Saccharomyces cerevisiae

150 known processes

KAR2 (YJL034W)

Kar2p

(Aliases: GRP78)

KAR2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
modification dependent macromolecule catabolic process GO:0043632 203 0.999
ubiquitin dependent protein catabolic process GO:0006511 181 0.998
srp dependent cotranslational protein targeting to membrane GO:0006614 14 0.998
transmembrane transport GO:0055085 349 0.995
protein transmembrane transport GO:0071806 82 0.993
protein localization to endoplasmic reticulum GO:0070972 47 0.992
intracellular protein transmembrane transport GO:0065002 80 0.988
protein targeting to er GO:0045047 39 0.988
proteasomal protein catabolic process GO:0010498 141 0.987
cellular protein catabolic process GO:0044257 213 0.982
protein catabolic process GO:0030163 221 0.981
establishment of protein localization to endoplasmic reticulum GO:0072599 40 0.980
modification dependent protein catabolic process GO:0019941 181 0.979
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 137 0.974
er associated ubiquitin dependent protein catabolic process GO:0030433 46 0.970
protein folding GO:0006457 94 0.960
proteolysis involved in cellular protein catabolic process GO:0051603 198 0.943
proteolysis GO:0006508 268 0.941
cellular macromolecule catabolic process GO:0044265 363 0.932
srp dependent cotranslational protein targeting to membrane translocation GO:0006616 9 0.928
cotranslational protein targeting to membrane GO:0006613 15 0.911
single organism cellular localization GO:1902580 375 0.892
establishment of protein localization to organelle GO:0072594 278 0.844
protein targeting GO:0006605 272 0.823
establishment of protein localization GO:0045184 367 0.817
single organism membrane organization GO:0044802 275 0.777
intracellular protein transport GO:0006886 319 0.748
protein targeting to membrane GO:0006612 52 0.726
protein transport GO:0015031 345 0.620
protein modification by small protein conjugation GO:0032446 144 0.563
Mouse
protein localization to organelle GO:0033365 337 0.544
protein refolding GO:0042026 16 0.529
establishment of protein localization to membrane GO:0090150 99 0.523
membrane organization GO:0061024 276 0.499
posttranslational protein targeting to membrane GO:0006620 17 0.488
macromolecule catabolic process GO:0009057 383 0.479
protein localization to membrane GO:0072657 102 0.321
protein modification by small protein conjugation or removal GO:0070647 172 0.308
Mouse
intracellular protein transmembrane import GO:0044743 67 0.290
purine containing compound catabolic process GO:0072523 332 0.268
carbohydrate derivative catabolic process GO:1901136 339 0.261
nucleus organization GO:0006997 62 0.255
protein targeting to mitochondrion GO:0006626 56 0.243
ribonucleoside metabolic process GO:0009119 389 0.243
regulation of protein modification process GO:0031399 110 0.226
Mouse
nucleoside phosphate metabolic process GO:0006753 458 0.223
response to external stimulus GO:0009605 158 0.223
Human Zebrafish
nucleoside catabolic process GO:0009164 335 0.206
ribonucleoside catabolic process GO:0042454 332 0.201
single organism catabolic process GO:0044712 619 0.200
purine ribonucleotide catabolic process GO:0009154 327 0.197
ribonucleoprotein complex subunit organization GO:0071826 152 0.192
apoptotic process GO:0006915 30 0.191
Human
ncrna processing GO:0034470 330 0.168
response to nutrient levels GO:0031667 150 0.156
Human
ribonucleotide metabolic process GO:0009259 377 0.152
cellular response to starvation GO:0009267 90 0.147
Human
purine nucleoside triphosphate metabolic process GO:0009144 356 0.146
regulation of protein ubiquitination GO:0031396 20 0.141
Mouse
cytoskeleton organization GO:0007010 230 0.139
Fly
regulation of molecular function GO:0065009 320 0.133
Yeast Mouse
response to extracellular stimulus GO:0009991 156 0.127
Human
protein localization to mitochondrion GO:0070585 63 0.126
mitochondrial transport GO:0006839 76 0.120
reproductive process GO:0022414 248 0.120
ribose phosphate metabolic process GO:0019693 384 0.116
purine nucleoside catabolic process GO:0006152 330 0.115
glycosyl compound catabolic process GO:1901658 335 0.113
glycosyl compound metabolic process GO:1901657 398 0.112
protein ubiquitination GO:0016567 118 0.109
Mouse
rrna metabolic process GO:0016072 244 0.108
regulation of biological quality GO:0065008 391 0.104
Human
establishment of protein localization to mitochondrion GO:0072655 63 0.102
programmed cell death GO:0012501 30 0.099
Human
nucleoside metabolic process GO:0009116 394 0.098
purine containing compound metabolic process GO:0072521 400 0.098
purine ribonucleoside metabolic process GO:0046128 380 0.097
regulation of localization GO:0032879 127 0.092
Human
mitochondrion organization GO:0007005 261 0.088
response to organic substance GO:0010033 182 0.088
rrna processing GO:0006364 227 0.087
purine ribonucleoside triphosphate metabolic process GO:0009205 354 0.085
nucleoside triphosphate catabolic process GO:0009143 329 0.084
nucleoside triphosphate metabolic process GO:0009141 364 0.083
protein import GO:0017038 122 0.082
rna splicing via transesterification reactions GO:0000375 118 0.079
protein folding in endoplasmic reticulum GO:0034975 13 0.079
carbohydrate derivative metabolic process GO:1901135 549 0.077
sexual reproduction GO:0019953 216 0.075
organophosphate metabolic process GO:0019637 597 0.075
positive regulation of macromolecule metabolic process GO:0010604 394 0.074
Mouse
multi organism process GO:0051704 233 0.074
nucleotide catabolic process GO:0009166 330 0.073
regulation of protein metabolic process GO:0051246 237 0.072
Mouse
organophosphate catabolic process GO:0046434 338 0.072
developmental process GO:0032502 261 0.071
Human Mouse Worm
regulation of protein modification by small protein conjugation or removal GO:1903320 29 0.071
Mouse
rna splicing GO:0008380 131 0.070
cell communication GO:0007154 345 0.070
Human Mouse Worm
nucleobase containing compound catabolic process GO:0034655 479 0.069
response to topologically incorrect protein GO:0035966 38 0.069
positive regulation of protein modification by small protein conjugation or removal GO:1903322 12 0.069
Mouse
organic cyclic compound catabolic process GO:1901361 499 0.069
nucleobase containing small molecule metabolic process GO:0055086 491 0.069
microtubule organizing center organization GO:0031023 33 0.068
Fly
organonitrogen compound catabolic process GO:1901565 404 0.068
purine nucleotide catabolic process GO:0006195 328 0.067
nucleoside phosphate catabolic process GO:1901292 331 0.066
purine ribonucleotide metabolic process GO:0009150 372 0.066
response to chemical GO:0042221 390 0.066
secretion GO:0046903 50 0.065
macromolecular complex disassembly GO:0032984 80 0.065
cellular nitrogen compound catabolic process GO:0044270 494 0.062
cellular response to topologically incorrect protein GO:0035967 32 0.059
Mouse Worm
purine nucleoside metabolic process GO:0042278 380 0.059
posttranscriptional regulation of gene expression GO:0010608 115 0.059
Fly
microtubule cytoskeleton organization GO:0000226 109 0.058
Fly
multi organism reproductive process GO:0044703 216 0.058
purine nucleotide metabolic process GO:0006163 376 0.058
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.057
Mouse
response to starvation GO:0042594 96 0.057
Human
regulation of catalytic activity GO:0050790 307 0.056
Yeast Mouse
signaling GO:0023052 208 0.055
Mouse Worm
multi organism cellular process GO:0044764 120 0.054
purine ribonucleoside catabolic process GO:0046130 330 0.053
regulation of cellular component organization GO:0051128 334 0.051
cell death GO:0008219 30 0.049
Human
heterocycle catabolic process GO:0046700 494 0.049
purine nucleoside triphosphate catabolic process GO:0009146 329 0.049
ribonucleotide catabolic process GO:0009261 327 0.046
cation transport GO:0006812 166 0.045
ion transport GO:0006811 274 0.045
homeostatic process GO:0042592 227 0.045
organelle fission GO:0048285 272 0.044
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 109 0.044
signal transduction GO:0007165 208 0.043
Mouse Worm
regulation of cellular component biogenesis GO:0044087 112 0.041
negative regulation of macromolecule metabolic process GO:0010605 375 0.041
Fly
misfolded or incompletely synthesized protein catabolic process GO:0006515 21 0.041
regulation of cellular protein metabolic process GO:0032268 232 0.040
Mouse
chaperone mediated protein folding GO:0061077 3 0.040
gene silencing by rna GO:0031047 3 0.038
Fly
protein phosphorylation GO:0006468 197 0.038
Mouse
death GO:0016265 30 0.038
Human
positive regulation of molecular function GO:0044093 185 0.037
Mouse
mrna splicing via spliceosome GO:0000398 108 0.037
phosphorylation GO:0016310 291 0.037
Mouse
gene silencing GO:0016458 151 0.036
Fly
positive regulation of protein metabolic process GO:0051247 93 0.036
Mouse
single organism signaling GO:0044700 208 0.036
Mouse Worm
regulation of response to stimulus GO:0048583 157 0.035
Mouse
regulation of gene expression epigenetic GO:0040029 147 0.034
Fly
ribonucleoside triphosphate metabolic process GO:0009199 356 0.033
regulation of phosphorus metabolic process GO:0051174 230 0.032
Mouse
purine ribonucleoside triphosphate catabolic process GO:0009207 327 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 409 0.032
Mouse
response to unfolded protein GO:0006986 29 0.032
oxidation reduction process GO:0055114 353 0.031
protein complex biogenesis GO:0070271 314 0.031
regulation of phosphate metabolic process GO:0019220 230 0.031
Mouse
ribosomal subunit export from nucleus GO:0000054 46 0.030
maintenance of location in cell GO:0051651 58 0.030
Human
karyogamy involved in conjugation with cellular fusion GO:0000742 15 0.030
negative regulation of cellular component organization GO:0051129 109 0.030
meiotic nuclear division GO:0007126 163 0.029
regulation of cellular localization GO:0060341 50 0.029
regulation of transport GO:0051049 85 0.028
karyogamy GO:0000741 17 0.028
regulation of hydrolase activity GO:0051336 133 0.028
Mouse
cellular response to chemical stimulus GO:0070887 315 0.028
Mouse Rat Worm
response to abiotic stimulus GO:0009628 159 0.028
ribonucleoside monophosphate metabolic process GO:0009161 265 0.027
purine ribonucleoside monophosphate catabolic process GO:0009169 224 0.027
protein complex assembly GO:0006461 302 0.027
ribonucleoside triphosphate catabolic process GO:0009203 327 0.027
protein import into mitochondrial matrix GO:0030150 20 0.026
organelle fusion GO:0048284 85 0.026
aromatic compound catabolic process GO:0019439 491 0.025
carbohydrate biosynthetic process GO:0016051 82 0.025
regulation of purine nucleotide catabolic process GO:0033121 106 0.024
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 46 0.024
regulation of catabolic process GO:0009894 199 0.024
metal ion homeostasis GO:0055065 79 0.024
positive regulation of cell death GO:0010942 3 0.023
maintenance of protein location in cell GO:0032507 50 0.023
Human
negative regulation of cellular metabolic process GO:0031324 407 0.023
nucleotide metabolic process GO:0009117 453 0.023
growth GO:0040007 157 0.023
atp catabolic process GO:0006200 224 0.023
ribonucleoside monophosphate catabolic process GO:0009158 224 0.022
ribonucleoprotein complex disassembly GO:0032988 11 0.022
cellular response to organic substance GO:0071310 159 0.022
Mouse Worm
positive regulation of programmed cell death GO:0043068 3 0.022
telomere organization GO:0032200 75 0.022
nucleoside monophosphate catabolic process GO:0009125 224 0.022
positive regulation of apoptotic process GO:0043065 3 0.021
conjugation with cellular fusion GO:0000747 106 0.021
ribosome biogenesis GO:0042254 335 0.020
cell growth GO:0016049 89 0.020
cellular response to nutrient levels GO:0031669 144 0.020
Human
nuclear division GO:0000280 263 0.019
negative regulation of protein modification process GO:0031400 37 0.019
carbohydrate metabolic process GO:0005975 252 0.019
secretion by cell GO:0032940 50 0.019
purine nucleoside monophosphate catabolic process GO:0009128 224 0.019
mitotic cell cycle process GO:1903047 294 0.019
negative regulation of cellular protein metabolic process GO:0032269 85 0.019
positive regulation of protein ubiquitination GO:0031398 7 0.018
Mouse
carboxylic acid metabolic process GO:0019752 338 0.018
inclusion body assembly GO:0070841 1 0.018
guanosine containing compound metabolic process GO:1901068 111 0.017
endoplasmic reticulum unfolded protein response GO:0030968 23 0.017
Mouse Worm
gtp catabolic process GO:0006184 107 0.017
positive regulation of rna splicing GO:0033120 2 0.017
mrna metabolic process GO:0016071 269 0.017
protein maturation GO:0051604 76 0.017
regulation of nucleotide metabolic process GO:0006140 110 0.016
cellular homeostasis GO:0019725 138 0.016
organonitrogen compound biosynthetic process GO:1901566 314 0.016
translational elongation GO:0006414 32 0.016
mitotic cell cycle GO:0000278 306 0.016
positive regulation of hydrolase activity GO:0051345 112 0.016
Mouse
pyrimidine containing compound metabolic process GO:0072527 37 0.015
establishment of ribosome localization GO:0033753 46 0.015
regulation of phosphorylation GO:0042325 86 0.014
Mouse
rna catabolic process GO:0006401 118 0.014
regulation of gtpase activity GO:0043087 84 0.014
guanosine containing compound catabolic process GO:1901069 109 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 262 0.013
ribonucleoprotein complex localization GO:0071166 46 0.013
regulation of purine nucleotide metabolic process GO:1900542 109 0.013
chemical homeostasis GO:0048878 137 0.013
peptidyl amino acid modification GO:0018193 116 0.013
ion homeostasis GO:0050801 118 0.013
meiotic cell cycle GO:0051321 272 0.013
generation of precursor metabolites and energy GO:0006091 147 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.013
posttranslational protein targeting to membrane translocation GO:0031204 9 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.012
autophagy GO:0006914 106 0.012
er nucleus signaling pathway GO:0006984 23 0.012
Mouse Worm
establishment of organelle localization GO:0051656 96 0.012
response to organic cyclic compound GO:0014070 1 0.012
single organism membrane budding GO:1902591 21 0.012
regulation of cellular catabolic process GO:0031329 195 0.012
organophosphate biosynthetic process GO:0090407 182 0.012
membrane budding GO:0006900 22 0.012
single organism developmental process GO:0044767 258 0.012
Human Mouse Worm
negative regulation of transcription dna templated GO:0045892 258 0.012
regulation of signal transduction GO:0009966 114 0.011
Mouse
atp metabolic process GO:0046034 251 0.011
response to toxic substance GO:0009636 9 0.011
Rat
transition metal ion homeostasis GO:0055076 59 0.011
negative regulation of gene expression GO:0010629 312 0.011
Fly
purine nucleoside monophosphate metabolic process GO:0009126 262 0.011
conjugation GO:0000746 107 0.011
cellular response to unfolded protein GO:0034620 23 0.011
Mouse Worm
negative regulation of nucleic acid templated transcription GO:1903507 260 0.011
macromolecule methylation GO:0043414 85 0.011
cellular ion homeostasis GO:0006873 112 0.011
cellular developmental process GO:0048869 191 0.011
telomere maintenance GO:0000723 74 0.011
regulation of rna splicing GO:0043484 3 0.011
protein complex disassembly GO:0043241 70 0.011
response to temperature stimulus GO:0009266 74 0.011
regulation of signaling GO:0023051 119 0.010
Mouse
mrna processing GO:0006397 185 0.010
cellular protein complex disassembly GO:0043624 42 0.010
ion transmembrane transport GO:0034220 200 0.010
cellular response to heat GO:0034605 53 0.010
response to uv GO:0009411 4 0.010
positive regulation of signaling GO:0023056 20 0.010
negative regulation of protein metabolic process GO:0051248 85 0.010

KAR2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012