Saccharomyces cerevisiae

158 known processes

TOP2 (YNL088W)

Top2p

(Aliases: TRF3,TOR3)

TOP2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic cell cycle process GO:1903047 294 0.806
mitotic cell cycle GO:0000278 306 0.560
dna repair GO:0006281 236 0.463
positive regulation of macromolecule biosynthetic process GO:0010557 325 0.372
Mouse
nuclear division GO:0000280 263 0.340
positive regulation of rna biosynthetic process GO:1902680 286 0.286
Mouse
nucleoside phosphate metabolic process GO:0006753 458 0.249
positive regulation of gene expression GO:0010628 321 0.231
Mouse
dna conformation change GO:0071103 98 0.217
positive regulation of transcription dna templated GO:0045893 286 0.212
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.202
Human Mouse
protein localization to nucleus GO:0034504 74 0.190
positive regulation of rna metabolic process GO:0051254 294 0.186
Human Mouse
organelle fission GO:0048285 272 0.160
negative regulation of macromolecule metabolic process GO:0010605 375 0.150
Worm
g2 m transition of mitotic cell cycle GO:0000086 38 0.149
positive regulation of macromolecule metabolic process GO:0010604 394 0.144
Human Mouse
cellular response to dna damage stimulus GO:0006974 287 0.136
Human
macromolecule catabolic process GO:0009057 383 0.131
cell cycle checkpoint GO:0000075 82 0.129
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.127
aromatic compound catabolic process GO:0019439 491 0.127
nucleoside catabolic process GO:0009164 335 0.125
regulation of cellular protein metabolic process GO:0032268 232 0.116
positive regulation of transcription from rna polymerase ii promoter GO:0045944 252 0.115
Mouse
response to chemical GO:0042221 390 0.113
cell cycle phase transition GO:0044770 144 0.113
protein catabolic process GO:0030163 221 0.111
positive regulation of nucleic acid templated transcription GO:1903508 286 0.110
Mouse
organophosphate metabolic process GO:0019637 597 0.109
meiotic cell cycle GO:0051321 272 0.108
microtubule based process GO:0007017 117 0.107
mitotic nuclear division GO:0007067 131 0.106
purine nucleotide metabolic process GO:0006163 376 0.104
regulation of cell cycle process GO:0010564 150 0.103
negative regulation of biosynthetic process GO:0009890 312 0.099
negative regulation of gene expression GO:0010629 312 0.098
Worm
positive regulation of cellular biosynthetic process GO:0031328 336 0.098
Mouse
ribonucleotide metabolic process GO:0009259 377 0.096
mrna metabolic process GO:0016071 269 0.095
regulation of transcription from rna polymerase ii promoter GO:0006357 394 0.091
Mouse
mitotic cell cycle phase transition GO:0044772 141 0.090
nucleocytoplasmic transport GO:0006913 163 0.086
negative regulation of cell cycle process GO:0010948 86 0.085
regulation of cell cycle GO:0051726 195 0.085
protein complex assembly GO:0006461 302 0.085
protein localization to organelle GO:0033365 337 0.084
nucleobase containing compound catabolic process GO:0034655 479 0.081
purine nucleoside triphosphate catabolic process GO:0009146 329 0.074
purine ribonucleoside metabolic process GO:0046128 380 0.072
negative regulation of cellular biosynthetic process GO:0031327 312 0.070
organonitrogen compound catabolic process GO:1901565 404 0.067
carbohydrate derivative metabolic process GO:1901135 549 0.066
negative regulation of gene expression epigenetic GO:0045814 147 0.065
nuclear transport GO:0051169 165 0.065
regulation of biological quality GO:0065008 391 0.063
positive regulation of nucleobase containing compound metabolic process GO:0045935 409 0.061
Human Mouse
mrna processing GO:0006397 185 0.061
regulation of protein metabolic process GO:0051246 237 0.061
cytoskeleton organization GO:0007010 230 0.060
glycosyl compound catabolic process GO:1901658 335 0.059
heterocycle catabolic process GO:0046700 494 0.056
gene silencing GO:0016458 151 0.054
Worm
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 109 0.053
negative regulation of transcription dna templated GO:0045892 258 0.052
purine nucleoside metabolic process GO:0042278 380 0.052
microtubule cytoskeleton organization GO:0000226 109 0.051
ribonucleoside metabolic process GO:0009119 389 0.050
positive regulation of dna templated transcription elongation GO:0032786 42 0.050
regulation of protein modification process GO:0031399 110 0.049
dna replication GO:0006260 147 0.047
regulation of organelle organization GO:0033043 243 0.047
cellular amine metabolic process GO:0044106 51 0.047
methylation GO:0032259 101 0.045
cellular macromolecule catabolic process GO:0044265 363 0.044
mitotic cell cycle checkpoint GO:0007093 56 0.043
organic cyclic compound catabolic process GO:1901361 499 0.043
purine ribonucleoside monophosphate metabolic process GO:0009167 262 0.043
ubiquitin dependent protein catabolic process GO:0006511 181 0.043
nucleobase containing small molecule metabolic process GO:0055086 491 0.043
rna splicing GO:0008380 131 0.040
protein complex biogenesis GO:0070271 314 0.040
amine metabolic process GO:0009308 51 0.040
proteolysis GO:0006508 268 0.040
phosphorylation GO:0016310 291 0.040
response to abiotic stimulus GO:0009628 159 0.039
regulation of cellular component organization GO:0051128 334 0.039
single organism catabolic process GO:0044712 619 0.038
purine ribonucleoside triphosphate metabolic process GO:0009205 354 0.038
nucleotide metabolic process GO:0009117 453 0.038
meiotic nuclear division GO:0007126 163 0.037
modification dependent macromolecule catabolic process GO:0043632 203 0.037
glycosyl compound metabolic process GO:1901657 398 0.036
negative regulation of mitotic cell cycle phase transition GO:1901991 57 0.033
negative regulation of cell cycle GO:0045786 91 0.033
positive regulation of cellular protein metabolic process GO:0032270 89 0.033
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.033
cellular response to abiotic stimulus GO:0071214 62 0.032
ribonucleoside triphosphate metabolic process GO:0009199 356 0.032
cellular protein catabolic process GO:0044257 213 0.032
atp catabolic process GO:0006200 224 0.032
negative regulation of protein metabolic process GO:0051248 85 0.032
regulation of cell division GO:0051302 113 0.032
response to oxidative stress GO:0006979 99 0.031
establishment of protein localization to organelle GO:0072594 278 0.031
positive regulation of biosynthetic process GO:0009891 336 0.031
Mouse
positive regulation of protein metabolic process GO:0051247 93 0.031
negative regulation of chromosome organization GO:2001251 39 0.030
cellular nitrogen compound catabolic process GO:0044270 494 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.030
nucleoside phosphate biosynthetic process GO:1901293 80 0.029
nucleus localization GO:0051647 22 0.028
growth of unicellular organism as a thread of attached cells GO:0070783 105 0.028
response to uv GO:0009411 4 0.028
dna dependent dna replication GO:0006261 115 0.027
purine nucleoside monophosphate catabolic process GO:0009128 224 0.027
atp metabolic process GO:0046034 251 0.027
negative regulation of nucleic acid templated transcription GO:1903507 260 0.026
regulation of protein localization GO:0032880 62 0.026
nucleoside metabolic process GO:0009116 394 0.026
posttranscriptional regulation of gene expression GO:0010608 115 0.026
Worm
ribonucleoside triphosphate catabolic process GO:0009203 327 0.026
chromatin remodeling GO:0006338 80 0.026
nucleoside monophosphate catabolic process GO:0009125 224 0.026
nucleotide catabolic process GO:0009166 330 0.026
cell wall organization or biogenesis GO:0071554 190 0.025
purine nucleoside catabolic process GO:0006152 330 0.025
cell differentiation GO:0030154 161 0.025
Mouse
cell communication GO:0007154 345 0.025
purine ribonucleotide catabolic process GO:0009154 327 0.025
developmental process involved in reproduction GO:0003006 159 0.024
regulation of catabolic process GO:0009894 199 0.024
septin ring assembly GO:0000921 14 0.024
organophosphate catabolic process GO:0046434 338 0.023
double strand break repair GO:0006302 105 0.023
purine nucleotide catabolic process GO:0006195 328 0.023
cellular ketone metabolic process GO:0042180 63 0.022
ribonucleoside monophosphate metabolic process GO:0009161 265 0.022
positive regulation of cellular catabolic process GO:0031331 128 0.022
ribonucleotide catabolic process GO:0009261 327 0.022
multi organism reproductive process GO:0044703 216 0.022
protein processing GO:0016485 64 0.021
regulation of dna metabolic process GO:0051052 100 0.021
regulation of cellular component biogenesis GO:0044087 112 0.021
mrna 3 end processing GO:0031124 54 0.020
regulation of gene expression epigenetic GO:0040029 147 0.020
Worm
cellular protein complex assembly GO:0043623 209 0.020
response to heat GO:0009408 69 0.020
chromatin silencing at silent mating type cassette GO:0030466 53 0.020
regulation of dna templated transcription elongation GO:0032784 44 0.020
nucleoside phosphate catabolic process GO:1901292 331 0.020
negative regulation of cellular metabolic process GO:0031324 407 0.020
mrna splicing via spliceosome GO:0000398 108 0.019
nucleic acid phosphodiester bond hydrolysis GO:0090305 194 0.019
ribose phosphate metabolic process GO:0019693 384 0.019
intracellular protein transport GO:0006886 319 0.019
negative regulation of cellular component organization GO:0051129 109 0.019
protein modification by small protein conjugation GO:0032446 144 0.018
dna strand elongation GO:0022616 29 0.018
positive regulation of programmed cell death GO:0043068 3 0.018
Human
external encapsulating structure organization GO:0045229 146 0.018
single organism nuclear import GO:1902593 56 0.018
regulation of cellular amino acid metabolic process GO:0006521 16 0.018
regulation of nuclear division GO:0051783 103 0.018
chemical homeostasis GO:0048878 137 0.018
protein targeting to nucleus GO:0044744 57 0.017
dna integrity checkpoint GO:0031570 41 0.017
carbohydrate derivative catabolic process GO:1901136 339 0.017
nucleoside triphosphate metabolic process GO:0009141 364 0.017
regulation of cellular catabolic process GO:0031329 195 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 327 0.017
organic acid metabolic process GO:0006082 352 0.017
negative regulation of protein catabolic process GO:0042177 27 0.017
dna packaging GO:0006323 55 0.017
Human Mouse
cell cycle g2 m phase transition GO:0044839 39 0.016
positive regulation of catalytic activity GO:0043085 178 0.016
generation of precursor metabolites and energy GO:0006091 147 0.016
nucleosome assembly GO:0006334 16 0.016
cell growth GO:0016049 89 0.016
transcription elongation from rna polymerase ii promoter GO:0006368 81 0.016
regulation of molecular function GO:0065009 320 0.016
reproductive process GO:0022414 248 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 224 0.016
cell aging GO:0007569 70 0.016
single organism developmental process GO:0044767 258 0.016
Mouse Worm
negative regulation of cellular protein metabolic process GO:0032269 85 0.016
negative regulation of rna biosynthetic process GO:1902679 260 0.015
regulation of response to stimulus GO:0048583 157 0.015
negative regulation of organelle organization GO:0010639 103 0.015
positive regulation of organelle organization GO:0010638 85 0.015
dna recombination GO:0006310 172 0.015
nucleotide biosynthetic process GO:0009165 79 0.015
ribonucleoside monophosphate catabolic process GO:0009158 224 0.015
reproduction of a single celled organism GO:0032505 191 0.014
sexual reproduction GO:0019953 216 0.014
protein import into nucleus GO:0006606 55 0.014
regulation of gene silencing GO:0060968 41 0.014
protein modification by small protein conjugation or removal GO:0070647 172 0.014
alcohol metabolic process GO:0006066 112 0.014
protein acetylation GO:0006473 59 0.014
regulation of protein phosphorylation GO:0001932 75 0.014
cellular response to chemical stimulus GO:0070887 315 0.014
protein dna complex subunit organization GO:0071824 153 0.014
chromatin assembly GO:0031497 35 0.014
nucleoside triphosphate catabolic process GO:0009143 329 0.014
protein phosphorylation GO:0006468 197 0.014
rna splicing via transesterification reactions GO:0000375 118 0.014
regulation of cellular amine metabolic process GO:0033238 21 0.014
developmental process GO:0032502 261 0.013
Mouse Worm
lipid metabolic process GO:0006629 269 0.013
regulation of rna splicing GO:0043484 3 0.013
positive regulation of cell cycle GO:0045787 32 0.013
negative regulation of mitotic cell cycle GO:0045930 63 0.013
cellular response to oxidative stress GO:0034599 94 0.013
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 38 0.013
meiosis i GO:0007127 92 0.013
fungal type cell wall organization or biogenesis GO:0071852 169 0.013
positive regulation of protein complex assembly GO:0031334 39 0.013
maintenance of location GO:0051235 66 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.013
chromatin assembly or disassembly GO:0006333 60 0.013
nuclear import GO:0051170 57 0.013
lipid localization GO:0010876 60 0.012
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 2 0.012
single organism reproductive process GO:0044702 159 0.012
pseudohyphal growth GO:0007124 75 0.012
cell wall organization GO:0071555 146 0.012
growth GO:0040007 157 0.012
positive regulation of catabolic process GO:0009896 135 0.012
membrane organization GO:0061024 276 0.012
signaling GO:0023052 208 0.012
regulation of cellular ketone metabolic process GO:0010565 42 0.012
protein transport GO:0015031 345 0.012
negative regulation of cell cycle phase transition GO:1901988 59 0.012
positive regulation of cellular component organization GO:0051130 116 0.011
positive regulation of apoptotic process GO:0043065 3 0.011
Human
nucleosome organization GO:0034728 63 0.011
regulation of transcription by chromatin organization GO:0034401 19 0.011
regulation of catalytic activity GO:0050790 307 0.011
chromosome separation GO:0051304 33 0.011
chromatin organization GO:0006325 242 0.011
multi organism process GO:0051704 233 0.011
Human
protein ubiquitination GO:0016567 118 0.011
regulation of cell cycle phase transition GO:1901987 70 0.011
cellular chemical homeostasis GO:0055082 123 0.011
reciprocal meiotic recombination GO:0007131 54 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 198 0.010
covalent chromatin modification GO:0016569 119 0.010
anatomical structure development GO:0048856 160 0.010
Mouse Worm
oxidation reduction process GO:0055114 353 0.010
purine containing compound catabolic process GO:0072523 332 0.010

TOP2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org