Caenorhabditis elegans

48 known processes

aph-2 (CELE_ZC434.6)

Protein APH-2

aph-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organ development GO:0048513 1102 0.533
Fly
regulation of macromolecule metabolic process GO:0060255 421 0.505
endocytosis GO:0006897 819 0.455
regulation of rna biosynthetic process GO:2001141 165 0.340
post embryonic development GO:0009791 2152 0.321
establishment of localization GO:0051234 1171 0.313
regulation of cellular biosynthetic process GO:0031326 189 0.296
nucleobase containing compound metabolic process GO:0006139 406 0.279
regulation of metabolic process GO:0019222 478 0.261
regulation of multicellular organismal development GO:2000026 317 0.252
Fly
cellular nitrogen compound biosynthetic process GO:0044271 192 0.247
cell part morphogenesis GO:0032990 152 0.237
transport GO:0006810 1093 0.235
locomotion GO:0040011 1634 0.229
organ morphogenesis GO:0009887 67 0.223
Fly
organic cyclic compound biosynthetic process GO:1901362 195 0.220
nucleobase containing compound biosynthetic process GO:0034654 184 0.211
gene expression GO:0010467 412 0.206
regulation of locomotion GO:0040012 161 0.205
vesicle mediated transport GO:0016192 852 0.190
cell projection morphogenesis GO:0048858 148 0.188
regulation of multicellular organismal process GO:0051239 726 0.187
Fly
regionalization GO:0003002 31 0.186
neurogenesis GO:0022008 236 0.175
Fly
rna biosynthetic process GO:0032774 169 0.174
regulation of gene expression epigenetic GO:0040029 163 0.171
neuron differentiation GO:0030182 217 0.171
Fly
single organism signaling GO:0044700 401 0.165
rna metabolic process GO:0016070 228 0.165
development of primary sexual characteristics GO:0045137 840 0.151
regulation of nucleic acid templated transcription GO:1903506 165 0.148
nucleic acid metabolic process GO:0090304 299 0.145
regulation of biosynthetic process GO:0009889 189 0.144
cellular localization GO:0051641 360 0.142
regulation of transcription from rna polymerase ii promoter GO:0006357 145 0.142
embryo development GO:0009790 3052 0.139
purine nucleoside catabolic process GO:0006152 75 0.137
macromolecule localization GO:0033036 771 0.136
regulation of cellular component organization GO:0051128 248 0.136
determination of adult lifespan GO:0008340 812 0.130
cell division GO:0051301 262 0.127
embryo development ending in birth or egg hatching GO:0009792 2992 0.127
aromatic compound biosynthetic process GO:0019438 192 0.125
gene silencing GO:0016458 143 0.124
body morphogenesis GO:0010171 620 0.121
ribonucleoside triphosphate metabolic process GO:0009199 87 0.117
regulation of primary metabolic process GO:0080090 292 0.117
response to chemical GO:0042221 356 0.116
regulation of nucleobase containing compound metabolic process GO:0019219 222 0.113
organelle organization GO:0006996 783 0.113
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 45 0.112
regulation of biological quality GO:0065008 741 0.111
Mouse
macromolecule biosynthetic process GO:0009059 250 0.110
positive regulation of developmental growth GO:0048639 354 0.110
negative regulation of cellular metabolic process GO:0031324 95 0.110
developmental process involved in reproduction GO:0003006 1165 0.109
nervous system development GO:0007399 253 0.108
Fly
axon development GO:0061564 163 0.107
reproductive structure development GO:0048608 850 0.105
positive regulation of cellular process GO:0048522 332 0.104
cellular component morphogenesis GO:0032989 318 0.103
Fly
ribose phosphate metabolic process GO:0019693 99 0.103
positive regulation of developmental process GO:0051094 408 0.102
regulation of developmental process GO:0050793 684 0.101
Fly
head development GO:0060322 1 0.101
negative regulation of rna metabolic process GO:0051253 53 0.100
negative regulation of biological process GO:0048519 567 0.098
negative regulation of macromolecule metabolic process GO:0010605 229 0.098
negative regulation of nucleic acid templated transcription GO:1903507 53 0.098
taxis GO:0042330 128 0.098
ribonucleotide metabolic process GO:0009259 99 0.097
developmental growth GO:0048589 412 0.093
phagocytosis GO:0006909 115 0.093
cell morphogenesis involved in neuron differentiation GO:0048667 111 0.092
Fly
cell death GO:0008219 547 0.092
organelle fission GO:0048285 363 0.091
vesicle fusion GO:0006906 5 0.091
nucleoside metabolic process GO:0009116 99 0.090
positive regulation of macromolecule biosynthetic process GO:0010557 109 0.090
small molecule metabolic process GO:0044281 186 0.087
regulation of developmental growth GO:0048638 389 0.087
single organism reproductive process GO:0044702 1196 0.087
positive regulation of rna metabolic process GO:0051254 103 0.086
biosynthetic process GO:0009058 323 0.086
gamete generation GO:0007276 461 0.086
cellular macromolecule biosynthetic process GO:0034645 247 0.086
multicellular organismal reproductive process GO:0048609 815 0.084
lipid localization GO:0010876 573 0.083
negative regulation of gene expression GO:0010629 217 0.083
regulation of gene expression GO:0010468 366 0.083
organophosphate metabolic process GO:0019637 125 0.082
regulation of growth GO:0040008 409 0.082
regulation of transcription dna templated GO:0006355 164 0.081
response to external stimulus GO:0009605 289 0.080
meiotic cell cycle GO:0051321 335 0.079
single organism transport GO:0044765 447 0.079
regulation of macromolecule biosynthetic process GO:0010556 189 0.079
signaling GO:0023052 401 0.077
axonogenesis GO:0007409 102 0.077
regulation of cell migration GO:0030334 55 0.076
response to temperature stimulus GO:0009266 66 0.075
regulation of multicellular organism growth GO:0040014 373 0.074
inductive cell migration GO:0040039 145 0.073
regulation of cell communication GO:0010646 176 0.072
positive regulation of nucleobase containing compound metabolic process GO:0045935 134 0.072
neuron projection morphogenesis GO:0048812 114 0.072
regulation of cellular metabolic process GO:0031323 305 0.072
heterocycle biosynthetic process GO:0018130 187 0.072
behavior GO:0007610 527 0.070
hermaphrodite genitalia development GO:0040035 734 0.070
generation of neurons GO:0048699 235 0.069
Fly
positive regulation of nucleic acid templated transcription GO:1903508 102 0.068
maintenance of location GO:0051235 580 0.067
response to wounding GO:0009611 4 0.066
neuron projection development GO:0031175 187 0.066
transcription from rna polymerase ii promoter GO:0006366 149 0.066
organonitrogen compound metabolic process GO:1901564 151 0.065
Mouse
lipid storage GO:0019915 565 0.064
pattern specification process GO:0007389 59 0.064
positive regulation of biosynthetic process GO:0009891 109 0.063
regulation of cellular macromolecule biosynthetic process GO:2000112 188 0.062
regulation of cell differentiation GO:0045595 81 0.062
Fly
regeneration GO:0031099 4 0.062
positive regulation of transcription dna templated GO:0045893 102 0.061
single organism organelle organization GO:1902589 501 0.061
transcription dna templated GO:0006351 168 0.060
positive regulation of multicellular organismal process GO:0051240 417 0.060
regulation of response to stimulus GO:0048583 243 0.059
positive regulation of growth GO:0045927 369 0.058
multicellular organism growth GO:0035264 385 0.058
regulation of nitrogen compound metabolic process GO:0051171 222 0.058
aging GO:0007568 812 0.057
mapk cascade GO:0000165 31 0.056
regulation of organelle organization GO:0033043 164 0.055
receptor mediated endocytosis GO:0006898 715 0.055
posttranscriptional gene silencing by rna GO:0035194 143 0.055
system process GO:0003008 136 0.055
protein localization GO:0008104 205 0.054
purine ribonucleoside catabolic process GO:0046130 75 0.054
ribonucleoside catabolic process GO:0042454 77 0.054
sex differentiation GO:0007548 909 0.054
apoptotic process GO:0006915 478 0.053
phosphate containing compound metabolic process GO:0006796 232 0.052
neuron development GO:0048666 199 0.052
Fly
glycosyl compound metabolic process GO:1901657 100 0.052
positive regulation of multicellular organism growth GO:0040018 352 0.051
cell cycle GO:0007049 526 0.051
single organism localization GO:1902578 518 0.050
single organism membrane fusion GO:0044801 13 0.050
cellular component movement GO:0006928 388 0.050
regulation of localization GO:0032879 194 0.049
purine nucleoside metabolic process GO:0042278 92 0.049
organic substance biosynthetic process GO:1901576 323 0.049
chemotaxis GO:0006935 120 0.048
sensory organ morphogenesis GO:0090596 2 0.048
Fly
cellular homeostasis GO:0019725 22 0.047
cell surface receptor signaling pathway GO:0007166 149 0.047
multi organism reproductive process GO:0044703 867 0.047
negative regulation of gene expression epigenetic GO:0045814 2 0.047
purine ribonucleotide catabolic process GO:0009154 75 0.046
engulfment of apoptotic cell GO:0043652 94 0.046
cellular component assembly GO:0022607 293 0.046
macromolecular complex subunit organization GO:0043933 320 0.046
positive regulation of rna biosynthetic process GO:1902680 102 0.046
purine ribonucleoside triphosphate catabolic process GO:0009207 72 0.046
ras protein signal transduction GO:0007265 31 0.046
nucleoside triphosphate catabolic process GO:0009143 72 0.045
regulation of anatomical structure morphogenesis GO:0022603 51 0.045
Fly
carbohydrate derivative catabolic process GO:1901136 82 0.045
death GO:0016265 547 0.044
gonad development GO:0008406 840 0.043
negative regulation of metabolic process GO:0009892 240 0.043
reproductive system development GO:0061458 850 0.043
cell migration GO:0016477 306 0.043
small gtpase mediated signal transduction GO:0007264 32 0.043
mitotic nuclear division GO:0007067 89 0.042
regulation of neuron projection development GO:0010975 31 0.041
protein metabolic process GO:0019538 422 0.040
Mouse Fly
gene silencing by rna GO:0031047 143 0.040
anatomical structure formation involved in morphogenesis GO:0048646 250 0.040
regulation of neuron differentiation GO:0045664 40 0.040
Fly
chromosome organization GO:0051276 104 0.040
regulation of neurotransmitter secretion GO:0046928 16 0.040
purine containing compound catabolic process GO:0072523 75 0.040
aromatic compound catabolic process GO:0019439 116 0.039
regulation of cellular component movement GO:0051270 62 0.039
programmed cell death GO:0012501 500 0.038
response to heat GO:0009408 50 0.038
regulation of post embryonic development GO:0048580 260 0.038
glycosyl compound catabolic process GO:1901658 79 0.037
regulation of neurotransmitter levels GO:0001505 36 0.037
cellular component biogenesis GO:0044085 297 0.037
molting cycle collagen and cuticulin based cuticle GO:0018996 281 0.037
muscle tissue development GO:0060537 1 0.037
carbohydrate derivative metabolic process GO:1901135 141 0.037
nucleoside phosphate metabolic process GO:0006753 108 0.037
chromatin modification GO:0016568 32 0.037
cell proliferation GO:0008283 116 0.037
Mouse
positive regulation of macromolecule metabolic process GO:0010604 149 0.037
positive regulation of transcription from rna polymerase ii promoter GO:0045944 98 0.036
rna localization GO:0006403 3 0.036
regulation of neurotransmitter transport GO:0051588 16 0.036
synaptic transmission GO:0007268 106 0.036
positive regulation of gene expression GO:0010628 112 0.036
multicellular organismal aging GO:0010259 812 0.035
secretion by cell GO:0032940 138 0.035
signal transduction GO:0007165 317 0.035
establishment or maintenance of cell polarity GO:0007163 63 0.035
muscle structure development GO:0061061 191 0.034
purine nucleotide catabolic process GO:0006195 75 0.034
nucleotide catabolic process GO:0009166 77 0.034
cellular biosynthetic process GO:0044249 315 0.034
neurological system process GO:0050877 53 0.034
growth GO:0040007 562 0.033
posttranscriptional regulation of gene expression GO:0010608 166 0.033
negative regulation of nucleobase containing compound metabolic process GO:0045934 63 0.033
negative regulation of developmental process GO:0051093 227 0.033
cell morphogenesis GO:0000902 163 0.033
Fly
regulation of secretion GO:0051046 29 0.033
positive regulation of locomotion GO:0040017 42 0.033
purine nucleoside triphosphate catabolic process GO:0009146 72 0.032
regulation of rna metabolic process GO:0051252 173 0.032
organic cyclic compound catabolic process GO:1901361 119 0.032
membrane organization GO:0061024 135 0.032
multi multicellular organism process GO:0044706 390 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 87 0.032
nucleobase containing small molecule metabolic process GO:0055086 115 0.032
positive regulation of cellular metabolic process GO:0031325 178 0.032
ribonucleoside triphosphate catabolic process GO:0009203 72 0.031
ribonucleoprotein complex assembly GO:0022618 4 0.031
purine ribonucleoside metabolic process GO:0046128 92 0.031
regulation of cell size GO:0008361 30 0.031
membrane fusion GO:0061025 16 0.031
cell projection organization GO:0030030 231 0.031
positive regulation of neurogenesis GO:0050769 4 0.031
organophosphate catabolic process GO:0046434 81 0.030
phagocytosis engulfment GO:0006911 98 0.030
germ cell development GO:0007281 351 0.030
post embryonic organ development GO:0048569 336 0.030
oxoacid metabolic process GO:0043436 47 0.029
homeostatic process GO:0042592 51 0.029
Mouse
heterocycle catabolic process GO:0046700 119 0.029
regulation of organ morphogenesis GO:2000027 4 0.029
Fly
ribonucleotide catabolic process GO:0009261 75 0.029
chromatin organization GO:0006325 32 0.029
axon guidance GO:0007411 82 0.028
chromatin remodeling GO:0006338 2 0.028
phosphorus metabolic process GO:0006793 232 0.028
negative regulation of transcription dna templated GO:0045892 53 0.028
female gamete generation GO:0007292 254 0.028
regulation of nematode larval development GO:0061062 260 0.028
cellular protein modification process GO:0006464 207 0.027
peptidyl tyrosine phosphorylation GO:0018108 2 0.027
cell fate commitment GO:0045165 139 0.027
phagosome maturation involved in apoptotic cell clearance GO:0090386 13 0.027
multicellular organism reproduction GO:0032504 819 0.027
dendrite development GO:0016358 42 0.027
meiotic nuclear division GO:0007126 300 0.027
nucleobase containing compound catabolic process GO:0034655 114 0.026
axis specification GO:0009798 23 0.026
cell growth GO:0016049 44 0.026
nucleic acid templated transcription GO:0097659 169 0.025
regulation of protein serine threonine kinase activity GO:0071900 18 0.025
regulation of signaling GO:0023051 172 0.025
protein oligomerization GO:0051259 4 0.025
cuticle development GO:0042335 100 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 134 0.025
histone modification GO:0016570 30 0.025
stem cell division GO:0017145 18 0.025
cell motility GO:0048870 313 0.024
anterior posterior pattern specification GO:0009952 27 0.024
purine containing compound metabolic process GO:0072521 95 0.024
nucleotide metabolic process GO:0009117 108 0.024
cell cycle process GO:0022402 482 0.024
organic substance transport GO:0071702 113 0.024
cellular protein metabolic process GO:0044267 279 0.023
Fly
neurotransmitter transport GO:0006836 32 0.023
organelle fusion GO:0048284 8 0.023
apoptotic cell clearance GO:0043277 111 0.023
regulation of signal transduction GO:0009966 135 0.023
molting cycle GO:0042303 281 0.023
rna interference GO:0016246 137 0.023
protein complex assembly GO:0006461 186 0.023
reproductive behavior GO:0019098 387 0.022
collagen and cuticulin based cuticle development GO:0040002 99 0.022
establishment of localization in cell GO:0051649 318 0.022
establishment of organelle localization GO:0051656 123 0.022
membrane invagination GO:0010324 98 0.022
guanosine containing compound catabolic process GO:1901069 48 0.022
chromosome segregation GO:0007059 180 0.022
cell cell signaling GO:0007267 118 0.022
Fly
nucleoside phosphate catabolic process GO:1901292 77 0.022
negative regulation of cellular process GO:0048523 239 0.022
response to abiotic stimulus GO:0009628 152 0.022
catabolic process GO:0009056 318 0.022
purine nucleotide metabolic process GO:0006163 95 0.021
secretion GO:0046903 147 0.021
regulation of phosphorus metabolic process GO:0051174 81 0.020
regulation of behavior GO:0050795 97 0.020
regulation of synaptic transmission GO:0050804 34 0.020
regulation of multi organism process GO:0043900 69 0.020
nucleoside catabolic process GO:0009164 78 0.020
negative regulation of cellular biosynthetic process GO:0031327 65 0.020
oocyte construction GO:0007308 2 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 63 0.020
wnt signaling pathway GO:0016055 27 0.019
organonitrogen compound catabolic process GO:1901565 90 0.019
ribonucleoside metabolic process GO:0009119 98 0.019
macromolecule catabolic process GO:0009057 202 0.019
organic acid metabolic process GO:0006082 47 0.018
carboxylic acid metabolic process GO:0019752 34 0.018
sexual reproduction GO:0019953 546 0.018
axonal fasciculation GO:0007413 79 0.018
developmental cell growth GO:0048588 39 0.018
neuron recognition GO:0008038 83 0.017
vulval development GO:0040025 333 0.017
regulation of cell motility GO:2000145 57 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
purine nucleoside triphosphate metabolic process GO:0009144 87 0.017
actin filament based process GO:0030029 191 0.017
purine ribonucleotide metabolic process GO:0009150 95 0.017
protein modification process GO:0036211 207 0.017
localization of cell GO:0051674 313 0.017
nucleoside triphosphate metabolic process GO:0009141 87 0.016
development of primary male sexual characteristics GO:0046546 4 0.016
oviposition GO:0018991 364 0.016
single organism catabolic process GO:0044712 129 0.016
negative regulation of rna biosynthetic process GO:1902679 53 0.016
posttranscriptional gene silencing GO:0016441 143 0.016
cellular amine metabolic process GO:0044106 15 0.016
phosphorylation GO:0016310 116 0.016
regulation of programmed cell death GO:0043067 50 0.015
regulation of cell development GO:0060284 49 0.015
Fly
protein complex subunit organization GO:0071822 280 0.015
meiotic cell cycle process GO:1903046 170 0.015
covalent chromatin modification GO:0016569 30 0.015
cellular amino acid metabolic process GO:0006520 15 0.015
macromolecular complex assembly GO:0065003 193 0.015
regulation of lipid metabolic process GO:0019216 4 0.014
neurotransmitter secretion GO:0007269 26 0.014
organ growth GO:0035265 5 0.014
neural precursor cell proliferation GO:0061351 9 0.014
cellular catabolic process GO:0044248 199 0.014
amine metabolic process GO:0009308 15 0.014
regulation of exocytosis GO:0017157 1 0.014
regulation of nuclear division GO:0051783 115 0.014
pigmentation GO:0043473 2 0.013
regulation of reproductive process GO:2000241 66 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
regulation of molecular function GO:0065009 89 0.013
cell type specific apoptotic process GO:0097285 4 0.013
cell development GO:0048468 696 0.013
Fly
genitalia development GO:0048806 741 0.013
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 9 0.013
regulation of transport GO:0051049 91 0.013
striated muscle cell differentiation GO:0051146 158 0.013
asymmetric stem cell division GO:0098722 8 0.012
actomyosin structure organization GO:0031032 154 0.012
cellular nitrogen compound catabolic process GO:0044270 119 0.012
positive regulation of cellular biosynthetic process GO:0031328 109 0.012
dosage compensation GO:0007549 13 0.012
neuroblast division GO:0055057 9 0.012
multi organism reproductive behavior GO:0044705 387 0.012
cellular ketone metabolic process GO:0042180 14 0.012
positive regulation of transport GO:0051050 32 0.012
negative regulation of multicellular organismal process GO:0051241 236 0.012
negative regulation of cellular component organization GO:0051129 33 0.012
muscle cell differentiation GO:0042692 171 0.012
cell morphogenesis involved in differentiation GO:0000904 112 0.012
Fly
establishment of spindle localization GO:0051293 51 0.012
internal peptidyl lysine acetylation GO:0018393 3 0.012
multicellular organismal reproductive behavior GO:0033057 384 0.012
regulation of cellular localization GO:0060341 42 0.012
epithelial cell differentiation GO:0030855 17 0.012
canonical wnt signaling pathway GO:0060070 3 0.012
organelle localization GO:0051640 127 0.012
asymmetric protein localization GO:0008105 35 0.012
asymmetric cell division GO:0008356 36 0.011
multi organism behavior GO:0051705 389 0.011
negative regulation of post embryonic development GO:0048581 208 0.011
myosin filament organization GO:0031033 138 0.011
embryonic morphogenesis GO:0048598 152 0.011
asymmetric neuroblast division GO:0055059 8 0.011
regulation of cell projection organization GO:0031344 38 0.011
learning or memory GO:0007611 27 0.011
cell recognition GO:0008037 85 0.011
nucleoside monophosphate metabolic process GO:0009123 46 0.011
oogenesis GO:0048477 229 0.011
response to endogenous stimulus GO:0009719 33 0.011
actin cytoskeleton organization GO:0030036 184 0.011
lamellipodium assembly GO:0030032 2 0.011
regulation of anatomical structure size GO:0090066 46 0.011
macromolecule modification GO:0043412 218 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 65 0.011
cellular component assembly involved in morphogenesis GO:0010927 183 0.011
regulation of asymmetric cell division GO:0009786 13 0.011
sterol transport GO:0015918 4 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
regulation of protein metabolic process GO:0051246 81 0.010
regulation of neurogenesis GO:0050767 40 0.010
Fly
anatomical structure homeostasis GO:0060249 11 0.010
skeletal muscle organ development GO:0060538 3 0.010
peptidyl lysine acetylation GO:0018394 3 0.010
mitotic sister chromatid segregation GO:0000070 38 0.010
regulation of cell division GO:0051302 142 0.010

aph-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025