|
|
regulation of cyclase activity
|
GO:0031279 |
12 |
0.678
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
216 |
0.676
|
|
|
|
blood vessel development
|
GO:0001568 |
246 |
0.649
|
|
|
|
positive regulation of blood circulation
|
GO:1903524 |
2 |
0.590
|
|
|
|
vasculature development
|
GO:0001944 |
278 |
0.572
|
|
|
|
smooth muscle contraction
|
GO:0006939 |
2 |
0.542
|
Rat |
|
|
aging
|
GO:0007568 |
2 |
0.418
|
|
|
|
cell migration
|
GO:0016477 |
237 |
0.413
|
|
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
5 |
0.407
|
Zebrafish Mouse |
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
21 |
0.395
|
Zebrafish |
|
|
signal transduction
|
GO:0007165 |
455 |
0.380
|
Zebrafish Mouse |
|
|
response to chemical
|
GO:0042221 |
320 |
0.377
|
|
|
|
vasculogenesis
|
GO:0001570 |
41 |
0.365
|
|
|
|
cell motility
|
GO:0048870 |
244 |
0.318
|
|
|
|
cellular component movement
|
GO:0006928 |
335 |
0.309
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
20 |
0.306
|
Zebrafish |
|
|
regulation of muscle contraction
|
GO:0006937 |
3 |
0.305
|
Rat |
|
|
immune system process
|
GO:0002376 |
241 |
0.297
|
|
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
5 |
0.283
|
Zebrafish Mouse |
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
3 |
0.277
|
|
|
|
heart development
|
GO:0007507 |
313 |
0.275
|
Mouse |
|
|
lymph vessel development
|
GO:0001945 |
27 |
0.265
|
|
|
|
camp metabolic process
|
GO:0046058 |
11 |
0.256
|
Zebrafish |
|
|
regulation of metabolic process
|
GO:0019222 |
359 |
0.249
|
|
|
|
regulation of multicellular organismal process
|
GO:0051239 |
277 |
0.220
|
Rat |
|
|
actin filament based process
|
GO:0030029 |
64 |
0.218
|
|
|
|
response to external stimulus
|
GO:0009605 |
264 |
0.218
|
Rat |
|
|
regulation of blood vessel size
|
GO:0050880 |
2 |
0.213
|
|
|
|
gtp metabolic process
|
GO:0046039 |
4 |
0.204
|
|
|
|
positive regulation of transport
|
GO:0051050 |
2 |
0.193
|
|
|
|
positive regulation of camp biosynthetic process
|
GO:0030819 |
2 |
0.187
|
|
|
|
positive regulation of biological process
|
GO:0048518 |
253 |
0.185
|
Mouse |
|
|
immune system development
|
GO:0002520 |
191 |
0.179
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
2 |
0.179
|
|
|
|
regulation of signal transduction
|
GO:0009966 |
225 |
0.171
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
15 |
0.152
|
|
|
|
localization of cell
|
GO:0051674 |
244 |
0.148
|
|
|
|
regulation of stem cell proliferation
|
GO:0072091 |
2 |
0.147
|
|
|
|
macromolecule modification
|
GO:0043412 |
111 |
0.146
|
|
|
|
response to stress
|
GO:0006950 |
263 |
0.146
|
Rat |
|
|
stem cell proliferation
|
GO:0072089 |
4 |
0.140
|
|
|
|
defense response
|
GO:0006952 |
47 |
0.138
|
Rat |
|
|
blood vessel endothelial cell migration
|
GO:0043534 |
18 |
0.138
|
|
|
|
protein modification process
|
GO:0036211 |
100 |
0.137
|
|
|
|
regulation of camp biosynthetic process
|
GO:0030817 |
9 |
0.135
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
20 |
0.135
|
Zebrafish |
|
|
regulation of blood circulation
|
GO:1903522 |
32 |
0.133
|
|
|
|
response to wounding
|
GO:0009611 |
116 |
0.133
|
Rat |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
74 |
0.132
|
Zebrafish Mouse |
|
|
locomotion
|
GO:0040011 |
313 |
0.130
|
|
|
|
negative regulation of cellular process
|
GO:0048523 |
283 |
0.129
|
|
|
|
regulation of cellular metabolic process
|
GO:0031323 |
320 |
0.129
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
97 |
0.129
|
|
|
|
nitrogen compound metabolic process
|
GO:0006807 |
319 |
0.128
|
Zebrafish |
|
|
organic substance biosynthetic process
|
GO:1901576 |
289 |
0.128
|
Zebrafish |
|
|
morphogenesis of an epithelium
|
GO:0002009 |
333 |
0.126
|
|
|
|
regulation of tube size
|
GO:0035150 |
2 |
0.126
|
|
|
|
cell surface receptor signaling pathway
|
GO:0007166 |
325 |
0.126
|
Zebrafish Mouse |
|
|
angiogenesis
|
GO:0001525 |
158 |
0.120
|
|
|
|
response to other organism
|
GO:0051707 |
97 |
0.119
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
143 |
0.118
|
|
|
|
lymph vessel morphogenesis
|
GO:0036303 |
25 |
0.116
|
|
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
15 |
0.116
|
|
|
|
regulation of biological quality
|
GO:0065008 |
263 |
0.114
|
|
|
|
phosphorus metabolic process
|
GO:0006793 |
109 |
0.113
|
Zebrafish |
|
|
positive regulation of endothelial cell proliferation
|
GO:0001938 |
1 |
0.112
|
|
|
|
single organism metabolic process
|
GO:0044710 |
217 |
0.112
|
Zebrafish |
|
|
tube morphogenesis
|
GO:0035239 |
349 |
0.109
|
|
|
|
cellular macromolecule metabolic process
|
GO:0044260 |
391 |
0.109
|
|
|
|
multi organism process
|
GO:0051704 |
134 |
0.109
|
Fly |
|
|
cognition
|
GO:0050890 |
1 |
0.108
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
97 |
0.107
|
|
|
|
camp biosynthetic process
|
GO:0006171 |
11 |
0.107
|
Zebrafish |
|
|
epithelial tube morphogenesis
|
GO:0060562 |
148 |
0.106
|
|
|
|
positive regulation of lyase activity
|
GO:0051349 |
6 |
0.104
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
63 |
0.103
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
336 |
0.102
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
28 |
0.101
|
Zebrafish |
|
|
positive regulation of leukocyte migration
|
GO:0002687 |
2 |
0.097
|
|
|
|
positive regulation of camp metabolic process
|
GO:0030816 |
2 |
0.097
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
25 |
0.096
|
|
|
|
single organism localization
|
GO:1902578 |
225 |
0.095
|
|
|
|
artery development
|
GO:0060840 |
22 |
0.094
|
|
|
|
response to bacterium
|
GO:0009617 |
58 |
0.093
|
|
|
|
muscle system process
|
GO:0003012 |
20 |
0.092
|
Rat |
|
|
regulation of developmental process
|
GO:0050793 |
247 |
0.092
|
|
|
|
regulation of catalytic activity
|
GO:0050790 |
55 |
0.092
|
|
|
|
negative regulation of biological process
|
GO:0048519 |
304 |
0.090
|
Rat |
|
|
regulation of signaling
|
GO:0023051 |
235 |
0.090
|
|
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
15 |
0.089
|
|
|
|
response to organic substance
|
GO:0010033 |
153 |
0.089
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
27 |
0.089
|
Zebrafish |
|
|
regulation of cell communication
|
GO:0010646 |
232 |
0.088
|
|
|
|
regulation of nitrogen compound metabolic process
|
GO:0051171 |
251 |
0.088
|
|
|
|
macrophage differentiation
|
GO:0030225 |
7 |
0.086
|
|
|
|
protein secretion
|
GO:0009306 |
1 |
0.085
|
|
|
|
programmed cell death
|
GO:0012501 |
119 |
0.085
|
|
|
|
cellular protein modification process
|
GO:0006464 |
100 |
0.085
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
1 |
0.083
|
|
|
|
regulation of protein transport
|
GO:0051223 |
3 |
0.082
|
|
|
|
apoptotic process
|
GO:0006915 |
116 |
0.080
|
|
|
|
neurological system process
|
GO:0050877 |
62 |
0.079
|
|
|
|
heterocycle biosynthetic process
|
GO:0018130 |
215 |
0.078
|
Zebrafish |
|
|
regulation of primary metabolic process
|
GO:0080090 |
311 |
0.078
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
2 |
0.078
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
1 |
0.077
|
|
|
|
regulation of response to stimulus
|
GO:0048583 |
269 |
0.076
|
Rat |
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
20 |
0.075
|
Zebrafish |
|
|
myeloid cell differentiation
|
GO:0030099 |
86 |
0.075
|
|
|
|
muscle tissue development
|
GO:0060537 |
110 |
0.075
|
|
|
|
pericardium development
|
GO:0060039 |
1 |
0.075
|
|
|
|
death
|
GO:0016265 |
121 |
0.073
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
48 |
0.073
|
|
|
|
regulation of immune system process
|
GO:0002682 |
34 |
0.072
|
|
|
|
intracellular signal transduction
|
GO:0035556 |
85 |
0.072
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
1 |
0.071
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
116 |
0.070
|
|
|
|
cellular response to organic substance
|
GO:0071310 |
105 |
0.070
|
|
|
|
endothelium development
|
GO:0003158 |
25 |
0.069
|
|
|
|
regulation of apoptotic process
|
GO:0042981 |
98 |
0.069
|
|
|
|
multicellular organismal response to stress
|
GO:0033555 |
2 |
0.069
|
|
|
|
protein metabolic process
|
GO:0019538 |
183 |
0.068
|
|
|
|
amine metabolic process
|
GO:0009308 |
2 |
0.068
|
|
|
|
determination of left right symmetry
|
GO:0007368 |
179 |
0.067
|
|
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
8 |
0.067
|
|
|
|
regulation of lyase activity
|
GO:0051339 |
12 |
0.067
|
|
|
|
patterning of blood vessels
|
GO:0001569 |
15 |
0.067
|
|
|
|
regulation of cell shape
|
GO:0008360 |
1 |
0.067
|
|
|
|
stem cell division
|
GO:0017145 |
1 |
0.067
|
|
|
|
vascular process in circulatory system
|
GO:0003018 |
6 |
0.067
|
|
|
|
renal system process
|
GO:0003014 |
14 |
0.066
|
|
|
|
positive regulation of purine nucleotide biosynthetic process
|
GO:1900373 |
8 |
0.064
|
|
|
|
neuron differentiation
|
GO:0030182 |
353 |
0.064
|
|
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
18 |
0.064
|
Zebrafish |
|
|
regulation of intracellular protein transport
|
GO:0033157 |
3 |
0.064
|
|
|
|
phosphate containing compound metabolic process
|
GO:0006796 |
108 |
0.063
|
Zebrafish |
|
|
single organism organelle organization
|
GO:1902589 |
199 |
0.063
|
|
|
|
regulation of multicellular organismal development
|
GO:2000026 |
223 |
0.063
|
|
|
|
embryonic organ development
|
GO:0048568 |
381 |
0.062
|
|
|
|
generation of neurons
|
GO:0048699 |
385 |
0.061
|
|
|
|
muscle organ development
|
GO:0007517 |
101 |
0.061
|
|
|
|
heart contraction
|
GO:0060047 |
71 |
0.061
|
|
|
|
cellular nitrogen compound biosynthetic process
|
GO:0044271 |
218 |
0.061
|
Zebrafish |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
58 |
0.061
|
|
|
|
larval development
|
GO:0002164 |
2 |
0.060
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
2 |
0.059
|
|
|
|
renal absorption
|
GO:0070293 |
1 |
0.058
|
|
|
|
positive regulation of cellular metabolic process
|
GO:0031325 |
94 |
0.058
|
|
|
|
organonitrogen compound metabolic process
|
GO:1901564 |
74 |
0.058
|
Zebrafish |
|
|
cellular localization
|
GO:0051641 |
97 |
0.057
|
|
|
|
regulation of systemic arterial blood pressure
|
GO:0003073 |
1 |
0.056
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
2 |
0.056
|
|
|
|
cellular protein metabolic process
|
GO:0044267 |
129 |
0.056
|
|
|
|
regionalization
|
GO:0003002 |
274 |
0.056
|
|
|
|
cell substrate junction assembly
|
GO:0007044 |
2 |
0.055
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
3 |
0.055
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
17 |
0.055
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
4 |
0.054
|
|
|
|
multicellular organism growth
|
GO:0035264 |
4 |
0.053
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
2 |
0.053
|
|
|
|
positive regulation of neural precursor cell proliferation
|
GO:2000179 |
1 |
0.053
|
|
|
|
tissue migration
|
GO:0090130 |
37 |
0.052
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
2 |
0.052
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
110 |
0.052
|
|
|
|
positive regulation of cellular biosynthetic process
|
GO:0031328 |
68 |
0.051
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
4 |
0.051
|
|
|
|
regulation of cellular biosynthetic process
|
GO:0031326 |
245 |
0.051
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
1 |
0.050
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
4 |
0.050
|
|
|
|
determination of heart left right asymmetry
|
GO:0061371 |
117 |
0.049
|
|
|
|
cellular component biogenesis
|
GO:0044085 |
178 |
0.049
|
|
|
|
sprouting angiogenesis
|
GO:0002040 |
53 |
0.049
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
1 |
0.049
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
1 |
0.048
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
26 |
0.048
|
|
|
|
regulation of immune response
|
GO:0050776 |
14 |
0.048
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
21 |
0.048
|
Zebrafish |
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
130 |
0.048
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
2 |
0.048
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
122 |
0.048
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
3 |
0.048
|
|
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
1 |
0.047
|
|
|
|
response to vitamin b3
|
GO:0033552 |
2 |
0.047
|
|
|
|
regulation of blood pressure
|
GO:0008217 |
1 |
0.047
|
|
|
|
pericardium morphogenesis
|
GO:0003344 |
1 |
0.047
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
33 |
0.046
|
|
|
|
lymphangiogenesis
|
GO:0001946 |
25 |
0.046
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
15 |
0.046
|
Mouse |
|
|
muscle structure development
|
GO:0061061 |
196 |
0.045
|
|
|
|
cell projection assembly
|
GO:0030031 |
64 |
0.045
|
|
|
|
regulation of nucleobase containing compound metabolic process
|
GO:0019219 |
250 |
0.045
|
|
|
|
nucleobase containing compound metabolic process
|
GO:0006139 |
274 |
0.045
|
Zebrafish |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
106 |
0.045
|
|
|
|
positive regulation of stem cell proliferation
|
GO:2000648 |
1 |
0.045
|
|
|
|
cellular aromatic compound metabolic process
|
GO:0006725 |
295 |
0.044
|
Zebrafish |
|
|
negative regulation of small gtpase mediated signal transduction
|
GO:0051058 |
1 |
0.044
|
|
|
|
regulation of rna biosynthetic process
|
GO:2001141 |
213 |
0.044
|
|
|
|
epiboly involved in gastrulation with mouth forming second
|
GO:0055113 |
35 |
0.044
|
|
|
|
regulation of cell substrate adhesion
|
GO:0010810 |
1 |
0.044
|
|
|
|
osteoclast development
|
GO:0036035 |
1 |
0.043
|
|
|
|
cellular response to chemical stimulus
|
GO:0070887 |
157 |
0.043
|
|
|
|
positive regulation of nitrogen compound metabolic process
|
GO:0051173 |
69 |
0.043
|
|
|
|
artery morphogenesis
|
GO:0048844 |
14 |
0.042
|
|
|
|
developmental growth
|
GO:0048589 |
166 |
0.042
|
|
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
3 |
0.042
|
|
|
|
positive regulation of cellular process
|
GO:0048522 |
201 |
0.042
|
Mouse |
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
27 |
0.041
|
Zebrafish |
|
|
regulation of programmed cell death
|
GO:0043067 |
101 |
0.041
|
|
|
|
behavior
|
GO:0007610 |
74 |
0.041
|
Fly |
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
3 |
0.041
|
|
|
|
actin filament based movement
|
GO:0030048 |
1 |
0.040
|
|
|
|
cardiac muscle cell differentiation
|
GO:0055007 |
30 |
0.040
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
3 |
0.040
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
43 |
0.040
|
Zebrafish |
|
|
protein localization to nucleus
|
GO:0034504 |
3 |
0.040
|
|
|
|
positive regulation of muscle tissue development
|
GO:1901863 |
1 |
0.039
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
4 |
0.039
|
|
|
|
regulation of transcription dna templated
|
GO:0006355 |
213 |
0.039
|
|
|
|
heart process
|
GO:0003015 |
71 |
0.039
|
|
|
|
circulatory system process
|
GO:0003013 |
87 |
0.039
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
4 |
0.039
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
3 |
0.038
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
2 |
0.038
|
|
|
|
blood circulation
|
GO:0008015 |
87 |
0.038
|
|
|
|
regulation of transcription from rna polymerase ii promoter in response to oxidative stress
|
GO:0043619 |
0 |
0.038
|
|
|
|
immune response
|
GO:0006955 |
28 |
0.037
|
|
|
|
small molecule metabolic process
|
GO:0044281 |
77 |
0.037
|
Zebrafish |
|
|
cell morphogenesis
|
GO:0000902 |
289 |
0.037
|
|
|
|
determination of bilateral symmetry
|
GO:0009855 |
204 |
0.037
|
|
|
|
establishment of localization
|
GO:0051234 |
244 |
0.037
|
|
|
|
eye development
|
GO:0001654 |
277 |
0.037
|
|
|
|
heterocycle metabolic process
|
GO:0046483 |
290 |
0.036
|
Zebrafish |
|
|
striated muscle cell differentiation
|
GO:0051146 |
129 |
0.036
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
0 |
0.036
|
|
|
|
epithelial cell migration
|
GO:0010631 |
25 |
0.036
|
|
|
|
organic cyclic compound biosynthetic process
|
GO:1901362 |
223 |
0.036
|
Zebrafish |
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
1 |
0.036
|
|
|
|
sensory organ development
|
GO:0007423 |
393 |
0.035
|
|
|
|
synaptic growth at neuromuscular junction
|
GO:0051124 |
2 |
0.035
|
|
|
|
sensory perception of pain
|
GO:0019233 |
1 |
0.035
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
25 |
0.035
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
3 |
0.035
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
191 |
0.035
|
|
|
|
cellular biosynthetic process
|
GO:0044249 |
286 |
0.034
|
Zebrafish |
|
|
regulation of cell death
|
GO:0010941 |
103 |
0.034
|
|
|
|
response to growth factor
|
GO:0070848 |
39 |
0.034
|
|
|
|
exocytosis
|
GO:0006887 |
1 |
0.034
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
9 |
0.034
|
|
|
|
defense response to other organism
|
GO:0098542 |
33 |
0.034
|
|
|
|
cellular component assembly
|
GO:0022607 |
170 |
0.034
|
|
|
|
regulation of phosphorus metabolic process
|
GO:0051174 |
43 |
0.034
|
|
|
|
hemopoiesis
|
GO:0030097 |
183 |
0.034
|
|
|
|
regulation of phosphorylation
|
GO:0042325 |
26 |
0.033
|
|
|
|
biosynthetic process
|
GO:0009058 |
294 |
0.033
|
Zebrafish |
|
|
stem cell maintenance
|
GO:0019827 |
4 |
0.033
|
|
|
|
regulation of response to stress
|
GO:0080134 |
36 |
0.033
|
Rat |
|
|
transport
|
GO:0006810 |
220 |
0.032
|
|
|
|
aromatic compound biosynthetic process
|
GO:0019438 |
217 |
0.032
|
Zebrafish |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
3 |
0.032
|
|
|
|
innate immune response
|
GO:0045087 |
13 |
0.032
|
|
|
|
actin mediated cell contraction
|
GO:0070252 |
1 |
0.032
|
|
|
|
rna biosynthetic process
|
GO:0032774 |
181 |
0.032
|
|
|
|
positive regulation of cyclase activity
|
GO:0031281 |
6 |
0.031
|
|
|
|
transcription from rna polymerase ii promoter
|
GO:0006366 |
80 |
0.031
|
|
|
|
endoderm development
|
GO:0007492 |
49 |
0.031
|
|
|
|
cell migration involved in sprouting angiogenesis
|
GO:0002042 |
8 |
0.031
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
1 |
0.031
|
|
|
|
gtp catabolic process
|
GO:0006184 |
2 |
0.030
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
28 |
0.030
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
1 |
0.030
|
|
|
|
cell death
|
GO:0008219 |
121 |
0.030
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
23 |
0.030
|
|
|
|
regulation of molecular function
|
GO:0065009 |
70 |
0.030
|
|
|
|
phosphorylation
|
GO:0016310 |
69 |
0.030
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
11 |
0.030
|
|
|
|
cell projection organization
|
GO:0030030 |
284 |
0.029
|
|
|
|
regulation of cardiac muscle tissue development
|
GO:0055024 |
1 |
0.029
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
3 |
0.029
|
|
|
|
regulation of biosynthetic process
|
GO:0009889 |
250 |
0.029
|
|
|
|
regulation of multicellular organismal metabolic process
|
GO:0044246 |
2 |
0.029
|
|
|
|
negative regulation of neural precursor cell proliferation
|
GO:2000178 |
1 |
0.029
|
|
|
|
positive regulation of leukocyte chemotaxis
|
GO:0002690 |
1 |
0.029
|
|
|
|
cardiac atrium morphogenesis
|
GO:0003209 |
2 |
0.029
|
|
|
|
regulation of macromolecule metabolic process
|
GO:0060255 |
317 |
0.028
|
|
|
|
phospholipase c activating g protein coupled receptor signaling pathway
|
GO:0007200 |
2 |
0.028
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
4 |
0.028
|
|
|
|
cell chemotaxis
|
GO:0060326 |
17 |
0.028
|
|
|
|
cellular response to radiation
|
GO:0071478 |
4 |
0.028
|
|
|
|
embryonic heart tube morphogenesis
|
GO:0003143 |
108 |
0.028
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
9 |
0.027
|
|
|
|
regulation of striated muscle cell differentiation
|
GO:0051153 |
6 |
0.027
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
1 |
0.027
|
|
|
|
nucleotide metabolic process
|
GO:0009117 |
28 |
0.027
|
Zebrafish |
|
|
germ line stem cell maintenance
|
GO:0030718 |
2 |
0.027
|
|
|
|
actomyosin structure organization
|
GO:0031032 |
53 |
0.027
|
|
|
|
wound healing
|
GO:0042060 |
90 |
0.027
|
|
|
|
organic substance catabolic process
|
GO:1901575 |
28 |
0.027
|
|
|
|
endocrine process
|
GO:0050886 |
2 |
0.027
|
|
|
|
positive regulation of cell communication
|
GO:0010647 |
56 |
0.027
|
|
|
|
cardiocyte differentiation
|
GO:0035051 |
44 |
0.027
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
0 |
0.027
|
|
|
|
brain development
|
GO:0007420 |
293 |
0.027
|
|
|
|
regulation of synapse organization
|
GO:0050807 |
3 |
0.027
|
|
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
18 |
0.027
|
Zebrafish |
|
|
positive regulation of signal transduction
|
GO:0009967 |
56 |
0.026
|
|
|
|
organic substance transport
|
GO:0071702 |
58 |
0.026
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
3 |
0.026
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
1 |
0.026
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
3 |
0.026
|
|
|
|
endothelial cell migration
|
GO:0043542 |
19 |
0.026
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
39 |
0.026
|
|
|
|
very long chain fatty acid metabolic process
|
GO:0000038 |
4 |
0.026
|
|
|
|
maintenance of location
|
GO:0051235 |
4 |
0.026
|
|
|
|
venous blood vessel development
|
GO:0060841 |
9 |
0.026
|
|
|
|
developmental cell growth
|
GO:0048588 |
52 |
0.026
|
|
|
|
regulation of organ growth
|
GO:0046620 |
3 |
0.026
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
4 |
0.025
|
|
|
|
regulation of transcription from rna polymerase ii promoter in response to stress
|
GO:0043618 |
0 |
0.025
|
|
|
|
growth
|
GO:0040007 |
174 |
0.025
|
|
|
|
cellular extravasation
|
GO:0045123 |
1 |
0.025
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
2 |
0.025
|
Rat |
|
|
response to hypoxia
|
GO:0001666 |
25 |
0.025
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
64 |
0.025
|
|
|
|
b cell mediated immunity
|
GO:0019724 |
3 |
0.025
|
|
|
|
gene expression
|
GO:0010467 |
252 |
0.025
|
|
|
|
gastrulation
|
GO:0007369 |
208 |
0.025
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
32 |
0.025
|
|
|
|
positive regulation of multicellular organismal process
|
GO:0051240 |
52 |
0.024
|
|
|
|
carbohydrate derivative metabolic process
|
GO:1901135 |
61 |
0.024
|
Zebrafish |
|
|
negative regulation of secretion
|
GO:0051048 |
2 |
0.024
|
|
|
|
regulation of intracellular signal transduction
|
GO:1902531 |
57 |
0.024
|
|
|
|
epithelium migration
|
GO:0090132 |
25 |
0.024
|
|
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
1 |
0.024
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
246 |
0.024
|
|
|
|
establishment of localization in cell
|
GO:0051649 |
77 |
0.024
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
1 |
0.024
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
68 |
0.024
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
55 |
0.024
|
|
|
|
specification of symmetry
|
GO:0009799 |
204 |
0.024
|
|
|
|
striated muscle cell development
|
GO:0055002 |
108 |
0.024
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
0 |
0.023
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
7 |
0.023
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
1 |
0.023
|
|
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
1 |
0.023
|
|
|
|
ion transport
|
GO:0006811 |
114 |
0.023
|
|
|
|
regulation of vasculogenesis
|
GO:2001212 |
1 |
0.023
|
|
|
|
multicellular organismal reproductive process
|
GO:0048609 |
35 |
0.023
|
Fly |
|
|
embryonic heart tube development
|
GO:0035050 |
133 |
0.023
|
|
|
|
single organism nuclear import
|
GO:1902593 |
3 |
0.023
|
|
|
|
organophosphate metabolic process
|
GO:0019637 |
37 |
0.023
|
Zebrafish |
|
|
establishment of protein localization to organelle
|
GO:0072594 |
4 |
0.023
|
|
|
|
cell cycle
|
GO:0007049 |
93 |
0.023
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
4 |
0.022
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
1 |
0.022
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
2 |
0.022
|
|
|
|
neurotransmitter transport
|
GO:0006836 |
2 |
0.022
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
51 |
0.022
|
|
|
|
tissue remodeling
|
GO:0048771 |
4 |
0.022
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
2 |
0.022
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
60 |
0.022
|
|
|
|
oxoacid metabolic process
|
GO:0043436 |
31 |
0.022
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
4 |
0.022
|
|
|
|
response to ketone
|
GO:1901654 |
1 |
0.022
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
4 |
0.022
|
|
|
|
blood coagulation
|
GO:0007596 |
12 |
0.022
|
|
|
|
system process
|
GO:0003008 |
185 |
0.022
|
Rat |
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
1 |
0.022
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
55 |
0.021
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
16 |
0.021
|
|
|
|
regulation of heart growth
|
GO:0060420 |
2 |
0.021
|
|
|
|
estrogen metabolic process
|
GO:0008210 |
2 |
0.021
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
3 |
0.021
|
|
|
|
regulation of dna templated transcription elongation
|
GO:0032784 |
3 |
0.021
|
|
|
|
homeostatic process
|
GO:0042592 |
142 |
0.021
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
2 |
0.021
|
|
|
|
regulation of rna metabolic process
|
GO:0051252 |
224 |
0.021
|
|
|
|
immunoglobulin mediated immune response
|
GO:0016064 |
3 |
0.021
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
142 |
0.021
|
|
|
|
single organism transport
|
GO:0044765 |
206 |
0.021
|
|
|
|
positive regulation of gene expression
|
GO:0010628 |
71 |
0.021
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
1 |
0.020
|
|
|
|
cell growth
|
GO:0016049 |
57 |
0.020
|
|
|
|
nuclear import
|
GO:0051170 |
3 |
0.020
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
0 |
0.020
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
17 |
0.020
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
139 |
0.020
|
|
|
|
multicellular organismal water homeostasis
|
GO:0050891 |
1 |
0.020
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
1 |
0.020
|
|
|
|
regulation of protein localization to plasma membrane
|
GO:1903076 |
1 |
0.020
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
20 |
0.020
|
Zebrafish |
|
|
embryonic hemopoiesis
|
GO:0035162 |
53 |
0.020
|
|
|
|
neuron neuron synaptic transmission
|
GO:0007270 |
1 |
0.020
|
|
|
|
epiboly
|
GO:0090504 |
41 |
0.020
|
|
|
|
muscle contraction
|
GO:0006936 |
18 |
0.020
|
Rat |
|
|
regulation of protein ubiquitination
|
GO:0031396 |
3 |
0.020
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
2 |
0.020
|
|
|
|
protein import
|
GO:0017038 |
3 |
0.020
|
|
|
|
regulation of localization
|
GO:0032879 |
104 |
0.019
|
|
|
|
positive regulation of response to stimulus
|
GO:0048584 |
80 |
0.019
|
|
|
|
positive regulation of cell substrate adhesion
|
GO:0010811 |
1 |
0.019
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
1 |
0.019
|
|
|
|
heart morphogenesis
|
GO:0003007 |
156 |
0.019
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
4 |
0.019
|
|
|
|
cardiac atrium development
|
GO:0003230 |
4 |
0.019
|
|
|
|
regulation of system process
|
GO:0044057 |
40 |
0.019
|
Rat |
|
|
cellular nitrogen compound metabolic process
|
GO:0034641 |
290 |
0.019
|
Zebrafish |
|
|
regulation of metal ion transport
|
GO:0010959 |
4 |
0.019
|
|
|
|
carboxylic acid metabolic process
|
GO:0019752 |
22 |
0.019
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
15 |
0.018
|
|
|
|
adherens junction organization
|
GO:0034332 |
4 |
0.018
|
|
|
|
regulation of membrane repolarization
|
GO:0060306 |
1 |
0.018
|
|
|
|
regulation of binding
|
GO:0051098 |
3 |
0.018
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
1 |
0.018
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
2 |
0.018
|
|
|
|
nuclear transport
|
GO:0051169 |
4 |
0.018
|
|
|
|
positive regulation of catalytic activity
|
GO:0043085 |
25 |
0.018
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
24 |
0.018
|
|
|
|
cellular response to vascular endothelial growth factor stimulus
|
GO:0035924 |
3 |
0.018
|
|
|
|
regulation of hematopoietic progenitor cell differentiation
|
GO:1901532 |
1 |
0.018
|
|
|
|
positive regulation of biosynthetic process
|
GO:0009891 |
68 |
0.018
|
|
|
|
cardiac muscle cell development
|
GO:0055013 |
20 |
0.018
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
3 |
0.018
|
|
|
|
positive regulation of molecular function
|
GO:0044093 |
33 |
0.018
|
|
|
|
ribose phosphate metabolic process
|
GO:0019693 |
27 |
0.018
|
Zebrafish |
|
|
urea transmembrane transport
|
GO:0071918 |
9 |
0.018
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
3 |
0.018
|
|
|
|
regulation of establishment of protein localization to plasma membrane
|
GO:0090003 |
1 |
0.018
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
3 |
0.017
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
3 |
0.017
|
|
|
|
regulation of cell migration involved in sprouting angiogenesis
|
GO:0090049 |
3 |
0.017
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
8 |
0.017
|
|
|
|
endosomal transport
|
GO:0016197 |
2 |
0.017
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
3 |
0.017
|
|
|
|
vascular endothelial growth factor signaling pathway
|
GO:0038084 |
3 |
0.017
|
|
|
|
macromolecule localization
|
GO:0033036 |
54 |
0.017
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
1 |
0.017
|
|
|
|
regulation of cell development
|
GO:0060284 |
100 |
0.017
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
15 |
0.017
|
|
|
|
endothelial cell differentiation
|
GO:0045446 |
20 |
0.017
|
|
|
|
cell cycle process
|
GO:0022402 |
53 |
0.017
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
1 |
0.017
|
|
|
|
regulation of protein processing
|
GO:0070613 |
10 |
0.017
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
91 |
0.017
|
|
|
|
organic cyclic compound metabolic process
|
GO:1901360 |
301 |
0.017
|
Zebrafish |
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
2 |
0.017
|
|
|
|
cytokinesis
|
GO:0000910 |
3 |
0.017
|
|
|
|
protein activation cascade
|
GO:0072376 |
6 |
0.017
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
3 |
0.017
|
|
|
|
cell proliferation
|
GO:0008283 |
80 |
0.017
|
Mouse |
|
|
sensory perception
|
GO:0007600 |
39 |
0.017
|
|
|
|
negative regulation of metabolic process
|
GO:0009892 |
86 |
0.017
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
5 |
0.017
|
|
|
|
skeletal muscle organ development
|
GO:0060538 |
78 |
0.017
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
23 |
0.017
|
Zebrafish |
|
|
regulation of exocytosis
|
GO:0017157 |
1 |
0.017
|
|
|
|
cell migration involved in gastrulation
|
GO:0042074 |
79 |
0.016
|
|
|
|
taxis
|
GO:0042330 |
109 |
0.016
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
1 |
0.016
|
|
|
|
water homeostasis
|
GO:0030104 |
4 |
0.016
|
|
|
|
protein phosphorylation
|
GO:0006468 |
47 |
0.016
|
|
|
|
positive regulation of muscle cell differentiation
|
GO:0051149 |
1 |
0.016
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
4 |
0.016
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
2 |
0.016
|
|
|
|
cardiac cell development
|
GO:0055006 |
21 |
0.016
|
|
|
|
organic acid metabolic process
|
GO:0006082 |
31 |
0.016
|
|
|
|
microglia differentiation
|
GO:0014004 |
1 |
0.016
|
|
|
|
chemical homeostasis
|
GO:0048878 |
49 |
0.016
|
|
|
|
transcription elongation from rna polymerase ii promoter
|
GO:0006368 |
3 |
0.016
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
29 |
0.016
|
Zebrafish |
|
|
cytoskeleton organization
|
GO:0007010 |
96 |
0.016
|
|
|
|
cellular response to decreased oxygen levels
|
GO:0036294 |
1 |
0.016
|
|
|
|
antimicrobial humoral response
|
GO:0019730 |
2 |
0.016
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
7 |
0.016
|
|
|
|
positive regulation of metabolic process
|
GO:0009893 |
108 |
0.016
|
|
|
|
regulation of macromolecule biosynthetic process
|
GO:0010556 |
225 |
0.016
|
|
|
|
negative regulation of cellular metabolic process
|
GO:0031324 |
77 |
0.016
|
|
|
|
synaptic vesicle localization
|
GO:0097479 |
1 |
0.015
|
|
|
|
regulation of phosphate metabolic process
|
GO:0019220 |
43 |
0.015
|
|
|
|
positive regulation of histone modification
|
GO:0031058 |
1 |
0.015
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
2 |
0.015
|
|
|
|
regulation of dna templated transcription in response to stress
|
GO:0043620 |
0 |
0.015
|
|
|
|
regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042516 |
1 |
0.015
|
|
|
|
regulation of mesenchymal cell proliferation
|
GO:0010464 |
1 |
0.015
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
3 |
0.015
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
8 |
0.015
|
|
|
|
regulation of synapse assembly
|
GO:0051963 |
3 |
0.015
|
|
|
|
response to oxygen levels
|
GO:0070482 |
25 |
0.015
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
22 |
0.015
|
|
|
|
synaptic vesicle transport
|
GO:0048489 |
1 |
0.015
|
|
|
|
tissue homeostasis
|
GO:0001894 |
25 |
0.015
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
2 |
0.015
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
2 |
0.015
|
|
|
|
germ line stem cell division
|
GO:0042078 |
1 |
0.015
|
|
|
|
proteolysis
|
GO:0006508 |
38 |
0.015
|
|
|
|
positive regulation of striated muscle tissue development
|
GO:0045844 |
1 |
0.015
|
|
|
|
protein localization
|
GO:0008104 |
40 |
0.015
|
|
