Danio rerio

18 known processes

cd74

CD74 molecule, major histocompatibility complex, class II invariant chain

(Aliases: MGC158500,iclp2,MGC123161,zgc:123161,Iclp-2)

cd74 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule metabolic process GO:0044260 391 0.403
hematopoietic or lymphoid organ development GO:0048534 191 0.274
sensory organ development GO:0007423 393 0.204
immune system development GO:0002520 191 0.197
regulation of cell communication GO:0010646 232 0.115
negative regulation of cellular process GO:0048523 283 0.103
regulation of metabolic process GO:0019222 359 0.102
modification dependent macromolecule catabolic process GO:0043632 3 0.084
regulation of protein transport GO:0051223 3 0.077
inner ear development GO:0048839 126 0.076
regulation of multicellular organismal process GO:0051239 277 0.076
multicellular organismal metabolic process GO:0044236 2 0.075
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.075
sensory system development GO:0048880 76 0.074
positive regulation of muscle cell differentiation GO:0051149 1 0.073
ubiquitin dependent protein catabolic process GO:0006511 3 0.064
immune system process GO:0002376 241 0.061
regulation of synapse organization GO:0050807 3 0.060
regulation of signal transduction GO:0009966 225 0.057
stem cell proliferation GO:0072089 4 0.054
aging GO:0007568 2 0.053
death GO:0016265 121 0.053
regulation of production of molecular mediator of immune response GO:0002700 1 0.051
regionalization GO:0003002 274 0.049
regulation of multicellular organismal development GO:2000026 223 0.048
proteasomal protein catabolic process GO:0010498 2 0.048
regulation of stem cell proliferation GO:0072091 2 0.047
b cell differentiation GO:0030183 1 0.047
heterocycle biosynthetic process GO:0018130 215 0.046
cellular protein catabolic process GO:0044257 4 0.046
embryonic organ development GO:0048568 381 0.045
regulation of programmed cell death GO:0043067 101 0.044
signal transduction GO:0007165 455 0.043
regulation of macromolecule metabolic process GO:0060255 317 0.042
nuclear transport GO:0051169 4 0.041
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.040
leukocyte proliferation GO:0070661 1 0.040
response to chemical GO:0042221 320 0.040
actin polymerization or depolymerization GO:0008154 2 0.040
heterocycle metabolic process GO:0046483 290 0.040
lateral line development GO:0048882 66 0.040
actin mediated cell contraction GO:0070252 1 0.039
cellular ketone metabolic process GO:0042180 11 0.039
negative regulation of biological process GO:0048519 304 0.039
regulation of cell shape GO:0008360 1 0.039
positive regulation of transport GO:0051050 2 0.039
embryonic skeletal system morphogenesis GO:0048704 93 0.038
regulation of cell death GO:0010941 103 0.038
vasculature development GO:0001944 278 0.037
regulation of response to stimulus GO:0048583 269 0.037
cell surface receptor signaling pathway GO:0007166 325 0.036
cell death GO:0008219 121 0.036
hemopoiesis GO:0030097 183 0.035
gtp metabolic process GO:0046039 4 0.035
positive regulation of immune effector process GO:0002699 3 0.035
regulation of protein complex assembly GO:0043254 3 0.034
cellular amine metabolic process GO:0044106 2 0.034
blood vessel morphogenesis GO:0048514 216 0.033
biosynthetic process GO:0009058 294 0.033
regulation of cell activation GO:0050865 1 0.033
protein secretion GO:0009306 1 0.033
negative regulation of protein phosphorylation GO:0001933 4 0.033
cellular nitrogen compound metabolic process GO:0034641 290 0.033
blood vessel development GO:0001568 246 0.032
immunoglobulin mediated immune response GO:0016064 3 0.032
regulation of synapse assembly GO:0051963 3 0.032
response to hexose GO:0009746 3 0.031
cell motility GO:0048870 244 0.031
regulation of tube size GO:0035150 2 0.030
embryonic organ morphogenesis GO:0048562 274 0.030
regulation of developmental process GO:0050793 247 0.030
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.030
production of molecular mediator of immune response GO:0002440 2 0.030
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.030
single organism metabolic process GO:0044710 217 0.030
chordate embryonic development GO:0043009 271 0.029
programmed cell death GO:0012501 119 0.029
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.028
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.028
somatic muscle development GO:0007525 4 0.028
b cell mediated immunity GO:0019724 3 0.028
i kappab kinase nf kappab signaling GO:0007249 4 0.027
positive regulation of secretion GO:0051047 1 0.027
b cell activation GO:0042113 2 0.027
actin filament based process GO:0030029 64 0.027
positive regulation of map kinase activity GO:0043406 3 0.026
extrinsic apoptotic signaling pathway GO:0097191 3 0.026
regulation of synaptic plasticity GO:0048167 1 0.026
centrosome organization GO:0051297 1 0.026
amine metabolic process GO:0009308 2 0.026
collagen metabolic process GO:0032963 2 0.025
mononuclear cell proliferation GO:0032943 1 0.025
cellular nitrogen compound biosynthetic process GO:0044271 218 0.025
homeostatic process GO:0042592 142 0.025
regulation of primary metabolic process GO:0080090 311 0.025
regulation of muscle contraction GO:0006937 3 0.025
response to external stimulus GO:0009605 264 0.025
nucleobase containing compound metabolic process GO:0006139 274 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.024
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.024
spermatid development GO:0007286 2 0.024
cellular component morphogenesis GO:0032989 336 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.024
muscle organ development GO:0007517 101 0.024
protein import GO:0017038 3 0.023
liver development GO:0001889 96 0.023
retina morphogenesis in camera type eye GO:0060042 79 0.023
positive regulation of stress activated mapk cascade GO:0032874 3 0.023
cellular aromatic compound metabolic process GO:0006725 295 0.023
positive regulation of secretion by cell GO:1903532 1 0.023
single organism membrane fusion GO:0044801 2 0.022
angiogenesis GO:0001525 158 0.022
protein import into nucleus GO:0006606 3 0.022
phagocytosis GO:0006909 3 0.022
skeletal muscle organ development GO:0060538 78 0.022
rna metabolic process GO:0016070 219 0.022
positive regulation of cellular process GO:0048522 201 0.022
regulation of signaling GO:0023051 235 0.022
positive regulation of notch signaling pathway GO:0045747 3 0.022
aromatic compound biosynthetic process GO:0019438 217 0.021
response to carbohydrate GO:0009743 3 0.021
negative regulation of protein kinase activity GO:0006469 4 0.021
nucleocytoplasmic transport GO:0006913 4 0.021
regulation of dna recombination GO:0000018 2 0.021
organelle fusion GO:0048284 3 0.021
regulation of establishment of protein localization GO:0070201 4 0.021
positive regulation of signaling GO:0023056 56 0.021
negative regulation of programmed cell death GO:0043069 58 0.021
membrane fusion GO:0061025 2 0.021
regulation of nitrogen compound metabolic process GO:0051171 251 0.021
positive regulation of catabolic process GO:0009896 4 0.021
neuron differentiation GO:0030182 353 0.021
negative regulation of kinase activity GO:0033673 4 0.021
regulation of endocrine process GO:0044060 2 0.021
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.020
response to other organism GO:0051707 97 0.020
intracellular signal transduction GO:0035556 85 0.020
response to monosaccharide GO:0034284 3 0.020
locomotion GO:0040011 313 0.020
somatic stem cell maintenance GO:0035019 1 0.020
endosomal transport GO:0016197 2 0.020
protein metabolic process GO:0019538 183 0.020
negative regulation of myeloid cell differentiation GO:0045638 1 0.020
cell activation GO:0001775 16 0.020
skeletal system development GO:0001501 181 0.020
microtubule organizing center organization GO:0031023 1 0.020
regulation of stem cell differentiation GO:2000736 4 0.020
centrosome cycle GO:0007098 1 0.019
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.019
peptidyl serine modification GO:0018209 2 0.019
autophagy GO:0006914 4 0.019
cell migration GO:0016477 237 0.019
tissue remodeling GO:0048771 4 0.019
synaptic growth at neuromuscular junction GO:0051124 2 0.019
cellular localization GO:0051641 97 0.019
positive regulation of response to stimulus GO:0048584 80 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
nuclear import GO:0051170 3 0.019
negative regulation of synapse assembly GO:0051964 2 0.019
axonal defasciculation GO:0007414 2 0.019
lymphocyte proliferation GO:0046651 1 0.019
regulation of striated muscle contraction GO:0006942 2 0.019
regulation of calcium ion transport GO:0051924 2 0.019
regulation of biological quality GO:0065008 263 0.019
negative regulation of cellular metabolic process GO:0031324 77 0.019
leukocyte differentiation GO:0002521 25 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.019
positive regulation of biological process GO:0048518 253 0.018
response to abiotic stimulus GO:0009628 122 0.018
positive regulation of cytoskeleton organization GO:0051495 3 0.018
regulation of gene expression GO:0010468 265 0.018
sprouting angiogenesis GO:0002040 53 0.018
response to organic substance GO:0010033 153 0.018
immune response GO:0006955 28 0.018
protein targeting to nucleus GO:0044744 3 0.018
oxoacid metabolic process GO:0043436 31 0.018
regulation of multicellular organism growth GO:0040014 4 0.018
actin filament polymerization GO:0030041 2 0.017
positive regulation of cytokine production GO:0001819 2 0.017
cellular response to organic substance GO:0071310 105 0.017
positive regulation of muscle tissue development GO:1901863 1 0.017
cellular response to chemical stimulus GO:0070887 157 0.017
transcription dna templated GO:0006351 181 0.017
cellular response to retinoic acid GO:0071300 1 0.017
muscle cell development GO:0055001 115 0.017
sensory perception of chemical stimulus GO:0007606 3 0.017
regulation of organ growth GO:0046620 3 0.017
hatching GO:0035188 4 0.017
camera type eye development GO:0043010 222 0.017
tyrosine phosphorylation of stat protein GO:0007260 1 0.017
nucleobase containing compound biosynthetic process GO:0034654 205 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.017
protein localization to nucleus GO:0034504 3 0.017
ribonucleoside monophosphate catabolic process GO:0009158 4 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
astrocyte differentiation GO:0048708 1 0.017
cell morphogenesis GO:0000902 289 0.017
negative regulation of signal transduction GO:0009968 94 0.017
viral process GO:0016032 1 0.017
t cell activation GO:0042110 6 0.016
organic cyclic compound biosynthetic process GO:1901362 223 0.016
regulation of binding GO:0051098 3 0.016
negative regulation of macromolecule metabolic process GO:0010605 76 0.016
positive regulation of muscle organ development GO:0048636 1 0.016
localization of cell GO:0051674 244 0.016
macromolecule modification GO:0043412 111 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
regulation of erythrocyte differentiation GO:0045646 2 0.016
regulation of skeletal muscle tissue development GO:0048641 4 0.016
macromolecular complex subunit organization GO:0043933 74 0.016
stem cell maintenance GO:0019827 4 0.016
embryonic skeletal system development GO:0048706 97 0.016
multicellular organism growth GO:0035264 4 0.016
gtp catabolic process GO:0006184 2 0.016
multi organism cellular process GO:0044764 2 0.016
regulation of cytokine production GO:0001817 3 0.016
positive regulation of multicellular organismal process GO:0051240 52 0.016
retina development in camera type eye GO:0060041 146 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
embryonic cranial skeleton morphogenesis GO:0048701 90 0.016
cellular protein metabolic process GO:0044267 129 0.016
positive regulation of cell activation GO:0050867 1 0.015
monocyte differentiation GO:0030224 2 0.015
negative regulation of response to stimulus GO:0048585 104 0.015
erk1 and erk2 cascade GO:0070371 4 0.015
striated muscle contraction GO:0006941 12 0.015
positive regulation of striated muscle tissue development GO:0045844 1 0.015
muscle structure development GO:0061061 196 0.015
establishment of protein localization to organelle GO:0072594 4 0.015
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.015
developmental programmed cell death GO:0010623 4 0.015
regulation of cell killing GO:0031341 2 0.015
positive regulation of cell cycle GO:0045787 3 0.015
regulation of purine nucleotide catabolic process GO:0033121 2 0.015
dorsal ventral pattern formation GO:0009953 125 0.015
morphogenesis of an epithelium GO:0002009 333 0.015
positive regulation of cell killing GO:0031343 2 0.015
complement activation GO:0006956 3 0.015
regulation of cellular metabolic process GO:0031323 320 0.015
regulation of nucleic acid templated transcription GO:1903506 213 0.015
regulation of metal ion transport GO:0010959 4 0.015
ventricular cardiac muscle tissue development GO:0003229 3 0.015
single organism nuclear import GO:1902593 3 0.015
regulation of mrna processing GO:0050684 3 0.014
immunoglobulin production GO:0002377 1 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
lateral inhibition GO:0046331 1 0.014
regulation of transmembrane transporter activity GO:0022898 2 0.014
larval development GO:0002164 2 0.014
cellular component disassembly GO:0022411 1 0.014
response to drug GO:0042493 3 0.014
renal tubule morphogenesis GO:0061333 1 0.014
regulation of blood coagulation GO:0030193 1 0.014
positive regulation of protein polymerization GO:0032273 2 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
regulation of nucleoside metabolic process GO:0009118 2 0.014
organic substance biosynthetic process GO:1901576 289 0.014
negative regulation of immune response GO:0050777 2 0.014
regulation of gtpase activity GO:0043087 2 0.014
negative regulation of leukocyte differentiation GO:1902106 1 0.014
digestive tract development GO:0048565 265 0.014
smooth muscle contraction GO:0006939 2 0.014
regulation of glial cell differentiation GO:0045685 4 0.014
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
maintenance of location GO:0051235 4 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.014
regulation of leukocyte mediated cytotoxicity GO:0001910 1 0.014
protein targeting to membrane GO:0006612 1 0.014
tissue migration GO:0090130 37 0.014
regulation of molecular function GO:0065009 70 0.014
regulation of cell differentiation GO:0045595 142 0.013
regulation of blood vessel size GO:0050880 2 0.013
protein stabilization GO:0050821 2 0.013
digestive system development GO:0055123 289 0.013
protein polymerization GO:0051258 4 0.013
interspecies interaction between organisms GO:0044419 4 0.013
response to glucose GO:0009749 3 0.013
organic substance transport GO:0071702 58 0.013
peptide transport GO:0015833 1 0.013
regulation of cardiac muscle contraction GO:0055117 2 0.013
apoptotic process GO:0006915 116 0.013
regulation of myotube differentiation GO:0010830 2 0.013
cell substrate adhesion GO:0031589 4 0.013
regulation of locomotion GO:0040012 55 0.013
regulation of transcription dna templated GO:0006355 213 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
muscle tissue development GO:0060537 110 0.013
positive regulation of ras gtpase activity GO:0032320 1 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
homeostasis of number of cells GO:0048872 62 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
exocytosis GO:0006887 1 0.013
cell matrix adhesion GO:0007160 4 0.013
establishment of localization GO:0051234 244 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
regulation of apoptotic process GO:0042981 98 0.013
protein dephosphorylation GO:0006470 3 0.013
positive regulation of cell differentiation GO:0045597 30 0.013
regulation of rna metabolic process GO:0051252 224 0.013
protein phosphorylation GO:0006468 47 0.013
somite development GO:0061053 96 0.013
calcium ion transport into cytosol GO:0060402 3 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
embryonic digestive tract development GO:0048566 4 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
actin filament based movement GO:0030048 1 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
generation of neurons GO:0048699 385 0.012
cell killing GO:0001906 2 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
multicellular organismal macromolecule metabolic process GO:0044259 2 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
regulation of response to cytokine stimulus GO:0060759 3 0.012
response to biotic stimulus GO:0009607 97 0.012
definitive hemopoiesis GO:0060216 18 0.012
regulation of autophagy GO:0010506 3 0.012
cell cycle g1 s phase transition GO:0044843 1 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
organic acid metabolic process GO:0006082 31 0.012
regulation of jak stat cascade GO:0046425 3 0.012
regulation of hormone secretion GO:0046883 2 0.012
ion transport GO:0006811 114 0.012
ameboidal type cell migration GO:0001667 143 0.012
positive regulation of programmed cell death GO:0043068 29 0.012
nucleoside monophosphate catabolic process GO:0009125 4 0.012
negative regulation of cytokine production GO:0001818 1 0.012
protein complex disassembly GO:0043241 1 0.012
muscle hypertrophy GO:0014896 2 0.012
positive regulation of neuron death GO:1901216 1 0.012
convergent extension GO:0060026 118 0.012
macromolecular complex disassembly GO:0032984 1 0.012
sensory perception of pain GO:0019233 1 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
immune effector process GO:0002252 23 0.012
response to wounding GO:0009611 116 0.012
cell aging GO:0007569 2 0.012
embryonic digestive tract morphogenesis GO:0048557 3 0.012
epithelium migration GO:0090132 25 0.012
epithelial cell morphogenesis GO:0003382 2 0.012
regulation of neuronal synaptic plasticity GO:0048168 1 0.012
negative regulation of mitosis GO:0045839 3 0.012
striated muscle cell development GO:0055002 108 0.012
myeloid cell differentiation GO:0030099 86 0.011
mitotic dna damage checkpoint GO:0044773 4 0.011
response to topologically incorrect protein GO:0035966 2 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
carbohydrate homeostasis GO:0033500 1 0.011
somitogenesis GO:0001756 87 0.011
regulation of actin filament based process GO:0032970 9 0.011
alternative mrna splicing via spliceosome GO:0000380 1 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
positive regulation of myeloid cell differentiation GO:0045639 2 0.011
organ regeneration GO:0031100 1 0.011
regulation of protein targeting GO:1903533 2 0.011
negative regulation of cell communication GO:0010648 96 0.011
regulation of intracellular protein transport GO:0033157 3 0.011
hormone secretion GO:0046879 2 0.011
stem cell differentiation GO:0048863 117 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
negative regulation of cell death GO:0060548 60 0.011
negative regulation of gene expression GO:0010629 65 0.011
positive regulation of epithelial cell differentiation GO:0030858 2 0.011
positive regulation of protein complex assembly GO:0031334 2 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
organelle organization GO:0006996 227 0.011
convergent extension involved in gastrulation GO:0060027 71 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
striated muscle tissue development GO:0014706 110 0.011
lipid storage GO:0019915 1 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.011
muscle cell migration GO:0014812 4 0.011
regulation of systemic arterial blood pressure GO:0003073 1 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.011
macromolecule biosynthetic process GO:0009059 227 0.011
regulation of protein binding GO:0043393 3 0.011
phosphorylation GO:0016310 69 0.011
response to stress GO:0006950 263 0.011
single organism organelle organization GO:1902589 199 0.011
regulation of protein polymerization GO:0032271 2 0.011
positive regulation of leukocyte chemotaxis GO:0002690 1 0.011
nephron morphogenesis GO:0072028 2 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
eye development GO:0001654 277 0.011
gland development GO:0048732 143 0.011
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.011
ribosomal small subunit biogenesis GO:0042274 2 0.011
meiotic cell cycle process GO:1903046 3 0.011
erythrocyte differentiation GO:0030218 54 0.011
homeostasis of number of cells within a tissue GO:0048873 4 0.011
otic vesicle development GO:0071599 42 0.011
activation of mapk activity GO:0000187 3 0.010
organic cyclic compound metabolic process GO:1901360 301 0.010
cellular component movement GO:0006928 335 0.010
positive regulation of leukocyte differentiation GO:1902107 1 0.010
guanosine containing compound catabolic process GO:1901069 2 0.010
somatic cell dna recombination GO:0016444 1 0.010
positive regulation of striated muscle cell differentiation GO:0051155 1 0.010
regulation of lipid transport GO:0032368 4 0.010
response to unfolded protein GO:0006986 2 0.010
regulation of erk1 and erk2 cascade GO:0070372 4 0.010
protein homooligomerization GO:0051260 3 0.010
regulation of phosphorus metabolic process GO:0051174 43 0.010
regulation of epithelial cell proliferation GO:0050678 3 0.010
multicellular organismal response to stress GO:0033555 2 0.010
sequestering of metal ion GO:0051238 3 0.010
regulation of cell projection assembly GO:0060491 4 0.010
positive regulation of translation GO:0045727 1 0.010

cd74 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
immune system disease DOID:2914 0 0.020
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
muscular disease DOID:0080000 0 0.013
musculoskeletal system disease DOID:17 0 0.013
nervous system disease DOID:863 0 0.011
muscle tissue disease DOID:66 0 0.010