Saccharomyces cerevisiae

106 known processes

SIC1 (YLR079W)

Sic1p

(Aliases: SDB25)

SIC1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 287 0.966
mitotic cell cycle phase transition GO:0044772 141 0.957
negative regulation of cellular metabolic process GO:0031324 407 0.952
regulation of transferase activity GO:0051338 83 0.932
regulation of protein modification process GO:0031399 110 0.925
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 19 0.852
negative regulation of macromolecule metabolic process GO:0010605 375 0.847
organelle fission GO:0048285 272 0.829
regulation of protein phosphorylation GO:0001932 75 0.810
regulation of kinase activity GO:0043549 71 0.799
nuclear division GO:0000280 263 0.795
cell cycle phase transition GO:0044770 144 0.775
regulation of catalytic activity GO:0050790 307 0.740
g1 s transition of mitotic cell cycle GO:0000082 64 0.727
regulation of molecular function GO:0065009 320 0.708
mitotic cell cycle process GO:1903047 294 0.648
phosphorylation GO:0016310 291 0.632
regulation of cell cycle GO:0051726 195 0.626
regulation of organelle organization GO:0033043 243 0.601
mitotic cell cycle GO:0000278 306 0.595
negative regulation of cell cycle GO:0045786 91 0.589
positive regulation of protein phosphorylation GO:0001934 28 0.583
regulation of cellular component organization GO:0051128 334 0.581
positive regulation of phosphorylation GO:0042327 33 0.558
dna replication GO:0006260 147 0.554
mitotic nuclear division GO:0007067 131 0.536
response to abiotic stimulus GO:0009628 159 0.534
regulation of cellular protein metabolic process GO:0032268 232 0.519
regulation of protein kinase activity GO:0045859 67 0.513
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.506
negative regulation of cell cycle process GO:0010948 86 0.504
regulation of protein serine threonine kinase activity GO:0071900 41 0.502
negative regulation of gene expression GO:0010629 312 0.496
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.473
negative regulation of rna metabolic process GO:0051253 262 0.456
chromatin organization GO:0006325 242 0.442
chromatin silencing GO:0006342 147 0.437
regulation of phosphorylation GO:0042325 86 0.424
g2 m transition of mitotic cell cycle GO:0000086 38 0.419
protein phosphorylation GO:0006468 197 0.413
cellular response to chemical stimulus GO:0070887 315 0.402
positive regulation of transcription dna templated GO:0045893 286 0.402
spindle checkpoint GO:0031577 35 0.399
regulation of protein metabolic process GO:0051246 237 0.393
cell cycle g2 m phase transition GO:0044839 39 0.393
regulation of cell cycle process GO:0010564 150 0.392
cell cycle dna replication GO:0044786 36 0.391
chromatin modification GO:0016568 200 0.378
regulation of transcription from rna polymerase ii promoter GO:0006357 394 0.374
negative regulation of biosynthetic process GO:0009890 312 0.371
dna repair GO:0006281 236 0.368
positive regulation of phosphate metabolic process GO:0045937 147 0.364
regulation of dna metabolic process GO:0051052 100 0.363
cellular response to organic substance GO:0071310 159 0.362
positive regulation of gene expression GO:0010628 321 0.353
positive regulation of nucleobase containing compound metabolic process GO:0045935 409 0.350
negative regulation of mitotic cell cycle phase transition GO:1901991 57 0.336
mitotic cell cycle checkpoint GO:0007093 56 0.333
microtubule based movement GO:0007018 18 0.327
positive regulation of phosphorus metabolic process GO:0010562 147 0.322
organelle assembly GO:0070925 118 0.313
cellular response to external stimulus GO:0071496 150 0.311
regulation of phosphate metabolic process GO:0019220 230 0.310
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 27 0.305
negative regulation of rna biosynthetic process GO:1902679 260 0.305
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.301
cell communication GO:0007154 345 0.288
cell cycle g1 s phase transition GO:0044843 64 0.287
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.284
positive regulation of cellular biosynthetic process GO:0031328 336 0.282
negative regulation of nucleic acid templated transcription GO:1903507 260 0.279
cellular response to oxygen containing compound GO:1901701 43 0.274
covalent chromatin modification GO:0016569 119 0.272
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.262
response to organic substance GO:0010033 182 0.261
positive regulation of macromolecule metabolic process GO:0010604 394 0.259
positive regulation of protein metabolic process GO:0051247 93 0.255
negative regulation of mitotic cell cycle GO:0045930 63 0.252
regulation of biological quality GO:0065008 391 0.252
positive regulation of protein modification process GO:0031401 49 0.249
regulation of localization GO:0032879 127 0.246
dna packaging GO:0006323 55 0.243
negative regulation of phosphorylation GO:0042326 28 0.237
negative regulation of organelle organization GO:0010639 103 0.221
positive regulation of macromolecule biosynthetic process GO:0010557 325 0.212
negative regulation of transcription dna templated GO:0045892 258 0.211
developmental process GO:0032502 261 0.202
meiotic nuclear division GO:0007126 163 0.200
cellular response to nutrient levels GO:0031669 144 0.198
regulation of mitotic cell cycle phase transition GO:1901990 68 0.197
positive regulation of cellular component organization GO:0051130 116 0.197
cell division GO:0051301 205 0.183
protein localization to organelle GO:0033365 337 0.183
negative regulation of protein metabolic process GO:0051248 85 0.182
regulation of cellular catabolic process GO:0031329 195 0.179
regulation of protein ubiquitination GO:0031396 20 0.172
signaling GO:0023052 208 0.163
meiotic cell cycle process GO:1903046 229 0.161
negative regulation of cell cycle phase transition GO:1901988 59 0.160
peptidyl amino acid modification GO:0018193 116 0.159
anatomical structure development GO:0048856 160 0.152
negative regulation of protein modification process GO:0031400 37 0.152
regulation of dna replication GO:0006275 51 0.147
response to oxygen containing compound GO:1901700 61 0.145
negative regulation of cellular component organization GO:0051129 109 0.143
regulation of chromosome organization GO:0033044 66 0.138
chromosome segregation GO:0007059 159 0.138
mitotic spindle checkpoint GO:0071174 34 0.137
cell cycle checkpoint GO:0000075 82 0.135
regulation of phosphorus metabolic process GO:0051174 230 0.132
negative regulation of gene expression epigenetic GO:0045814 147 0.131
dephosphorylation GO:0016311 127 0.127
histone modification GO:0016570 119 0.125
single organism developmental process GO:0044767 258 0.124
negative regulation of cellular biosynthetic process GO:0031327 312 0.122
metal ion homeostasis GO:0055065 79 0.121
negative regulation of cellular protein metabolic process GO:0032269 85 0.120
conjugation with cellular fusion GO:0000747 106 0.119
response to external stimulus GO:0009605 158 0.117
positive regulation of cellular protein metabolic process GO:0032270 89 0.116
chromatin remodeling GO:0006338 80 0.111
negative regulation of phosphate metabolic process GO:0045936 49 0.111
positive regulation of rna metabolic process GO:0051254 294 0.110
endosomal transport GO:0016197 86 0.107
glucan metabolic process GO:0044042 44 0.104
response to inorganic substance GO:0010035 47 0.099
dna replication initiation GO:0006270 48 0.097
negative regulation of phosphorus metabolic process GO:0010563 49 0.096
positive regulation of biosynthetic process GO:0009891 336 0.095
protein dephosphorylation GO:0006470 40 0.095
regulation of cell cycle phase transition GO:1901987 70 0.092
aging GO:0007568 71 0.092
regulation of response to stimulus GO:0048583 157 0.088
negative regulation of protein phosphorylation GO:0001933 24 0.088
cellular glucan metabolic process GO:0006073 44 0.086
response to chemical GO:0042221 390 0.080
dna dependent dna replication GO:0006261 115 0.079
cellular response to starvation GO:0009267 90 0.078
transcription from rna polymerase i promoter GO:0006360 63 0.077
maintenance of location GO:0051235 66 0.077
regulation of spindle pole body separation GO:0010695 9 0.077
regulation of nuclear division GO:0051783 103 0.076
carbohydrate metabolic process GO:0005975 252 0.076
protein complex disassembly GO:0043241 70 0.076
positive regulation of organelle organization GO:0010638 85 0.074
chromosome condensation GO:0030261 19 0.073
mrna metabolic process GO:0016071 269 0.071
positive regulation of dna metabolic process GO:0051054 26 0.071
rna 3 end processing GO:0031123 88 0.069
positive regulation of transcription from rna polymerase ii promoter GO:0045944 252 0.069
establishment of protein localization GO:0045184 367 0.069
metal ion transport GO:0030001 75 0.067
regulation of chromatin modification GO:1903308 23 0.067
macromolecule catabolic process GO:0009057 383 0.066
positive regulation of nucleic acid templated transcription GO:1903508 286 0.066
response to nutrient levels GO:0031667 150 0.065
polysaccharide metabolic process GO:0005976 60 0.065
double strand break repair GO:0006302 105 0.064
cation transport GO:0006812 166 0.063
ion transport GO:0006811 274 0.063
single organism catabolic process GO:0044712 619 0.062
positive regulation of catalytic activity GO:0043085 178 0.061
regulation of developmental process GO:0050793 30 0.061
regulation of mitotic cell cycle GO:0007346 107 0.060
cellular macromolecule catabolic process GO:0044265 363 0.060
dna conformation change GO:0071103 98 0.060
regulation of protein localization GO:0032880 62 0.059
positive regulation of transcription from rna polymerase i promoter GO:0045943 19 0.058
regulation of chromosome segregation GO:0051983 44 0.056
regulation of cell communication GO:0010646 124 0.055
positive regulation of dna templated transcription elongation GO:0032786 42 0.055
multi organism reproductive process GO:0044703 216 0.052
signal transduction GO:0007165 208 0.051
meiotic cell cycle GO:0051321 272 0.051
response to hypoxia GO:0001666 4 0.050
regulation of catabolic process GO:0009894 199 0.050
negative regulation of catabolic process GO:0009895 43 0.049
regulation of cellular localization GO:0060341 50 0.047
multi organism cellular process GO:0044764 120 0.046
negative regulation of dna metabolic process GO:0051053 36 0.045
positive regulation of rna biosynthetic process GO:1902680 286 0.045
cellular response to pheromone GO:0071444 88 0.045
regulation of transport GO:0051049 85 0.044
nucleobase containing compound catabolic process GO:0034655 479 0.044
growth GO:0040007 157 0.044
cellular component disassembly GO:0022411 86 0.044
establishment of organelle localization GO:0051656 96 0.044
positive regulation of dna replication GO:0045740 11 0.043
organelle localization GO:0051640 128 0.043
positive regulation of cytoskeleton organization GO:0051495 39 0.042
mrna 3 end processing GO:0031124 54 0.041
macromolecular complex disassembly GO:0032984 80 0.041
regulation of dephosphorylation GO:0035303 18 0.041
regulation of meiosis GO:0040020 42 0.041
monovalent inorganic cation transport GO:0015672 78 0.040
purine ribonucleotide catabolic process GO:0009154 327 0.040
cellular nitrogen compound catabolic process GO:0044270 494 0.040
mrna processing GO:0006397 185 0.039
cytoskeleton organization GO:0007010 230 0.039
positive regulation of spindle pole body separation GO:0010696 7 0.039
regulation of dna dependent dna replication initiation GO:0030174 21 0.038
regulation of response to nutrient levels GO:0032107 20 0.038
nucleoside triphosphate metabolic process GO:0009141 364 0.037
regulation of chromatin organization GO:1902275 23 0.037
cell aging GO:0007569 70 0.037
autophagy GO:0006914 106 0.037
single organism carbohydrate metabolic process GO:0044723 237 0.036
protein modification by small protein conjugation GO:0032446 144 0.036
positive regulation of chromatin modification GO:1903310 13 0.036
response to organic cyclic compound GO:0014070 1 0.035
heterocycle catabolic process GO:0046700 494 0.034
microtubule based process GO:0007017 117 0.034
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 51 0.034
nucleotide metabolic process GO:0009117 453 0.034
intracellular protein transport GO:0006886 319 0.033
maintenance of location in cell GO:0051651 58 0.033
recombinational repair GO:0000725 64 0.033
regulation of dna templated transcription elongation GO:0032784 44 0.032
response to osmotic stress GO:0006970 83 0.032
cellular response to abiotic stimulus GO:0071214 62 0.031
cellular response to oxidative stress GO:0034599 94 0.031
cell wall organization or biogenesis GO:0071554 190 0.030
negative regulation of protein depolymerization GO:1901880 12 0.030
nucleoside phosphate catabolic process GO:1901292 331 0.030
cellular homeostasis GO:0019725 138 0.029
regulation of protein dephosphorylation GO:0035304 4 0.029
cellular polysaccharide metabolic process GO:0044264 55 0.029
positive regulation of transferase activity GO:0051347 28 0.028
purine nucleotide metabolic process GO:0006163 376 0.028
negative regulation of molecular function GO:0044092 68 0.028
regulation of signal transduction GO:0009966 114 0.028
cellular cation homeostasis GO:0030003 100 0.027
macroautophagy GO:0016236 55 0.027
regulation of protein modification by small protein conjugation or removal GO:1903320 29 0.027
positive regulation of molecular function GO:0044093 185 0.026
phosphorylation of rna polymerase ii c terminal domain GO:0070816 20 0.026
protein targeting GO:0006605 272 0.026
posttranscriptional regulation of gene expression GO:0010608 115 0.026
regulation of gene expression epigenetic GO:0040029 147 0.026
spindle pole body separation GO:0000073 13 0.025
mitotic metaphase plate congression GO:0007080 8 0.025
mitotic sister chromatid segregation GO:0000070 85 0.025
ribonucleoside triphosphate catabolic process GO:0009203 327 0.025
positive regulation of intracellular signal transduction GO:1902533 16 0.025
generation of precursor metabolites and energy GO:0006091 147 0.025
response to oxidative stress GO:0006979 99 0.025
negative regulation of cellular catabolic process GO:0031330 43 0.025
cellular response to hypoxia GO:0071456 4 0.024
protein localization to chromosome GO:0034502 28 0.024
protein complex biogenesis GO:0070271 314 0.023
nucleus organization GO:0006997 62 0.023
cellular chemical homeostasis GO:0055082 123 0.023
protein transport GO:0015031 345 0.023
regulation of chromatin silencing at telomere GO:0031938 27 0.023
glycogen metabolic process GO:0005977 30 0.022
proteolysis GO:0006508 268 0.022
cellular ion homeostasis GO:0006873 112 0.022
purine containing compound metabolic process GO:0072521 400 0.022
response to temperature stimulus GO:0009266 74 0.021
carboxylic acid biosynthetic process GO:0046394 152 0.021
single organism cellular localization GO:1902580 375 0.021
chromatin silencing at silent mating type cassette GO:0030466 53 0.021
energy reserve metabolic process GO:0006112 32 0.020
double strand break repair via homologous recombination GO:0000724 54 0.020
cellular response to decreased oxygen levels GO:0036294 7 0.020
positive regulation of kinase activity GO:0033674 24 0.020
regulation of ubiquitin protein transferase activity GO:0051438 8 0.020
chromosome localization GO:0050000 20 0.020
regulation of intracellular transport GO:0032386 26 0.020
developmental growth GO:0048589 3 0.020
protein modification by small protein conjugation or removal GO:0070647 172 0.020
gtp catabolic process GO:0006184 107 0.020
positive regulation of histone modification GO:0031058 12 0.019
aromatic compound catabolic process GO:0019439 491 0.019
establishment of protein localization to organelle GO:0072594 278 0.019
purine nucleotide catabolic process GO:0006195 328 0.019
synaptonemal complex organization GO:0070193 16 0.019
double strand break repair via nonhomologous end joining GO:0006303 27 0.019
nucleoside metabolic process GO:0009116 394 0.019
monovalent inorganic cation homeostasis GO:0055067 32 0.019
negative regulation of cell division GO:0051782 66 0.018
fungal type cell wall organization GO:0031505 145 0.018
positive regulation of cell cycle process GO:0090068 31 0.018
maintenance of protein location in cell GO:0032507 50 0.018
nucleotide catabolic process GO:0009166 330 0.018
purine nucleoside triphosphate catabolic process GO:0009146 329 0.017
response to acid chemical GO:0001101 19 0.017
response to drug GO:0042493 41 0.017
regulation of transcription from rna polymerase i promoter GO:0006356 36 0.017
nucleoside catabolic process GO:0009164 335 0.017
purine ribonucleoside catabolic process GO:0046130 330 0.017
regulation of establishment of protein localization GO:0070201 17 0.016
organonitrogen compound catabolic process GO:1901565 404 0.016
nucleoside phosphate metabolic process GO:0006753 458 0.016
organic cyclic compound catabolic process GO:1901361 499 0.016
negative regulation of chromosome organization GO:2001251 39 0.016
protein complex assembly GO:0006461 302 0.016
regulation of microtubule based process GO:0032886 32 0.016
meiotic g2 mi transition GO:0008315 1 0.016
homeostatic process GO:0042592 227 0.016
regulation of meiotic cell cycle GO:0051445 43 0.015
positive regulation of transcription from rna polymerase ii promoter in response to osmotic stress GO:0061393 8 0.015
intracellular signal transduction GO:0035556 112 0.015
negative regulation of catalytic activity GO:0043086 60 0.015
protein ubiquitination GO:0016567 118 0.015
cellular monovalent inorganic cation homeostasis GO:0030004 27 0.015
regulation of signaling GO:0023051 119 0.015
nucleobase containing small molecule metabolic process GO:0055086 491 0.015
regulation of histone modification GO:0031056 18 0.015
cation homeostasis GO:0055080 105 0.015
cellular response to extracellular stimulus GO:0031668 150 0.015
conjugation GO:0000746 107 0.015
carboxylic acid metabolic process GO:0019752 338 0.014
regulation of response to external stimulus GO:0032101 20 0.014
reproductive process GO:0022414 248 0.014
positive regulation of protein kinase activity GO:0045860 22 0.014
ribonucleotide catabolic process GO:0009261 327 0.014
negative regulation of transferase activity GO:0051348 31 0.014
histone phosphorylation GO:0016572 3 0.014
organophosphate catabolic process GO:0046434 338 0.014
regulation of generation of precursor metabolites and energy GO:0043467 23 0.014
replicative cell aging GO:0001302 46 0.014
response to fatty acid GO:0070542 5 0.014
nuclear dna replication GO:0033260 27 0.014
response to extracellular stimulus GO:0009991 156 0.013
regulation of dna dependent dna replication GO:0090329 37 0.013
regulation of dna templated transcription in response to stress GO:0043620 51 0.013
peroxisome organization GO:0007031 68 0.013
negative regulation of protein complex disassembly GO:0043242 14 0.013
carbohydrate derivative catabolic process GO:1901136 339 0.013
response to hydrogen peroxide GO:0042542 12 0.013
positive regulation of cell death GO:0010942 3 0.013
cellular response to inorganic substance GO:0071241 11 0.013
multi organism process GO:0051704 233 0.012
cellular polysaccharide biosynthetic process GO:0033692 38 0.012
positive regulation of catabolic process GO:0009896 135 0.012
regulation of glucose metabolic process GO:0010906 27 0.012
regulation of cell division GO:0051302 113 0.012
sexual reproduction GO:0019953 216 0.012
regulation of sodium ion transport GO:0002028 1 0.012
regulation of cellular component size GO:0032535 50 0.012
cellular response to acid chemical GO:0071229 16 0.012
meiosis i GO:0007127 92 0.011
regulation of lipid metabolic process GO:0019216 45 0.011
microtubule depolymerization GO:0007019 8 0.011
response to toxic substance GO:0009636 9 0.011
mitotic spindle organization GO:0007052 30 0.011
regulation of vesicle mediated transport GO:0060627 39 0.011
response to uv GO:0009411 4 0.011
spindle pole body organization GO:0051300 33 0.011
positive regulation of intracellular transport GO:0032388 4 0.011
positive regulation of cellular catabolic process GO:0031331 128 0.011
regulation of mitotic spindle organization GO:0060236 8 0.011
negative regulation of cytoskeleton organization GO:0051494 24 0.011
cellular response to iron ion GO:0071281 3 0.010
regulation of mrna metabolic process GO:1903311 17 0.010
attachment of spindle microtubules to kinetochore GO:0008608 25 0.010
cytoskeleton dependent cytokinesis GO:0061640 65 0.010
guanosine containing compound catabolic process GO:1901069 109 0.010
regulation of mitosis GO:0007088 65 0.010
regulation of lipid catabolic process GO:0050994 4 0.010
cell differentiation GO:0030154 161 0.010
nuclear transport GO:0051169 165 0.010
cellular component movement GO:0006928 20 0.010

SIC1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org