Danio rerio

21 known processes

nptx2b

neuronal pentraxin 2b

nptx2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of biological process GO:0048518 253 0.111
response to stress GO:0006950 263 0.077
g protein coupled receptor signaling pathway GO:0007186 74 0.075
response to abiotic stimulus GO:0009628 122 0.072
central nervous system development GO:0007417 387 0.071
sensory perception of chemical stimulus GO:0007606 3 0.069
regulation of biological quality GO:0065008 263 0.062
cellular component morphogenesis GO:0032989 336 0.053
amine metabolic process GO:0009308 2 0.053
signal transduction GO:0007165 455 0.050
gene expression GO:0010467 252 0.047
generation of neurons GO:0048699 385 0.045
single organism metabolic process GO:0044710 217 0.045
cellular ketone metabolic process GO:0042180 11 0.044
response to chemical GO:0042221 320 0.044
cellular response to chemical stimulus GO:0070887 157 0.043
chemosensory behavior GO:0007635 1 0.043
sequestering of calcium ion GO:0051208 3 0.043
cellular nitrogen compound metabolic process GO:0034641 290 0.043
larval development GO:0002164 2 0.042
regulation of macromolecule metabolic process GO:0060255 317 0.042
response to organic substance GO:0010033 153 0.042
rna metabolic process GO:0016070 219 0.041
neuron projection morphogenesis GO:0048812 161 0.041
stem cell proliferation GO:0072089 4 0.041
behavior GO:0007610 74 0.040
Mouse
regulation of biosynthetic process GO:0009889 250 0.040
nitrogen compound metabolic process GO:0006807 319 0.040
aromatic compound biosynthetic process GO:0019438 217 0.039
regulation of synaptic plasticity GO:0048167 1 0.039
carboxylic acid metabolic process GO:0019752 22 0.038
response to external stimulus GO:0009605 264 0.037
cognition GO:0050890 1 0.037
Mouse
meiotic nuclear division GO:0007126 4 0.036
organic substance biosynthetic process GO:1901576 289 0.036
regulation of purine nucleotide biosynthetic process GO:1900371 15 0.035
stem cell maintenance GO:0019827 4 0.035
regulation of metal ion transport GO:0010959 4 0.035
cell surface receptor signaling pathway GO:0007166 325 0.034
sequestering of metal ion GO:0051238 3 0.033
phototransduction GO:0007602 2 0.033
maintenance of location GO:0051235 4 0.033
circadian rhythm GO:0007623 19 0.033
regulation of meiotic cell cycle GO:0051445 1 0.032
establishment of protein localization to organelle GO:0072594 4 0.032
regulation of metabolic process GO:0019222 359 0.032
cell projection morphogenesis GO:0048858 244 0.032
chordate embryonic development GO:0043009 271 0.032
regulation of cellular amine metabolic process GO:0033238 0 0.031
neurotransmitter transport GO:0006836 2 0.031
regulation of nitrogen compound metabolic process GO:0051171 251 0.031
biosynthetic process GO:0009058 294 0.031
female sex differentiation GO:0046660 4 0.031
positive regulation of cellular process GO:0048522 201 0.031
neuron differentiation GO:0030182 353 0.030
adult behavior GO:0030534 2 0.030
small molecule metabolic process GO:0044281 77 0.030
negative regulation of sequestering of calcium ion GO:0051283 4 0.030
regulation of cellular biosynthetic process GO:0031326 245 0.030
single organism transport GO:0044765 206 0.030
cellular amine metabolic process GO:0044106 2 0.030
cellular macromolecule biosynthetic process GO:0034645 224 0.030
aging GO:0007568 2 0.030
regulation of multicellular organismal process GO:0051239 277 0.030
heterocycle metabolic process GO:0046483 290 0.029
brain development GO:0007420 293 0.029
guanosine containing compound metabolic process GO:1901068 4 0.029
negative regulation of cellular process GO:0048523 283 0.029
organic cyclic compound metabolic process GO:1901360 301 0.029
positive regulation of map kinase activity GO:0043406 3 0.028
cellular aromatic compound metabolic process GO:0006725 295 0.028
locomotor rhythm GO:0045475 3 0.028
cellular macromolecule metabolic process GO:0044260 391 0.028
cell projection organization GO:0030030 284 0.028
regulation of sequestering of calcium ion GO:0051282 4 0.028
regulation of dendrite development GO:0050773 3 0.028
cellular component movement GO:0006928 335 0.027
activation of mapk activity GO:0000187 3 0.026
regulation of purine nucleotide catabolic process GO:0033121 2 0.026
oxoacid metabolic process GO:0043436 31 0.026
cellular biosynthetic process GO:0044249 286 0.026
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.026
detection of visible light GO:0009584 12 0.026
neurotransmitter secretion GO:0007269 2 0.026
transmembrane transport GO:0055085 120 0.026
regulation of cellular ketone metabolic process GO:0010565 7 0.025
neuroblast proliferation GO:0007405 2 0.025
ion transmembrane transport GO:0034220 91 0.025
lipid storage GO:0019915 1 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
regulation of gene expression GO:0010468 265 0.025
nucleic acid templated transcription GO:0097659 181 0.025
detection of stimulus GO:0051606 29 0.025
organonitrogen compound metabolic process GO:1901564 74 0.025
regulation of reproductive process GO:2000241 4 0.024
response to other organism GO:0051707 97 0.024
single organism localization GO:1902578 225 0.024
phototransduction visible light GO:0007603 2 0.024
organic cyclic compound biosynthetic process GO:1901362 223 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.024
organic acid metabolic process GO:0006082 31 0.024
gtp metabolic process GO:0046039 4 0.024
macromolecule biosynthetic process GO:0009059 227 0.024
homeostatic process GO:0042592 142 0.023
guanosine containing compound catabolic process GO:1901069 2 0.023
autophagy GO:0006914 4 0.023
vasculature development GO:0001944 278 0.023
establishment of localization GO:0051234 244 0.023
meiotic cell cycle process GO:1903046 3 0.023
embryonic organ development GO:0048568 381 0.022
nuclear transport GO:0051169 4 0.022
regulation of primary metabolic process GO:0080090 311 0.022
cellular response to radiation GO:0071478 4 0.022
positive regulation of transport GO:0051050 2 0.022
glucose homeostasis GO:0042593 1 0.022
transport GO:0006810 220 0.022
regulation of blood vessel size GO:0050880 2 0.022
regulation of protein catabolic process GO:0042176 1 0.022
positive regulation of catabolic process GO:0009896 4 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
neuron neuron synaptic transmission GO:0007270 1 0.021
cellular protein catabolic process GO:0044257 4 0.021
positive regulation of cell cycle GO:0045787 3 0.021
gtp catabolic process GO:0006184 2 0.021
nuclear import GO:0051170 3 0.021
regulation of nucleotide catabolic process GO:0030811 2 0.021
response to carbohydrate GO:0009743 3 0.021
regulation of multicellular organism growth GO:0040014 4 0.020
system process GO:0003008 185 0.020
Mouse
blood circulation GO:0008015 87 0.020
modification dependent protein catabolic process GO:0019941 3 0.020
carbohydrate homeostasis GO:0033500 1 0.020
heterocycle biosynthetic process GO:0018130 215 0.020
protein import GO:0017038 3 0.020
positive regulation of cellular component biogenesis GO:0044089 3 0.020
cellular nitrogen compound biosynthetic process GO:0044271 218 0.020
stem cell division GO:0017145 1 0.020
regulation of transcription dna templated GO:0006355 213 0.019
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
regulation of protein transport GO:0051223 3 0.019
negative regulation of protein kinase activity GO:0006469 4 0.019
cell morphogenesis GO:0000902 289 0.019
phagocytosis GO:0006909 3 0.019
axon development GO:0061564 166 0.019
regulation of rna metabolic process GO:0051252 224 0.019
ion transport GO:0006811 114 0.019
regulation of cell shape GO:0008360 1 0.019
modification dependent macromolecule catabolic process GO:0043632 3 0.019
regulation of circadian rhythm GO:0042752 4 0.019
rna biosynthetic process GO:0032774 181 0.019
neuron projection development GO:0031175 180 0.018
regulation of multicellular organismal development GO:2000026 223 0.018
regulation of neurotransmitter secretion GO:0046928 1 0.018
nucleobase containing compound biosynthetic process GO:0034654 205 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
regulation of cellular metabolic process GO:0031323 320 0.018
regulation of cell communication GO:0010646 232 0.018
cellular response to starvation GO:0009267 1 0.018
regulation of stem cell proliferation GO:0072091 2 0.018
nucleotide biosynthetic process GO:0009165 21 0.017
regulation of synapse organization GO:0050807 3 0.017
development of primary female sexual characteristics GO:0046545 4 0.017
regulation of neuron projection development GO:0010975 40 0.017
cellular response to external stimulus GO:0071496 2 0.017
negative regulation of biological process GO:0048519 304 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
heart morphogenesis GO:0003007 156 0.017
regulation of establishment of protein localization GO:0070201 4 0.017
developmental programmed cell death GO:0010623 4 0.017
regulation of calcium ion transport GO:0051924 2 0.017
cell part morphogenesis GO:0032990 246 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.017
response to monosaccharide GO:0034284 3 0.017
central nervous system neuron differentiation GO:0021953 74 0.017
multicellular organism growth GO:0035264 4 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
somatic muscle development GO:0007525 4 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
positive regulation of reproductive process GO:2000243 2 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.017
carbohydrate biosynthetic process GO:0016051 1 0.016
positive regulation of protein complex assembly GO:0031334 2 0.016
response to alkaloid GO:0043279 2 0.016
nucleic acid metabolic process GO:0090304 244 0.016
regulation of neuronal synaptic plasticity GO:0048168 1 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
cellular response to light stimulus GO:0071482 4 0.016
rna localization GO:0006403 4 0.016
ubiquitin dependent protein catabolic process GO:0006511 3 0.016
calcium mediated signaling GO:0019722 2 0.016
cellular component assembly GO:0022607 170 0.016
cellular carbohydrate metabolic process GO:0044262 4 0.016
regulation of gtp catabolic process GO:0033124 2 0.016
response to biotic stimulus GO:0009607 97 0.016
negative regulation of protein phosphorylation GO:0001933 4 0.016
hormone secretion GO:0046879 2 0.016
cell growth GO:0016049 57 0.016
regulation of tube size GO:0035150 2 0.016
forebrain cell migration GO:0021885 1 0.016
protein targeting to nucleus GO:0044744 3 0.016
negative regulation of kinase activity GO:0033673 4 0.016
neuron projection guidance GO:0097485 86 0.016
cyclic nucleotide biosynthetic process GO:0009190 18 0.016
cytokinesis GO:0000910 3 0.016
cellular response to nutrient levels GO:0031669 2 0.016
detection of abiotic stimulus GO:0009582 24 0.015
sensory organ development GO:0007423 393 0.015
regulation of transmembrane transporter activity GO:0022898 2 0.015
cyclic purine nucleotide metabolic process GO:0052652 18 0.015
regulation of protein complex assembly GO:0043254 3 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
regulation of dendrite morphogenesis GO:0048814 3 0.015
positive regulation of cellular metabolic process GO:0031325 94 0.015
calcium ion import GO:0070509 4 0.015
regulation of neural precursor cell proliferation GO:2000177 3 0.015
cellular component disassembly GO:0022411 1 0.015
cilium assembly GO:0042384 58 0.015
positive regulation of camp biosynthetic process GO:0030819 2 0.015
regulation of binding GO:0051098 3 0.015
cell migration GO:0016477 237 0.015
multi organism process GO:0051704 134 0.015
neuron development GO:0048666 262 0.015
sleep GO:0030431 1 0.015
inositol lipid mediated signaling GO:0048017 2 0.015
proteasomal protein catabolic process GO:0010498 2 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
hormone transport GO:0009914 2 0.015
ribonucleotide biosynthetic process GO:0009260 20 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
phagocytosis engulfment GO:0006911 1 0.015
lipid catabolic process GO:0016042 4 0.015
positive regulation of metabolic process GO:0009893 108 0.015
photoreceptor cell fate commitment GO:0046552 1 0.015
regulation of dna replication GO:0006275 3 0.014
cilium morphogenesis GO:0060271 85 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
actin polymerization or depolymerization GO:0008154 2 0.014
membrane invagination GO:0010324 1 0.014
synaptic vesicle localization GO:0097479 1 0.014
single organism nuclear import GO:1902593 3 0.014
inorganic ion transmembrane transport GO:0098660 57 0.014
regulation of neuron differentiation GO:0045664 56 0.014
lipid metabolic process GO:0006629 52 0.014
regulation of gtpase activity GO:0043087 2 0.014
ion homeostasis GO:0050801 41 0.014
mesenchymal cell differentiation GO:0048762 87 0.014
regulation of cell activation GO:0050865 1 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
response to drug GO:0042493 3 0.014
epiboly GO:0090504 41 0.013
response to light stimulus GO:0009416 46 0.013
cell morphogenesis involved in differentiation GO:0000904 195 0.013
sensory perception GO:0007600 39 0.013
protein localization to nucleus GO:0034504 3 0.013
gastrulation GO:0007369 208 0.013
centrosome organization GO:0051297 1 0.013
thermosensory behavior GO:0040040 1 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
angiogenesis GO:0001525 158 0.013
protein import into nucleus GO:0006606 3 0.013
golgi vesicle transport GO:0048193 3 0.013
neural precursor cell proliferation GO:0061351 20 0.013
compound eye development GO:0048749 2 0.013
cation transmembrane transport GO:0098655 65 0.013
mitochondrial transport GO:0006839 2 0.013
regulation of macromolecule biosynthetic process GO:0010556 225 0.013
response to radiation GO:0009314 51 0.013
leukocyte proliferation GO:0070661 1 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
female gonad development GO:0008585 4 0.013
multicellular organismal response to stress GO:0033555 2 0.013
mesenchyme development GO:0060485 127 0.013
neuron remodeling GO:0016322 1 0.012
response to amine GO:0014075 1 0.012
peptidyl serine modification GO:0018209 2 0.012
regulation of protein targeting GO:1903533 2 0.012
regulation of neurotransmitter transport GO:0051588 1 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
detection of external stimulus GO:0009581 24 0.012
carbohydrate derivative metabolic process GO:1901135 61 0.012
peptidyl serine phosphorylation GO:0018105 1 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
digestive tract morphogenesis GO:0048546 231 0.012
regulation of synapse assembly GO:0051963 3 0.012
purine nucleotide biosynthetic process GO:0006164 20 0.012
response to amino acid GO:0043200 2 0.012
synaptic growth at neuromuscular junction GO:0051124 2 0.012
positive regulation of secretion GO:0051047 1 0.012
cellular response to organic substance GO:0071310 105 0.012
negative regulation of synapse assembly GO:0051964 2 0.012
response to amphetamine GO:0001975 1 0.012
digestive tract development GO:0048565 265 0.012
regulation of transporter activity GO:0032409 2 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
post embryonic organ development GO:0048569 4 0.012
negative regulation of dna metabolic process GO:0051053 4 0.012
immune system development GO:0002520 191 0.012
protein polymerization GO:0051258 4 0.012
cell matrix adhesion GO:0007160 4 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
response to hydrogen peroxide GO:0042542 3 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
inorganic cation transmembrane transport GO:0098662 50 0.012
carbohydrate derivative biosynthetic process GO:1901137 43 0.011
regulation of jak stat cascade GO:0046425 3 0.011
neurological system process GO:0050877 62 0.011
Mouse
regulation of protein ubiquitination GO:0031396 3 0.011
positive regulation of gtpase activity GO:0043547 1 0.011
transcription dna templated GO:0006351 181 0.011
blood vessel morphogenesis GO:0048514 216 0.011
head development GO:0060322 303 0.011
regulation of signaling GO:0023051 235 0.011
establishment of synaptic vesicle localization GO:0097480 1 0.011
positive regulation of blood circulation GO:1903524 2 0.011
protein homooligomerization GO:0051260 3 0.011
positive regulation of stem cell proliferation GO:2000648 1 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.011
centrosome cycle GO:0007098 1 0.011
protein complex disassembly GO:0043241 1 0.011
regionalization GO:0003002 274 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
atp catabolic process GO:0006200 4 0.011
macromolecular complex disassembly GO:0032984 1 0.011
release of sequestered calcium ion into cytosol GO:0051209 3 0.011
single organism biosynthetic process GO:0044711 71 0.011
regulation of autophagy GO:0010506 3 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
single organism organelle organization GO:1902589 199 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
immune system process GO:0002376 241 0.011
convergent extension GO:0060026 118 0.011
positive regulation of rna biosynthetic process GO:1902680 57 0.011
negative regulation of protein transport GO:0051224 3 0.011
glial cell migration GO:0008347 3 0.011
response to glucose GO:0009749 3 0.011
antimicrobial humoral response GO:0019730 2 0.011
heart process GO:0003015 71 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
regulation of protein polymerization GO:0032271 2 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
spermatid development GO:0007286 2 0.011
b cell activation GO:0042113 2 0.011
microtubule organizing center organization GO:0031023 1 0.011
purine ribonucleotide biosynthetic process GO:0009152 20 0.011
nucleoside monophosphate catabolic process GO:0009125 4 0.011
alcohol biosynthetic process GO:0046165 2 0.011
spermatid differentiation GO:0048515 2 0.011
peptide metabolic process GO:0006518 1 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
intracellular mrna localization GO:0008298 1 0.011
exocytosis GO:0006887 1 0.011
neuronal action potential GO:0019228 18 0.011
nucleoside phosphate biosynthetic process GO:1901293 21 0.011
regulation of signal transduction GO:0009966 225 0.010
synaptic vesicle transport GO:0048489 1 0.010
meiotic chromosome segregation GO:0045132 3 0.010
response to uv GO:0009411 3 0.010
positive regulation of macromolecule metabolic process GO:0010604 93 0.010
calcium ion transport into cytosol GO:0060402 3 0.010
regulation of developmental process GO:0050793 247 0.010
cation transport GO:0006812 81 0.010
synaptic vesicle endocytosis GO:0048488 1 0.010
regulation of cell projection assembly GO:0060491 4 0.010
regulation of ph GO:0006885 3 0.010
purine containing compound biosynthetic process GO:0072522 20 0.010
neuromuscular process controlling balance GO:0050885 3 0.010
positive regulation of dna metabolic process GO:0051054 1 0.010
cellular response to oxygen levels GO:0071453 1 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
organic substance transport GO:0071702 58 0.010
visual perception GO:0007601 17 0.010
transmission of nerve impulse GO:0019226 19 0.010
regulation of stem cell differentiation GO:2000736 4 0.010
protein localization to plasma membrane GO:0072659 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
catecholamine metabolic process GO:0006584 2 0.010
regulation of localization GO:0032879 104 0.010
regulation of response to stimulus GO:0048583 269 0.010
negative regulation of catabolic process GO:0009895 3 0.010
liver development GO:0001889 96 0.010

nptx2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.062
sensory system disease DOID:0050155 0 0.062
disease of anatomical entity DOID:7 0 0.062
eye and adnexa disease DOID:1492 0 0.062
nervous system disease DOID:863 0 0.062
eye disease DOID:5614 0 0.062
retinal degeneration DOID:8466 0 0.034
retinitis pigmentosa DOID:10584 0 0.019
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
musculoskeletal system disease DOID:17 0 0.011
disease of metabolism DOID:0014667 0 0.011