Danio rerio

21 known processes

opa1

optic atrophy 1 (human)

(Aliases: wu:fb77a10,zgc:92092,fb77a10,wu:fk62d06)

opa1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 2 0.091
larval development GO:0002164 2 0.088
Worm
negative regulation of biological process GO:0048519 304 0.070
Mouse
nitrogen compound metabolic process GO:0006807 319 0.069
tube morphogenesis GO:0035239 349 0.062
Mouse
regulation of establishment of protein localization GO:0070201 4 0.058
regulation of response to stimulus GO:0048583 269 0.055
Mouse
regulation of biological quality GO:0065008 263 0.053
chordate embryonic development GO:0043009 271 0.051
Mouse
brain development GO:0007420 293 0.051
stem cell maintenance GO:0019827 4 0.047
central nervous system development GO:0007417 387 0.045
organonitrogen compound metabolic process GO:1901564 74 0.045
multicellular organism growth GO:0035264 4 0.044
Worm
cell surface receptor signaling pathway GO:0007166 325 0.044
regulation of reproductive process GO:2000241 4 0.043
heterocycle metabolic process GO:0046483 290 0.043
response to glucocorticoid GO:0051384 1 0.043
regulation of multicellular organism growth GO:0040014 4 0.040
Worm
regulation of macromolecule metabolic process GO:0060255 317 0.039
regulation of multicellular organismal process GO:0051239 277 0.039
Worm
regulation of metabolic process GO:0019222 359 0.039
g1 s transition of mitotic cell cycle GO:0000082 1 0.038
protein localization to plasma membrane GO:0072659 1 0.038
organic substance biosynthetic process GO:1901576 289 0.038
regulation of protein complex assembly GO:0043254 3 0.038
cellular response to external stimulus GO:0071496 2 0.038
establishment of protein localization to plasma membrane GO:0090002 1 0.037
adult behavior GO:0030534 2 0.037
pericardium development GO:0060039 1 0.036
positive regulation of transport GO:0051050 2 0.036
cell cycle g1 s phase transition GO:0044843 1 0.036
regulation of cellular amino acid metabolic process GO:0006521 0 0.036
single organism membrane fusion GO:0044801 2 0.035
Mouse Worm
energy reserve metabolic process GO:0006112 2 0.035
regulation of gene expression GO:0010468 265 0.035
digestive tract development GO:0048565 265 0.035
regulation of protein transport GO:0051223 3 0.033
small molecule metabolic process GO:0044281 77 0.032
cellular nitrogen compound metabolic process GO:0034641 290 0.032
maintenance of location GO:0051235 4 0.031
cellular biosynthetic process GO:0044249 286 0.031
establishment of protein localization to organelle GO:0072594 4 0.031
nucleobase containing compound metabolic process GO:0006139 274 0.031
positive regulation of cell adhesion GO:0045785 1 0.030
head development GO:0060322 303 0.030
gtp catabolic process GO:0006184 2 0.030
gastrulation GO:0007369 208 0.030
regulation of meiotic cell cycle GO:0051445 1 0.030
cellular response to extracellular stimulus GO:0031668 2 0.029
cellular macromolecule metabolic process GO:0044260 391 0.029
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.029
morphogenesis of an epithelium GO:0002009 333 0.027
Mouse
homeostatic process GO:0042592 142 0.027
negative regulation of response to stimulus GO:0048585 104 0.027
Mouse
organic cyclic compound metabolic process GO:1901360 301 0.026
regulation of cell shape GO:0008360 1 0.026
regulation of cell development GO:0060284 100 0.026
neuron differentiation GO:0030182 353 0.026
cellular component morphogenesis GO:0032989 336 0.025
guanosine containing compound metabolic process GO:1901068 4 0.025
regulation of cellular metabolic process GO:0031323 320 0.025
regulation of synapse organization GO:0050807 3 0.025
response to chemical GO:0042221 320 0.025
Worm
regulation of synapse assembly GO:0051963 3 0.025
guanosine containing compound catabolic process GO:1901069 2 0.025
negative regulation of protein transport GO:0051224 3 0.024
embryonic organ morphogenesis GO:0048562 274 0.024
response to drug GO:0042493 3 0.024
neuron development GO:0048666 262 0.024
cell migration involved in gastrulation GO:0042074 79 0.023
membrane fusion GO:0061025 2 0.023
Mouse Worm
regulation of protein localization to plasma membrane GO:1903076 1 0.023
sensory organ development GO:0007423 393 0.023
digestive tract morphogenesis GO:0048546 231 0.022
negative regulation of cytokine production GO:0001818 1 0.022
cognition GO:0050890 1 0.022
regulation of cell communication GO:0010646 232 0.022
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.022
signal transduction GO:0007165 455 0.022
Mouse
protein secretion GO:0009306 1 0.021
embryonic organ development GO:0048568 381 0.021
gtp metabolic process GO:0046039 4 0.021
generation of neurons GO:0048699 385 0.021
heterocycle biosynthetic process GO:0018130 215 0.021
single organism metabolic process GO:0044710 217 0.021
cellular amide metabolic process GO:0043603 4 0.021
gene expression GO:0010467 252 0.021
regulation of cellular biosynthetic process GO:0031326 245 0.021
regulation of cytokine production GO:0001817 3 0.021
heart development GO:0007507 313 0.021
protein import GO:0017038 3 0.020
cellular response to nutrient levels GO:0031669 2 0.020
determination of left right symmetry GO:0007368 179 0.020
oxidation reduction process GO:0055114 41 0.020
stem cell development GO:0048864 82 0.020
cellular ketone metabolic process GO:0042180 11 0.020
regulation of establishment of protein localization to plasma membrane GO:0090003 1 0.020
wnt signaling pathway GO:0016055 80 0.020
biosynthetic process GO:0009058 294 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
microtubule organizing center organization GO:0031023 1 0.020
centrosome duplication GO:0051298 1 0.020
regulation of blood pressure GO:0008217 1 0.019
proteasomal protein catabolic process GO:0010498 2 0.019
cellular aromatic compound metabolic process GO:0006725 295 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
organic cyclic compound biosynthetic process GO:1901362 223 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.019
ameboidal type cell migration GO:0001667 143 0.019
digestive system development GO:0055123 289 0.019
germ line stem cell maintenance GO:0030718 2 0.019
localization of cell GO:0051674 244 0.019
angiogenesis GO:0001525 158 0.019
regulation of rho protein signal transduction GO:0035023 2 0.019
positive regulation of cell cycle GO:0045787 3 0.019
cytoskeleton dependent cytokinesis GO:0061640 3 0.019
positive regulation of secretion GO:0051047 1 0.019
primary neural tube formation GO:0014020 1 0.019
Mouse
gene silencing by mirna GO:0035195 3 0.018
regulation of signaling GO:0023051 235 0.018
Mouse
regulation of cytoplasmic transport GO:1903649 4 0.018
regulation of cellular amine metabolic process GO:0033238 0 0.018
regulation of nitrogen compound metabolic process GO:0051171 251 0.018
cellular amine metabolic process GO:0044106 2 0.018
cellular response to radiation GO:0071478 4 0.018
phagocytosis GO:0006909 3 0.018
nucleobase containing compound biosynthetic process GO:0034654 205 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.018
regulation of binding GO:0051098 3 0.018
ras protein signal transduction GO:0007265 7 0.018
amine metabolic process GO:0009308 2 0.018
ubiquitin dependent protein catabolic process GO:0006511 3 0.017
nucleic acid templated transcription GO:0097659 181 0.017
cellular component disassembly GO:0022411 1 0.017
cell projection assembly GO:0030031 64 0.017
regulation of inflammatory response GO:0050727 2 0.017
sensory organ morphogenesis GO:0090596 200 0.017
meiotic cell cycle process GO:1903046 3 0.017
positive regulation of secretion by cell GO:1903532 1 0.017
cellular component biogenesis GO:0044085 178 0.017
energy homeostasis GO:0097009 3 0.017
growth GO:0040007 174 0.017
Worm
protein polymerization GO:0051258 4 0.017
regulation of primary metabolic process GO:0080090 311 0.017
multicellular organismal metabolic process GO:0044236 2 0.017
single organism organelle organization GO:1902589 199 0.017
cell projection morphogenesis GO:0048858 244 0.017
mrna cleavage involved in gene silencing by mirna GO:0035279 1 0.017
nuclear transport GO:0051169 4 0.017
vasculature development GO:0001944 278 0.017
locomotion GO:0040011 313 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
Mouse Worm
multi organism process GO:0051704 134 0.016
negative regulation of ras protein signal transduction GO:0046580 1 0.016
cell morphogenesis involved in differentiation GO:0000904 195 0.016
nucleocytoplasmic transport GO:0006913 4 0.016
mitochondrion organization GO:0007005 4 0.016
cell migration GO:0016477 237 0.016
positive regulation of camp biosynthetic process GO:0030819 2 0.016
aromatic compound biosynthetic process GO:0019438 217 0.016
protein metabolic process GO:0019538 183 0.016
Worm
pericardium morphogenesis GO:0003344 1 0.015
morphogenesis of an epithelial sheet GO:0002011 49 0.015
protein acetylation GO:0006473 2 0.015
response to stress GO:0006950 263 0.015
Mouse Worm
cell motility GO:0048870 244 0.015
organic acid metabolic process GO:0006082 31 0.015
cell projection organization GO:0030030 284 0.015
centrosome cycle GO:0007098 1 0.015
developmental growth involved in morphogenesis GO:0060560 86 0.015
rna metabolic process GO:0016070 219 0.015
response to corticosteroid GO:0031960 1 0.015
striated muscle tissue development GO:0014706 110 0.015
rna localization GO:0006403 4 0.015
cellular amino acid metabolic process GO:0006520 7 0.015
cellular component assembly GO:0022607 170 0.015
exocytosis GO:0006887 1 0.015
regulation of microtubule cytoskeleton organization GO:0070507 3 0.015
positive regulation of catabolic process GO:0009896 4 0.015
blood vessel development GO:0001568 246 0.015
cell part morphogenesis GO:0032990 246 0.015
organonitrogen compound biosynthetic process GO:1901566 47 0.015
protein localization to nucleus GO:0034504 3 0.015
regulation of purine nucleotide catabolic process GO:0033121 2 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
single organism biosynthetic process GO:0044711 71 0.014
response to uv GO:0009411 3 0.014
negative regulation of secretion GO:0051048 2 0.014
regulation of synaptic plasticity GO:0048167 1 0.014
atp catabolic process GO:0006200 4 0.014
cell morphogenesis GO:0000902 289 0.014
gene silencing by rna GO:0031047 4 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
rna 3 end processing GO:0031123 2 0.014
positive regulation of neuron death GO:1901216 1 0.014
cellular macromolecule biosynthetic process GO:0034645 224 0.014
muscle structure development GO:0061061 196 0.014
phosphate containing compound metabolic process GO:0006796 108 0.014
meiotic nuclear division GO:0007126 4 0.014
oxoacid metabolic process GO:0043436 31 0.014
negative regulation of metabolic process GO:0009892 86 0.014
regulation of signal transduction GO:0009966 225 0.014
Mouse
response to external stimulus GO:0009605 264 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
single organism nuclear import GO:1902593 3 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
regulation of gtpase activity GO:0043087 2 0.014
peptide transport GO:0015833 1 0.014
axonogenesis GO:0007409 152 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
mesenchymal cell development GO:0014031 78 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
negative regulation of reproductive process GO:2000242 3 0.013
phosphorus metabolic process GO:0006793 109 0.013
regulation of nucleic acid templated transcription GO:1903506 213 0.013
macromolecular complex disassembly GO:0032984 1 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
cellular localization GO:0051641 97 0.013
nuclear import GO:0051170 3 0.013
i kappab kinase nf kappab signaling GO:0007249 4 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
regulation of protein targeting GO:1903533 2 0.013
cell cycle arrest GO:0007050 1 0.013
skeletal system development GO:0001501 181 0.013
regulation of metal ion transport GO:0010959 4 0.013
cellular component movement GO:0006928 335 0.012
developmental maturation GO:0021700 34 0.012
response to nutrient GO:0007584 3 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.012
post embryonic organ development GO:0048569 4 0.012
negative regulation of cellular process GO:0048523 283 0.012
Mouse
negative regulation of protein complex assembly GO:0031333 1 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
synaptic growth at neuromuscular junction GO:0051124 2 0.012
protein import into nucleus GO:0006606 3 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
chemosensory behavior GO:0007635 1 0.012
compound eye development GO:0048749 2 0.012
protein targeting to nucleus GO:0044744 3 0.012
small gtpase mediated signal transduction GO:0007264 8 0.012
endosomal transport GO:0016197 2 0.012
negative regulation of defense response GO:0031348 2 0.012
cellular extravasation GO:0045123 1 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
system process GO:0003008 185 0.012
negative regulation of protein localization to nucleus GO:1900181 2 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
protein complex disassembly GO:0043241 1 0.012
organelle fusion GO:0048284 3 0.012
Mouse Worm
cellular protein catabolic process GO:0044257 4 0.012
regulation of nucleoside metabolic process GO:0009118 2 0.012
peptide metabolic process GO:0006518 1 0.012
carbohydrate homeostasis GO:0033500 1 0.012
positive regulation of protein complex assembly GO:0031334 2 0.012
positive regulation of cellular process GO:0048522 201 0.012
positive regulation of gtp catabolic process GO:0033126 1 0.012
rho protein signal transduction GO:0007266 5 0.012
cell substrate adhesion GO:0031589 4 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
positive regulation of biological process GO:0048518 253 0.011
Worm
neuron projection development GO:0031175 180 0.011
cellular response to starvation GO:0009267 1 0.011
cell matrix adhesion GO:0007160 4 0.011
centrosome organization GO:0051297 1 0.011
alcohol biosynthetic process GO:0046165 2 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
regulation of developmental process GO:0050793 247 0.011
Worm
peptidyl serine modification GO:0018209 2 0.011
carbohydrate derivative metabolic process GO:1901135 61 0.011
positive regulation of cell substrate adhesion GO:0010811 1 0.011
response to endogenous stimulus GO:0009719 83 0.011
regulation of mitochondrion organization GO:0010821 1 0.011
Mouse
neuron projection morphogenesis GO:0048812 161 0.011
gland development GO:0048732 143 0.011
mitotic dna damage checkpoint GO:0044773 4 0.011
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
camera type eye development GO:0043010 222 0.011
amide biosynthetic process GO:0043604 1 0.011
intracellular mrna localization GO:0008298 1 0.011
protein acylation GO:0043543 3 0.011
single organism transport GO:0044765 206 0.011
multicellular organismal macromolecule metabolic process GO:0044259 2 0.011
negative regulation of catabolic process GO:0009895 3 0.011
regulation of cell activation GO:0050865 1 0.011
regulation of cellular extravasation GO:0002691 1 0.011
organism emergence from protective structure GO:0071684 4 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
immune system process GO:0002376 241 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
phagocytosis engulfment GO:0006911 1 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
lymphocyte proliferation GO:0046651 1 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
ribonucleotide metabolic process GO:0009259 27 0.011
locomotor rhythm GO:0045475 3 0.011
determination of bilateral symmetry GO:0009855 204 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.011
cytokinesis GO:0000910 3 0.011
chemotaxis GO:0006935 104 0.011
regulation of autophagy GO:0010506 3 0.011
mitotic cytokinesis GO:0000281 3 0.011
organelle organization GO:0006996 227 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
establishment of localization in cell GO:0051649 77 0.010
lateral inhibition GO:0046331 1 0.010
regulation of neural precursor cell proliferation GO:2000177 3 0.010
cellular response to chemical stimulus GO:0070887 157 0.010
regulation of biosynthetic process GO:0009889 250 0.010
axon development GO:0061564 166 0.010
regulation of mrna processing GO:0050684 3 0.010
negative regulation of intracellular protein transport GO:0090317 3 0.010
eye development GO:0001654 277 0.010
macromolecule modification GO:0043412 111 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.010
tube closure GO:0060606 1 0.010
Mouse
purine nucleoside monophosphate catabolic process GO:0009128 4 0.010
negative regulation of cellular catabolic process GO:0031330 3 0.010
regulation of cellular component organization GO:0051128 86 0.010
Mouse
response to ketone GO:1901654 1 0.010
hormone secretion GO:0046879 2 0.010
transcription dna templated GO:0006351 181 0.010
negative regulation of signal transduction GO:0009968 94 0.010
Mouse
tissue remodeling GO:0048771 4 0.010
negative regulation of multi organism process GO:0043901 3 0.010
negative regulation of cytoplasmic transport GO:1903650 2 0.010
rna biosynthetic process GO:0032774 181 0.010
organic substance transport GO:0071702 58 0.010
macromolecule biosynthetic process GO:0009059 227 0.010
positive regulation of cell death GO:0010942 29 0.010
positive regulation of gtpase activity GO:0043547 1 0.010
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.010
negative regulation of multicellular organismal process GO:0051241 69 0.010
regulation of macromolecule biosynthetic process GO:0010556 225 0.010
negative regulation of translation GO:0017148 1 0.010

opa1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
musculoskeletal system disease DOID:17 0 0.016
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.010