Danio rerio

50 known processes

arrb2a

arrestin, beta 2a

(Aliases: zgc:66353,hm:zeh0294,wu:fc14e09,zeh0294,fc14e09)

arrb2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regionalization GO:0003002 274 0.100
chordate embryonic development GO:0043009 271 0.078
biosynthetic process GO:0009058 294 0.076
Human
single organism organelle organization GO:1902589 199 0.074
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.065
Human
stem cell proliferation GO:0072089 4 0.065
regulation of rna biosynthetic process GO:2001141 213 0.063
Human
macromolecule biosynthetic process GO:0009059 227 0.063
Human
determination of bilateral symmetry GO:0009855 204 0.062
cognition GO:0050890 1 0.062
negative regulation of biological process GO:0048519 304 0.061
Human Mouse Fly
organic substance biosynthetic process GO:1901576 289 0.061
Human
regulation of metabolic process GO:0019222 359 0.056
compound eye development GO:0048749 2 0.056
determination of left right symmetry GO:0007368 179 0.056
cellular nitrogen compound metabolic process GO:0034641 290 0.055
Human
sensory organ development GO:0007423 393 0.051
regulation of primary metabolic process GO:0080090 311 0.047
Human Mouse Fly
neuron differentiation GO:0030182 353 0.047
negative regulation of cellular process GO:0048523 283 0.046
Human Mouse Fly
cellular component biogenesis GO:0044085 178 0.046
nucleobase containing compound metabolic process GO:0006139 274 0.046
Human
cellular component movement GO:0006928 335 0.045
regulation of biosynthetic process GO:0009889 250 0.044
Human
system process GO:0003008 185 0.044
Zebrafish
mesenchyme development GO:0060485 127 0.043
nucleic acid templated transcription GO:0097659 181 0.043
Human
synaptic growth at neuromuscular junction GO:0051124 2 0.042
cell projection morphogenesis GO:0048858 244 0.042
cilium morphogenesis GO:0060271 85 0.042
positive regulation of stem cell proliferation GO:2000648 1 0.042
regulation of gene expression GO:0010468 265 0.041
Human Fly
heterocycle metabolic process GO:0046483 290 0.041
Human
segmentation GO:0035282 97 0.040
regulation of stem cell proliferation GO:0072091 2 0.040
digestive system development GO:0055123 289 0.039
Fly
regulation of synapse organization GO:0050807 3 0.039
transcription dna templated GO:0006351 181 0.039
Human
positive regulation of neural precursor cell proliferation GO:2000179 1 0.039
central nervous system development GO:0007417 387 0.039
chemosensory behavior GO:0007635 1 0.038
regulation of macromolecule metabolic process GO:0060255 317 0.037
regulation of macromolecule biosynthetic process GO:0010556 225 0.037
Human
heart development GO:0007507 313 0.037
hemopoiesis GO:0030097 183 0.036
Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.036
Human
nucleic acid metabolic process GO:0090304 244 0.036
Human
neurotransmitter secretion GO:0007269 2 0.035
ear development GO:0043583 127 0.034
neuroblast proliferation GO:0007405 2 0.034
embryonic organ development GO:0048568 381 0.034
skeletal system development GO:0001501 181 0.033
cellular macromolecule biosynthetic process GO:0034645 224 0.033
Human
signal transduction GO:0007165 455 0.033
Human Zebrafish Mouse Fly
cell substrate adhesion GO:0031589 4 0.033
positive regulation of cell cycle GO:0045787 3 0.033
regulation of meiotic cell cycle GO:0051445 1 0.033
response to chemical GO:0042221 320 0.032
brain development GO:0007420 293 0.032
specification of symmetry GO:0009799 204 0.031
somite development GO:0061053 96 0.031
muscle cell differentiation GO:0042692 139 0.031
organelle organization GO:0006996 227 0.031
eye development GO:0001654 277 0.031
cellular biosynthetic process GO:0044249 286 0.031
Human
cellular component assembly involved in morphogenesis GO:0010927 107 0.031
head development GO:0060322 303 0.031
rna metabolic process GO:0016070 219 0.031
Human
anterior posterior pattern specification GO:0009952 152 0.031
heart morphogenesis GO:0003007 156 0.031
nitrogen compound metabolic process GO:0006807 319 0.030
Human
cellular macromolecule metabolic process GO:0044260 391 0.030
phagocytosis GO:0006909 3 0.030
regulation of synapse assembly GO:0051963 3 0.030
stem cell division GO:0017145 1 0.029
embryonic organ morphogenesis GO:0048562 274 0.029
stem cell maintenance GO:0019827 4 0.028
rna biosynthetic process GO:0032774 181 0.028
Human
blood vessel development GO:0001568 246 0.028
protein metabolic process GO:0019538 183 0.028
Human Mouse Fly
neurotransmitter transport GO:0006836 2 0.028
cell part morphogenesis GO:0032990 246 0.028
larval development GO:0002164 2 0.027
Fly
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.027
localization of cell GO:0051674 244 0.027
cell surface receptor signaling pathway GO:0007166 325 0.027
Human Zebrafish Mouse Fly
camera type eye development GO:0043010 222 0.027
epithelial cell differentiation GO:0030855 116 0.027
vasculature development GO:0001944 278 0.026
regulation of response to stimulus GO:0048583 269 0.026
cellular response to organic substance GO:0071310 105 0.026
Human
cilium assembly GO:0042384 58 0.026
gene expression GO:0010467 252 0.025
Human Fly
hematopoietic or lymphoid organ development GO:0048534 191 0.025
Fly
membrane invagination GO:0010324 1 0.025
adult behavior GO:0030534 2 0.025
Mouse
sleep GO:0030431 1 0.024
positive regulation of biological process GO:0048518 253 0.024
Human Mouse Worm Fly
cellular protein catabolic process GO:0044257 4 0.024
Human
regulation of multicellular organismal development GO:2000026 223 0.024
Fly
proteasomal protein catabolic process GO:0010498 2 0.024
Human
gastrulation GO:0007369 208 0.024
Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.024
Human
response to external stimulus GO:0009605 264 0.024
regeneration GO:0031099 91 0.024
regulation of cellular metabolic process GO:0031323 320 0.024
cellular component assembly GO:0022607 170 0.024
cell projection organization GO:0030030 284 0.023
cilium organization GO:0044782 71 0.023
rostrocaudal neural tube patterning GO:0021903 29 0.023
regulation of rna metabolic process GO:0051252 224 0.023
Human
regulation of cellular ketone metabolic process GO:0010565 7 0.023
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.023
Human
regulation of biological quality GO:0065008 263 0.022
Fly
regulation of nervous system development GO:0051960 90 0.022
heterocycle biosynthetic process GO:0018130 215 0.022
Human
locomotion GO:0040011 313 0.022
dorsal ventral pattern formation GO:0009953 125 0.022
positive regulation of developmental process GO:0051094 50 0.022
circadian sleep wake cycle process GO:0022410 2 0.022
regulation of tube size GO:0035150 2 0.022
inner ear development GO:0048839 126 0.022
muscle structure development GO:0061061 196 0.021
Zebrafish
embryonic skeletal system development GO:0048706 97 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
morphogenesis of an epithelium GO:0002009 333 0.021
positive regulation of cellular process GO:0048522 201 0.020
Human Mouse Fly
aromatic compound biosynthetic process GO:0019438 217 0.020
Human
embryonic viscerocranium morphogenesis GO:0048703 52 0.020
neural tube patterning GO:0021532 33 0.020
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.020
Fly
response to monosaccharide GO:0034284 3 0.020
generation of neurons GO:0048699 385 0.020
positive regulation of cellular component biogenesis GO:0044089 3 0.020
nucleocytoplasmic transport GO:0006913 4 0.020
regulation of signal transduction GO:0009966 225 0.020
Human Zebrafish Mouse Fly
cell morphogenesis GO:0000902 289 0.020
regulation of developmental process GO:0050793 247 0.020
Fly
proepicardium development GO:0003342 4 0.020
somitogenesis GO:0001756 87 0.020
olfactory bulb development GO:0021772 4 0.020
glucose homeostasis GO:0042593 1 0.019
regulation of cell activation GO:0050865 1 0.019
negative regulation of synapse assembly GO:0051964 2 0.019
circulatory system process GO:0003013 87 0.019
polarized epithelial cell differentiation GO:0030859 4 0.019
cellular protein modification process GO:0006464 100 0.019
Human Mouse Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.019
Human
embryonic heart tube morphogenesis GO:0003143 108 0.018
olfactory lobe development GO:0021988 4 0.018
regulation of multicellular organism growth GO:0040014 4 0.018
histone lysine demethylation GO:0070076 2 0.018
response to hexose GO:0009746 3 0.018
epidermal cell fate specification GO:0009957 4 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
cellular ketone metabolic process GO:0042180 11 0.018
aging GO:0007568 2 0.018
regulation of dendrite development GO:0050773 3 0.018
multicellular organism growth GO:0035264 4 0.018
axon development GO:0061564 166 0.018
regulation of neural precursor cell proliferation GO:2000177 3 0.018
stem cell development GO:0048864 82 0.018
cellular response to lipopolysaccharide GO:0071222 3 0.018
neuron development GO:0048666 262 0.018
transcription from rna polymerase ii promoter GO:0006366 80 0.017
Human
embryo development ending in birth or egg hatching GO:0009792 271 0.017
regulation of blood vessel size GO:0050880 2 0.017
determination of heart left right asymmetry GO:0061371 117 0.017
phagocytosis engulfment GO:0006911 1 0.017
mechanoreceptor differentiation GO:0042490 37 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
protein import GO:0017038 3 0.017
positive regulation of stress activated mapk cascade GO:0032874 3 0.017
nucleic acid transport GO:0050657 2 0.017
blood vessel morphogenesis GO:0048514 216 0.017
circadian sleep wake cycle sleep GO:0050802 1 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
neuron fate determination GO:0048664 2 0.017
neurological system process GO:0050877 62 0.017
Zebrafish
peptidyl lysine acetylation GO:0018394 2 0.016
axonogenesis GO:0007409 152 0.016
macromolecule modification GO:0043412 111 0.016
Human Mouse Fly
cytokinesis GO:0000910 3 0.016
maintenance of location GO:0051235 4 0.016
cellular component morphogenesis GO:0032989 336 0.016
embryonic hemopoiesis GO:0035162 53 0.016
nuclear transport GO:0051169 4 0.016
regulation of cell projection assembly GO:0060491 4 0.016
cell matrix adhesion GO:0007160 4 0.016
cell proliferation GO:0008283 80 0.016
alcohol biosynthetic process GO:0046165 2 0.016
sensory perception of chemical stimulus GO:0007606 3 0.016
angiogenesis GO:0001525 158 0.016
cellular amine metabolic process GO:0044106 2 0.016
regulation of cellular amine metabolic process GO:0033238 0 0.016
camera type eye morphogenesis GO:0048593 108 0.016
spermatid development GO:0007286 2 0.016
cell projection assembly GO:0030031 64 0.016
digestive tract morphogenesis GO:0048546 231 0.016
Fly
rna localization GO:0006403 4 0.016
germ line stem cell maintenance GO:0030718 2 0.016
behavior GO:0007610 74 0.016
organonitrogen compound metabolic process GO:1901564 74 0.016
protein secretion GO:0009306 1 0.016
homeostatic process GO:0042592 142 0.016
epithelial cell development GO:0002064 42 0.016
carbohydrate biosynthetic process GO:0016051 1 0.016
neuron projection morphogenesis GO:0048812 161 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.015
Human
regulation of cell substrate adhesion GO:0010810 1 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
Human
muscle organ development GO:0007517 101 0.015
Zebrafish
negative regulation of developmental process GO:0051093 65 0.015
Fly
regulation of transcription dna templated GO:0006355 213 0.015
Human
sensory system development GO:0048880 76 0.015
regulation of cell differentiation GO:0045595 142 0.015
Fly
locomotor rhythm GO:0045475 3 0.015
blood circulation GO:0008015 87 0.015
connective tissue development GO:0061448 99 0.015
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.015
negative regulation of kinase activity GO:0033673 4 0.015
Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
Human
nucleobase containing compound transport GO:0015931 2 0.015
sensory organ morphogenesis GO:0090596 200 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
regulation of cellular biosynthetic process GO:0031326 245 0.014
Human
regulation of filopodium assembly GO:0051489 2 0.014
regulation of jak stat cascade GO:0046425 3 0.014
spermatid differentiation GO:0048515 2 0.014
positive regulation of transport GO:0051050 2 0.014
Human
cell morphogenesis involved in differentiation GO:0000904 195 0.014
lipid storage GO:0019915 1 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
neuron projection development GO:0031175 180 0.014
epidermis development GO:0008544 48 0.014
single organism metabolic process GO:0044710 217 0.014
Human
regulation of nucleoside metabolic process GO:0009118 2 0.014
tissue remodeling GO:0048771 4 0.014
negative regulation of response to stimulus GO:0048585 104 0.014
Human Mouse Fly
taxis GO:0042330 109 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
Human Fly
ubiquitin dependent protein catabolic process GO:0006511 3 0.014
Human
striated muscle cell differentiation GO:0051146 129 0.014
skin development GO:0043588 54 0.014
glial cell migration GO:0008347 3 0.014
axon ensheathment in central nervous system GO:0032291 2 0.014
startle response GO:0001964 4 0.014
negative regulation of metabolic process GO:0009892 86 0.014
Human Fly
meiotic cell cycle process GO:1903046 3 0.014
somatic muscle development GO:0007525 4 0.014
neuron projection regeneration GO:0031102 16 0.014
cellular response to molecule of bacterial origin GO:0071219 3 0.014
response to carbohydrate GO:0009743 3 0.013
regulation of stem cell differentiation GO:2000736 4 0.013
inner ear receptor cell differentiation GO:0060113 29 0.013
positive regulation of catabolic process GO:0009896 4 0.013
establishment of rna localization GO:0051236 3 0.013
heart process GO:0003015 71 0.013
striated muscle cell development GO:0055002 108 0.013
establishment of localization GO:0051234 244 0.013
Human
negative regulation of multicellular organismal process GO:0051241 69 0.013
Mouse Fly
growth GO:0040007 174 0.013
Worm
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.013
regulation of cell development GO:0060284 100 0.013
response to glucose GO:0009749 3 0.013
forebrain development GO:0030900 96 0.013
endocardial cushion formation GO:0003272 2 0.013
cellular aromatic compound metabolic process GO:0006725 295 0.013
Human
regulation of dendrite morphogenesis GO:0048814 3 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
Human Fly
establishment of protein localization to organelle GO:0072594 4 0.013
regulation of cell death GO:0010941 103 0.013
regulation of neurogenesis GO:0050767 87 0.013
organelle assembly GO:0070925 110 0.013
cell motility GO:0048870 244 0.013
regulation of blood pressure GO:0008217 1 0.013
nuclear import GO:0051170 3 0.013
hair cell differentiation GO:0035315 32 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.013
neural tube development GO:0021915 62 0.013
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.013
erythrocyte development GO:0048821 24 0.013
oxoacid metabolic process GO:0043436 31 0.013
septum transversum development GO:0003343 4 0.013
developmental growth GO:0048589 166 0.013
regulation of signaling GO:0023051 235 0.013
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
protein acetylation GO:0006473 2 0.012
positive regulation of neurogenesis GO:0050769 24 0.012
regulation of cell communication GO:0010646 232 0.012
Human Zebrafish Mouse Fly
gtp metabolic process GO:0046039 4 0.012
regulation of p38mapk cascade GO:1900744 1 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
Human Mouse Fly
mesenchymal cell differentiation GO:0048762 87 0.012
intracellular signal transduction GO:0035556 85 0.012
Human Mouse
carbohydrate homeostasis GO:0033500 1 0.012
rhombomere 5 development GO:0021571 4 0.012
response to abiotic stimulus GO:0009628 122 0.012
central nervous system neuron differentiation GO:0021953 74 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.012
cellular response to external stimulus GO:0071496 2 0.012
gtp catabolic process GO:0006184 2 0.012
regulation of reproductive process GO:2000241 4 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
positive regulation of cell development GO:0010720 25 0.012
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
auditory receptor cell fate determination GO:0042668 2 0.012
myeloid cell development GO:0061515 32 0.012
smooth muscle contraction GO:0006939 2 0.012
regulation of protein transport GO:0051223 3 0.012
positive regulation of cell activation GO:0050867 1 0.012
endocrine system development GO:0035270 65 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
amine metabolic process GO:0009308 2 0.012
negative regulation of neurogenesis GO:0050768 20 0.012
response to organic substance GO:0010033 153 0.012
Human
positive regulation of cellular catabolic process GO:0031331 3 0.012
regulation of inflammatory response GO:0050727 2 0.012
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
Fly
nerve development GO:0021675 45 0.011
cell fate commitment GO:0045165 99 0.011
actin polymerization or depolymerization GO:0008154 2 0.011
response to wounding GO:0009611 116 0.011
Fly
erythrocyte differentiation GO:0030218 54 0.011
cell cycle arrest GO:0007050 1 0.011
protein localization to nucleus GO:0034504 3 0.011
stem cell differentiation GO:0048863 117 0.011
eye morphogenesis GO:0048592 144 0.011
embryonic heart tube development GO:0035050 133 0.011
muscle cell development GO:0055001 115 0.011
cell fate specification GO:0001708 68 0.011
immune system development GO:0002520 191 0.011
Fly
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
inner ear receptor cell fate commitment GO:0060120 4 0.011
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.011
regulation of gtpase activity GO:0043087 2 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
sex determination GO:0007530 1 0.011
regulation of neuron differentiation GO:0045664 56 0.011
regulation of protein complex assembly GO:0043254 3 0.011
lens fiber cell development GO:0070307 3 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
mitotic cell cycle embryonic GO:0045448 2 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
heart contraction GO:0060047 71 0.011
regulation of establishment of protein localization GO:0070201 4 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
Human Fly
lateral line system development GO:0048925 76 0.011
phosphorylation GO:0016310 69 0.011
Human Mouse Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.011
renal system development GO:0072001 94 0.011
cellular component disassembly GO:0022411 1 0.011
internal peptidyl lysine acetylation GO:0018393 2 0.011
negative regulation of biosynthetic process GO:0009890 55 0.011
negative regulation of cellular biosynthetic process GO:0031327 55 0.011
macromolecular complex disassembly GO:0032984 1 0.011
small molecule metabolic process GO:0044281 77 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
Human
modification dependent protein catabolic process GO:0019941 3 0.011
Human
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
positive regulation of jnk cascade GO:0046330 3 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
retina development in camera type eye GO:0060041 146 0.010
positive regulation of notch signaling pathway GO:0045747 3 0.010
regulation of cytoplasmic transport GO:1903649 4 0.010
protein polymerization GO:0051258 4 0.010
negative regulation of cellular metabolic process GO:0031324 77 0.010
Human Fly
response to stress GO:0006950 263 0.010
Human Fly
guanosine containing compound metabolic process GO:1901068 4 0.010
endoderm development GO:0007492 49 0.010
rhombomere 6 development GO:0021572 4 0.010
transport GO:0006810 220 0.010
Human
primary neural tube formation GO:0014020 1 0.010
hatching GO:0035188 4 0.010
peripheral nervous system development GO:0007422 55 0.010
endocardial cushion morphogenesis GO:0003203 3 0.010
single organism nuclear import GO:1902593 3 0.010
neural crest cell differentiation GO:0014033 72 0.010
positive regulation of nucleic acid templated transcription GO:1903508 57 0.010
sensory perception of mechanical stimulus GO:0050954 16 0.010
lateral line development GO:0048882 66 0.010
activation of mapkkk activity GO:0000185 1 0.010
negative regulation of translation GO:0017148 1 0.010
cellular response to chemical stimulus GO:0070887 157 0.010

arrb2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.054
cardiovascular system disease DOID:1287 0 0.020
nervous system disease DOID:863 0 0.018
disease of cellular proliferation DOID:14566 0 0.012
disease of metabolism DOID:0014667 0 0.011
sensory system disease DOID:0050155 0 0.010
eye and adnexa disease DOID:1492 0 0.010