815 0.157
single organism transport GO:0044765 447 0.140
vesicle mediated transport GO:0016192 852 0.138
response to abiotic stimulus GO:0009628 152 0.136
negative regulation of biological process GO:0048519 567 0.136
organelle organization GO:0006996 783 0.133
death GO:0016265 547 0.129
positive regulation of multicellular organismal process GO:0051240 417 0.129
Human
regulation of biological quality GO:0065008 741 0.126
signaling GO:0023052 401 0.119
organelle fission GO:0048285 363 0.118
generation of neurons GO:0048699 235 0.116
receptor mediated endocytosis GO:0006898 715 0.113
sexual reproduction GO:0019953 546 0.112
macromolecule localization GO:0033036 771 0.105
regulation of growth GO:0040008 409 0.100
cell morphogenesis GO:0000902 163 0.100
positive regulation of metabolic process GO:0009893 187 0.097
purine nucleoside metabolic process GO:0042278 92 0.097
vulval development GO:0040025 333 0.096
programmed cell death GO:0012501 500 0.095
regulation of developmental growth GO:0048638 389 0.092
regulation of response to stimulus GO:0048583 243 0.091
heterocycle biosynthetic process GO:0018130 187 0.087
cell development GO:0048468 696 0.082
developmental growth GO:0048589 412 0.082
cytoskeleton organization GO:0007010 339 0.081
regulation of gene expression epigenetic GO:0040029 163 0.080
single organism signaling GO:0044700 401 0.080
negative regulation of vulval development GO:0040027 206 0.078
cellular component movement GO:0006928 388 0.076
Human
single organism localization GO:1902578 518 0.076
cellular response to stress GO:0033554 162 0.076
body morphogenesis GO:0010171 620 0.074
cellular component morphogenesis GO:0032989 318 0.072
positive regulation of multicellular organism growth GO:0040018 352 0.070
positive regulation of developmental growth GO:0048639 354 0.069
positive regulation of growth GO:0045927 369 0.069
maintenance of location GO:0051235 580 0.069
macromolecule catabolic process GO:0009057 202 0.069
protein metabolic process GO:0019538 422 0.068
Human
single organism cellular localization GO:1902580 72 0.068
meiotic cell cycle process GO:1903046 170 0.067
anatomical structure formation involved in morphogenesis GO:0048646 250 0.066
apoptotic process GO:0006915 478 0.066
carbohydrate derivative metabolic process GO:1901135 141 0.064
cellular protein modification process GO:0006464 207 0.064
multicellular organism reproduction GO:0032504 819 0.063
mitotic sister chromatid segregation GO:0000070 38 0.063
catabolic process GO:0009056 318 0.062
spindle localization GO:0051653 51 0.062
inductive cell migration GO:0040039 145 0.061
multicellular organism growth GO:0035264 385 0.060
meiotic cell cycle GO:0051321 335 0.060
positive regulation of cellular process GO:0048522 332 0.059
Human
regulation of metabolic process GO:0019222 478 0.059
defense response GO:0006952 296 0.059
lipid storage GO:0019915 565 0.059
regulation of vulval development GO:0040028 248 0.058
cellular catabolic process GO:0044248 199 0.058
regulation of multicellular organism growth GO:0040014 373 0.058
multi organism reproductive process GO:0044703 867 0.057
cell motility GO:0048870 313 0.057
Human
localization of cell GO:0051674 313 0.057
Human
regulation of multicellular organismal development GO:2000026 317 0.056
cellular response to dna damage stimulus GO:0006974 41 0.053
negative regulation of multicellular organismal process GO:0051241 236 0.053
membrane organization GO:0061024 135 0.052
response to chemical GO:0042221 356 0.052
lipid localization GO:0010876 573 0.052
neuron projection morphogenesis GO:0048812 114 0.051
protein deubiquitination GO:0016579 2 0.051
cell division GO:0051301 262 0.051
aromatic compound biosynthetic process GO:0019438 192 0.050
female gamete generation GO:0007292 254 0.050
negative regulation of cellular process GO:0048523 239 0.049
negative regulation of gene expression epigenetic GO:0045814 2 0.048
transcription dna templated GO:0006351 168 0.048
negative regulation of developmental process GO:0051093 227 0.047
regulation of gene expression GO:0010468 366 0.046
gene expression GO:0010467 412 0.046
neurogenesis GO:0022008 236 0.045
phosphate containing compound metabolic process GO:0006796 232 0.045
macromolecular complex subunit organization GO:0043933 320 0.045
neuron differentiation GO:0030182 217 0.045
protein catabolic process GO:0030163 162 0.044
cell projection morphogenesis GO:0048858 148 0.043
cellular component assembly GO:0022607 293 0.043
nucleobase containing compound biosynthetic process GO:0034654 184 0.043
behavior GO:0007610 527 0.043
response to external biotic stimulus GO:0043207 101 0.043
regulation of reproductive process GO:2000241 66 0.042
protein complex biogenesis GO:0070271 186 0.041
attachment of mitotic spindle microtubules to kinetochore GO:0051315 6 0.041
regulation of cellular component organization GO:0051128 248 0.040
chromosome organization GO:0051276 104 0.040
germ cell development GO:0007281 351 0.039
cellular nitrogen compound biosynthetic process GO:0044271 192 0.038
establishment of localization in cell GO:0051649 318 0.038
regulation of signaling GO:0023051 172 0.038
cellular macromolecular complex assembly GO:0034622 184 0.038
mitotic nuclear division GO:0007067 89 0.038
cellular protein complex assembly GO:0043623 178 0.038
negative regulation of transcription dna templated GO:0045892 53 0.038
protein complex subunit organization GO:0071822 280 0.038
regulation of cell communication GO:0010646 176 0.037
gene silencing GO:0016458 143 0.036
head development GO:0060322 1 0.036
neuron development GO:0048666 199 0.036
multicellular organismal reproductive behavior GO:0033057 384 0.036
cell part morphogenesis GO:0032990 152 0.035
regulation of macromolecule metabolic process GO:0060255 421 0.034
reproductive behavior GO:0019098 387 0.034
signal transduction GO:0007165 317 0.034
macromolecule modification GO:0043412 218 0.034
posttranscriptional regulation of gene expression GO:0010608 166 0.033
organophosphate catabolic process GO:0046434 81 0.033
small molecule metabolic process GO:0044281 186 0.033
macromolecule biosynthetic process GO:0009059 250 0.033
neuron projection development GO:0031175 187 0.033
cellular protein metabolic process GO:0044267 279 0.032
organelle localization GO:0051640 127 0.032
positive regulation of macromolecule metabolic process GO:0010604 149 0.031
innate immune response GO:0045087 190 0.031
cell migration GO:0016477 306 0.031
Human
single organism membrane fusion GO:0044801 13 0.030
response to other organism GO:0051707 101 0.029
protein modification process GO:0036211 207 0.028
ribonucleoside monophosphate metabolic process GO:0009161 45 0.027
ribonucleotide catabolic process GO:0009261 75 0.027
purine ribonucleotide metabolic process GO:0009150 95 0.027
small gtpase mediated signal transduction GO:0007264 32 0.027
organonitrogen compound metabolic process GO:1901564 151 0.026
response to temperature stimulus GO:0009266 66 0.026
response to wounding GO:0009611 4 0.026
rna biosynthetic process GO:0032774 169 0.026
organic substance catabolic process GO:1901575 294 0.026
negative regulation of gene expression GO:0010629 217 0.025
nucleic acid templated transcription GO:0097659 169 0.025
organophosphate metabolic process GO:0019637 125 0.025
posttranscriptional gene silencing by rna GO:0035194 143 0.025
cellular component assembly involved in morphogenesis GO:0010927 183 0.024
cellular localization GO:0051641 360 0.024
cellular component biogenesis GO:0044085 297 0.024
multi multicellular organism process GO:0044706 390 0.024
biosynthetic process GO:0009058 323 0.024
organelle assembly GO:0070925 214 0.024
protein modification by small protein conjugation or removal GO:0070647 40 0.024
macromolecule glycosylation GO:0043413 18 0.024
organic cyclic compound biosynthetic process GO:1901362 195 0.024
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.024
regulation of transport GO:0051049 91 0.024
gene silencing by rna GO:0031047 143 0.024
negative regulation of nematode larval development GO:0061064 208 0.024
regulation of response to stress GO:0080134 28 0.024
posttranscriptional gene silencing GO:0016441 143 0.023
microtubule based process GO:0007017 182 0.023
cellular process involved in reproduction in multicellular organism GO:0022412 351 0.023
regulation of multi organism process GO:0043900 69 0.022
single fertilization GO:0007338 61 0.022
golgi vesicle transport GO:0048193 3 0.022
aromatic compound catabolic process GO:0019439 116 0.022
pronuclear migration GO:0035046 51 0.022
nucleobase containing compound metabolic process GO:0006139 406 0.022
cell projection organization GO:0030030 231 0.022
nuclear migration GO:0007097 54 0.022
rna metabolic process GO:0016070 228 0.022
nucleoside phosphate catabolic process GO:1901292 77 0.021
macromolecular complex assembly GO:0065003 193 0.021
nucleoside phosphate metabolic process GO:0006753 108 0.021
negative regulation of post embryonic development GO:0048581 208 0.021
regulation of nematode larval development GO:0061062 260 0.021
nucleoside monophosphate metabolic process GO:0009123 46 0.020
regulation of chromosome segregation GO:0051983 20 0.020
establishment of organelle localization GO:0051656 123 0.020
phagocytosis GO:0006909 115 0.019
response to bacterium GO:0009617 86 0.019
cellular response to inorganic substance GO:0071241 3 0.019
cellular ketone metabolic process GO:0042180 14 0.019
skeletal muscle organ development GO:0060538 3 0.019
negative regulation of neurogenesis GO:0050768 4 0.019
muscle tissue development GO:0060537 1 0.019
metaphase anaphase transition of cell cycle GO:0044784 15 0.019
engulfment of apoptotic cell GO:0043652 94 0.019
positive regulation of molecular function GO:0044093 61 0.019
regulation of transcription dna templated GO:0006355 164 0.018
digestive system development GO:0055123 122 0.018
cellular nitrogen compound catabolic process GO:0044270 119 0.018
negative regulation of rna biosynthetic process GO:1902679 53 0.018
positive regulation of cell morphogenesis involved in differentiation GO:0010770 4 0.018
mitotic cell cycle process GO:1903047 194 0.018
oogenesis GO:0048477 229 0.018
positive regulation of cellular metabolic process GO:0031325 178 0.018
membrane invagination GO:0010324 98 0.018
ribose phosphate metabolic process GO:0019693 99 0.018
cell fate commitment GO:0045165 139 0.018
purine containing compound metabolic process GO:0072521 95 0.018
homeostatic process GO:0042592 51 0.017
regulation of post embryonic development GO:0048580 260 0.017
system process GO:0003008 136 0.017
heterocycle catabolic process GO:0046700 119 0.017
nucleobase containing small molecule metabolic process GO:0055086 115 0.017
ribonucleoside catabolic process GO:0042454 77 0.017
protein complex assembly GO:0006461 186 0.017
striated muscle myosin thick filament assembly GO:0071688 138 0.017
nucleobase containing compound catabolic process GO:0034655 114 0.017
single organism catabolic process GO:0044712 129 0.017
negative regulation of nucleic acid templated transcription GO:1903507 53 0.017
regulation of localization GO:0032879 194 0.017
Human
actin cytoskeleton organization GO:0030036 184 0.016
nucleic acid metabolic process GO:0090304 299 0.016
nucleoside metabolic process GO:0009116 99 0.016
protein localization GO:0008104 205 0.016
intracellular signal transduction GO:0035556 96 0.016
glycoprotein metabolic process GO:0009100 29 0.016
regulation of response to wounding GO:1903034 1 0.016
regulation of organelle organization GO:0033043 164 0.016
single organism intracellular transport GO:1902582 70 0.016
negative regulation of macromolecule metabolic process GO:0010605 229 0.016
rna interference GO:0016246 137 0.015
single organism biosynthetic process GO:0044711 91 0.015
cell cycle process GO:0022402 482 0.015
glycosyl compound metabolic process GO:1901657 100 0.015
nucleoside catabolic process GO:0009164 78 0.015
organic cyclic compound catabolic process GO:1901361 119 0.015
cell type specific apoptotic process GO:0097285 4 0.015
cellular protein catabolic process GO:0044257 37 0.015
regulation of nucleic acid templated transcription GO:1903506 165 0.015
phagocytosis engulfment GO:0006911 98 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
collagen and cuticulin based cuticle development GO:0040002 99 0.015
regulation of protein metabolic process GO:0051246 81 0.014
response to heat GO:0009408 50 0.014
nucleotide metabolic process GO:0009117 108 0.014
organelle fusion GO:0048284 8 0.014
chromatin remodeling GO:0006338 2 0.014
dna duplex unwinding GO:0032508 3 0.014
immune response GO:0006955 192 0.014
neurological system process GO:0050877 53 0.014
regulation of cell division GO:0051302 142 0.014
regulation of cell differentiation GO:0045595 81 0.014
multi organism reproductive behavior GO:0044705 387 0.014
cell cycle GO:0007049 526 0.013
cellular macromolecule localization GO:0070727 75 0.013
cytoskeleton dependent cytokinesis GO:0061640 35 0.013
purine ribonucleotide catabolic process GO:0009154 75 0.013
regulation of apoptotic process GO:0042981 36 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.013
cell morphogenesis involved in differentiation GO:0000904 112 0.013
intracellular transport GO:0046907 77 0.013
tube development GO:0035295 126 0.013
establishment of mitotic spindle localization GO:0040001 41 0.013
actomyosin structure organization GO:0031032 154 0.013
purine nucleotide catabolic process GO:0006195 75 0.013
mating behavior GO:0007617 32 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 43 0.013
multi organism behavior GO:0051705 389 0.013
protein polymerization GO:0051258 26 0.013
nucleoside triphosphate metabolic process GO:0009141 87 0.013
organic substance transport GO:0071702 113 0.012
regulation of cellular ketone metabolic process GO:0010565 3 0.012
nucleus localization GO:0051647 55 0.012
purine ribonucleoside metabolic process GO:0046128 92 0.012
ribonucleoside triphosphate catabolic process GO:0009203 72 0.012
muscle cell differentiation GO:0042692 171 0.012
negative regulation of rna metabolic process GO:0051253 53 0.012
establishment of spindle localization GO:0051293 51 0.012
regulation of behavior GO:0050795 97 0.012
myofibril assembly GO:0030239 154 0.012
muscle cell development GO:0055001 158 0.012
positive regulation of vulval development GO:0040026 52 0.012
response to biotic stimulus GO:0009607 101 0.012
maintenance of protein location GO:0045185 15 0.012
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.012
regulation of phosphorylation GO:0042325 45 0.012
carbohydrate derivative catabolic process GO:1901136 82 0.012
negative regulation of cell communication GO:0010648 61 0.012
cytokinesis GO:0000910 80 0.012
negative regulation of signaling GO:0023057 61 0.012
specification of axis polarity GO:0065001 13 0.012
actin filament based process GO:0030029 191 0.012
defense response to other organism GO:0098542 100 0.012
cellular biosynthetic process GO:0044249 315 0.012
dna metabolic process GO:0006259 74 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 3 0.012
establishment of spindle orientation GO:0051294 34 0.012
response to organic substance GO:0010033 131 0.012
regulation of cellular metabolic process GO:0031323 305 0.012
proteolysis GO:0006508 61 0.012
Human
regulation of cell morphogenesis GO:0022604 40 0.011
ribonucleoside metabolic process GO:0009119 98 0.011
protein modification by small protein conjugation GO:0032446 31 0.011
meiotic nuclear division GO:0007126 300 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 29 0.011
autophagy GO:0006914 29 0.011
nucleoside triphosphate catabolic process GO:0009143 72 0.011
purine nucleoside catabolic process GO:0006152 75 0.011
negative regulation of signal transduction GO:0009968 60 0.011
eating behavior GO:0042755 59 0.011
regulation of defense response GO:0031347 10 0.011
defense response to bacterium GO:0042742 86 0.011
regulation of cytoskeleton organization GO:0051493 41 0.011
positive regulation of cell cycle GO:0045787 55 0.011
striated muscle cell development GO:0055002 157 0.011
negative regulation of response to stimulus GO:0048585 73 0.011
ribonucleoside triphosphate metabolic process GO:0009199 87 0.011
atp metabolic process GO:0046034 42 0.011
positive regulation of chromosome organization GO:2001252 2 0.011
regulation of canonical wnt signaling pathway GO:0060828 1 0.011
regulation of nuclear division GO:0051783 115 0.011
oviposition GO:0018991 364 0.011
purine ribonucleoside catabolic process GO:0046130 75 0.011
regulation of apoptotic signaling pathway GO:2001233 1 0.011
anterior posterior axis specification GO:0009948 17 0.010
single organism behavior GO:0044708 83 0.010
phosphorus metabolic process GO:0006793 232 0.010
cellular macromolecule biosynthetic process GO:0034645 247 0.010
spermatogenesis GO:0007283 41 0.010
ribonucleoprotein complex assembly GO:0022618 4 0.010
pigmentation GO:0043473 2 0.010
mrna processing GO:0006397 13 0.010
positive regulation of nematode larval development GO:0061063 54 0.010
purine nucleoside monophosphate catabolic process GO:0009128 28 0.010
nuclear pore distribution GO:0031081 2 0.010

clp-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
cancer DOID:162 0 0.011
gastrointestinal system cancer DOID:3119 0 0.011
nervous system disease DOID:863 0 0.011