Danio rerio

67 known processes

psen1

presenilin 1

(Aliases: pre1,zf-PS1,psen,zfPS1)

psen1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
signal transduction GO:0007165 455 0.803
neuron projection morphogenesis GO:0048812 161 0.638
Mouse Fly
transport GO:0006810 220 0.609
Human Mouse Fly
neuron differentiation GO:0030182 353 0.560
Mouse Fly
establishment of localization GO:0051234 244 0.558
Human Mouse Fly
cation transport GO:0006812 81 0.540
Human Mouse Fly
nucleobase containing compound metabolic process GO:0006139 274 0.524
Mouse
cognition GO:0050890 1 0.484
Mouse
generation of neurons GO:0048699 385 0.478
Mouse Fly
response to external stimulus GO:0009605 264 0.476
Mouse Worm
immune system process GO:0002376 241 0.458
Mouse
positive regulation of cellular process GO:0048522 201 0.457
Mouse Worm
positive regulation of transport GO:0051050 2 0.424
cellular macromolecule metabolic process GO:0044260 391 0.423
Mouse Fly
small molecule metabolic process GO:0044281 77 0.382
neuron development GO:0048666 262 0.376
Mouse Fly
metal ion transport GO:0030001 58 0.370
Human Fly
axon development GO:0061564 166 0.354
Mouse
cellular component movement GO:0006928 335 0.338
Mouse
establishment of protein localization to organelle GO:0072594 4 0.332
larval development GO:0002164 2 0.330
neuron projection development GO:0031175 180 0.327
Mouse Fly
cell projection morphogenesis GO:0048858 244 0.326
Mouse Fly
cell projection organization GO:0030030 284 0.322
Mouse Fly
vasculature development GO:0001944 278 0.317
cell morphogenesis GO:0000902 289 0.304
Mouse Fly
single organism localization GO:1902578 225 0.303
Human Mouse Fly
positive regulation of cellular catabolic process GO:0031331 3 0.286
Mouse
cell surface receptor signaling pathway GO:0007166 325 0.280
regulation of transferase activity GO:0051338 16 0.276
Mouse
regulation of synapse organization GO:0050807 3 0.271
cell fate commitment GO:0045165 99 0.264
Mouse Worm Fly
cell morphogenesis involved in differentiation GO:0000904 195 0.259
Mouse
protein metabolic process GO:0019538 183 0.253
regulation of multicellular organismal process GO:0051239 277 0.251
Mouse
regulation of metabolic process GO:0019222 359 0.246
Human Mouse
phosphate containing compound metabolic process GO:0006796 108 0.246
Human Mouse
regulation of cellular metabolic process GO:0031323 320 0.242
Human Mouse
cellular protein metabolic process GO:0044267 129 0.233
Mouse Fly
neurological system process GO:0050877 62 0.232
Mouse
organic substance transport GO:0071702 58 0.227
Mouse
regulation of synapse assembly GO:0051963 3 0.221
response to organic substance GO:0010033 153 0.219
Worm
carbohydrate derivative metabolic process GO:1901135 61 0.219
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.218
blood vessel development GO:0001568 246 0.202
Mouse
regulation of developmental process GO:0050793 247 0.198
Mouse
positive regulation of cellular component biogenesis GO:0044089 3 0.197
response to growth factor GO:0070848 39 0.193
Worm
enzyme linked receptor protein signaling pathway GO:0007167 106 0.191
Mouse Worm
response to stress GO:0006950 263 0.189
Mouse
adult behavior GO:0030534 2 0.185
locomotion GO:0040011 313 0.182
Mouse
organic cyclic compound metabolic process GO:1901360 301 0.181
Mouse
system process GO:0003008 185 0.181
Mouse
regulation of signaling GO:0023051 235 0.180
Mouse Worm Fly
protein modification process GO:0036211 100 0.179
Mouse
cellular protein modification process GO:0006464 100 0.174
Mouse
synaptic growth at neuromuscular junction GO:0051124 2 0.174
regulation of reproductive process GO:2000241 4 0.171
regulation of signal transduction GO:0009966 225 0.171
Mouse Worm Fly
heart morphogenesis GO:0003007 156 0.170
Mouse
aging GO:0007568 2 0.170
heterocycle metabolic process GO:0046483 290 0.170
Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.167
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.166
Mouse
death GO:0016265 121 0.166
Human Mouse
single organism transport GO:0044765 206 0.164
Human Mouse Fly
phosphorus metabolic process GO:0006793 109 0.164
Human Mouse
regulation of vesicle mediated transport GO:0060627 9 0.163
regulation of macromolecule metabolic process GO:0060255 317 0.161
Mouse
axonogenesis GO:0007409 152 0.161
Mouse
developmental growth GO:0048589 166 0.157
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.156
Mouse
positive regulation of signaling GO:0023056 56 0.152
Mouse Worm
regulation of nucleic acid templated transcription GO:1903506 213 0.152
Mouse
rna metabolic process GO:0016070 219 0.152
Mouse
immune system development GO:0002520 191 0.151
Mouse
reproduction GO:0000003 40 0.150
Worm
nucleic acid templated transcription GO:0097659 181 0.149
Mouse
morphogenesis of an epithelium GO:0002009 333 0.147
Mouse
response to endogenous stimulus GO:0009719 83 0.144
Worm
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.144
Mouse
pole plasm assembly GO:0007315 4 0.143
regulation of cellular response to growth factor stimulus GO:0090287 35 0.142
Worm
cation homeostasis GO:0055080 33 0.140
Human Mouse
organic substance biosynthetic process GO:1901576 289 0.140
Mouse
maintenance of location GO:0051235 4 0.140
nucleocytoplasmic transport GO:0006913 4 0.139
cell part morphogenesis GO:0032990 246 0.139
Mouse Fly
central nervous system development GO:0007417 387 0.138
protein phosphorylation GO:0006468 47 0.138
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.137
gtp catabolic process GO:0006184 2 0.133
cell growth GO:0016049 57 0.133
cortical cytoskeleton organization GO:0030865 1 0.132
nucleobase containing compound biosynthetic process GO:0034654 205 0.132
Mouse
regulation of multicellular organismal development GO:2000026 223 0.129
Mouse
heart development GO:0007507 313 0.127
Mouse
positive regulation of cell cycle GO:0045787 3 0.126
aromatic compound biosynthetic process GO:0019438 217 0.126
Mouse
response to chemical GO:0042221 320 0.126
Worm
exocytosis GO:0006887 1 0.125
Mouse
cellular response to endogenous stimulus GO:0071495 68 0.125
Worm
response to drug GO:0042493 3 0.125
intracellular signal transduction GO:0035556 85 0.125
Mouse
protein targeting to nucleus GO:0044744 3 0.124
oxoacid metabolic process GO:0043436 31 0.123
single organism nuclear import GO:1902593 3 0.123
digestive system development GO:0055123 289 0.123
gtp metabolic process GO:0046039 4 0.122
transmembrane transport GO:0055085 120 0.121
Human
cellular nitrogen compound metabolic process GO:0034641 290 0.121
cellular response to growth factor stimulus GO:0071363 39 0.120
Worm
regulation of purine nucleotide catabolic process GO:0033121 2 0.119
multicellular organism reproduction GO:0032504 35 0.119
Worm
macromolecule localization GO:0033036 54 0.119
Mouse Worm
wound healing GO:0042060 90 0.118
regulation of biological quality GO:0065008 263 0.115
Human Mouse
regulation of cell communication GO:0010646 232 0.115
Mouse Worm Fly
protein import into nucleus GO:0006606 3 0.115
autophagy GO:0006914 4 0.115
Mouse
cellular ketone metabolic process GO:0042180 11 0.113
regulation of protein transport GO:0051223 3 0.113
angiogenesis GO:0001525 158 0.112
multi organism process GO:0051704 134 0.112
Worm
cellular biosynthetic process GO:0044249 286 0.112
Mouse
macromolecule biosynthetic process GO:0009059 227 0.112
Mouse
phagocytosis GO:0006909 3 0.111
eye development GO:0001654 277 0.111
regulation of intracellular protein transport GO:0033157 3 0.111
regulation of gene expression GO:0010468 265 0.110
Mouse
regulation of primary metabolic process GO:0080090 311 0.110
Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.108
Mouse
single organism metabolic process GO:0044710 217 0.107
Mouse
protein import GO:0017038 3 0.107
digestive tract development GO:0048565 265 0.106
guanosine containing compound metabolic process GO:1901068 4 0.105
regulation of transport GO:0051049 45 0.104
regulation of rna biosynthetic process GO:2001141 213 0.104
Mouse
regulation of establishment of protein localization GO:0070201 4 0.103
regulation of response to stimulus GO:0048583 269 0.103
Mouse Worm Fly
positive regulation of cell communication GO:0010647 56 0.103
Mouse Worm
growth GO:0040007 174 0.101
cellular catabolic process GO:0044248 27 0.099
Mouse
signal transduction by phosphorylation GO:0023014 18 0.099
Mouse
hemopoiesis GO:0030097 183 0.099
Mouse
response to temperature stimulus GO:0009266 15 0.099
Worm
positive regulation of protein complex assembly GO:0031334 2 0.098
organic substance catabolic process GO:1901575 28 0.098
Mouse
negative regulation of cellular process GO:0048523 283 0.098
Human Mouse
regulation of phosphorus metabolic process GO:0051174 43 0.096
Human Mouse
regulation of gtp catabolic process GO:0033124 2 0.095
regulation of autophagy GO:0010506 3 0.095
nucleic acid metabolic process GO:0090304 244 0.095
Mouse
small gtpase mediated signal transduction GO:0007264 8 0.095
ion transport GO:0006811 114 0.094
Human Mouse Fly
cation transmembrane transport GO:0098655 65 0.094
Human
regulation of cell death GO:0010941 103 0.091
Human Mouse
response to abiotic stimulus GO:0009628 122 0.090
Worm
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.090
protein localization to nucleus GO:0034504 3 0.089
compound eye development GO:0048749 2 0.089
regulation of cell shape GO:0008360 1 0.089
tube morphogenesis GO:0035239 349 0.089
Mouse
rna biosynthetic process GO:0032774 181 0.089
Mouse
macromolecule modification GO:0043412 111 0.088
Mouse
guanosine containing compound catabolic process GO:1901069 2 0.087
tissue remodeling GO:0048771 4 0.087
positive regulation of secretion by cell GO:1903532 1 0.086
regulation of kinase activity GO:0043549 15 0.086
Mouse
blood vessel morphogenesis GO:0048514 216 0.085
cell migration GO:0016477 237 0.083
Mouse
nuclear transport GO:0051169 4 0.083
response to wounding GO:0009611 116 0.082
regulation of cellular protein metabolic process GO:0032268 52 0.082
Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.080
Mouse
positive regulation of catabolic process GO:0009896 4 0.080
Mouse
female gamete generation GO:0007292 14 0.080
lipid storage GO:0019915 1 0.080
segmentation GO:0035282 97 0.079
Mouse
intracellular mrna localization GO:0008298 1 0.078
positive regulation of biological process GO:0048518 253 0.078
Human Mouse Worm
organonitrogen compound metabolic process GO:1901564 74 0.078
stem cell fate commitment GO:0048865 1 0.076
regulation of cellular ketone metabolic process GO:0010565 7 0.075
cellular amino acid metabolic process GO:0006520 7 0.075
chemosensory behavior GO:0007635 1 0.075
negative regulation of secretion GO:0051048 2 0.075
regulation of cytoplasmic transport GO:1903649 4 0.074
regulation of nucleotide catabolic process GO:0030811 2 0.074
motor neuron axon guidance GO:0008045 23 0.074
regulation of nervous system development GO:0051960 90 0.073
Mouse
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9 0.072
regulation of endocytosis GO:0030100 7 0.070
specification of symmetry GO:0009799 204 0.070
Mouse
purine nucleotide metabolic process GO:0006163 27 0.070
amine metabolic process GO:0009308 2 0.070
determination of bilateral symmetry GO:0009855 204 0.070
Mouse
sensory perception GO:0007600 39 0.070
regulation of protein kinase b signaling GO:0051896 8 0.070
synaptic transmission GO:0007268 35 0.068
Mouse
cortical actin cytoskeleton organization GO:0030866 1 0.068
regulation of protein ubiquitination GO:0031396 3 0.068
Mouse
carboxylic acid metabolic process GO:0019752 22 0.067
cellular response to organic substance GO:0071310 105 0.067
Worm
cellular component morphogenesis GO:0032989 336 0.067
Mouse Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.067
Mouse
cellular response to nutrient levels GO:0031669 2 0.067
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.066
oocyte axis specification GO:0007309 5 0.065
regulation of molecular function GO:0065009 70 0.065
Human Mouse
cellular response to external stimulus GO:0071496 2 0.065
Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.065
positive regulation of dna metabolic process GO:0051054 1 0.065
regulation of epithelial cell proliferation GO:0050678 3 0.063
positive regulation of map kinase activity GO:0043406 3 0.063
Mouse
neuroblast proliferation GO:0007405 2 0.063
apoptotic process GO:0006915 116 0.063
Human Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.063
Mouse
gastrulation GO:0007369 208 0.063
regulation of wound healing GO:0061041 2 0.062
regulation of catalytic activity GO:0050790 55 0.062
Human Mouse
pyruvate metabolic process GO:0006090 1 0.062
regulation of multicellular organism growth GO:0040014 4 0.062
regulation of localization GO:0032879 104 0.061
positive regulation of molecular function GO:0044093 33 0.061
Human Mouse
phosphorylation GO:0016310 69 0.061
Human Mouse
negative regulation of synapse assembly GO:0051964 2 0.060
negative regulation of cell cycle GO:0045786 14 0.060
transmission of nerve impulse GO:0019226 19 0.060
regulation of cellular biosynthetic process GO:0031326 245 0.059
Mouse
developmental maturation GO:0021700 34 0.059
Mouse
behavior GO:0007610 74 0.058
positive regulation of catalytic activity GO:0043085 25 0.058
Human Mouse
erk1 and erk2 cascade GO:0070371 4 0.058
protein secretion GO:0009306 1 0.058
apoptotic signaling pathway GO:0097190 23 0.058
Mouse
anterior posterior pattern specification GO:0009952 152 0.058
Mouse
response to biotic stimulus GO:0009607 97 0.057
regulation of erk1 and erk2 cascade GO:0070372 4 0.056
calcium ion transport GO:0006816 18 0.056
Human
positive regulation of metabolic process GO:0009893 108 0.055
Human Mouse
nuclear import GO:0051170 3 0.055
nitrogen compound metabolic process GO:0006807 319 0.055
multicellular organism growth GO:0035264 4 0.055
positive regulation of apoptotic signaling pathway GO:2001235 1 0.055
neuron death GO:0070997 21 0.055
Mouse
protein localization GO:0008104 40 0.054
Mouse Worm
response to alkaloid GO:0043279 2 0.053
leukocyte proliferation GO:0070661 1 0.053
regulation of protein modification process GO:0031399 29 0.053
Mouse
cellular component disassembly GO:0022411 1 0.053
cytoplasm organization GO:0007028 4 0.053
programmed cell death GO:0012501 119 0.052
Human Mouse
regulation of meiotic cell cycle GO:0051445 1 0.052
chemotaxis GO:0006935 104 0.052
cellular amine metabolic process GO:0044106 2 0.052
cellular response to chemical stimulus GO:0070887 157 0.052
Worm
skeletal system morphogenesis GO:0048705 102 0.051
Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.051
Mouse
alpha amino acid metabolic process GO:1901605 3 0.051
cellular response to stress GO:0033554 62 0.051
Mouse
regulation of gtpase activity GO:0043087 2 0.051
cytoskeleton dependent cytokinesis GO:0061640 3 0.051
regulation of nucleoside metabolic process GO:0009118 2 0.051
embryonic heart tube development GO:0035050 133 0.051
Mouse
regulation of apoptotic process GO:0042981 98 0.050
Human Mouse
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.050
response to external biotic stimulus GO:0043207 97 0.049
rna localization GO:0006403 4 0.049
negative regulation of signaling GO:0023057 96 0.049
Mouse
cell death GO:0008219 121 0.049
Human Mouse
negative regulation of kinase activity GO:0033673 4 0.048
Mouse
ion homeostasis GO:0050801 41 0.048
Human Mouse
ras protein signal transduction GO:0007265 7 0.048
fin regeneration GO:0031101 51 0.048
regulation of transcription dna templated GO:0006355 213 0.047
Mouse
stem cell proliferation GO:0072089 4 0.046
regulation of protein complex assembly GO:0043254 3 0.046
sensory system development GO:0048880 76 0.046
regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902253 5 0.046
positive regulation of wound healing GO:0090303 1 0.045
heterocycle biosynthetic process GO:0018130 215 0.045
Mouse
divalent metal ion transport GO:0070838 20 0.045
Human
positive regulation of cellular biosynthetic process GO:0031328 68 0.045
regulation of cellular component organization GO:0051128 86 0.045
Mouse
neurotransmitter secretion GO:0007269 2 0.045
Mouse
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.045
brain development GO:0007420 293 0.045
axon cargo transport GO:0008088 2 0.045
regulation of carbohydrate metabolic process GO:0006109 4 0.044
actin polymerization or depolymerization GO:0008154 2 0.044
wnt signaling pathway GO:0016055 80 0.044
response to other organism GO:0051707 97 0.044
digestive tract morphogenesis GO:0048546 231 0.044
transcription from rna polymerase iii promoter GO:0006383 1 0.043
embryo development ending in birth or egg hatching GO:0009792 271 0.043
Mouse
negative regulation of growth GO:0045926 10 0.043
regulation of nucleocytoplasmic transport GO:0046822 2 0.043
regulation of intracellular signal transduction GO:1902531 57 0.043
Mouse
regulation of oligodendrocyte differentiation GO:0048713 1 0.043
dorsal ventral pattern formation GO:0009953 125 0.043
Mouse Fly
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.043
regulation of ion transmembrane transport GO:0034765 18 0.042
regulation of cellular amine metabolic process GO:0033238 0 0.042
cellular localization GO:0051641 97 0.042
Mouse
regulation of cell activation GO:0050865 1 0.042
regionalization GO:0003002 274 0.042
Mouse Fly
axon guidance GO:0007411 86 0.042
negative regulation of multicellular organismal process GO:0051241 69 0.041
Mouse
organic acid metabolic process GO:0006082 31 0.041
regulation of purine nucleotide metabolic process GO:1900542 17 0.041
positive regulation of secretion GO:0051047 1 0.040
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.040
single organism behavior GO:0044708 24 0.040
Mouse
negative regulation of biological process GO:0048519 304 0.039
Human Mouse
cytokinesis GO:0000910 3 0.039
sensory perception of chemical stimulus GO:0007606 3 0.039
single organism cellular localization GO:1902580 46 0.039
glial cell migration GO:0008347 3 0.039
negative regulation of apoptotic signaling pathway GO:2001234 10 0.039
Mouse
stem cell division GO:0017145 1 0.038
spermatid differentiation GO:0048515 2 0.038
meiotic cell cycle process GO:1903046 3 0.038
hematopoietic or lymphoid organ development GO:0048534 191 0.038
Mouse
embryonic organ morphogenesis GO:0048562 274 0.038
Mouse
cell fate specification GO:0001708 68 0.038
Mouse Worm
neuronal action potential GO:0019228 18 0.037
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.037
protein dephosphorylation GO:0006470 3 0.037
negative regulation of response to stimulus GO:0048585 104 0.037
Mouse
establishment or maintenance of cell polarity GO:0007163 29 0.037
organophosphate metabolic process GO:0019637 37 0.037
muscle structure development GO:0061061 196 0.037
regulation of metal ion transport GO:0010959 4 0.036
regulation of apoptotic signaling pathway GO:2001233 12 0.036
Mouse
regulation of ion transport GO:0043269 22 0.036
nucleobase containing small molecule metabolic process GO:0055086 32 0.036
reciprocal meiotic recombination GO:0007131 1 0.036
neuron projection guidance GO:0097485 86 0.036
transcription dna templated GO:0006351 181 0.036
Mouse
regulation of rna metabolic process GO:0051252 224 0.036
Mouse
regulation of oocyte development GO:0060281 3 0.035
embryonic heart tube morphogenesis GO:0003143 108 0.035
Mouse
vesicle mediated transport GO:0016192 22 0.035
Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.035
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.035
Mouse
peptidyl serine modification GO:0018209 2 0.035
cellular carbohydrate metabolic process GO:0044262 4 0.035
regulation of dendrite development GO:0050773 3 0.035
synaptic vesicle transport GO:0048489 1 0.035
Mouse
regulation of protein targeting GO:1903533 2 0.035
protein polymerization GO:0051258 4 0.035
mononuclear cell proliferation GO:0032943 1 0.034
homeostasis of number of cells GO:0048872 62 0.034
peptidyl serine phosphorylation GO:0018105 1 0.034
pancreas development GO:0031016 84 0.034
circulatory system process GO:0003013 87 0.034
negative regulation of catabolic process GO:0009895 3 0.034
Mouse
positive regulation of macromolecule metabolic process GO:0010604 93 0.033
Mouse
positive regulation of epithelial cell proliferation GO:0050679 1 0.033
calcium ion import GO:0070509 4 0.033
regulation of nucleotide metabolic process GO:0006140 17 0.033
germ cell development GO:0007281 22 0.033
regulation of circadian rhythm GO:0042752 4 0.033
cellular response to organic cyclic compound GO:0071407 38 0.033
organelle organization GO:0006996 227 0.032
Mouse Fly
leukocyte homeostasis GO:0001776 2 0.032
chemical homeostasis GO:0048878 49 0.032
Human Mouse
regulation of biosynthetic process GO:0009889 250 0.032
Mouse
multicellular organismal reproductive process GO:0048609 35 0.032
Worm
response to lipid GO:0033993 60 0.032
skeletal system development GO:0001501 181 0.032
Mouse
ribose phosphate metabolic process GO:0019693 27 0.031
regulation of protein catabolic process GO:0042176 1 0.031
Mouse
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.031
response to oxygen containing compound GO:1901700 55 0.031
vesicle localization GO:0051648 27 0.031
Mouse
regulation of phosphate metabolic process GO:0019220 43 0.031
Human Mouse
regulation of immune system process GO:0002682 34 0.031
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.031
Mouse
mesenchyme development GO:0060485 127 0.031
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.030
cellular response to extracellular stimulus GO:0031668 2 0.030
Mouse
regulation of protein localization to nucleus GO:1900180 2 0.030
response to hormone GO:0009725 48 0.030
single organism cell adhesion GO:0098602 29 0.030
Human Fly
cellular protein catabolic process GO:0044257 4 0.030
Mouse
neurotransmitter transport GO:0006836 2 0.030
Mouse
membrane invagination GO:0010324 1 0.029
regulation of locomotion GO:0040012 55 0.029
positive regulation of signal transduction GO:0009967 56 0.029
Mouse Worm
neuromuscular junction development GO:0007528 9 0.029
cytokinetic process GO:0032506 2 0.029
stem cell maintenance GO:0019827 4 0.029
neuron apoptotic process GO:0051402 20 0.029
Mouse
taxis GO:0042330 109 0.028
biosynthetic process GO:0009058 294 0.028
Mouse
striated muscle tissue development GO:0014706 110 0.028
positive regulation of cellular amine metabolic process GO:0033240 0 0.028
female meiotic division GO:0007143 2 0.028
establishment of localization in cell GO:0051649 77 0.028
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.028
negative regulation of signal transduction GO:0009968 94 0.028
Mouse
microtubule based process GO:0007017 60 0.028
negative regulation of cell communication GO:0010648 96 0.027
Mouse
head development GO:0060322 303 0.027
gland development GO:0048732 143 0.027
Mouse
multi organism reproductive process GO:0044703 36 0.027
Worm
regulation of establishment or maintenance of cell polarity GO:0032878 2 0.027
oogenesis GO:0048477 14 0.027
cell migration involved in heart development GO:0060973 22 0.027
negative regulation of cell death GO:0060548 60 0.027
Human Mouse
regulation of protein phosphorylation GO:0001932 18 0.027
Mouse
odontogenesis of dentin containing tooth GO:0042475 1 0.026
positive regulation of nucleoside metabolic process GO:0045979 1 0.026
lateral line development GO:0048882 66 0.026
signal transduction in absence of ligand GO:0038034 1 0.026
negative regulation of protein processing GO:0010955 10 0.026
Mouse
regulation of stem cell proliferation GO:0072091 2 0.026
response to bacterium GO:0009617 58 0.026
single organism organelle organization GO:1902589 199 0.026
positive regulation of response to stimulus GO:0048584 80 0.026
Mouse Worm
axis specification GO:0009798 43 0.026
single organism reproductive process GO:0044702 40 0.026
organelle fusion GO:0048284 3 0.026
positive regulation of nucleotide catabolic process GO:0030813 1 0.026
oocyte anterior posterior axis specification GO:0007314 4 0.026
action potential GO:0001508 19 0.026
regulation of transmembrane transport GO:0034762 18 0.026
transcription from rna polymerase ii promoter GO:0006366 80 0.025
Mouse
regulation of neurotransmitter secretion GO:0046928 1 0.025
actin filament based movement GO:0030048 1 0.025
calcium ion dependent exocytosis GO:0017156 1 0.025
sympathetic nervous system development GO:0048485 3 0.025
proximal distal pattern formation GO:0009954 1 0.025
regulation of binding GO:0051098 3 0.025
Mouse
regulation of cell projection assembly GO:0060491 4 0.025
energy reserve metabolic process GO:0006112 2 0.025
cellular component biogenesis GO:0044085 178 0.025
Mouse
peptidyl tyrosine modification GO:0018212 5 0.025
Mouse
positive regulation of biosynthetic process GO:0009891 68 0.024
positive regulation of cell proliferation GO:0008284 15 0.024
mitotic cell cycle embryonic GO:0045448 2 0.024
carbohydrate biosynthetic process GO:0016051 1 0.024
protein kinase b signaling GO:0043491 9 0.024
inorganic ion transmembrane transport GO:0098660 57 0.024
Human
tissue regeneration GO:0042246 74 0.024
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.024
pigmentation GO:0043473 85 0.024
regulation of striated muscle contraction GO:0006942 2 0.024
post embryonic organ morphogenesis GO:0048563 1 0.023
Worm
positive regulation of cellular metabolic process GO:0031325 94 0.023
Mouse
divalent inorganic cation transport GO:0072511 21 0.023
Human
nucleotide metabolic process GO:0009117 28 0.023
regulation of signal transduction by p53 class mediator GO:1901796 9 0.023
synaptic vesicle localization GO:0097479 1 0.023
Mouse
cellular response to starvation GO:0009267 1 0.023
Mouse
positive regulation of chromatin modification GO:1903310 1 0.023
segment polarity determination GO:0007367 1 0.023
positive regulation of phosphorus metabolic process GO:0010562 21 0.023
Mouse
inorganic cation transmembrane transport GO:0098662 50 0.023
Human
rho protein signal transduction GO:0007266 5 0.023
establishment or maintenance of bipolar cell polarity GO:0061245 12 0.023
morphogenesis of an epithelial fold GO:0060571 1 0.023
response to light stimulus GO:0009416 46 0.022
morphogenesis of follicular epithelium GO:0016333 1 0.022
regulation of cellular protein catabolic process GO:1903362 1 0.022
Mouse
mechanosensory behavior GO:0007638 2 0.022
reciprocal dna recombination GO:0035825 1 0.022
regulation of synaptic plasticity GO:0048167 1 0.022
Mouse
regulation of mitochondrion organization GO:0010821 1 0.022
regulation of calcium ion transport GO:0051924 2 0.022
muscle tissue development GO:0060537 110 0.022
mechanosensory lateral line system development GO:0048881 49 0.022
regulation of carbohydrate biosynthetic process GO:0043255 1 0.022
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.022
forebrain development GO:0030900 96 0.022
Mouse
positive regulation of gtp catabolic process GO:0033126 1 0.022
osteoclast differentiation GO:0030316 1 0.022
regulation of protein import into nucleus GO:0042306 2 0.022
regulation of neural precursor cell proliferation GO:2000177 3 0.022
regulation of mrna processing GO:0050684 3 0.022
establishment of protein localization to plasma membrane GO:0090002 1 0.022
localization of cell GO:0051674 244 0.021
Mouse
negative regulation of protein transport GO:0051224 3 0.021
specification of axis polarity GO:0065001 4 0.021
single organism biosynthetic process GO:0044711 71 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.021
Mouse
cell maturation GO:0048469 23 0.021
regulation of cell proliferation GO:0042127 37 0.021
cellular component assembly GO:0022607 170 0.021
Mouse

psen1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.061
disease of cellular proliferation DOID:14566 0 0.061
organ system cancer DOID:0050686 0 0.061
gastrointestinal system cancer DOID:3119 0 0.045
disease of anatomical entity DOID:7 0 0.028
Human
nervous system disease DOID:863 0 0.027
Human