Saccharomyces cerevisiae

81 known processes

RAD53 (YPL153C)

Rad53p

(Aliases: MEC2,SPK1,LSD1)

RAD53 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair GO:0006302 105 0.999
dna repair GO:0006281 236 0.999
dna recombination GO:0006310 172 0.999
meiosis i GO:0007127 92 0.998
dna conformation change GO:0071103 98 0.992
recombinational repair GO:0000725 64 0.989
double strand break repair via homologous recombination GO:0000724 54 0.988
cellular response to dna damage stimulus GO:0006974 287 0.984
reciprocal meiotic recombination GO:0007131 54 0.971
mitotic cell cycle process GO:1903047 294 0.970
negative regulation of cell cycle process GO:0010948 86 0.957
Yeast
telomere organization GO:0032200 75 0.950
mitotic cell cycle GO:0000278 306 0.948
dna replication GO:0006260 147 0.941
reciprocal dna recombination GO:0035825 54 0.931
mitotic sister chromatid segregation GO:0000070 85 0.923
negative regulation of mitotic cell cycle GO:0045930 63 0.920
negative regulation of cell cycle GO:0045786 91 0.914
Yeast
nuclear division GO:0000280 263 0.907
Yeast
regulation of dna metabolic process GO:0051052 100 0.890
Yeast
dna integrity checkpoint GO:0031570 41 0.882
telomere maintenance GO:0000723 74 0.878
regulation of cell cycle process GO:0010564 150 0.875
Yeast
chromosome condensation GO:0030261 19 0.856
dna packaging GO:0006323 55 0.851
cell cycle checkpoint GO:0000075 82 0.842
dna damage checkpoint GO:0000077 29 0.841
protein complex biogenesis GO:0070271 314 0.832
mitotic sister chromatid cohesion GO:0007064 38 0.783
regulation of cell cycle GO:0051726 195 0.777
Yeast
negative regulation of mitotic cell cycle phase transition GO:1901991 57 0.707
meiotic nuclear division GO:0007126 163 0.698
Yeast
dna dependent dna replication GO:0006261 115 0.687
negative regulation of cell cycle phase transition GO:1901988 59 0.667
meiotic cell cycle process GO:1903046 229 0.660
Yeast
mitotic cell cycle checkpoint GO:0007093 56 0.657
regulation of dna replication GO:0006275 51 0.622
Yeast
dna replication initiation GO:0006270 48 0.610
chromosome segregation GO:0007059 159 0.601
negative regulation of cellular metabolic process GO:0031324 407 0.585
non recombinational repair GO:0000726 33 0.581
regulation of g2 m transition of mitotic cell cycle GO:0010389 8 0.579
negative regulation of dna metabolic process GO:0051053 36 0.569
Yeast
mitotic cell cycle phase transition GO:0044772 141 0.560
organelle fission GO:0048285 272 0.549
Yeast
negative regulation of nucleobase containing compound metabolic process GO:0045934 295 0.546
Yeast
double strand break repair via break induced replication GO:0000727 25 0.542
protein phosphorylation GO:0006468 197 0.527
sister chromatid cohesion GO:0007062 49 0.484
phosphorylation GO:0016310 291 0.476
regulation of chromosome organization GO:0033044 66 0.441
reproductive process GO:0022414 248 0.436
dna unwinding involved in dna replication GO:0006268 13 0.432
regulation of cellular component organization GO:0051128 334 0.430
Yeast
single organism signaling GO:0044700 208 0.423
Yeast
regulation of cellular protein metabolic process GO:0032268 232 0.411
Yeast
organic cyclic compound catabolic process GO:1901361 499 0.396
cell cycle g1 s phase transition GO:0044843 64 0.354
regulation of cell cycle phase transition GO:1901987 70 0.341
regulation of organelle organization GO:0033043 243 0.341
Yeast
negative regulation of dna replication GO:0008156 15 0.330
Yeast
telomere maintenance via telomerase GO:0007004 21 0.319
heterocycle catabolic process GO:0046700 494 0.319
rna dependent dna replication GO:0006278 25 0.303
nucleic acid phosphodiester bond hydrolysis GO:0090305 194 0.288
regulation of mitotic cell cycle GO:0007346 107 0.286
cell cycle dna replication GO:0044786 36 0.281
telomere maintenance via telomere lengthening GO:0010833 22 0.278
regulation of protein kinase activity GO:0045859 67 0.273
dna geometric change GO:0032392 43 0.273
negative regulation of chromosome organization GO:2001251 39 0.272
regulation of protein modification process GO:0031399 110 0.265
Yeast
regulation of cell cycle g2 m phase transition GO:1902749 8 0.251
cellular nitrogen compound catabolic process GO:0044270 494 0.248
aromatic compound catabolic process GO:0019439 491 0.242
regulation of meiosis GO:0040020 42 0.240
Yeast
regulation of dna dependent dna replication GO:0090329 37 0.238
Yeast
negative regulation of cellular biosynthetic process GO:0031327 312 0.223
Yeast
dna strand elongation GO:0022616 29 0.222
macromolecule catabolic process GO:0009057 383 0.214
nucleoside phosphate metabolic process GO:0006753 458 0.211
sister chromatid segregation GO:0000819 93 0.210
regulation of catalytic activity GO:0050790 307 0.206
nucleoside phosphate biosynthetic process GO:1901293 80 0.202
cell division GO:0051301 205 0.202
Yeast
regulation of mitotic cell cycle phase transition GO:1901990 68 0.201
dna topological change GO:0006265 10 0.184
nucleotide excision repair GO:0006289 50 0.170
regulation of protein serine threonine kinase activity GO:0071900 41 0.167
meiotic cell cycle GO:0051321 272 0.164
Yeast
protein complex assembly GO:0006461 302 0.161
negative regulation of biosynthetic process GO:0009890 312 0.160
Yeast
nucleotide metabolic process GO:0009117 453 0.157
mitotic nuclear division GO:0007067 131 0.157
regulation of nuclear division GO:0051783 103 0.156
Yeast
anatomical structure homeostasis GO:0060249 74 0.154
dna duplex unwinding GO:0032508 42 0.150
dna dependent dna replication maintenance of fidelity GO:0045005 14 0.148
Yeast
mitotic dna integrity checkpoint GO:0044774 18 0.147
regulation of biological quality GO:0065008 391 0.145
organonitrogen compound catabolic process GO:1901565 404 0.144
single organism catabolic process GO:0044712 619 0.140
regulation of protein phosphorylation GO:0001932 75 0.135
Yeast
regulation of kinase activity GO:0043549 71 0.134
negative regulation of macromolecule biosynthetic process GO:0010558 291 0.126
Yeast
nucleobase containing small molecule metabolic process GO:0055086 491 0.126
cell cycle phase transition GO:0044770 144 0.123
regulation of protein metabolic process GO:0051246 237 0.121
Yeast
cell differentiation GO:0030154 161 0.121
organophosphate biosynthetic process GO:0090407 182 0.120
sexual reproduction GO:0019953 216 0.120
negative regulation of cellular component organization GO:0051129 109 0.119
Yeast
regulation of meiotic cell cycle GO:0051445 43 0.116
Yeast
glycosyl compound catabolic process GO:1901658 335 0.115
glycosyl compound metabolic process GO:1901657 398 0.115
dna catabolic process GO:0006308 42 0.109
signal transduction GO:0007165 208 0.109
Yeast
purine containing compound catabolic process GO:0072523 332 0.107
nucleobase containing compound catabolic process GO:0034655 479 0.107
mitotic recombination GO:0006312 55 0.106
regulation of phosphorylation GO:0042325 86 0.104
negative regulation of cellular macromolecule biosynthetic process GO:2000113 289 0.101
Yeast
mitotic dna damage checkpoint GO:0044773 11 0.101
negative regulation of sister chromatid segregation GO:0033046 24 0.099
homeostatic process GO:0042592 227 0.097
positive regulation of protein modification process GO:0031401 49 0.096
Yeast
single organism reproductive process GO:0044702 159 0.096
regulation of response to stress GO:0080134 57 0.093
negative regulation of macromolecule metabolic process GO:0010605 375 0.091
Yeast
dna strand elongation involved in dna replication GO:0006271 26 0.091
regulation of cell division GO:0051302 113 0.087
Yeast
multi organism reproductive process GO:0044703 216 0.086
conjugation GO:0000746 107 0.086
regulation of meiosis i GO:0060631 14 0.085
telomere maintenance via recombination GO:0000722 32 0.084
regulation of molecular function GO:0065009 320 0.082
regulation of transferase activity GO:0051338 83 0.082
negative regulation of cell division GO:0051782 66 0.081
Yeast
cellular ketone metabolic process GO:0042180 63 0.079
double strand break repair via nonhomologous end joining GO:0006303 27 0.079
ribonucleotide metabolic process GO:0009259 377 0.077
positive regulation of protein metabolic process GO:0051247 93 0.076
Yeast
regulation of mitosis GO:0007088 65 0.075
purine nucleotide metabolic process GO:0006163 376 0.073
positive regulation of phosphorylation GO:0042327 33 0.072
Yeast
g1 s transition of mitotic cell cycle GO:0000082 64 0.070
purine ribonucleotide metabolic process GO:0009150 372 0.069
positive regulation of phosphorus metabolic process GO:0010562 147 0.068
Yeast
nucleoside metabolic process GO:0009116 394 0.068
negative regulation of mitotic sister chromatid separation GO:2000816 23 0.067
signaling GO:0023052 208 0.067
Yeast
carbohydrate derivative metabolic process GO:1901135 549 0.067
replication fork protection GO:0048478 6 0.067
Yeast
intracellular signal transduction GO:0035556 112 0.066
meiotic chromosome segregation GO:0045132 31 0.065
positive regulation of cell cycle process GO:0090068 31 0.065
cytoskeleton organization GO:0007010 230 0.064
positive regulation of catalytic activity GO:0043085 178 0.064
nucleoside triphosphate catabolic process GO:0009143 329 0.063
purine ribonucleoside catabolic process GO:0046130 330 0.063
regulation of dna dependent dna replication initiation GO:0030174 21 0.062
reproduction of a single celled organism GO:0032505 191 0.062
Yeast
negative regulation of transcription dna templated GO:0045892 258 0.061
nucleoside catabolic process GO:0009164 335 0.061
mitotic sister chromatid separation GO:0051306 26 0.059
telomere capping GO:0016233 10 0.058
ribonucleoside metabolic process GO:0009119 389 0.058
purine nucleoside catabolic process GO:0006152 330 0.057
organophosphate metabolic process GO:0019637 597 0.056
protein dna complex assembly GO:0065004 105 0.056
regulation of dna recombination GO:0000018 24 0.056
purine nucleoside triphosphate catabolic process GO:0009146 329 0.055
purine ribonucleoside metabolic process GO:0046128 380 0.054
negative regulation of cell cycle g2 m phase transition GO:1902750 5 0.054
conjugation with cellular fusion GO:0000747 106 0.053
negative regulation of catabolic process GO:0009895 43 0.053
lagging strand elongation GO:0006273 10 0.052
regulation of phosphate metabolic process GO:0019220 230 0.052
metaphase anaphase transition of cell cycle GO:0044784 28 0.051
dna biosynthetic process GO:0071897 33 0.050
negative regulation of cellular catabolic process GO:0031330 43 0.050
cellular developmental process GO:0048869 191 0.049
Yeast
single organism developmental process GO:0044767 258 0.049
Yeast
mitotic spindle assembly checkpoint GO:0007094 23 0.048
regulation of cellular response to stress GO:0080135 50 0.048
cellular response to chemical stimulus GO:0070887 315 0.047
Yeast
ribonucleoside catabolic process GO:0042454 332 0.047
nucleoside phosphate catabolic process GO:1901292 331 0.047
regulation of metaphase anaphase transition of cell cycle GO:1902099 27 0.047
protein dna complex subunit organization GO:0071824 153 0.046
dna double strand break processing GO:0000729 8 0.045
g2 m transition of mitotic cell cycle GO:0000086 38 0.045
response to organic cyclic compound GO:0014070 1 0.044
establishment of nucleus localization GO:0040023 22 0.044
ribonucleotide catabolic process GO:0009261 327 0.043
response to abiotic stimulus GO:0009628 159 0.043
Yeast
negative regulation of organelle organization GO:0010639 103 0.042
Yeast
negative regulation of protein metabolic process GO:0051248 85 0.042
ribose phosphate metabolic process GO:0019693 384 0.042
reproductive process in single celled organism GO:0022413 145 0.042
nuclear dna replication GO:0033260 27 0.041
mitotic spindle checkpoint GO:0071174 34 0.041
purine nucleoside metabolic process GO:0042278 380 0.041
mitotic cytokinesis GO:0000281 58 0.041
chromosome separation GO:0051304 33 0.041
hexose metabolic process GO:0019318 78 0.040
Yeast
regulation of phosphorus metabolic process GO:0051174 230 0.040
cell cycle g2 m phase transition GO:0044839 39 0.039
regulation of response to stimulus GO:0048583 157 0.038
negative regulation of dna dependent dna replication GO:2000104 8 0.038
Yeast
meiotic mismatch repair GO:0000710 9 0.037
purine ribonucleoside triphosphate catabolic process GO:0009207 327 0.037
purine ribonucleotide catabolic process GO:0009154 327 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 394 0.035
mating type switching GO:0007533 28 0.035
purine nucleotide catabolic process GO:0006195 328 0.035
negative regulation of mitotic sister chromatid segregation GO:0033048 24 0.034
nucleotide catabolic process GO:0009166 330 0.034
cellular amino acid metabolic process GO:0006520 225 0.034
double strand break repair via single strand annealing GO:0045002 7 0.034
gene conversion at mating type locus GO:0007534 11 0.034
meiotic recombination checkpoint GO:0051598 9 0.034
Yeast
chromatin assembly or disassembly GO:0006333 60 0.033
cellular amine metabolic process GO:0044106 51 0.033
negative regulation of gene expression GO:0010629 312 0.033
negative regulation of cellular protein metabolic process GO:0032269 85 0.033
heteroduplex formation GO:0030491 9 0.033
cell communication GO:0007154 345 0.033
Yeast
negative regulation of nucleic acid templated transcription GO:1903507 260 0.032
carbohydrate derivative catabolic process GO:1901136 339 0.032
ribonucleoside triphosphate catabolic process GO:0009203 327 0.032
regulation of mitotic sister chromatid segregation GO:0033047 30 0.032
negative regulation of gene expression epigenetic GO:0045814 147 0.031
negative regulation of rna metabolic process GO:0051253 262 0.031
oxidation reduction process GO:0055114 353 0.030
multi organism process GO:0051704 233 0.030
negative regulation of phosphate metabolic process GO:0045936 49 0.030
positive regulation of dna metabolic process GO:0051054 26 0.030
microtubule based process GO:0007017 117 0.029
purine ribonucleoside triphosphate metabolic process GO:0009205 354 0.028
double strand break repair via synthesis dependent strand annealing GO:0045003 12 0.028
developmental process GO:0032502 261 0.028
Yeast
regulation of intracellular signal transduction GO:1902531 78 0.028
developmental process involved in reproduction GO:0003006 159 0.028
regulation of mitotic metaphase anaphase transition GO:0030071 27 0.028
establishment of mitotic sister chromatid cohesion GO:0034087 15 0.028
negative regulation of rna biosynthetic process GO:1902679 260 0.028
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.028
posttranscriptional regulation of gene expression GO:0010608 115 0.028
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 27 0.028
positive regulation of cellular protein metabolic process GO:0032270 89 0.027
Yeast
positive regulation of protein phosphorylation GO:0001934 28 0.027
Yeast
regulation of cellular amine metabolic process GO:0033238 21 0.027
amine metabolic process GO:0009308 51 0.027
peptidyl amino acid modification GO:0018193 116 0.027
dna catabolic process endonucleolytic GO:0000737 31 0.026
establishment of organelle localization GO:0051656 96 0.026
purine nucleoside triphosphate metabolic process GO:0009144 356 0.025
vesicle mediated transport GO:0016192 335 0.025
purine containing compound metabolic process GO:0072521 400 0.025
microtubule cytoskeleton organization GO:0000226 109 0.025
positive regulation of cellular component organization GO:0051130 116 0.024
maintenance of dna repeat elements GO:0043570 20 0.024
negative regulation of nuclear division GO:0051784 62 0.023
Yeast
organophosphate catabolic process GO:0046434 338 0.023
spindle organization GO:0007051 37 0.023
ribonucleoside triphosphate metabolic process GO:0009199 356 0.023
dna replication checkpoint GO:0000076 9 0.022
nucleoside triphosphate metabolic process GO:0009141 364 0.022
response to uv GO:0009411 4 0.021
cell budding GO:0007114 48 0.021
Yeast
regulation of cellular amino acid metabolic process GO:0006521 16 0.021
regulation of multi organism process GO:0043900 20 0.021
meiotic dna double strand break processing GO:0000706 5 0.020
sex determination GO:0007530 32 0.020
cell wall organization GO:0071555 146 0.020
nucleoside monophosphate metabolic process GO:0009123 267 0.020
meiotic dna double strand break formation GO:0042138 12 0.020
positive regulation of intracellular protein transport GO:0090316 3 0.020
base excision repair GO:0006284 14 0.020
response to osmotic stress GO:0006970 83 0.020
Yeast
mismatch repair GO:0006298 14 0.019
positive regulation of programmed cell death GO:0043068 3 0.019
apoptotic process GO:0006915 30 0.019
meiotic cell cycle checkpoint GO:0033313 10 0.019
Yeast
regulation of cellular catabolic process GO:0031329 195 0.019
chromatin silencing GO:0006342 147 0.019
positive regulation of cell death GO:0010942 3 0.018
organonitrogen compound biosynthetic process GO:1901566 314 0.018
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 23 0.018
positive regulation of protein modification by small protein conjugation or removal GO:1903322 12 0.018
dephosphorylation GO:0016311 127 0.018
regulation of signal transduction GO:0009966 114 0.018
mating type determination GO:0007531 32 0.018
regulation of hydrolase activity GO:0051336 133 0.018
cellular response to organic substance GO:0071310 159 0.018
regulation of homeostatic process GO:0032844 19 0.018
organelle assembly GO:0070925 118 0.017
histone phosphorylation GO:0016572 3 0.017
ubiquitin dependent protein catabolic process GO:0006511 181 0.017
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 19 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 262 0.017
positive regulation of cytoplasmic transport GO:1903651 4 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 300 0.017
Yeast
positive regulation of molecular function GO:0044093 185 0.017
positive regulation of macromolecule metabolic process GO:0010604 394 0.017
Yeast
fungal type cell wall organization GO:0031505 145 0.016
negative regulation of phosphorus metabolic process GO:0010563 49 0.016
sphingolipid biosynthetic process GO:0030148 29 0.016
anatomical structure morphogenesis GO:0009653 160 0.016
Yeast
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 36 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 224 0.016
atp catabolic process GO:0006200 224 0.016
chromatin assembly GO:0031497 35 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 412 0.016
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 30 0.016
negative regulation of catalytic activity GO:0043086 60 0.015
response to organic substance GO:0010033 182 0.015
response to chemical GO:0042221 390 0.015
Yeast
gene conversion GO:0035822 14 0.015
cellular response to osmotic stress GO:0071470 50 0.015
Yeast
synapsis GO:0007129 19 0.015
purine nucleoside monophosphate catabolic process GO:0009128 224 0.015
ribonucleoside monophosphate metabolic process GO:0009161 265 0.015
synaptonemal complex assembly GO:0007130 12 0.015
mitotic spindle organization GO:0007052 30 0.015
positive regulation of apoptotic process GO:0043065 3 0.014
response to starvation GO:0042594 96 0.014
cellular macromolecule catabolic process GO:0044265 363 0.014
cytoskeleton dependent cytokinesis GO:0061640 65 0.014
regulation of dna repair GO:0006282 14 0.014
peptidyl lysine acetylation GO:0018394 52 0.014
ribonucleoside monophosphate catabolic process GO:0009158 224 0.014
purine nucleoside monophosphate metabolic process GO:0009126 262 0.013
dna catabolic process exonucleolytic GO:0000738 19 0.013
growth GO:0040007 157 0.013
Yeast
nucleotide biosynthetic process GO:0009165 79 0.013
negative regulation of proteasomal protein catabolic process GO:1901799 25 0.013
negative regulation of exit from mitosis GO:0001100 16 0.013
endocytosis GO:0006897 90 0.013
positive regulation of catabolic process GO:0009896 135 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 29 0.013
positive regulation of nuclear division GO:0051785 9 0.013
nucleoside monophosphate catabolic process GO:0009125 224 0.013
negative regulation of cellular carbohydrate metabolic process GO:0010677 17 0.013
actin cytoskeleton organization GO:0030036 100 0.013
mitotic chromosome condensation GO:0007076 11 0.012
regulation of protein catabolic process GO:0042176 40 0.012
protein modification by small protein conjugation GO:0032446 144 0.012
g2 dna damage checkpoint GO:0031572 1 0.012
oxoacid metabolic process GO:0043436 351 0.012
positive regulation of dna replication GO:0045740 11 0.012
protein dephosphorylation GO:0006470 40 0.012
negative regulation of protein catabolic process GO:0042177 27 0.012
positive regulation of spindle pole body separation GO:0010696 7 0.011
negative regulation of proteolysis GO:0045861 33 0.011
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 5 0.011
atp metabolic process GO:0046034 251 0.011
membrane lipid biosynthetic process GO:0046467 54 0.011
positive regulation of protein kinase activity GO:0045860 22 0.011
intracellular protein transport GO:0006886 319 0.011
carbohydrate derivative biosynthetic process GO:1901137 181 0.011
regulation of response to extracellular stimulus GO:0032104 20 0.011
negative regulation of mitosis GO:0045839 39 0.011
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 27 0.011
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 35 0.011
regulation of cell communication GO:0010646 124 0.011
sporulation resulting in formation of a cellular spore GO:0030435 129 0.010
monosaccharide metabolic process GO:0005996 83 0.010
Yeast
regulation of chromosome segregation GO:0051983 44 0.010
cellular component morphogenesis GO:0032989 97 0.010
Yeast
glucose metabolic process GO:0006006 65 0.010
Yeast

RAD53 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.015