Saccharomyces cerevisiae

118 known processes

TOP1 (YOL006C)

Top1p

(Aliases: MAK17,MAK1)

TOP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair GO:0006302 105 0.745
macromolecule catabolic process GO:0009057 383 0.735
dna recombination GO:0006310 172 0.579
negative regulation of gene expression GO:0010629 312 0.426
cellular macromolecule catabolic process GO:0044265 363 0.413
regulation of gene expression epigenetic GO:0040029 147 0.308
nucleic acid phosphodiester bond hydrolysis GO:0090305 194 0.291
dna conformation change GO:0071103 98 0.217
nucleobase containing compound catabolic process GO:0034655 479 0.214
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.206
mrna metabolic process GO:0016071 269 0.202
double strand break repair via homologous recombination GO:0000724 54 0.183
cellular response to dna damage stimulus GO:0006974 287 0.160
chromatin silencing GO:0006342 147 0.156
membrane organization GO:0061024 276 0.151
chromatin organization GO:0006325 242 0.150
single organism membrane organization GO:0044802 275 0.146
dna packaging GO:0006323 55 0.141
regulation of dna metabolic process GO:0051052 100 0.137
regulation of dna replication GO:0006275 51 0.134
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.115
protein catabolic process GO:0030163 221 0.114
rna catabolic process GO:0006401 118 0.112
chromatin assembly or disassembly GO:0006333 60 0.110
dna dependent dna replication GO:0006261 115 0.109
aromatic compound catabolic process GO:0019439 491 0.103
cellular nitrogen compound catabolic process GO:0044270 494 0.100
negative regulation of cellular biosynthetic process GO:0031327 312 0.087
negative regulation of transcription dna templated GO:0045892 258 0.081
meiotic cell cycle process GO:1903046 229 0.080
organic cyclic compound catabolic process GO:1901361 499 0.079
cellular component disassembly GO:0022411 86 0.079
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.074
sister chromatid cohesion GO:0007062 49 0.069
mating type switching GO:0007533 28 0.067
negative regulation of gene expression epigenetic GO:0045814 147 0.066
chromosome condensation GO:0030261 19 0.065
regulation of dna dependent dna replication GO:0090329 37 0.065
recombinational repair GO:0000725 64 0.062
response to extracellular stimulus GO:0009991 156 0.061
translation GO:0006412 230 0.061
negative regulation of cellular metabolic process GO:0031324 407 0.060
cellular lipid metabolic process GO:0044255 229 0.057
sex determination GO:0007530 32 0.056
regulation of response to dna damage stimulus GO:2001020 17 0.056
mitotic sister chromatid segregation GO:0000070 85 0.056
dna replication initiation GO:0006270 48 0.054
nucleocytoplasmic transport GO:0006913 163 0.053
double strand break repair via nonhomologous end joining GO:0006303 27 0.052
rrna metabolic process GO:0016072 244 0.049
regulation of biological quality GO:0065008 391 0.048
autophagy GO:0006914 106 0.047
positive regulation of gene expression GO:0010628 321 0.046
transcription from rna polymerase i promoter GO:0006360 63 0.046
response to external stimulus GO:0009605 158 0.045
negative regulation of rna metabolic process GO:0051253 262 0.045
proteolysis involved in cellular protein catabolic process GO:0051603 198 0.045
non recombinational repair GO:0000726 33 0.045
heterocycle catabolic process GO:0046700 494 0.045
negative regulation of macromolecule metabolic process GO:0010605 375 0.045
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.045
negative regulation of biosynthetic process GO:0009890 312 0.045
dna repair GO:0006281 236 0.044
dna templated transcription initiation GO:0006352 71 0.044
protein complex disassembly GO:0043241 70 0.044
chromatin silencing at rdna GO:0000183 32 0.043
dna catabolic process GO:0006308 42 0.041
nuclear transport GO:0051169 165 0.040
positive regulation of macromolecule biosynthetic process GO:0010557 325 0.039
single organism cellular localization GO:1902580 375 0.039
negative regulation of nucleic acid templated transcription GO:1903507 260 0.038
multi organism process GO:0051704 233 0.035
gene silencing GO:0016458 151 0.034
cellular response to external stimulus GO:0071496 150 0.033
regulation of organelle organization GO:0033043 243 0.033
positive regulation of rna metabolic process GO:0051254 294 0.031
negative regulation of cellular component organization GO:0051129 109 0.031
developmental process involved in reproduction GO:0003006 159 0.031
negative regulation of cell cycle GO:0045786 91 0.031
protein transport GO:0015031 345 0.030
negative regulation of chromosome organization GO:2001251 39 0.029
rna localization GO:0006403 112 0.029
multi organism reproductive process GO:0044703 216 0.029
reciprocal dna recombination GO:0035825 54 0.029
organelle assembly GO:0070925 118 0.026
cellular response to nutrient levels GO:0031669 144 0.026
negative regulation of rna biosynthetic process GO:1902679 260 0.024
sexual reproduction GO:0019953 216 0.024
cellular amine metabolic process GO:0044106 51 0.023
response to chemical GO:0042221 390 0.023
Human
chromatin silencing at telomere GO:0006348 84 0.022
nucleus organization GO:0006997 62 0.022
response to uv GO:0009411 4 0.022
mitotic recombination GO:0006312 55 0.022
amine metabolic process GO:0009308 51 0.022
homeostatic process GO:0042592 227 0.021
replicative cell aging GO:0001302 46 0.020
protein ubiquitination GO:0016567 118 0.020
protein modification by small protein conjugation GO:0032446 144 0.020
cell cycle phase transition GO:0044770 144 0.019
establishment of protein localization to organelle GO:0072594 278 0.019
negative regulation of organelle organization GO:0010639 103 0.019
sister chromatid segregation GO:0000819 93 0.019
regulation of cell cycle process GO:0010564 150 0.019
negative regulation of dna metabolic process GO:0051053 36 0.019
glycerolipid metabolic process GO:0046486 108 0.019
cellular response to heat GO:0034605 53 0.019
organophosphate metabolic process GO:0019637 597 0.019
cellular protein complex disassembly GO:0043624 42 0.018
protein processing GO:0016485 64 0.018
nuclear export GO:0051168 124 0.018
nitrogen compound transport GO:0071705 212 0.018
single organism developmental process GO:0044767 258 0.018
Mouse
protein modification by small protein conjugation or removal GO:0070647 172 0.018
cellular ketone metabolic process GO:0042180 63 0.017
meiotic cell cycle GO:0051321 272 0.017
regulation of protein complex assembly GO:0043254 77 0.017
transcription dependent tethering of rna polymerase ii gene dna at nuclear periphery GO:0000972 19 0.017
cellular protein catabolic process GO:0044257 213 0.017
regulation of dna dependent dna replication initiation GO:0030174 21 0.017
single organism catabolic process GO:0044712 619 0.016
reproductive process in single celled organism GO:0022413 145 0.016
protein targeting GO:0006605 272 0.016
regulation of cellular amine metabolic process GO:0033238 21 0.016
positive regulation of apoptotic process GO:0043065 3 0.016
reproductive process GO:0022414 248 0.016
mitotic cell cycle GO:0000278 306 0.016
conjugation GO:0000746 107 0.016
dna replication GO:0006260 147 0.015
cell differentiation GO:0030154 161 0.015
gene conversion GO:0035822 14 0.015
positive regulation of nucleic acid templated transcription GO:1903508 286 0.015
chromatin silencing at silent mating type cassette GO:0030466 53 0.015
negative regulation of dna replication GO:0008156 15 0.015
response to nutrient levels GO:0031667 150 0.014
mating type determination GO:0007531 32 0.014
histone ubiquitination GO:0016574 17 0.014
protein maturation GO:0051604 76 0.014
carboxylic acid metabolic process GO:0019752 338 0.014
positive regulation of dna metabolic process GO:0051054 26 0.013
ncrna processing GO:0034470 330 0.013
cytoskeleton organization GO:0007010 230 0.013
rna 3 end processing GO:0031123 88 0.013
negative regulation of mitotic cell cycle GO:0045930 63 0.013
mrna catabolic process GO:0006402 93 0.013
chromatin remodeling GO:0006338 80 0.013
Human
macromolecular complex disassembly GO:0032984 80 0.013
programmed cell death GO:0012501 30 0.013
conjugation with cellular fusion GO:0000747 106 0.013
cellular response to extracellular stimulus GO:0031668 150 0.013
negative regulation of cellular carbohydrate metabolic process GO:0010677 17 0.013
dna double strand break processing GO:0000729 8 0.012
protein complex biogenesis GO:0070271 314 0.012
organonitrogen compound biosynthetic process GO:1901566 314 0.012
nucleotide excision repair GO:0006289 50 0.012
cellular response to abiotic stimulus GO:0071214 62 0.012
chemical homeostasis GO:0048878 137 0.012
negative regulation of cell cycle phase transition GO:1901988 59 0.012
nucleobase containing compound transport GO:0015931 124 0.012
regulation of generation of precursor metabolites and energy GO:0043467 23 0.012
posttranscriptional tethering of rna polymerase ii gene dna at nuclear periphery GO:0000973 16 0.011
protein dna complex assembly GO:0065004 105 0.011
chromosome organization involved in meiosis GO:0070192 32 0.011
positive regulation of programmed cell death GO:0043068 3 0.011
mrna export from nucleus in response to heat stress GO:0031990 11 0.011
positive regulation of mitotic cell cycle GO:0045931 16 0.011
regulation of cellular amino acid metabolic process GO:0006521 16 0.011
generation of precursor metabolites and energy GO:0006091 147 0.011
fungal type cell wall organization GO:0031505 145 0.011
positive regulation of cellular component organization GO:0051130 116 0.010
proteolysis GO:0006508 268 0.010
regulation of dna templated transcription elongation GO:0032784 44 0.010
regulation of cellular catabolic process GO:0031329 195 0.010
microtubule cytoskeleton organization GO:0000226 109 0.010
chromatin assembly GO:0031497 35 0.010

TOP1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org