Danio rerio

77 known processes

LOC100332039

ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like

LOC100332039 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
vasculature development GO:0001944 278 0.338
rna biosynthetic process GO:0032774 181 0.329
central nervous system development GO:0007417 387 0.290
blood vessel morphogenesis GO:0048514 216 0.251
organic cyclic compound biosynthetic process GO:1901362 223 0.239
lymphangiogenesis GO:0001946 25 0.226
positive regulation of biological process GO:0048518 253 0.207
regulation of multicellular organismal development GO:2000026 223 0.166
regulation of transcription dna templated GO:0006355 213 0.163
regulation of myotube differentiation GO:0010830 2 0.156
regulation of developmental process GO:0050793 247 0.155
biosynthetic process GO:0009058 294 0.130
heterocycle biosynthetic process GO:0018130 215 0.127
angiogenesis GO:0001525 158 0.121
regulation of synapse organization GO:0050807 3 0.116
cognition GO:0050890 1 0.108
immune system process GO:0002376 241 0.105
regulation of synapse assembly GO:0051963 3 0.103
regulation of skeletal muscle fiber development GO:0048742 2 0.101
organic substance biosynthetic process GO:1901576 289 0.101
blood vessel development GO:0001568 246 0.099
myotube differentiation GO:0014902 45 0.098
regulation of nucleic acid templated transcription GO:1903506 213 0.097
negative regulation of biological process GO:0048519 304 0.091
gene expression GO:0010467 252 0.087
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.084
generation of neurons GO:0048699 385 0.084
synaptic growth at neuromuscular junction GO:0051124 2 0.084
regulation of biosynthetic process GO:0009889 250 0.081
cellular component assembly GO:0022607 170 0.079
cellular macromolecule metabolic process GO:0044260 391 0.078
positive regulation of cellular component biogenesis GO:0044089 3 0.077
cellular component movement GO:0006928 335 0.072
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.071
larval development GO:0002164 2 0.068
nephron tubule morphogenesis GO:0072078 1 0.067
cell surface receptor signaling pathway GO:0007166 325 0.065
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.064
regulation of response to stimulus GO:0048583 269 0.064
response to external stimulus GO:0009605 264 0.064
cellular nitrogen compound biosynthetic process GO:0044271 218 0.063
single organism organelle organization GO:1902589 199 0.061
regulation of rna metabolic process GO:0051252 224 0.061
muscle structure development GO:0061061 196 0.061
developmental growth GO:0048589 166 0.060
regulation of skeletal muscle tissue development GO:0048641 4 0.060
transcription dna templated GO:0006351 181 0.058
nucleobase containing compound biosynthetic process GO:0034654 205 0.057
gastrulation GO:0007369 208 0.055
nitrogen compound metabolic process GO:0006807 319 0.054
positive regulation of synapse assembly GO:0051965 1 0.053
aromatic compound biosynthetic process GO:0019438 217 0.052
rna metabolic process GO:0016070 219 0.052
transcription from rna polymerase ii promoter GO:0006366 80 0.051
nucleic acid templated transcription GO:0097659 181 0.051
macromolecule biosynthetic process GO:0009059 227 0.050
regulation of lymphangiogenesis GO:1901490 4 0.050
regulation of receptor activity GO:0010469 2 0.048
muscle cell differentiation GO:0042692 139 0.048
regulation of anatomical structure morphogenesis GO:0022603 130 0.046
embryonic pattern specification GO:0009880 44 0.045
muscle fiber development GO:0048747 52 0.045
cellular nitrogen compound metabolic process GO:0034641 290 0.045
response to other organism GO:0051707 97 0.045
establishment of synaptic vesicle localization GO:0097480 1 0.044
cellular biosynthetic process GO:0044249 286 0.044
histone methylation GO:0016571 13 0.044
regulation of apoptotic process GO:0042981 98 0.043
maternal determination of anterior posterior axis embryo GO:0008358 4 0.043
regulation of cellular metabolic process GO:0031323 320 0.043
growth GO:0040007 174 0.042
response to biotic stimulus GO:0009607 97 0.042
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.042
cellular protein catabolic process GO:0044257 4 0.041
multicellular organism growth GO:0035264 4 0.041
striated muscle cell differentiation GO:0051146 129 0.041
response to bacterium GO:0009617 58 0.041
regulation of protein transport GO:0051223 3 0.040
anterior posterior pattern specification GO:0009952 152 0.040
myotube cell development GO:0014904 35 0.039
sensory organ morphogenesis GO:0090596 200 0.039
regulation of cellular biosynthetic process GO:0031326 245 0.038
regulation of epithelial cell proliferation GO:0050678 3 0.038
germ line stem cell maintenance GO:0030718 2 0.037
negative regulation of gene expression GO:0010629 65 0.037
regulation of cell development GO:0060284 100 0.037
morphogenesis of an epithelium GO:0002009 333 0.036
macromolecular complex subunit organization GO:0043933 74 0.036
head development GO:0060322 303 0.036
lymph vessel development GO:0001945 27 0.036
positive regulation of cellular process GO:0048522 201 0.036
regulation of protein binding GO:0043393 3 0.036
mesenchyme development GO:0060485 127 0.035
positive regulation of transport GO:0051050 2 0.035
immune system development GO:0002520 191 0.035
aging GO:0007568 2 0.034
cellular component biogenesis GO:0044085 178 0.034
glomerulus development GO:0032835 27 0.034
negative regulation of macromolecule metabolic process GO:0010605 76 0.034
striated muscle tissue development GO:0014706 110 0.033
muscle cell development GO:0055001 115 0.033
regulation of axonogenesis GO:0050770 32 0.033
synaptic vesicle transport GO:0048489 1 0.033
positive regulation of cell cycle GO:0045787 3 0.033
regulation of cell differentiation GO:0045595 142 0.032
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.032
hepaticobiliary system development GO:0061008 98 0.032
cellular macromolecule biosynthetic process GO:0034645 224 0.031
regulation of gene expression epigenetic GO:0040029 11 0.031
multi organism process GO:0051704 134 0.031
positive regulation of muscle organ development GO:0048636 1 0.031
bmp signaling pathway GO:0030509 52 0.031
tissue remodeling GO:0048771 4 0.030
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.030
cell motility GO:0048870 244 0.030
tube morphogenesis GO:0035239 349 0.030
cellular protein metabolic process GO:0044267 129 0.030
regulation of macromolecule metabolic process GO:0060255 317 0.030
regulation of multicellular organism growth GO:0040014 4 0.029
cell projection morphogenesis GO:0048858 244 0.029
stem cell maintenance GO:0019827 4 0.029
heterocycle metabolic process GO:0046483 290 0.029
response to fluid shear stress GO:0034405 2 0.029
muscle tissue development GO:0060537 110 0.029
forebrain cell migration GO:0021885 1 0.029
organic cyclic compound metabolic process GO:1901360 301 0.029
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.028
patterning of blood vessels GO:0001569 15 0.028
neurological system process GO:0050877 62 0.028
behavior GO:0007610 74 0.028
i kappab kinase nf kappab signaling GO:0007249 4 0.028
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.028
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.028
multicellular organismal metabolic process GO:0044236 2 0.028
inner ear development GO:0048839 126 0.028
cell projection organization GO:0030030 284 0.028
chordate embryonic development GO:0043009 271 0.027
regulation of glial cell differentiation GO:0045685 4 0.027
regulation of oligodendrocyte differentiation GO:0048713 1 0.027
digestive tract development GO:0048565 265 0.027
response to growth factor GO:0070848 39 0.027
cell cycle GO:0007049 93 0.026
actin filament based movement GO:0030048 1 0.026
aorta development GO:0035904 4 0.026
regulation of protein ubiquitination GO:0031396 3 0.026
regulation of bone mineralization GO:0030500 2 0.026
nephron epithelium development GO:0072009 16 0.026
skeletal system development GO:0001501 181 0.026
striated muscle cell development GO:0055002 108 0.025
cell substrate adhesion GO:0031589 4 0.025
regulation of metabolic process GO:0019222 359 0.025
synaptic vesicle localization GO:0097479 1 0.025
axonal defasciculation GO:0007414 2 0.025
cellular localization GO:0051641 97 0.025
nephron development GO:0072006 31 0.025
liver development GO:0001889 96 0.024
dorsal ventral pattern formation GO:0009953 125 0.024
regulation of gene expression GO:0010468 265 0.024
nucleic acid metabolic process GO:0090304 244 0.024
renal tubule morphogenesis GO:0061333 1 0.024
organelle organization GO:0006996 227 0.024
cartilage development GO:0051216 96 0.024
localization of cell GO:0051674 244 0.024
regulation of cell communication GO:0010646 232 0.023
positive regulation of epithelial cell differentiation GO:0030858 2 0.023
ubiquitin dependent protein catabolic process GO:0006511 3 0.023
protein metabolic process GO:0019538 183 0.023
convergent extension GO:0060026 118 0.023
collagen metabolic process GO:0032963 2 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.023
regionalization GO:0003002 274 0.023
oligodendrocyte differentiation GO:0048709 23 0.022
nephron epithelium morphogenesis GO:0072088 1 0.022
cell matrix adhesion GO:0007160 4 0.022
regulation of cellular response to growth factor stimulus GO:0090287 35 0.022
positive regulation of developmental process GO:0051094 50 0.022
regulation of calcium dependent cell cell adhesion GO:0046586 1 0.022
regulation of dendrite development GO:0050773 3 0.022
digestive system development GO:0055123 289 0.021
compound eye development GO:0048749 2 0.021
glycoprotein biosynthetic process GO:0009101 21 0.021
mononuclear cell proliferation GO:0032943 1 0.021
enzyme linked receptor protein signaling pathway GO:0007167 106 0.021
response to mechanical stimulus GO:0009612 24 0.021
mitotic cell cycle embryonic GO:0045448 2 0.021
neuron differentiation GO:0030182 353 0.021
regulation of protein targeting GO:1903533 2 0.021
segmentation GO:0035282 97 0.020
protein modification process GO:0036211 100 0.020
notch signaling pathway GO:0007219 35 0.020
glycoprotein metabolic process GO:0009100 23 0.020
phagocytosis GO:0006909 3 0.020
sensory organ development GO:0007423 393 0.020
branching morphogenesis of an epithelial tube GO:0048754 15 0.020
determination of heart left right asymmetry GO:0061371 117 0.020
organism emergence from protective structure GO:0071684 4 0.020
regulation of dna templated transcription elongation GO:0032784 3 0.020
central nervous system formation GO:0021556 1 0.020
negative regulation of multicellular organismal process GO:0051241 69 0.020
lateral inhibition GO:0046331 1 0.020
regulation of binding GO:0051098 3 0.020
regulation of vasculature development GO:1901342 33 0.020
response to external biotic stimulus GO:0043207 97 0.020
hemopoiesis GO:0030097 183 0.020
epithelial cell morphogenesis GO:0003382 2 0.020
single organism transport GO:0044765 206 0.019
epithelial cell differentiation GO:0030855 116 0.019
embryonic organ development GO:0048568 381 0.019
signal transduction GO:0007165 455 0.019
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.019
response to decreased oxygen levels GO:0036293 25 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
protein localization to nucleus GO:0034504 3 0.018
negative regulation of developmental process GO:0051093 65 0.018
cell morphogenesis involved in differentiation GO:0000904 195 0.018
adult behavior GO:0030534 2 0.018
regulation of neuron differentiation GO:0045664 56 0.018
odontogenesis of dentin containing tooth GO:0042475 1 0.018
cell adhesion GO:0007155 40 0.018
skeletal muscle tissue development GO:0007519 67 0.018
cell morphogenesis GO:0000902 289 0.018
transmembrane transport GO:0055085 120 0.018
regulation of primary metabolic process GO:0080090 311 0.018
positive regulation of multicellular organismal process GO:0051240 52 0.018
defense response to other organism GO:0098542 33 0.017
negative regulation of angiogenesis GO:0016525 7 0.017
macromolecule modification GO:0043412 111 0.017
organelle localization GO:0051640 49 0.017
regulation of cellular component organization GO:0051128 86 0.017
carbohydrate derivative biosynthetic process GO:1901137 43 0.017
nephron morphogenesis GO:0072028 2 0.017
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.017
positive regulation of muscle cell differentiation GO:0051149 1 0.017
negative regulation of cellular metabolic process GO:0031324 77 0.017
regulation of ion transmembrane transporter activity GO:0032412 2 0.017
reactive oxygen species biosynthetic process GO:1903409 1 0.017
regulation of growth GO:0040008 42 0.017
regulation of synaptic plasticity GO:0048167 1 0.017
sprouting angiogenesis GO:0002040 53 0.017
negative regulation of calcium dependent cell cell adhesion GO:0046588 1 0.017
fin development GO:0033333 77 0.016
determination of bilateral symmetry GO:0009855 204 0.016
regulation of protein localization to nucleus GO:1900180 2 0.016
regulation of organelle organization GO:0033043 29 0.016
defense response to bacterium GO:0042742 22 0.016
negative regulation of metabolic process GO:0009892 86 0.016
establishment of organelle localization GO:0051656 45 0.016
regulation of organelle assembly GO:1902115 4 0.016
appendage development GO:0048736 80 0.016
brain development GO:0007420 293 0.016
calcium ion dependent exocytosis GO:0017156 1 0.016
intracellular signal transduction GO:0035556 85 0.016
positive regulation of neural precursor cell proliferation GO:2000179 1 0.016
regulation of cardiac muscle tissue development GO:0055024 1 0.016
positive regulation of cell activation GO:0050867 1 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
positive regulation of glial cell differentiation GO:0045687 1 0.015
locomotion GO:0040011 313 0.015
connective tissue development GO:0061448 99 0.015
negative regulation of programmed cell death GO:0043069 58 0.015
cellular component morphogenesis GO:0032989 336 0.015
kidney vasculature development GO:0061440 2 0.015
neuroblast differentiation GO:0014016 1 0.015
regulation of organ growth GO:0046620 3 0.015
direct ossification GO:0036072 3 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
b cell activation GO:0042113 2 0.015
regulation of protein catabolic process GO:0042176 1 0.015
positive regulation of transcription dna templated GO:0045893 57 0.015
regulation of metal ion transport GO:0010959 4 0.015
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 8 0.015
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.015
regulation of mesenchymal cell proliferation GO:0010464 1 0.015
mitotic cell cycle process GO:1903047 48 0.015
fin morphogenesis GO:0033334 53 0.015
neuron neuron synaptic transmission GO:0007270 1 0.015
protein acetylation GO:0006473 2 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
taxis GO:0042330 109 0.014
morphogenesis of a branching epithelium GO:0061138 16 0.014
cell cell adhesion GO:0098609 6 0.014
regulation of cytokine production GO:0001817 3 0.014
positive regulation of secretion GO:0051047 1 0.014
regulation of cell death GO:0010941 103 0.014
neuromuscular synaptic transmission GO:0007274 2 0.014
mitotic cell cycle GO:0000278 64 0.014
negative regulation of epithelial cell proliferation GO:0050680 1 0.014
nucleocytoplasmic transport GO:0006913 4 0.014
spermatid development GO:0007286 2 0.014
meiotic chromosome segregation GO:0045132 3 0.014
single organism localization GO:1902578 225 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
response to antibiotic GO:0046677 1 0.014
regulation of muscle tissue development GO:1901861 6 0.014
synaptic vesicle recycling GO:0036465 1 0.014
nucleobase containing compound metabolic process GO:0006139 274 0.014
lymphocyte proliferation GO:0046651 1 0.014
neuroblast proliferation GO:0007405 2 0.013
meiotic cell cycle process GO:1903046 3 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
smooth muscle tissue development GO:0048745 1 0.013
negative regulation of cell death GO:0060548 60 0.013
eye development GO:0001654 277 0.013
neuron development GO:0048666 262 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
microtubule based process GO:0007017 60 0.013
axon guidance GO:0007411 86 0.013
response to chemical GO:0042221 320 0.013
cilium assembly GO:0042384 58 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.013
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.013
positive regulation of gastrulation GO:2000543 2 0.013
skeletal muscle fiber development GO:0048741 35 0.013
foregut morphogenesis GO:0007440 4 0.013
regulation of tube size GO:0035150 2 0.013
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.013
hatching GO:0035188 4 0.013
regulation of cell activation GO:0050865 1 0.013
defense response to gram negative bacterium GO:0050829 8 0.013
intramembranous ossification GO:0001957 3 0.013
chromosome organization GO:0051276 31 0.013
negative regulation of striated muscle cell differentiation GO:0051154 1 0.012
regulation of histone methylation GO:0031060 3 0.012
multicellular organismal macromolecule metabolic process GO:0044259 2 0.012
renal system development GO:0072001 94 0.012
phagocytosis engulfment GO:0006911 1 0.012
negative regulation of cellular process GO:0048523 283 0.012
defense response to fungus GO:0050832 2 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
regulation of multicellular organismal process GO:0051239 277 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
single organism metabolic process GO:0044710 217 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
gland development GO:0048732 143 0.012
negative regulation of chemotaxis GO:0050922 4 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.012
positive regulation of neutrophil migration GO:1902624 0 0.012
regulation of erythrocyte differentiation GO:0045646 2 0.012
cellular response to endogenous stimulus GO:0071495 68 0.012
protein complex localization GO:0031503 1 0.012
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.012
sexual reproduction GO:0019953 36 0.012
locomotor rhythm GO:0045475 3 0.012
regulation of striated muscle tissue development GO:0016202 6 0.012
negative regulation of signal transduction GO:0009968 94 0.012
collagen fibril organization GO:0030199 1 0.012
modification dependent macromolecule catabolic process GO:0043632 3 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
response to alkaloid GO:0043279 2 0.012
regulation of cell shape GO:0008360 1 0.012
regulation of muscle contraction GO:0006937 3 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
endodermal cell fate determination GO:0007493 2 0.012
venous blood vessel morphogenesis GO:0048845 3 0.012
embryo development ending in birth or egg hatching GO:0009792 271 0.012
circulatory system process GO:0003013 87 0.012
positive regulation of cell division GO:0051781 2 0.012
neuron migration GO:0001764 22 0.012
regulation of rna biosynthetic process GO:2001141 213 0.011
meiosis ii GO:0007135 1 0.011
protein homooligomerization GO:0051260 3 0.011
transport GO:0006810 220 0.011
positive regulation of catabolic process GO:0009896 4 0.011
regulation of blood vessel size GO:0050880 2 0.011
morphogenesis of follicular epithelium GO:0016333 1 0.011
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.011
heart valve formation GO:0003188 4 0.011
negative regulation of apoptotic process GO:0043066 55 0.011
negative regulation of muscle tissue development GO:1901862 2 0.011
cardiac atrium development GO:0003230 4 0.011
response to abiotic stimulus GO:0009628 122 0.011
heart jogging GO:0003146 40 0.011
glomerulus vasculature development GO:0072012 2 0.011
histone modification GO:0016570 20 0.011
skeletal muscle organ development GO:0060538 78 0.011
regulation of signal transduction GO:0009966 225 0.011
system process GO:0003008 185 0.011
regulation of endothelial cell proliferation GO:0001936 1 0.011
renal system vasculature morphogenesis GO:0061438 1 0.011
biological adhesion GO:0022610 40 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.011
regulation of organ morphogenesis GO:2000027 35 0.011
regulation of developmental growth GO:0048638 38 0.011
regulation of signaling GO:0023051 235 0.011
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.011
blood circulation GO:0008015 87 0.011
regulation of cellular component movement GO:0051270 55 0.011
renal system vasculature development GO:0061437 2 0.011
actin mediated cell contraction GO:0070252 1 0.011
bone morphogenesis GO:0060349 11 0.011
forebrain development GO:0030900 96 0.011
cellular response to growth factor stimulus GO:0071363 39 0.011
eye morphogenesis GO:0048592 144 0.011
dna templated transcription elongation GO:0006354 3 0.011
positive regulation of immune system process GO:0002684 17 0.011
locomotory behavior GO:0007626 34 0.011
determination of left right asymmetry in nervous system GO:0035545 4 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
neural retina development GO:0003407 49 0.011
programmed cell death GO:0012501 119 0.011
modification dependent protein catabolic process GO:0019941 3 0.010
positive regulation of nervous system development GO:0051962 25 0.010
neuroblast fate commitment GO:0014017 1 0.010
regulation of neurogenesis GO:0050767 87 0.010
cell part morphogenesis GO:0032990 246 0.010
cellular response to organic substance GO:0071310 105 0.010
negative regulation of tor signaling GO:0032007 2 0.010
regulation of actin cytoskeleton organization GO:0032956 8 0.010
negative regulation of immune response GO:0050777 2 0.010
negative regulation of transcription dna templated GO:0045892 45 0.010
regulation of membrane potential GO:0042391 23 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
endothelial cell proliferation GO:0001935 11 0.010
reproductive process GO:0022414 40 0.010
digestive tract morphogenesis GO:0048546 231 0.010
negative chemotaxis GO:0050919 1 0.010
axis specification GO:0009798 43 0.010
somitogenesis GO:0001756 87 0.010
secondary metabolic process GO:0019748 3 0.010
protein import GO:0017038 3 0.010

LOC100332039 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.058
nervous system disease DOID:863 0 0.054
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010