Saccharomyces cerevisiae

132 known processes

SIR3 (YLR442C)

Sir3p

(Aliases: STE8,CMT1,MAR2)

SIR3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.893
negative regulation of cellular metabolic process GO:0031324 407 0.888
negative regulation of macromolecule metabolic process GO:0010605 375 0.885
negative regulation of nucleic acid templated transcription GO:1903507 260 0.879
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.840
chromatin silencing GO:0006342 147 0.804
chromatin organization GO:0006325 242 0.749
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.746
gene silencing GO:0016458 151 0.733
negative regulation of gene expression GO:0010629 312 0.717
negative regulation of transcription dna templated GO:0045892 258 0.703
meiotic cell cycle GO:0051321 272 0.628
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.606
negative regulation of gene expression epigenetic GO:0045814 147 0.604
negative regulation of rna biosynthetic process GO:1902679 260 0.593
chromatin silencing at silent mating type cassette GO:0030466 53 0.585
chromatin modification GO:0016568 200 0.577
negative regulation of biosynthetic process GO:0009890 312 0.566
negative regulation of rna metabolic process GO:0051253 262 0.550
dna repair GO:0006281 236 0.498
cell division GO:0051301 205 0.491
negative regulation of cellular biosynthetic process GO:0031327 312 0.485
regulation of gene expression epigenetic GO:0040029 147 0.474
anatomical structure homeostasis GO:0060249 74 0.414
telomere organization GO:0032200 75 0.272
regulation of cell cycle process GO:0010564 150 0.260
regulation of cell division GO:0051302 113 0.256
telomere maintenance GO:0000723 74 0.248
protein complex biogenesis GO:0070271 314 0.237
protein complex assembly GO:0006461 302 0.226
aromatic compound catabolic process GO:0019439 491 0.203
regulation of cell cycle GO:0051726 195 0.196
response to pheromone involved in conjugation with cellular fusion GO:0000749 74 0.187
single organism developmental process GO:0044767 258 0.183
single organism catabolic process GO:0044712 619 0.177
protein ubiquitination GO:0016567 118 0.168
cytokinesis GO:0000910 92 0.165
cell cycle phase transition GO:0044770 144 0.164
meiotic nuclear division GO:0007126 163 0.150
cellular macromolecule catabolic process GO:0044265 363 0.145
response to organic substance GO:0010033 182 0.139
histone modification GO:0016570 119 0.136
carbohydrate derivative metabolic process GO:1901135 549 0.135
mitotic cell cycle phase transition GO:0044772 141 0.125
chromatin assembly or disassembly GO:0006333 60 0.124
nucleobase containing compound catabolic process GO:0034655 479 0.123
organelle fission GO:0048285 272 0.121
organophosphate metabolic process GO:0019637 597 0.112
cellular response to chemical stimulus GO:0070887 315 0.101
covalent chromatin modification GO:0016569 119 0.098
cell aging GO:0007569 70 0.096
regulation of nuclear division GO:0051783 103 0.095
macromolecule catabolic process GO:0009057 383 0.094
dna recombination GO:0006310 172 0.093
cellular protein catabolic process GO:0044257 213 0.091
organonitrogen compound catabolic process GO:1901565 404 0.090
aging GO:0007568 71 0.089
mitotic cell cycle GO:0000278 306 0.088
cellular nitrogen compound catabolic process GO:0044270 494 0.084
heterocycle catabolic process GO:0046700 494 0.084
regulation of organelle organization GO:0033043 243 0.083
double strand break repair GO:0006302 105 0.083
mitotic cytokinesis site selection GO:1902408 35 0.082
protein dna complex subunit organization GO:0071824 153 0.082
cellular bud site selection GO:0000282 35 0.079
methylation GO:0032259 101 0.077
protein dna complex assembly GO:0065004 105 0.075
positive regulation of rna biosynthetic process GO:1902680 286 0.074
regulation of cellular component organization GO:0051128 334 0.073
cytoskeleton dependent cytokinesis GO:0061640 65 0.073
response to pheromone GO:0019236 92 0.072
recombinational repair GO:0000725 64 0.070
negative regulation of transcription from rna polymerase ii promoter GO:0000122 137 0.070
homeostatic process GO:0042592 227 0.069
positive regulation of cellular component organization GO:0051130 116 0.067
signal transduction GO:0007165 208 0.067
protein modification by small protein conjugation GO:0032446 144 0.066
ribose phosphate metabolic process GO:0019693 384 0.066
cytokinetic process GO:0032506 78 0.065
carbohydrate metabolic process GO:0005975 252 0.065
cytokinesis site selection GO:0007105 40 0.063
cellular response to dna damage stimulus GO:0006974 287 0.062
carbohydrate derivative catabolic process GO:1901136 339 0.061
cell development GO:0048468 107 0.060
positive regulation of nucleobase containing compound metabolic process GO:0045935 409 0.059
ribonucleoside metabolic process GO:0009119 389 0.059
mitotic cytokinesis GO:0000281 58 0.058
meiotic cell cycle process GO:1903046 229 0.056
sexual sporulation resulting in formation of a cellular spore GO:0043935 113 0.055
regulation of biological quality GO:0065008 391 0.055
chromatin silencing at telomere GO:0006348 84 0.052
organic acid metabolic process GO:0006082 352 0.052
protein modification by small protein conjugation or removal GO:0070647 172 0.051
protein alkylation GO:0008213 48 0.051
regulation of protein complex assembly GO:0043254 77 0.051
nucleobase containing small molecule metabolic process GO:0055086 491 0.050
monocarboxylic acid metabolic process GO:0032787 122 0.050
single organism signaling GO:0044700 208 0.049
sexual sporulation GO:0034293 113 0.048
negative regulation of cell cycle process GO:0010948 86 0.048
regulation of transcription from rna polymerase ii promoter GO:0006357 394 0.048
organic cyclic compound catabolic process GO:1901361 499 0.048
anatomical structure development GO:0048856 160 0.047
positive regulation of macromolecule metabolic process GO:0010604 394 0.047
developmental process involved in reproduction GO:0003006 159 0.047
cell cycle checkpoint GO:0000075 82 0.047
glycosyl compound catabolic process GO:1901658 335 0.046
regulation of dna metabolic process GO:0051052 100 0.045
regulation of cellular catabolic process GO:0031329 195 0.045
developmental process GO:0032502 261 0.044
reproduction of a single celled organism GO:0032505 191 0.043
dna catabolic process GO:0006308 42 0.042
multi organism process GO:0051704 233 0.042
regulation of catabolic process GO:0009894 199 0.041
histone methylation GO:0016571 28 0.041
growth of unicellular organism as a thread of attached cells GO:0070783 105 0.041
reproductive process GO:0022414 248 0.040
regulation of dna dependent dna replication GO:0090329 37 0.040
macromolecule deacylation GO:0098732 27 0.040
actin cytoskeleton organization GO:0030036 100 0.040
sexual reproduction GO:0019953 216 0.039
single organism cellular localization GO:1902580 375 0.039
regulation of response to stimulus GO:0048583 157 0.039
cellular response to pheromone GO:0071444 88 0.038
positive regulation of rna metabolic process GO:0051254 294 0.038
signaling GO:0023052 208 0.038
single organism reproductive process GO:0044702 159 0.038
reciprocal meiotic recombination GO:0007131 54 0.038
nucleotide excision repair GO:0006289 50 0.037
cellular component morphogenesis GO:0032989 97 0.037
actin filament based process GO:0030029 104 0.036
regulation of chromosome organization GO:0033044 66 0.036
nucleoside phosphate metabolic process GO:0006753 458 0.036
dna replication GO:0006260 147 0.034
mitotic cytokinetic process GO:1902410 45 0.034
cellular response to nutrient levels GO:0031669 144 0.034
establishment of cell polarity GO:0030010 64 0.034
purine ribonucleoside metabolic process GO:0046128 380 0.034
regulation of cell cycle phase transition GO:1901987 70 0.034
regulation of phosphate metabolic process GO:0019220 230 0.033
positive regulation of transcription dna templated GO:0045893 286 0.033
anatomical structure formation involved in morphogenesis GO:0048646 136 0.033
nucleoside catabolic process GO:0009164 335 0.033
nucleotide metabolic process GO:0009117 453 0.032
anatomical structure morphogenesis GO:0009653 160 0.032
purine containing compound catabolic process GO:0072523 332 0.032
mitochondrion organization GO:0007005 261 0.031
cellular lipid metabolic process GO:0044255 229 0.031
nucleoside triphosphate catabolic process GO:0009143 329 0.031
mitotic cell cycle process GO:1903047 294 0.031
negative regulation of cell cycle phase transition GO:1901988 59 0.031
regulation of dna replication GO:0006275 51 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 325 0.030
replicative cell aging GO:0001302 46 0.030
regulation of nucleoside metabolic process GO:0009118 106 0.030
filamentous growth GO:0030447 124 0.029
ascospore formation GO:0030437 107 0.029
regulation of meiotic cell cycle GO:0051445 43 0.029
oxoacid metabolic process GO:0043436 351 0.029
cellular component assembly involved in morphogenesis GO:0010927 73 0.029
chromatin remodeling GO:0006338 80 0.028
negative regulation of chromatin silencing GO:0031936 25 0.028
macromolecule methylation GO:0043414 85 0.028
filamentous growth of a population of unicellular organisms GO:0044182 109 0.028
purine containing compound metabolic process GO:0072521 400 0.027
cellular protein complex assembly GO:0043623 209 0.027
regulation of transcription by chromatin organization GO:0034401 19 0.027
nuclear division GO:0000280 263 0.027
regulation of metaphase anaphase transition of cell cycle GO:1902099 27 0.026
double strand break repair via homologous recombination GO:0000724 54 0.026
cellular ketone metabolic process GO:0042180 63 0.026
ribonucleoside triphosphate metabolic process GO:0009199 356 0.026
glycosyl compound metabolic process GO:1901657 398 0.026
ribonucleotide catabolic process GO:0009261 327 0.025
response to chemical GO:0042221 390 0.025
protein methylation GO:0006479 48 0.025
establishment of protein localization GO:0045184 367 0.025
purine ribonucleoside catabolic process GO:0046130 330 0.024
regulation of purine nucleotide metabolic process GO:1900542 109 0.024
positive regulation of transcription from rna polymerase ii promoter GO:0045944 252 0.024
lipid metabolic process GO:0006629 269 0.024
multi organism reproductive process GO:0044703 216 0.024
cell communication GO:0007154 345 0.023
regulation of signaling GO:0023051 119 0.023
regulation of protein metabolic process GO:0051246 237 0.023
carboxylic acid metabolic process GO:0019752 338 0.023
purine nucleoside catabolic process GO:0006152 330 0.023
mitotic cell cycle checkpoint GO:0007093 56 0.023
organophosphate catabolic process GO:0046434 338 0.022
regulation of mitotic cell cycle GO:0007346 107 0.022
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 109 0.022
chromatin silencing at rdna GO:0000183 32 0.022
regulation of purine nucleotide catabolic process GO:0033121 106 0.022
ribonucleoprotein complex assembly GO:0022618 143 0.022
intracellular signal transduction GO:0035556 112 0.022
regulation of mitotic cell cycle phase transition GO:1901990 68 0.022
vesicle mediated transport GO:0016192 335 0.021
nucleoside phosphate catabolic process GO:1901292 331 0.021
positive regulation of transport GO:0051050 32 0.021
guanosine containing compound metabolic process GO:1901068 111 0.021
telomere maintenance via telomerase GO:0007004 21 0.021
regulation of protein modification process GO:0031399 110 0.021
purine ribonucleotide metabolic process GO:0009150 372 0.021
positive regulation of gene expression epigenetic GO:0045815 25 0.021
reproductive process in single celled organism GO:0022413 145 0.021
dna templated transcription elongation GO:0006354 91 0.020
nucleic acid phosphodiester bond hydrolysis GO:0090305 194 0.020
regulation of transport GO:0051049 85 0.020
positive regulation of cell communication GO:0010647 28 0.020
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 51 0.020
regulation of molecular function GO:0065009 320 0.020
nucleosome organization GO:0034728 63 0.019
intracellular protein transport GO:0006886 319 0.019
regulation of localization GO:0032879 127 0.019
regulation of gtpase activity GO:0043087 84 0.019
purine nucleoside triphosphate catabolic process GO:0009146 329 0.019
response to external stimulus GO:0009605 158 0.019
ion transport GO:0006811 274 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 198 0.018
regulation of cell communication GO:0010646 124 0.018
modification dependent protein catabolic process GO:0019941 181 0.018
cytoskeleton organization GO:0007010 230 0.018
telomere maintenance via telomere lengthening GO:0010833 22 0.018
purine nucleotide catabolic process GO:0006195 328 0.018
negative regulation of cell cycle GO:0045786 91 0.018
gtp metabolic process GO:0046039 107 0.017
regulation of cellular component biogenesis GO:0044087 112 0.017
ribonucleoside catabolic process GO:0042454 332 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 100 0.017
growth GO:0040007 157 0.017
cellular response to organic substance GO:0071310 159 0.017
organic hydroxy compound metabolic process GO:1901615 125 0.017
positive regulation of dna metabolic process GO:0051054 26 0.017
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 26 0.017
cellular developmental process GO:0048869 191 0.017
mrna metabolic process GO:0016071 269 0.017
sporulation GO:0043934 132 0.017
positive regulation of catalytic activity GO:0043085 178 0.017
regulation of protein localization GO:0032880 62 0.016
ribonucleotide metabolic process GO:0009259 377 0.016
regulation of nucleotide catabolic process GO:0030811 106 0.016
purine ribonucleotide catabolic process GO:0009154 327 0.016
response to abiotic stimulus GO:0009628 159 0.016
cellular response to abiotic stimulus GO:0071214 62 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.015
positive regulation of nucleotide catabolic process GO:0030813 97 0.015
regulation of gene silencing GO:0060968 41 0.015
sister chromatid segregation GO:0000819 93 0.015
regulation of cellular protein metabolic process GO:0032268 232 0.015
ribonucleoside triphosphate catabolic process GO:0009203 327 0.015
ribonucleoprotein complex subunit organization GO:0071826 152 0.015
invasive filamentous growth GO:0036267 65 0.015
conjugation with cellular fusion GO:0000747 106 0.015
purine nucleotide metabolic process GO:0006163 376 0.015
negative regulation of dna metabolic process GO:0051053 36 0.015
response to organic cyclic compound GO:0014070 1 0.015
reciprocal dna recombination GO:0035825 54 0.015
regulation of cellular ketone metabolic process GO:0010565 42 0.015
protein localization to chromosome GO:0034502 28 0.015
sporulation resulting in formation of a cellular spore GO:0030435 129 0.014
glycerophospholipid metabolic process GO:0006650 98 0.014
fatty acid metabolic process GO:0006631 51 0.014
protein localization to organelle GO:0033365 337 0.014
protein transport GO:0015031 345 0.014
purine nucleoside metabolic process GO:0042278 380 0.014
regulation of chromatin silencing GO:0031935 39 0.014
regulation of catalytic activity GO:0050790 307 0.014
positive regulation of catabolic process GO:0009896 135 0.014
mrna splicing via spliceosome GO:0000398 108 0.013
negative regulation of mitotic cell cycle GO:0045930 63 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 57 0.013
single organism carbohydrate metabolic process GO:0044723 237 0.013
chromatin assembly GO:0031497 35 0.013
nucleoside triphosphate metabolic process GO:0009141 364 0.013
regulation of filamentous growth of a population of unicellular organisms GO:1900428 36 0.013
asexual reproduction GO:0019954 48 0.013
g2 m transition of mitotic cell cycle GO:0000086 38 0.013
positive regulation of gene expression GO:0010628 321 0.013
response to starvation GO:0042594 96 0.013
regulation of dna templated transcription in response to stress GO:0043620 51 0.012
response to hypoxia GO:0001666 4 0.012
protein autophosphorylation GO:0046777 15 0.012
carbohydrate catabolic process GO:0016052 77 0.012
phospholipid metabolic process GO:0006644 125 0.012
regulation of nucleotide metabolic process GO:0006140 110 0.012
regulation of cellular amino acid metabolic process GO:0006521 16 0.012
glucose metabolic process GO:0006006 65 0.012
positive regulation of molecular function GO:0044093 185 0.012
negative regulation of cell division GO:0051782 66 0.012
regulation of phosphorylation GO:0042325 86 0.012
nucleoside metabolic process GO:0009116 394 0.011
telomere capping GO:0016233 10 0.011
regulation of gtp catabolic process GO:0033124 84 0.011
conjugation GO:0000746 107 0.011
regulation of protein phosphorylation GO:0001932 75 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 81 0.011
cellular response to external stimulus GO:0071496 150 0.011
negative regulation of dna replication GO:0008156 15 0.011
amine metabolic process GO:0009308 51 0.011
golgi vesicle transport GO:0048193 188 0.011
negative regulation of nuclear division GO:0051784 62 0.011
positive regulation of cellular catabolic process GO:0031331 128 0.011
cellular carbohydrate metabolic process GO:0044262 135 0.011
gtp catabolic process GO:0006184 107 0.010
nitrogen compound transport GO:0071705 212 0.010
dna templated transcription initiation GO:0006352 71 0.010
regulation of hydrolase activity GO:0051336 133 0.010
mrna processing GO:0006397 185 0.010
cellular component movement GO:0006928 20 0.010
chromosome segregation GO:0007059 159 0.010

SIR3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.018