Saccharomyces cerevisiae

42 known processes

MLH2 (YLR035C)

Mlh2p

MLH2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of macromolecule biosynthetic process GO:0010557 325 0.249
positive regulation of gene expression GO:0010628 321 0.184
negative regulation of rna biosynthetic process GO:1902679 260 0.182
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.178
negative regulation of macromolecule metabolic process GO:0010605 375 0.173
positive regulation of biosynthetic process GO:0009891 336 0.167
signaling GO:0023052 208 0.161
mrna catabolic process GO:0006402 93 0.159
macromolecule catabolic process GO:0009057 383 0.153
positive regulation of cellular biosynthetic process GO:0031328 336 0.152
nuclear division GO:0000280 263 0.146
negative regulation of gene expression GO:0010629 312 0.141
negative regulation of transcription dna templated GO:0045892 258 0.140
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.136
mrna metabolic process GO:0016071 269 0.127
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.125
positive regulation of transcription dna templated GO:0045893 286 0.125
negative regulation of biosynthetic process GO:0009890 312 0.118
positive regulation of rna biosynthetic process GO:1902680 286 0.116
positive regulation of rna metabolic process GO:0051254 294 0.110
response to chemical GO:0042221 390 0.108
organelle localization GO:0051640 128 0.102
single organism catabolic process GO:0044712 619 0.102
positive regulation of nucleobase containing compound metabolic process GO:0045935 409 0.102
heterocycle catabolic process GO:0046700 494 0.101
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 44 0.100
negative regulation of cellular biosynthetic process GO:0031327 312 0.099
cellular nitrogen compound catabolic process GO:0044270 494 0.097
negative regulation of cellular metabolic process GO:0031324 407 0.096
nucleobase containing compound catabolic process GO:0034655 479 0.096
positive regulation of nucleic acid templated transcription GO:1903508 286 0.096
negative regulation of rna metabolic process GO:0051253 262 0.092
dna repair GO:0006281 236 0.090
cellular macromolecule catabolic process GO:0044265 363 0.086
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.086
rna catabolic process GO:0006401 118 0.085
aromatic compound catabolic process GO:0019439 491 0.085
regulation of biological quality GO:0065008 391 0.081
nuclear transcribed mrna catabolic process GO:0000956 89 0.079
cellular response to chemical stimulus GO:0070887 315 0.078
organelle fission GO:0048285 272 0.077
positive regulation of macromolecule metabolic process GO:0010604 394 0.072
negative regulation of nucleic acid templated transcription GO:1903507 260 0.072
mitochondrion organization GO:0007005 261 0.071
cellular protein complex assembly GO:0043623 209 0.071
single organism signaling GO:0044700 208 0.069
positive regulation of transcription from rna polymerase ii promoter GO:0045944 252 0.065
organic cyclic compound catabolic process GO:1901361 499 0.062
meiotic nuclear division GO:0007126 163 0.060
protein modification by small protein conjugation GO:0032446 144 0.060
protein complex biogenesis GO:0070271 314 0.060
establishment of organelle localization GO:0051656 96 0.058
organic anion transport GO:0015711 114 0.057
dna recombination GO:0006310 172 0.057
transmembrane transport GO:0055085 349 0.056
reciprocal meiotic recombination GO:0007131 54 0.056
proteolysis involved in cellular protein catabolic process GO:0051603 198 0.056
growth GO:0040007 157 0.055
mrna processing GO:0006397 185 0.054
lipid localization GO:0010876 60 0.053
protein complex assembly GO:0006461 302 0.053
regulation of dna metabolic process GO:0051052 100 0.052
carboxylic acid metabolic process GO:0019752 338 0.052
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.052
protein modification by small protein conjugation or removal GO:0070647 172 0.049
rna 3 end processing GO:0031123 88 0.048
purine nucleoside metabolic process GO:0042278 380 0.048
regulation of transcription from rna polymerase ii promoter GO:0006357 394 0.047
organic acid metabolic process GO:0006082 352 0.046
non recombinational repair GO:0000726 33 0.045
signal transduction GO:0007165 208 0.045
single organism cellular localization GO:1902580 375 0.045
anion transport GO:0006820 145 0.045
oxoacid metabolic process GO:0043436 351 0.043
chromosome localization GO:0050000 20 0.042
meiotic cell cycle process GO:1903046 229 0.040
cytoskeleton organization GO:0007010 230 0.040
organelle assembly GO:0070925 118 0.039
multi organism process GO:0051704 233 0.038
protein catabolic process GO:0030163 221 0.038
gene silencing GO:0016458 151 0.038
regulation of protein metabolic process GO:0051246 237 0.037
translation GO:0006412 230 0.037
single organism reproductive process GO:0044702 159 0.037
carbohydrate catabolic process GO:0016052 77 0.036
filamentous growth of a population of unicellular organisms GO:0044182 109 0.036
organonitrogen compound biosynthetic process GO:1901566 314 0.035
atp metabolic process GO:0046034 251 0.034
chromosome organization involved in meiosis GO:0070192 32 0.034
nitrogen compound transport GO:0071705 212 0.033
regulation of gene expression epigenetic GO:0040029 147 0.033
protein ubiquitination GO:0016567 118 0.032
intracellular signal transduction GO:0035556 112 0.032
modification dependent macromolecule catabolic process GO:0043632 203 0.032
meiotic cell cycle GO:0051321 272 0.032
mrna 3 end processing GO:0031124 54 0.032
cellular chemical homeostasis GO:0055082 123 0.031
developmental process involved in reproduction GO:0003006 159 0.031
cell communication GO:0007154 345 0.031
double strand break repair GO:0006302 105 0.031
cellular response to dna damage stimulus GO:0006974 287 0.030
reproductive process GO:0022414 248 0.030
regulation of cellular component organization GO:0051128 334 0.029
homeostatic process GO:0042592 227 0.028
nucleobase containing small molecule metabolic process GO:0055086 491 0.028
dna dependent dna replication GO:0006261 115 0.028
regulation of cell cycle process GO:0010564 150 0.028
ribonucleoside metabolic process GO:0009119 389 0.028
purine ribonucleoside metabolic process GO:0046128 380 0.027
ion transport GO:0006811 274 0.026
nucleoside metabolic process GO:0009116 394 0.026
rrna metabolic process GO:0016072 244 0.026
response to organic cyclic compound GO:0014070 1 0.025
microtubule cytoskeleton organization GO:0000226 109 0.025
meiotic mismatch repair GO:0000710 9 0.025
filamentous growth GO:0030447 124 0.025
carbohydrate derivative metabolic process GO:1901135 549 0.025
double strand break repair via nonhomologous end joining GO:0006303 27 0.025
regulation of translation GO:0006417 89 0.025
regulation of signal transduction GO:0009966 114 0.024
single organism membrane organization GO:0044802 275 0.024
nucleoside phosphate metabolic process GO:0006753 458 0.024
regulation of cell cycle GO:0051726 195 0.024
negative regulation of transcription from rna polymerase ii promoter GO:0000122 137 0.024
meiosis i GO:0007127 92 0.024
reciprocal dna recombination GO:0035825 54 0.024
meiotic chromosome segregation GO:0045132 31 0.024
regulation of localization GO:0032879 127 0.024
chromosome segregation GO:0007059 159 0.023
nucleocytoplasmic transport GO:0006913 163 0.023
carbohydrate metabolic process GO:0005975 252 0.023
maintenance of location GO:0051235 66 0.023
regulation of response to stimulus GO:0048583 157 0.023
nuclear transport GO:0051169 165 0.023
chemical homeostasis GO:0048878 137 0.023
multi organism cellular process GO:0044764 120 0.022
cellular response to extracellular stimulus GO:0031668 150 0.022
organic acid transport GO:0015849 77 0.022
membrane organization GO:0061024 276 0.022
regulation of cellular component biogenesis GO:0044087 112 0.022
protein targeting GO:0006605 272 0.022
organophosphate metabolic process GO:0019637 597 0.022
invasive growth in response to glucose limitation GO:0001403 61 0.022
reproductive process in single celled organism GO:0022413 145 0.022
cell division GO:0051301 205 0.022
response to external stimulus GO:0009605 158 0.021
mrna splicing via spliceosome GO:0000398 108 0.021
rna splicing via transesterification reactions GO:0000375 118 0.021
posttranscriptional regulation of gene expression GO:0010608 115 0.021
mitotic recombination GO:0006312 55 0.021
chromatin organization GO:0006325 242 0.021
glycosyl compound metabolic process GO:1901657 398 0.021
negative regulation of response to stimulus GO:0048585 40 0.021
ribonucleoside monophosphate metabolic process GO:0009161 265 0.020
carboxylic acid transport GO:0046942 74 0.020
cellular response to nutrient levels GO:0031669 144 0.020
regulation of cell communication GO:0010646 124 0.020
polysaccharide metabolic process GO:0005976 60 0.020
regulation of response to stress GO:0080134 57 0.020
regulation of molecular function GO:0065009 320 0.020
regulation of cellular protein metabolic process GO:0032268 232 0.020
nucleoside monophosphate metabolic process GO:0009123 267 0.020
cellular cation homeostasis GO:0030003 100 0.020
ribonucleoprotein complex assembly GO:0022618 143 0.019
cellular component disassembly GO:0022411 86 0.019
multi organism reproductive process GO:0044703 216 0.019
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 109 0.019
response to extracellular stimulus GO:0009991 156 0.019
organonitrogen compound catabolic process GO:1901565 404 0.019
ribonucleoprotein complex subunit organization GO:0071826 152 0.019
mitotic cell cycle GO:0000278 306 0.019
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 26 0.019
negative regulation of cell cycle GO:0045786 91 0.018
maintenance of protein location GO:0045185 53 0.018
regulation of growth GO:0040008 50 0.018
modification dependent protein catabolic process GO:0019941 181 0.018
reproduction of a single celled organism GO:0032505 191 0.018
death GO:0016265 30 0.018
chromatin silencing GO:0006342 147 0.018
apoptotic process GO:0006915 30 0.018
mitochondrial genome maintenance GO:0000002 40 0.018
single organism developmental process GO:0044767 258 0.018
cation homeostasis GO:0055080 105 0.018
regulation of organelle organization GO:0033043 243 0.018
negative regulation of dna metabolic process GO:0051053 36 0.017
regulation of mitotic cell cycle phase transition GO:1901990 68 0.017
response to organic substance GO:0010033 182 0.017
cellular response to organic substance GO:0071310 159 0.017
single organism carbohydrate metabolic process GO:0044723 237 0.017
negative regulation of cellular component organization GO:0051129 109 0.017
lipid metabolic process GO:0006629 269 0.017
cellular response to oxidative stress GO:0034599 94 0.017
lipid transport GO:0006869 58 0.017
hexose metabolic process GO:0019318 78 0.017
establishment of protein localization to membrane GO:0090150 99 0.017
phosphorylation GO:0016310 291 0.016
mitotic cell cycle phase transition GO:0044772 141 0.016
cellular amine metabolic process GO:0044106 51 0.016
regulation of dna templated transcription in response to stress GO:0043620 51 0.016
dna replication GO:0006260 147 0.016
mismatch repair GO:0006298 14 0.016
regulation of catabolic process GO:0009894 199 0.016
regulation of cell division GO:0051302 113 0.016
cellular protein catabolic process GO:0044257 213 0.016
conjugation with cellular fusion GO:0000747 106 0.016
anatomical structure formation involved in morphogenesis GO:0048646 136 0.016
regulation of transport GO:0051049 85 0.015
developmental process GO:0032502 261 0.015
rna localization GO:0006403 112 0.015
sexual reproduction GO:0019953 216 0.015
conjugation GO:0000746 107 0.015
nuclear transcribed mrna poly a tail shortening GO:0000289 14 0.015
cell wall organization or biogenesis GO:0071554 190 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 354 0.015
response to osmotic stress GO:0006970 83 0.015
nucleotide excision repair GO:0006289 50 0.015
cellular response to starvation GO:0009267 90 0.015
establishment of protein localization to organelle GO:0072594 278 0.015
cell growth GO:0016049 89 0.014
negative regulation of gene expression epigenetic GO:0045814 147 0.014
dephosphorylation GO:0016311 127 0.014
cellular amino acid metabolic process GO:0006520 225 0.014
synapsis GO:0007129 19 0.014
peptidyl lysine modification GO:0018205 77 0.014
atp catabolic process GO:0006200 224 0.014
positive regulation of protein metabolic process GO:0051247 93 0.014
cellular homeostasis GO:0019725 138 0.014
regulation of cellular catabolic process GO:0031329 195 0.014
nucleobase containing compound transport GO:0015931 124 0.014
purine nucleoside monophosphate metabolic process GO:0009126 262 0.014
response to oxidative stress GO:0006979 99 0.013
purine nucleoside triphosphate metabolic process GO:0009144 356 0.013
proteolysis GO:0006508 268 0.013
regulation of filamentous growth of a population of unicellular organisms GO:1900428 36 0.013
peptidyl amino acid modification GO:0018193 116 0.013
chromatin silencing at silent mating type cassette GO:0030466 53 0.013
histone modification GO:0016570 119 0.013
response to nutrient levels GO:0031667 150 0.013
cell death GO:0008219 30 0.013
cellular developmental process GO:0048869 191 0.013
lipid biosynthetic process GO:0008610 170 0.013
methylation GO:0032259 101 0.013
amine metabolic process GO:0009308 51 0.013
cation transport GO:0006812 166 0.013
cell cycle g1 s phase transition GO:0044843 64 0.013
cellular transition metal ion homeostasis GO:0046916 59 0.013
chromatin modification GO:0016568 200 0.013
mitotic cell cycle process GO:1903047 294 0.012
glycerolipid metabolic process GO:0046486 108 0.012
positive regulation of molecular function GO:0044093 185 0.012
purine nucleoside monophosphate catabolic process GO:0009128 224 0.012
protein complex disassembly GO:0043241 70 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 327 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 224 0.012
organic hydroxy compound transport GO:0015850 41 0.012
spindle organization GO:0007051 37 0.012
generation of precursor metabolites and energy GO:0006091 147 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 262 0.012
regulation of metal ion transport GO:0010959 2 0.012
ribonucleoside triphosphate metabolic process GO:0009199 356 0.012
protein localization to mitochondrion GO:0070585 63 0.012
regulation of phosphorus metabolic process GO:0051174 230 0.012
cellular lipid metabolic process GO:0044255 229 0.012
nucleoside monophosphate catabolic process GO:0009125 224 0.012
intracellular protein transport GO:0006886 319 0.012
purine containing compound metabolic process GO:0072521 400 0.012
negative regulation of cell cycle process GO:0010948 86 0.012
covalent chromatin modification GO:0016569 119 0.012
response to starvation GO:0042594 96 0.012
positive regulation of phosphate metabolic process GO:0045937 147 0.012
protein dna complex subunit organization GO:0071824 153 0.012
cellular respiration GO:0045333 82 0.012
positive regulation of cellular component organization GO:0051130 116 0.012
nucleoside catabolic process GO:0009164 335 0.011
positive regulation of cellular protein metabolic process GO:0032270 89 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 194 0.011
cellular response to abiotic stimulus GO:0071214 62 0.011
single organism carbohydrate catabolic process GO:0044724 73 0.011
response to pheromone GO:0019236 92 0.011
carbohydrate derivative catabolic process GO:1901136 339 0.011
positive regulation of programmed cell death GO:0043068 3 0.011
negative regulation of cell cycle phase transition GO:1901988 59 0.011
metaphase plate congression GO:0051310 8 0.011
nuclear export GO:0051168 124 0.011
nucleotide metabolic process GO:0009117 453 0.011
negative regulation of organelle organization GO:0010639 103 0.011
negative regulation of cellular catabolic process GO:0031330 43 0.011
ribonucleoside monophosphate catabolic process GO:0009158 224 0.011
microtubule based process GO:0007017 117 0.011
cell cycle checkpoint GO:0000075 82 0.011
cellular carbohydrate metabolic process GO:0044262 135 0.011
regulation of phosphate metabolic process GO:0019220 230 0.011
telomere organization GO:0032200 75 0.011
purine ribonucleotide metabolic process GO:0009150 372 0.011
rna export from nucleus GO:0006405 88 0.011
cell cycle phase transition GO:0044770 144 0.011
transition metal ion homeostasis GO:0055076 59 0.011
monocarboxylic acid metabolic process GO:0032787 122 0.011
protein localization to organelle GO:0033365 337 0.011
purine nucleoside catabolic process GO:0006152 330 0.011
regulation of mitotic cell cycle GO:0007346 107 0.011
spindle assembly GO:0051225 9 0.011
regulation of catalytic activity GO:0050790 307 0.011
ribosome biogenesis GO:0042254 335 0.011
organic hydroxy compound metabolic process GO:1901615 125 0.010
organophosphate biosynthetic process GO:0090407 182 0.010
maintenance of location in cell GO:0051651 58 0.010
protein transport GO:0015031 345 0.010
detection of stimulus GO:0051606 4 0.010
regulation of signaling GO:0023051 119 0.010
cellular ketone metabolic process GO:0042180 63 0.010
dna conformation change GO:0071103 98 0.010

MLH2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.014