Danio rerio

79 known processes

smn1

survival motor neuron 1

(Aliases: smn,wu:fa12d01,fa12d01)

smn1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
gene expression GO:0010467 252 0.314
cellular nitrogen compound metabolic process GO:0034641 290 0.294
cellular aromatic compound metabolic process GO:0006725 295 0.285
larval development GO:0002164 2 0.262
Worm
nucleic acid templated transcription GO:0097659 181 0.214
regulation of gene expression GO:0010468 265 0.210
rna metabolic process GO:0016070 219 0.203
nucleic acid metabolic process GO:0090304 244 0.191
regulation of metabolic process GO:0019222 359 0.158
regulation of primary metabolic process GO:0080090 311 0.156
negative regulation of gene expression GO:0010629 65 0.141
negative regulation of biological process GO:0048519 304 0.140
Worm
nucleobase containing compound metabolic process GO:0006139 274 0.136
organic substance biosynthetic process GO:1901576 289 0.134
cellular macromolecule biosynthetic process GO:0034645 224 0.130
cellular macromolecule metabolic process GO:0044260 391 0.122
biosynthetic process GO:0009058 294 0.112
nitrogen compound metabolic process GO:0006807 319 0.097
regulation of transcription dna templated GO:0006355 213 0.091
regulation of nitrogen compound metabolic process GO:0051171 251 0.088
heterocycle metabolic process GO:0046483 290 0.086
cellular biosynthetic process GO:0044249 286 0.084
nuclear export GO:0051168 1 0.082
establishment of localization GO:0051234 244 0.082
nucleocytoplasmic transport GO:0006913 4 0.080
single organism transport GO:0044765 206 0.077
regulation of biosynthetic process GO:0009889 250 0.075
regulation of cellular metabolic process GO:0031323 320 0.073
establishment of localization in cell GO:0051649 77 0.073
regulation of rna metabolic process GO:0051252 224 0.071
apoptotic process GO:0006915 116 0.071
organic cyclic compound biosynthetic process GO:1901362 223 0.069
rna localization GO:0006403 4 0.068
locomotion GO:0040011 313 0.065
transport GO:0006810 220 0.062
modification dependent macromolecule catabolic process GO:0043632 3 0.060
rna biosynthetic process GO:0032774 181 0.060
nuclear transport GO:0051169 4 0.059
nuclear import GO:0051170 3 0.057
nucleobase containing compound biosynthetic process GO:0034654 205 0.057
protein localization to nucleus GO:0034504 3 0.056
regulation of macromolecule metabolic process GO:0060255 317 0.054
embryo development ending in birth or egg hatching GO:0009792 271 0.053
Worm
programmed cell death GO:0012501 119 0.051
cellular response to nutrient levels GO:0031669 2 0.051
cell death GO:0008219 121 0.050
cellular protein catabolic process GO:0044257 4 0.050
aromatic compound biosynthetic process GO:0019438 217 0.047
regulation of nucleic acid templated transcription GO:1903506 213 0.047
single organism metabolic process GO:0044710 217 0.047
organelle organization GO:0006996 227 0.045
Mouse Worm
multicellular organism growth GO:0035264 4 0.045
cellular response to starvation GO:0009267 1 0.044
cellular nitrogen compound biosynthetic process GO:0044271 218 0.044
protein targeting to nucleus GO:0044744 3 0.043
cell projection morphogenesis GO:0048858 244 0.043
organic cyclic compound metabolic process GO:1901360 301 0.041
transcription dna templated GO:0006351 181 0.041
establishment of protein localization to organelle GO:0072594 4 0.041
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.040
negative regulation of nucleic acid templated transcription GO:1903507 45 0.040
positive regulation of metabolic process GO:0009893 108 0.039
single organism organelle organization GO:1902589 199 0.038
Mouse Worm
negative regulation of intracellular transport GO:0032387 3 0.037
cellular protein modification process GO:0006464 100 0.037
developmental cell growth GO:0048588 52 0.037
developmental growth GO:0048589 166 0.037
sensory organ development GO:0007423 393 0.036
spliceosomal snrnp assembly GO:0000387 2 0.035
macromolecule modification GO:0043412 111 0.035
central nervous system development GO:0007417 387 0.035
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.034
Worm
response to alkaloid GO:0043279 2 0.034
regulation of establishment of protein localization GO:0070201 4 0.033
axonogenesis GO:0007409 152 0.033
response to drug GO:0042493 3 0.032
negative regulation of macromolecule metabolic process GO:0010605 76 0.031
death GO:0016265 121 0.031
chromatin modification GO:0016568 21 0.031
cellular response to extracellular stimulus GO:0031668 2 0.031
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.031
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.030
regulation of protein ubiquitination GO:0031396 3 0.030
protein import GO:0017038 3 0.030
cell morphogenesis involved in differentiation GO:0000904 195 0.030
aging GO:0007568 2 0.030
Worm
protein metabolic process GO:0019538 183 0.029
chromosome organization GO:0051276 31 0.029
single organism localization GO:1902578 225 0.029
neuron projection development GO:0031175 180 0.029
rna splicing GO:0008380 16 0.028
regulation of rna biosynthetic process GO:2001141 213 0.028
heterocycle biosynthetic process GO:0018130 215 0.027
dicarboxylic acid transport GO:0006835 1 0.027
protein import into nucleus GO:0006606 3 0.026
blood vessel development GO:0001568 246 0.026
regulation of multicellular organismal process GO:0051239 277 0.025
regulation of protein transport GO:0051223 3 0.025
regulation of nucleocytoplasmic transport GO:0046822 2 0.025
embryonic heart tube morphogenesis GO:0003143 108 0.025
single organism nuclear import GO:1902593 3 0.024
regulation of histone methylation GO:0031060 3 0.024
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
rna 3 end processing GO:0031123 2 0.024
adult behavior GO:0030534 2 0.024
regulation of cellular biosynthetic process GO:0031326 245 0.024
response to stress GO:0006950 263 0.023
negative regulation of rna biosynthetic process GO:1902679 45 0.023
positive regulation of chromatin modification GO:1903310 1 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.023
cellular response to external stimulus GO:0071496 2 0.023
negative regulation of transcription dna templated GO:0045892 45 0.023
viral process GO:0016032 1 0.022
growth GO:0040007 174 0.022
regulation of protein localization to nucleus GO:1900180 2 0.022
positive regulation of cellular amine metabolic process GO:0033240 0 0.021
protein modification process GO:0036211 100 0.021
regulation of intracellular protein transport GO:0033157 3 0.021
mrna processing GO:0006397 14 0.021
gtp metabolic process GO:0046039 4 0.020
rrna catabolic process GO:0016075 1 0.020
positive regulation of biological process GO:0048518 253 0.020
Worm
i kappab kinase nf kappab signaling GO:0007249 4 0.020
chromatin organization GO:0006325 22 0.019
cytoplasm organization GO:0007028 4 0.019
cell part morphogenesis GO:0032990 246 0.019
retina development in camera type eye GO:0060041 146 0.019
neuron projection extension GO:1990138 45 0.019
eye development GO:0001654 277 0.019
regulation of macromolecule biosynthetic process GO:0010556 225 0.019
lateral inhibition GO:0046331 1 0.019
histone demethylation GO:0016577 2 0.019
gland development GO:0048732 143 0.018
oocyte anterior posterior axis specification GO:0007314 4 0.018
gtp catabolic process GO:0006184 2 0.018
positive regulation of histone modification GO:0031058 1 0.018
positive regulation of transport GO:0051050 2 0.018
rna export from nucleus GO:0006405 1 0.018
maintenance of location GO:0051235 4 0.018
negative regulation of cytoplasmic transport GO:1903650 2 0.018
ubiquitin dependent protein catabolic process GO:0006511 3 0.018
cellular component morphogenesis GO:0032989 336 0.018
cell projection organization GO:0030030 284 0.017
negative regulation of rna metabolic process GO:0051253 48 0.017
transcription from rna polymerase ii promoter GO:0006366 80 0.017
keratinocyte differentiation GO:0030216 0 0.017
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 10 0.017
organism emergence from protective structure GO:0071684 4 0.017
meiotic chromosome segregation GO:0045132 3 0.017
regulation of gene expression epigenetic GO:0040029 11 0.017
positive regulation of epithelial cell proliferation GO:0050679 1 0.017
intracellular transport GO:0046907 32 0.017
regulation of cytoplasmic transport GO:1903649 4 0.017
dna templated transcription elongation GO:0006354 3 0.017
mrna splicing via spliceosome GO:0000398 10 0.017
cellular amine metabolic process GO:0044106 2 0.016
macromolecule biosynthetic process GO:0009059 227 0.016
neuron projection morphogenesis GO:0048812 161 0.016
regulation of protein import into nucleus GO:0042306 2 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.016
positive regulation of catabolic process GO:0009896 4 0.016
regulation of multicellular organism growth GO:0040014 4 0.016
nucleoside monophosphate catabolic process GO:0009125 4 0.016
protein secretion GO:0009306 1 0.016
interspecies interaction between organisms GO:0044419 4 0.016
response to corticosteroid GO:0031960 1 0.016
negative regulation of biosynthetic process GO:0009890 55 0.015
meiotic nuclear division GO:0007126 4 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
negative regulation of cellular process GO:0048523 283 0.015
Worm
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
regulation of heart growth GO:0060420 2 0.014
intracellular mrna localization GO:0008298 1 0.014
positive regulation of chromosome organization GO:2001252 1 0.014
sensory perception of chemical stimulus GO:0007606 3 0.014
regulation of developmental process GO:0050793 247 0.014
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.014
cell growth GO:0016049 57 0.014
signal transduction by p53 class mediator GO:0072331 13 0.014
response to abiotic stimulus GO:0009628 122 0.014
negative regulation of metabolic process GO:0009892 86 0.014
positive regulation of cellular catabolic process GO:0031331 3 0.014
positive regulation of muscle tissue development GO:1901863 1 0.014
negative regulation of protein transport GO:0051224 3 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.014
negative regulation of signal transduction by p53 class mediator GO:1901797 8 0.014
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.014
translational initiation GO:0006413 3 0.014
nucleic acid transport GO:0050657 2 0.014
neuron neuron synaptic transmission GO:0007270 1 0.014
regulation of reproductive process GO:2000241 4 0.013
maternal determination of anterior posterior axis embryo GO:0008358 4 0.013
organelle localization GO:0051640 49 0.013
cellular component biogenesis GO:0044085 178 0.013
Worm
cellular amino acid metabolic process GO:0006520 7 0.013
regulation of meiotic cell cycle GO:0051445 1 0.013
Worm
muscle structure development GO:0061061 196 0.013
Worm
female gonad development GO:0008585 4 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
macromolecule localization GO:0033036 54 0.013
autophagy GO:0006914 4 0.013
single organism cellular localization GO:1902580 46 0.013
muscle organ development GO:0007517 101 0.013
mitochondrion organization GO:0007005 4 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
multi organism cellular process GO:0044764 2 0.013
response to monosaccharide GO:0034284 3 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.012
atp catabolic process GO:0006200 4 0.012
pigment granule localization GO:0051875 25 0.012
proteasomal protein catabolic process GO:0010498 2 0.012
cellular response to biotic stimulus GO:0071216 3 0.012
anterior posterior pattern specification GO:0009952 152 0.012
histone lysine demethylation GO:0070076 2 0.012
histone lysine methylation GO:0034968 12 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.012
digestive tract development GO:0048565 265 0.012
generation of neurons GO:0048699 385 0.012
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 2 0.012
rna transport GO:0050658 2 0.012
protein polyubiquitination GO:0000209 4 0.012
signal transduction GO:0007165 455 0.011
regulation of epithelial cell proliferation GO:0050678 3 0.011
organic acid metabolic process GO:0006082 31 0.011
regulation of protein catabolic process GO:0042176 1 0.011
regulation of protein targeting GO:1903533 2 0.011
cellular protein metabolic process GO:0044267 129 0.011
positive regulation of cellular metabolic process GO:0031325 94 0.011
regulation of epithelial to mesenchymal transition GO:0010717 3 0.011
gamete generation GO:0007276 33 0.011
Worm
neuron development GO:0048666 262 0.011
pole plasm assembly GO:0007315 4 0.011
organonitrogen compound metabolic process GO:1901564 74 0.011
regulation of gtpase activity GO:0043087 2 0.011
guanosine containing compound catabolic process GO:1901069 2 0.011
response to glucocorticoid GO:0051384 1 0.011
synaptic growth at neuromuscular junction GO:0051124 2 0.011
leukocyte homeostasis GO:0001776 2 0.011
organic substance transport GO:0071702 58 0.011
regionalization GO:0003002 274 0.011
alpha amino acid metabolic process GO:1901605 3 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
epithelial cell differentiation GO:0030855 116 0.011
heart looping GO:0001947 94 0.011
macroautophagy GO:0016236 1 0.011
mrna transport GO:0051028 2 0.011
stem cell proliferation GO:0072089 4 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
neuron projection guidance GO:0097485 86 0.010
cellular component disassembly GO:0022411 1 0.010
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.010
modification dependent protein catabolic process GO:0019941 3 0.010
regulation of cell differentiation GO:0045595 142 0.010
hematopoietic or lymphoid organ development GO:0048534 191 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.010
vasculature development GO:0001944 278 0.010

smn1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.025
myopathy DOID:423 0 0.015
muscular disease DOID:0080000 0 0.015
heart disease DOID:114 0 0.015
cardiomyopathy DOID:0050700 0 0.015
disease of anatomical entity DOID:7 0 0.015
intrinsic cardiomyopathy DOID:0060036 0 0.015
cardiovascular system disease DOID:1287 0 0.015
musculoskeletal system disease DOID:17 0 0.015
muscle tissue disease DOID:66 0 0.015
nervous system disease DOID:863 0 0.012