Danio rerio

0 known processes

kpna2

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

(Aliases: MGC113902,zgc:113902,hm:zeh0389r,hm:zeh0389,zgc:86945)

kpna2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
establishment of localization GO:0051234 244 0.446
Human Mouse Worm
regulation of nucleocytoplasmic transport GO:0046822 2 0.400
cytoskeleton organization GO:0007010 96 0.391
spindle assembly involved in mitosis GO:0090307 1 0.384
single organism organelle organization GO:1902589 199 0.379
regulation of chromosome segregation GO:0051983 1 0.375
spindle assembly GO:0051225 2 0.293
hematopoietic or lymphoid organ development GO:0048534 191 0.282
regulation of establishment of protein localization GO:0070201 4 0.280
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.274
nuclear transport GO:0051169 4 0.269
Human Mouse Worm
cellular component assembly GO:0022607 170 0.260
transport GO:0006810 220 0.259
Human Mouse Worm
protein localization to nucleus GO:0034504 3 0.258
Human Mouse Worm
modification dependent protein catabolic process GO:0019941 3 0.255
regulation of protein targeting GO:1903533 2 0.247
cytoskeleton dependent cytokinesis GO:0061640 3 0.246
regulation of protein import into nucleus GO:0042306 2 0.240
regulation of cytoplasmic transport GO:1903649 4 0.239
mitotic cell cycle process GO:1903047 48 0.237
protein complex disassembly GO:0043241 1 0.214
centrosome duplication GO:0051298 1 0.211
protein targeting to nucleus GO:0044744 3 0.210
Human Mouse Worm
maintenance of location GO:0051235 4 0.207
cytokinesis GO:0000910 3 0.204
single organism transport GO:0044765 206 0.204
Human Mouse Worm
regulation of meiotic cell cycle GO:0051445 1 0.203
regulation of protein localization to nucleus GO:1900180 2 0.202
embryo development ending in birth or egg hatching GO:0009792 271 0.200
Worm
regulation of mitotic cell cycle GO:0007346 25 0.164
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.155
nuclear import GO:0051170 3 0.154
Human Mouse Worm
negative regulation of protein localization to nucleus GO:1900181 2 0.154
mitotic cytokinesis GO:0000281 3 0.152
cellular component disassembly GO:0022411 1 0.152
protein depolymerization GO:0051261 1 0.148
meiotic cell cycle process GO:1903046 3 0.147
negative regulation of cellular process GO:0048523 283 0.142
positive regulation of transport GO:0051050 2 0.140
protein import into nucleus GO:0006606 3 0.138
Human Mouse Worm
regulation of multicellular organismal process GO:0051239 277 0.136
multicellular organism growth GO:0035264 4 0.135
ubiquitin dependent protein catabolic process GO:0006511 3 0.135
single organism nuclear import GO:1902593 3 0.132
Human Mouse Worm
meiosis i GO:0007127 1 0.131
proteasomal protein catabolic process GO:0010498 2 0.130
apoptotic process GO:0006915 116 0.130
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.128
negative regulation of protein transport GO:0051224 3 0.123
regulation of protein transport GO:0051223 3 0.121
establishment of protein localization to organelle GO:0072594 4 0.119
Human Mouse Worm
protein import GO:0017038 3 0.119
Human Mouse Worm
macromolecular complex subunit organization GO:0043933 74 0.114
negative regulation of cellular catabolic process GO:0031330 3 0.113
regulation of protein catabolic process GO:0042176 1 0.112
histone phosphorylation GO:0016572 2 0.112
regulation of biological quality GO:0065008 263 0.112
negative regulation of catabolic process GO:0009895 3 0.111
microtubule organizing center organization GO:0031023 1 0.110
regulation of proteolysis GO:0030162 24 0.110
positive regulation of cell cycle GO:0045787 3 0.109
cell cycle GO:0007049 93 0.107
cytokinetic process GO:0032506 2 0.106
mitotic cell cycle GO:0000278 64 0.104
cleavage furrow formation GO:0036089 2 0.103
macromolecular complex disassembly GO:0032984 1 0.097
negative regulation of cell cycle process GO:0010948 9 0.097
larval development GO:0002164 2 0.097
regulation of protein depolymerization GO:1901879 1 0.095
negative regulation of nuclear division GO:0051784 3 0.095
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.094
oocyte maturation GO:0001556 4 0.093
response to stress GO:0006950 263 0.092
mitotic nuclear division GO:0007067 18 0.091
organelle organization GO:0006996 227 0.089
cellular component biogenesis GO:0044085 178 0.088
negative regulation of mitosis GO:0045839 3 0.088
negative regulation of cytoplasmic transport GO:1903650 2 0.083
regulation of localization GO:0032879 104 0.082
negative regulation of chromosome organization GO:2001251 1 0.082
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.080
chromosome organization involved in meiosis GO:0070192 1 0.076
immune system development GO:0002520 191 0.075
centrosome cycle GO:0007098 1 0.075
deoxyribonucleotide biosynthetic process GO:0009263 1 0.072
negative regulation of protein import into nucleus GO:0042308 2 0.071
microtubule based process GO:0007017 60 0.071
immune system process GO:0002376 241 0.070
microtubule polymerization or depolymerization GO:0031109 3 0.070
astral microtubule organization GO:0030953 1 0.070
female meiotic division GO:0007143 2 0.069
cell death GO:0008219 121 0.066
gene expression GO:0010467 252 0.064
meiosis ii GO:0007135 1 0.063
positive regulation of catabolic process GO:0009896 4 0.062
protein complex subunit organization GO:0071822 46 0.062
negative regulation of protein maturation GO:1903318 10 0.061
programmed cell death GO:0012501 119 0.061
protein secretion GO:0009306 1 0.060
nucleobase containing compound metabolic process GO:0006139 274 0.059
cellular protein modification process GO:0006464 100 0.059
regulation of multicellular organism growth GO:0040014 4 0.059
negative regulation of intracellular transport GO:0032387 3 0.058
sister chromatid segregation GO:0000819 6 0.058
death GO:0016265 121 0.058
regulation of microtubule depolymerization GO:0031114 1 0.058
negative regulation of biological process GO:0048519 304 0.058
nucleocytoplasmic transport GO:0006913 4 0.057
Human Mouse Worm
microtubule cytoskeleton organization GO:0000226 33 0.056
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.055
positive regulation of biological process GO:0048518 253 0.055
biosynthetic process GO:0009058 294 0.055
macromolecule modification GO:0043412 111 0.054
regulation of intracellular protein transport GO:0033157 3 0.054
cellular biosynthetic process GO:0044249 286 0.052
regulation of mitotic cell cycle phase transition GO:1901990 8 0.052
microtubule depolymerization GO:0007019 1 0.052
mitotic cell cycle checkpoint GO:0007093 5 0.051
cellular macromolecule metabolic process GO:0044260 391 0.051
negative regulation of intracellular protein transport GO:0090317 3 0.050
regulation of protein processing GO:0070613 10 0.050
regulation of developmental process GO:0050793 247 0.050
regulation of apoptotic process GO:0042981 98 0.049
regulation of synapse organization GO:0050807 3 0.049
cell proliferation GO:0008283 80 0.049
regulation of cell cycle GO:0051726 52 0.048
lateral inhibition GO:0046331 1 0.048
cellular protein metabolic process GO:0044267 129 0.048
hemopoiesis GO:0030097 183 0.047
cell cycle process GO:0022402 53 0.047
establishment of localization in cell GO:0051649 77 0.047
Human Mouse Worm
cellular lipid catabolic process GO:0044242 3 0.047
cellular protein catabolic process GO:0044257 4 0.046
protein metabolic process GO:0019538 183 0.046
protein modification process GO:0036211 100 0.046
meiotic nuclear division GO:0007126 4 0.045
organelle assembly GO:0070925 110 0.044
positive regulation of cellular catabolic process GO:0031331 3 0.044
angiogenesis GO:0001525 158 0.043
regulation of multicellular organismal development GO:2000026 223 0.043
protein homooligomerization GO:0051260 3 0.043
peptidyl serine modification GO:0018209 2 0.042
positive regulation of chromosome segregation GO:0051984 1 0.042
regulation of macromolecule metabolic process GO:0060255 317 0.042
negative regulation of mitotic cell cycle phase transition GO:1901991 5 0.041
single organism localization GO:1902578 225 0.041
Human Mouse Worm
proteolysis GO:0006508 38 0.041
fertilization GO:0009566 3 0.040
negative regulation of kinase activity GO:0033673 4 0.040
regulation of primary metabolic process GO:0080090 311 0.040
single organism intracellular transport GO:1902582 25 0.040
Human Mouse Worm
response to drug GO:0042493 3 0.039
centrosome organization GO:0051297 1 0.039
negative regulation of protein phosphorylation GO:0001933 4 0.038
negative regulation of protein kinase activity GO:0006469 4 0.038
regulation of cellular component organization GO:0051128 86 0.038
modification dependent macromolecule catabolic process GO:0043632 3 0.038
pyrimidine containing compound metabolic process GO:0072527 3 0.038
negative regulation of proteolysis GO:0045861 10 0.037
establishment of organelle localization GO:0051656 45 0.037
organelle localization GO:0051640 49 0.037
cellular component movement GO:0006928 335 0.037
protein polymerization GO:0051258 4 0.037
intracellular signal transduction GO:0035556 85 0.036
regulation of protein maturation GO:1903317 10 0.036
phagocytosis GO:0006909 3 0.036
negative regulation of mitotic cell cycle GO:0045930 11 0.036
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.036
cell surface receptor signaling pathway GO:0007166 325 0.035
cell migration GO:0016477 237 0.035
negative regulation of gene expression GO:0010629 65 0.035
regulation of cellular metabolic process GO:0031323 320 0.035
positive regulation of macromolecule metabolic process GO:0010604 93 0.034
cell cycle g2 m phase transition GO:0044839 4 0.034
vasculature development GO:0001944 278 0.034
single fertilization GO:0007338 3 0.034
regulation of programmed cell death GO:0043067 101 0.034
negative regulation of protein processing GO:0010955 10 0.033
positive regulation of chromosome organization GO:2001252 1 0.033
regulation of protein complex disassembly GO:0043244 1 0.032
positive regulation of cellular process GO:0048522 201 0.032
meiotic chromosome segregation GO:0045132 3 0.032
neuron projection development GO:0031175 180 0.032
mitotic metaphase plate congression GO:0007080 1 0.032
phosphate containing compound metabolic process GO:0006796 108 0.031
regulation of dendrite development GO:0050773 3 0.031
positive regulation of cellular metabolic process GO:0031325 94 0.031
single organism metabolic process GO:0044710 217 0.031
developmental growth GO:0048589 166 0.030
female meiosis ii GO:0007147 1 0.030
regulation of transport GO:0051049 45 0.030
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.030
regulation of cell proliferation GO:0042127 37 0.030
positive regulation of chromatin modification GO:1903310 1 0.030
response to antibiotic GO:0046677 1 0.030
blood vessel development GO:0001568 246 0.030
regulation of cell differentiation GO:0045595 142 0.029
amine metabolic process GO:0009308 2 0.029
cellular amino acid metabolic process GO:0006520 7 0.029
protein phosphorylation GO:0006468 47 0.029
mitotic cell cycle embryonic GO:0045448 2 0.028
negative regulation of apoptotic process GO:0043066 55 0.028
nucleus localization GO:0051647 8 0.027
peptidyl serine phosphorylation GO:0018105 1 0.027
signal transduction GO:0007165 455 0.027
dna catabolic process GO:0006308 1 0.026
digestive tract development GO:0048565 265 0.026
monovalent inorganic cation transport GO:0015672 42 0.026
growth GO:0040007 174 0.026
regulation of cellular amine metabolic process GO:0033238 0 0.026
cellular response to external stimulus GO:0071496 2 0.025
response to wounding GO:0009611 116 0.025
protein catabolic process GO:0030163 7 0.025
cellular nitrogen compound metabolic process GO:0034641 290 0.025
meiotic spindle organization GO:0000212 1 0.024
neuron development GO:0048666 262 0.024
regulation of microtubule polymerization or depolymerization GO:0031110 3 0.024
cellular amine metabolic process GO:0044106 2 0.023
regulation of mitosis GO:0007088 9 0.023
cell cycle g1 s phase transition GO:0044843 1 0.023
negative regulation of cellular component organization GO:0051129 16 0.023
nuclear migration GO:0007097 3 0.023
negative regulation of macromolecule metabolic process GO:0010605 76 0.023
negative regulation of cell division GO:0051782 4 0.023
regulation of molecular function GO:0065009 70 0.023
reproduction GO:0000003 40 0.023
regulation of microtubule cytoskeleton organization GO:0070507 3 0.023
positive regulation of cell division GO:0051781 2 0.022
intracellular transport GO:0046907 32 0.022
Human Mouse Worm
regulation of cellular protein catabolic process GO:1903362 1 0.022
regulation of synaptic plasticity GO:0048167 1 0.022
g1 s transition of mitotic cell cycle GO:0000082 1 0.022
neuroblast proliferation GO:0007405 2 0.022
cellular localization GO:0051641 97 0.021
Human Mouse Worm
negative regulation of meiotic cell cycle GO:0051447 1 0.021
cellular catabolic process GO:0044248 27 0.021
behavior GO:0007610 74 0.021
embryonic digestive tract morphogenesis GO:0048557 3 0.021
macromolecular complex assembly GO:0065003 35 0.021
regulation of establishment of planar polarity GO:0090175 4 0.021
phosphorus metabolic process GO:0006793 109 0.020
single organism reproductive process GO:0044702 40 0.020
regulation of heart growth GO:0060420 2 0.020
g2 m transition of mitotic cell cycle GO:0000086 4 0.020
microtubule based movement GO:0007018 33 0.020
nuclear division GO:0000280 23 0.020
regulation of protein ubiquitination GO:0031396 3 0.020
carboxylic acid metabolic process GO:0019752 22 0.019
catabolic process GO:0009056 32 0.019
mitotic g2 m transition checkpoint GO:0044818 3 0.019
peptidyl threonine phosphorylation GO:0018107 1 0.019
cell proliferation in forebrain GO:0021846 3 0.019
cellular response to retinoic acid GO:0071300 1 0.019
double strand break repair via homologous recombination GO:0000724 1 0.019
vesicle mediated transport GO:0016192 22 0.019
organic substance biosynthetic process GO:1901576 289 0.019
pronuclear migration GO:0035046 1 0.019
central nervous system development GO:0007417 387 0.018
response to biotic stimulus GO:0009607 97 0.018
negative regulation of cellular metabolic process GO:0031324 77 0.018
organic substance transport GO:0071702 58 0.018
Human Mouse Worm
cellular response to dna damage stimulus GO:0006974 24 0.018
negative regulation of organelle organization GO:0010639 4 0.018
deoxyribonucleotide metabolic process GO:0009262 1 0.018
blood vessel morphogenesis GO:0048514 216 0.018
adult behavior GO:0030534 2 0.018
positive regulation of histone modification GO:0031058 1 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
protein processing GO:0016485 12 0.018
cellular response to stress GO:0033554 62 0.018
regulation of gene expression GO:0010468 265 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
dna biosynthetic process GO:0071897 3 0.017
generation of neurons GO:0048699 385 0.017
cation transport GO:0006812 81 0.017
organic acid metabolic process GO:0006082 31 0.017
locomotion GO:0040011 313 0.017
ribonucleoside monophosphate catabolic process GO:0009158 4 0.017
mitotic dna integrity checkpoint GO:0044774 4 0.017
recombinational repair GO:0000725 1 0.017
heterocycle metabolic process GO:0046483 290 0.017
regulation of cytoskeleton organization GO:0051493 11 0.017
urogenital system development GO:0001655 97 0.016
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.016
positive regulation of dna metabolic process GO:0051054 1 0.016
nucleic acid metabolic process GO:0090304 244 0.016
regulation of response to stimulus GO:0048583 269 0.016
positive regulation of rna metabolic process GO:0051254 59 0.016
localization of cell GO:0051674 244 0.016
cell cycle arrest GO:0007050 1 0.016
homeostatic process GO:0042592 142 0.016
positive regulation of transcription dna templated GO:0045893 57 0.016
regulation of transferase activity GO:0051338 16 0.016
regulation of blood pressure GO:0008217 1 0.016
i kappab kinase nf kappab signaling GO:0007249 4 0.016
regulation of endopeptidase activity GO:0052548 23 0.016
regulation of protein metabolic process GO:0051246 56 0.015
wound healing GO:0042060 90 0.015
cellular aromatic compound metabolic process GO:0006725 295 0.015
protein maturation GO:0051604 12 0.015
cellular ketone metabolic process GO:0042180 11 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
digestive system development GO:0055123 289 0.015
rna metabolic process GO:0016070 219 0.015
negative regulation of cell death GO:0060548 60 0.015
protein dephosphorylation GO:0006470 3 0.015
positive regulation of cytoskeleton organization GO:0051495 3 0.015
positive regulation of metabolic process GO:0009893 108 0.015
double strand break repair GO:0006302 3 0.015
response to external stimulus GO:0009605 264 0.014
regulation of systemic arterial blood pressure GO:0003073 1 0.014
negative regulation of metabolic process GO:0009892 86 0.014
regulation of cellular protein metabolic process GO:0032268 52 0.014
cellular protein complex disassembly GO:0043624 1 0.014
single organism membrane fusion GO:0044801 2 0.014
organelle fusion GO:0048284 3 0.014
regulation of cell migration GO:0030334 40 0.014
response to organic substance GO:0010033 153 0.014
pyrimidine nucleotide metabolic process GO:0006220 1 0.014
stem cell maintenance GO:0019827 4 0.014
phosphorylation GO:0016310 69 0.014
protein modification by small protein conjugation or removal GO:0070647 14 0.014
cytoplasmic transport GO:0016482 11 0.014
Human Mouse Worm
regulation of cellular ketone metabolic process GO:0010565 7 0.014
cell cell signaling GO:0007267 52 0.014
regulation of cell projection organization GO:0031344 44 0.013
nitrogen compound metabolic process GO:0006807 319 0.013
organelle fission GO:0048285 23 0.013
transcription dna templated GO:0006351 181 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
regulation of dna replication GO:0006275 3 0.013
negative regulation of cellular protein metabolic process GO:0032269 16 0.013
cardiac atrium development GO:0003230 4 0.013
gene silencing by rna GO:0031047 4 0.013
reciprocal dna recombination GO:0035825 1 0.013
protein oligomerization GO:0051259 7 0.013
regulation of cell death GO:0010941 103 0.013
cellular nitrogen compound biosynthetic process GO:0044271 218 0.012
regulation of neural precursor cell proliferation GO:2000177 3 0.012
cell cycle phase transition GO:0044770 9 0.012
gland development GO:0048732 143 0.012
ameboidal type cell migration GO:0001667 143 0.012
regulation of nitrogen compound metabolic process GO:0051171 251 0.012
cellular macromolecular complex assembly GO:0034622 24 0.012
cellular protein localization GO:0034613 20 0.012
Human Mouse Worm
sensory organ development GO:0007423 393 0.012
lipid catabolic process GO:0016042 4 0.012
cell aging GO:0007569 2 0.012
g2 dna damage checkpoint GO:0031572 3 0.012
aromatic compound biosynthetic process GO:0019438 217 0.012
atp catabolic process GO:0006200 4 0.012
regulation of growth GO:0040008 42 0.012
regulation of protein modification process GO:0031399 29 0.012
protein complex biogenesis GO:0070271 30 0.012
action potential GO:0001508 19 0.011
regulation of protein binding GO:0043393 3 0.011
regulation of microtubule based process GO:0032886 6 0.011
male meiosis GO:0007140 2 0.011
posttranscriptional gene silencing by rna GO:0035194 3 0.011
cell projection organization GO:0030030 284 0.011
mitotic spindle organization GO:0007052 5 0.011
germ line stem cell maintenance GO:0030718 2 0.011
response to hypoxia GO:0001666 25 0.011
golgi organization GO:0007030 1 0.011
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.011
response to chemical GO:0042221 320 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
response to hormone GO:0009725 48 0.011
chromosome segregation GO:0007059 12 0.011
spermatid differentiation GO:0048515 2 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
microtubule polymerization GO:0046785 2 0.011
negative regulation of programmed cell death GO:0043069 58 0.011
oxoacid metabolic process GO:0043436 31 0.010
nucleoside monophosphate catabolic process GO:0009125 4 0.010
cell substrate adhesion GO:0031589 4 0.010
negative regulation of catalytic activity GO:0043086 21 0.010
regulation of metabolic process GO:0019222 359 0.010
heart development GO:0007507 313 0.010
spindle organization GO:0007051 5 0.010
multi organism process GO:0051704 134 0.010
regulation of protein complex assembly GO:0043254 3 0.010
regulation of stem cell proliferation GO:0072091 2 0.010
macromolecule catabolic process GO:0009057 15 0.010

kpna2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
gastrointestinal system cancer DOID:3119 0 0.015
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015