Danio rerio

21 known processes

rock2b

rho-associated, coiled-coil containing protein kinase 2b

(Aliases: si:dkey-65b13.10,si:dkey-65b13.7,cb64,sb:cb64)

rock2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
tube morphogenesis GO:0035239 349 0.342
Zebrafish Mouse Fly
carbohydrate derivative metabolic process GO:1901135 61 0.259
kupffer s vesicle development GO:0070121 50 0.197
heart development GO:0007507 313 0.151
determination of bilateral symmetry GO:0009855 204 0.130
regulation of nervous system development GO:0051960 90 0.113
Fly
negative regulation of biological process GO:0048519 304 0.107
Human Fly
cell part morphogenesis GO:0032990 246 0.100
Mouse Fly
organelle organization GO:0006996 227 0.092
Human Zebrafish Mouse Fly
regulation of neurological system process GO:0031644 2 0.084
specification of symmetry GO:0009799 204 0.081
carbohydrate derivative biosynthetic process GO:1901137 43 0.079
embryonic organ development GO:0048568 381 0.068
protein modification process GO:0036211 100 0.067
Human Fly
cellular component assembly GO:0022607 170 0.064
Fly
locomotion GO:0040011 313 0.061
Zebrafish Worm
single organism biosynthetic process GO:0044711 71 0.058
regulation of nitrogen compound metabolic process GO:0051171 251 0.056
chordate embryonic development GO:0043009 271 0.054
Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.050
Fly
regulation of blood coagulation GO:0030193 1 0.050
digestive tract morphogenesis GO:0048546 231 0.050
Zebrafish Fly
cilium organization GO:0044782 71 0.048
digestive system development GO:0055123 289 0.043
Zebrafish Fly
cellular aromatic compound metabolic process GO:0006725 295 0.042
signal transduction GO:0007165 455 0.040
Zebrafish Mouse Rat Fly
cell morphogenesis GO:0000902 289 0.040
Mouse Worm Fly
biosynthetic process GO:0009058 294 0.040
cellular protein modification process GO:0006464 100 0.039
Human Fly
cellular biosynthetic process GO:0044249 286 0.037
protein metabolic process GO:0019538 183 0.036
Human Zebrafish Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.035
Human Zebrafish Worm Fly
nitrogen compound metabolic process GO:0006807 319 0.035
neuron differentiation GO:0030182 353 0.035
Mouse Fly
angiogenesis GO:0001525 158 0.034
Human
cellular component biogenesis GO:0044085 178 0.034
Fly
nucleic acid metabolic process GO:0090304 244 0.033
anatomical structure arrangement GO:0048532 2 0.033
determination of left right symmetry GO:0007368 179 0.032
stem cell fate commitment GO:0048865 1 0.032
regulation of nucleotide catabolic process GO:0030811 2 0.032
membrane lipid biosynthetic process GO:0046467 2 0.031
lipid storage GO:0019915 1 0.029
cilium movement GO:0003341 26 0.029
cell surface receptor signaling pathway GO:0007166 325 0.029
Zebrafish Mouse Fly
muscle cell development GO:0055001 115 0.029
regulation of rna metabolic process GO:0051252 224 0.029
sphingolipid biosynthetic process GO:0030148 2 0.029
phagocytosis engulfment GO:0006911 1 0.028
regulation of neurogenesis GO:0050767 87 0.028
Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.028
cell projection assembly GO:0030031 64 0.027
neuroblast differentiation GO:0014016 1 0.027
organelle assembly GO:0070925 110 0.027
small gtpase mediated signal transduction GO:0007264 8 0.027
Rat Fly
glycoprotein biosynthetic process GO:0009101 21 0.027
positive regulation of cellular component biogenesis GO:0044089 3 0.026
Fly
rhombomere 5 morphogenesis GO:0021664 1 0.026
ras protein signal transduction GO:0007265 7 0.025
Rat Fly
cell projection organization GO:0030030 284 0.025
Mouse Fly
cellular macromolecule metabolic process GO:0044260 391 0.025
Human Zebrafish Fly
gene expression GO:0010467 252 0.025
modification dependent protein catabolic process GO:0019941 3 0.025
guanosine containing compound metabolic process GO:1901068 4 0.025
regulation of gene expression GO:0010468 265 0.024
vasculature development GO:0001944 278 0.024
Human
regulation of purine nucleotide catabolic process GO:0033121 2 0.024
regulation of cell projection organization GO:0031344 44 0.024
Fly
cellular component morphogenesis GO:0032989 336 0.024
Mouse Worm Fly
blood vessel morphogenesis GO:0048514 216 0.024
Human
heterocycle biosynthetic process GO:0018130 215 0.023
regulation of primary metabolic process GO:0080090 311 0.023
Fly
organic cyclic compound metabolic process GO:1901360 301 0.023
negative regulation of protein phosphorylation GO:0001933 4 0.023
blood vessel development GO:0001568 246 0.023
Human
transcription from rna polymerase ii promoter GO:0006366 80 0.022
epiboly GO:0090504 41 0.022
localization of cell GO:0051674 244 0.022
Zebrafish Worm
otolith formation GO:0032475 2 0.021
response to chemical GO:0042221 320 0.021
cilium morphogenesis GO:0060271 85 0.021
regulation of angiogenesis GO:0045765 26 0.021
Human
intracellular receptor signaling pathway GO:0030522 30 0.021
regulation of protein ubiquitination GO:0031396 3 0.021
organic substance biosynthetic process GO:1901576 289 0.021
nucleobase containing compound biosynthetic process GO:0034654 205 0.020
response to vitamin b3 GO:0033552 2 0.020
steroid hormone mediated signaling pathway GO:0043401 9 0.020
monoamine transport GO:0015844 1 0.019
negative regulation of protein transport GO:0051224 3 0.019
Fly
defense response GO:0006952 47 0.019
developmental growth GO:0048589 166 0.019
Fly
larval development GO:0002164 2 0.019
Worm
guanosine containing compound catabolic process GO:1901069 2 0.019
positive regulation of metabolic process GO:0009893 108 0.019
cell projection morphogenesis GO:0048858 244 0.019
Mouse Fly
regulation of rna biosynthetic process GO:2001141 213 0.019
phagocytosis GO:0006909 3 0.018
single organism membrane fusion GO:0044801 2 0.018
regulation of anatomical structure size GO:0090066 33 0.018
adult behavior GO:0030534 2 0.018
macromolecule biosynthetic process GO:0009059 227 0.018
rna metabolic process GO:0016070 219 0.018
negative regulation of response to stimulus GO:0048585 104 0.017
spindle assembly GO:0051225 2 0.017
aromatic compound biosynthetic process GO:0019438 217 0.017
lymph vessel morphogenesis GO:0036303 25 0.017
cellular response to endogenous stimulus GO:0071495 68 0.017
regulation of biosynthetic process GO:0009889 250 0.017
regulation of erk1 and erk2 cascade GO:0070372 4 0.017
regulation of multicellular organismal process GO:0051239 277 0.017
Human Zebrafish Fly
erk1 and erk2 cascade GO:0070371 4 0.016
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.016
regulation of blood circulation GO:1903522 32 0.016
gtp metabolic process GO:0046039 4 0.016
epithelial cell morphogenesis GO:0003382 2 0.016
Fly
regulation of nucleoside metabolic process GO:0009118 2 0.016
rhombomere boundary formation GO:0021654 10 0.016
cellular protein catabolic process GO:0044257 4 0.016
Zebrafish
regulation of nucleotide metabolic process GO:0006140 17 0.015
response to light stimulus GO:0009416 46 0.015
regulation of hemostasis GO:1900046 1 0.015
cell migration involved in gastrulation GO:0042074 79 0.015
Zebrafish
cellular protein metabolic process GO:0044267 129 0.015
Human Zebrafish Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.015
intracellular estrogen receptor signaling pathway GO:0030520 3 0.015
rna biosynthetic process GO:0032774 181 0.015
regulation of transcription dna templated GO:0006355 213 0.014
urogenital system development GO:0001655 97 0.014
nuclear transport GO:0051169 4 0.014
cell motility GO:0048870 244 0.014
Zebrafish Worm
negative regulation of stem cell differentiation GO:2000737 2 0.014
positive regulation of catabolic process GO:0009896 4 0.014
cilium assembly GO:0042384 58 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
cellular nitrogen compound metabolic process GO:0034641 290 0.014
cognition GO:0050890 1 0.014
regulation of neuron differentiation GO:0045664 56 0.014
Fly
membrane invagination GO:0010324 1 0.014
regulation of cell activation GO:0050865 1 0.013
glomerular epithelium development GO:0072010 12 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
establishment of localization GO:0051234 244 0.013
Fly
actin filament based movement GO:0030048 1 0.013
Fly
nuclear import GO:0051170 3 0.013
regulation of gtpase activity GO:0043087 2 0.013
positive regulation of locomotion GO:0040017 14 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
neuroblast proliferation GO:0007405 2 0.012
cell substrate adhesion GO:0031589 4 0.012
cell migration GO:0016477 237 0.012
Zebrafish Worm
nucleobase containing compound metabolic process GO:0006139 274 0.012
regulation of cellular biosynthetic process GO:0031326 245 0.012
negative regulation of signal transduction GO:0009968 94 0.012
single organism metabolic process GO:0044710 217 0.012
regulation of signal transduction GO:0009966 225 0.012
Fly
regulation of protein complex assembly GO:0043254 3 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
neuroblast fate commitment GO:0014017 1 0.012
cellular component disassembly GO:0022411 1 0.012
striated muscle cell development GO:0055002 108 0.012
regulation of metabolic process GO:0019222 359 0.012
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
ameboidal type cell migration GO:0001667 143 0.012
Zebrafish
autophagy GO:0006914 4 0.012
female sex differentiation GO:0046660 4 0.012
synaptic vesicle localization GO:0097479 1 0.012
cellular lipid metabolic process GO:0044255 36 0.012
cell substrate junction assembly GO:0007044 2 0.012
heterocycle metabolic process GO:0046483 290 0.011
regulation of protein catabolic process GO:0042176 1 0.011
macromolecule localization GO:0033036 54 0.011
Fly
macromolecule modification GO:0043412 111 0.011
Human Fly
regulation of dendrite development GO:0050773 3 0.011
regulation of cytokine production GO:0001817 3 0.011
taxis GO:0042330 109 0.011
cellular macromolecule biosynthetic process GO:0034645 224 0.011
embryonic organ morphogenesis GO:0048562 274 0.011
transcription dna templated GO:0006351 181 0.011
morphogenesis of an epithelium GO:0002009 333 0.011
Zebrafish Mouse Fly
hindbrain development GO:0030902 91 0.011
cellular component maintenance GO:0043954 3 0.011
cardiac muscle cell differentiation GO:0055007 30 0.011
organonitrogen compound biosynthetic process GO:1901566 47 0.011
neuron projection development GO:0031175 180 0.011
Mouse Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
system process GO:0003008 185 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
regulation of cell shape GO:0008360 1 0.010
Worm Fly
negative regulation of protein kinase activity GO:0006469 4 0.010
cerebellum formation GO:0021588 2 0.010
notch signaling pathway GO:0007219 35 0.010
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.010
Fly
rhombomere 5 development GO:0021571 4 0.010
negative regulation of macromolecule metabolic process GO:0010605 76 0.010
long chain fatty acid biosynthetic process GO:0042759 1 0.010

rock2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.022