Danio rerio

86 known processes

grem2

gremlin 2, cysteine knot superfamily

(Aliases: prdc,zgc:112207)

grem2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of stem cell proliferation GO:2000648 1 0.957
biosynthetic process GO:0009058 294 0.883
aromatic compound biosynthetic process GO:0019438 217 0.865
negative regulation of biological process GO:0048519 304 0.854
Zebrafish
cellular component movement GO:0006928 335 0.800
negative regulation of cellular process GO:0048523 283 0.776
Zebrafish
embryonic heart tube morphogenesis GO:0003143 108 0.681
Zebrafish
mesenchymal cell development GO:0014031 78 0.668
nucleobase containing compound biosynthetic process GO:0034654 205 0.648
rna biosynthetic process GO:0032774 181 0.633
immune system process GO:0002376 241 0.620
cellular aromatic compound metabolic process GO:0006725 295 0.603
regulation of transcription dna templated GO:0006355 213 0.601
regulation of biosynthetic process GO:0009889 250 0.593
regulation of multicellular organismal development GO:2000026 223 0.591
vasculature development GO:0001944 278 0.582
organic cyclic compound biosynthetic process GO:1901362 223 0.558
heterocycle biosynthetic process GO:0018130 215 0.554
chordate embryonic development GO:0043009 271 0.549
gene expression GO:0010467 252 0.546
central nervous system development GO:0007417 387 0.542
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 271 0.520
regulation of organ morphogenesis GO:2000027 35 0.514
skeletal system development GO:0001501 181 0.514
negative regulation of response to stimulus GO:0048585 104 0.509
Zebrafish
nerve development GO:0021675 45 0.493
melanin metabolic process GO:0006582 2 0.489
localization of cell GO:0051674 244 0.479
skeletal system morphogenesis GO:0048705 102 0.464
organic substance biosynthetic process GO:1901576 289 0.463
developmental growth involved in morphogenesis GO:0060560 86 0.457
angiogenesis GO:0001525 158 0.454
morphogenesis of an epithelial fold GO:0060571 1 0.451
morphogenesis of an epithelium GO:0002009 333 0.425
Zebrafish
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.409
regulation of metabolic process GO:0019222 359 0.409
regulation of stem cell proliferation GO:0072091 2 0.405
negative regulation of transcription dna templated GO:0045892 45 0.391
positive regulation of biological process GO:0048518 253 0.384
embryonic camera type eye formation GO:0060900 10 0.380
embryonic skeletal system development GO:0048706 97 0.372
response to external stimulus GO:0009605 264 0.371
mesenchymal cell proliferation GO:0010463 1 0.369
glomerulus vasculature development GO:0072012 2 0.364
blood vessel development GO:0001568 246 0.352
mesoderm development GO:0007498 88 0.346
Zebrafish
determination of bilateral symmetry GO:0009855 204 0.336
Zebrafish
cell migration GO:0016477 237 0.335
brain development GO:0007420 293 0.327
Zebrafish
regulation of epithelial cell proliferation GO:0050678 3 0.325
transcription dna templated GO:0006351 181 0.325
axon regeneration GO:0031103 14 0.319
locomotion GO:0040011 313 0.299
epithelial tube morphogenesis GO:0060562 148 0.299
Zebrafish
stem cell development GO:0048864 82 0.283
regulation of mesenchymal cell proliferation GO:0010464 1 0.277
axon development GO:0061564 166 0.274
head development GO:0060322 303 0.269
Zebrafish
negative regulation of rna metabolic process GO:0051253 48 0.269
mesenchymal cell differentiation GO:0048762 87 0.266
embryonic skeletal system morphogenesis GO:0048704 93 0.265
branching morphogenesis of an epithelial tube GO:0048754 15 0.263
regionalization GO:0003002 274 0.261
somite development GO:0061053 96 0.256
regulation of macromolecule metabolic process GO:0060255 317 0.246
secondary metabolic process GO:0019748 3 0.245
chemotaxis GO:0006935 104 0.244
regulation of response to stimulus GO:0048583 269 0.242
Zebrafish
cellular macromolecule biosynthetic process GO:0034645 224 0.236
response to wounding GO:0009611 116 0.235
stem cell proliferation GO:0072089 4 0.234
regulation of rna biosynthetic process GO:2001141 213 0.227
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.227
cell morphogenesis involved in differentiation GO:0000904 195 0.226
glial cell migration GO:0008347 3 0.226
nucleic acid metabolic process GO:0090304 244 0.219
regulation of heart growth GO:0060420 2 0.219
mesoderm morphogenesis GO:0048332 51 0.218
Zebrafish
macromolecule biosynthetic process GO:0009059 227 0.217
axonogenesis GO:0007409 152 0.210
circulatory system process GO:0003013 87 0.209
cranial nerve development GO:0021545 42 0.208
cellular nitrogen compound biosynthetic process GO:0044271 218 0.206
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.204
response to stress GO:0006950 263 0.203
neuron projection regeneration GO:0031102 16 0.202
nucleic acid templated transcription GO:0097659 181 0.202
blood vessel morphogenesis GO:0048514 216 0.201
peptide metabolic process GO:0006518 1 0.200
regulation of developmental process GO:0050793 247 0.197
regulation of axon guidance GO:1902667 8 0.196
cellular biosynthetic process GO:0044249 286 0.196
otic placode formation GO:0043049 23 0.195
neuron projection morphogenesis GO:0048812 161 0.195
cellular nitrogen compound metabolic process GO:0034641 290 0.191
somitogenesis GO:0001756 87 0.184
neuron differentiation GO:0030182 353 0.184
embryonic organ morphogenesis GO:0048562 274 0.181
Zebrafish
cellular macromolecule metabolic process GO:0044260 391 0.181
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.177
regulation of rna metabolic process GO:0051252 224 0.177
embryonic camera type eye morphogenesis GO:0048596 19 0.176
positive regulation of epithelial cell proliferation GO:0050679 1 0.175
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.170
odontogenesis of dentin containing tooth GO:0042475 1 0.170
regulation of axonogenesis GO:0050770 32 0.169
positive regulation of cellular process GO:0048522 201 0.165
muscle organ development GO:0007517 101 0.165
renal system vasculature development GO:0061437 2 0.165
fin regeneration GO:0031101 51 0.158
regulation of nitrogen compound metabolic process GO:0051171 251 0.157
generation of neurons GO:0048699 385 0.157
dorsal ventral pattern formation GO:0009953 125 0.156
regulation of cellular metabolic process GO:0031323 320 0.155
branchiomeric skeletal muscle development GO:0014707 3 0.153
negative regulation of macromolecule metabolic process GO:0010605 76 0.153
cartilage condensation GO:0001502 3 0.153
axial mesoderm development GO:0048318 10 0.150
sensory organ morphogenesis GO:0090596 200 0.149
melanin biosynthetic process GO:0042438 1 0.148
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.148
nucleobase containing compound metabolic process GO:0006139 274 0.147
muscle structure development GO:0061061 196 0.146
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.145
stem cell differentiation GO:0048863 117 0.145
axon guidance GO:0007411 86 0.145
hindbrain development GO:0030902 91 0.144
central nervous system neuron differentiation GO:0021953 74 0.143
retina development in camera type eye GO:0060041 146 0.143
negative regulation of multicellular organismal process GO:0051241 69 0.142
reproductive process GO:0022414 40 0.142
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.141
embryonic organ development GO:0048568 381 0.141
Zebrafish
cell motility GO:0048870 244 0.140
specification of symmetry GO:0009799 204 0.140
Zebrafish
regulation of cell proliferation GO:0042127 37 0.138
regulation of multicellular organismal process GO:0051239 277 0.137
fin development GO:0033333 77 0.135
pigment metabolic process GO:0042440 12 0.132
regulation of embryonic development GO:0045995 47 0.132
muscle cell differentiation GO:0042692 139 0.128
appendage development GO:0048736 80 0.127
cell proliferation GO:0008283 80 0.126
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.124
retinal ganglion cell axon guidance GO:0031290 35 0.124
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.123
neural plate anterior posterior regionalization GO:0021999 8 0.122
regeneration GO:0031099 91 0.120
regulation of locomotion GO:0040012 55 0.119
regulation of biological quality GO:0065008 263 0.117
regulation of reproductive process GO:2000241 4 0.116
regulation of primary metabolic process GO:0080090 311 0.115
endoderm development GO:0007492 49 0.114
Zebrafish
invagination involved in gastrulation with mouth forming second GO:0055109 1 0.112
morphogenesis of a branching structure GO:0001763 21 0.111
nose development GO:0043584 3 0.111
neural crest cell migration GO:0001755 42 0.110
negative regulation of gene expression GO:0010629 65 0.109
branching morphogenesis of a nerve GO:0048755 4 0.109
epithalamus development GO:0021538 10 0.107
neural crest cell development GO:0014032 62 0.106
specification of organ position GO:0010159 3 0.106
dopamine biosynthetic process GO:0042416 2 0.106
striated muscle cell development GO:0055002 108 0.106
striated muscle cell differentiation GO:0051146 129 0.106
embryonic cranial skeleton morphogenesis GO:0048701 90 0.103
negative regulation of signaling GO:0023057 96 0.103
Zebrafish
olfactory bulb development GO:0021772 4 0.103
pharyngeal system development GO:0060037 18 0.102
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.102
regulation of anatomical structure morphogenesis GO:0022603 130 0.102
negative regulation of developmental process GO:0051093 65 0.101
transcription from rna polymerase ii promoter GO:0006366 80 0.101
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.098
neuron projection extension GO:1990138 45 0.098
pigment granule organization GO:0048753 4 0.097
bmp signaling pathway involved in heart jogging GO:0003303 14 0.097
forebrain development GO:0030900 96 0.096
Zebrafish
regulation of axon extension GO:0030516 24 0.095
cell projection morphogenesis GO:0048858 244 0.095
nitrogen compound metabolic process GO:0006807 319 0.094
negative regulation of rna biosynthetic process GO:1902679 45 0.094
response to biotic stimulus GO:0009607 97 0.094
mesenchyme development GO:0060485 127 0.093
Zebrafish
ameboidal type cell migration GO:0001667 143 0.093
heart jogging GO:0003146 40 0.090
Zebrafish
female sex differentiation GO:0046660 4 0.090
regulation of cellular component movement GO:0051270 55 0.087
photoreceptor cell fate commitment GO:0046552 1 0.086
inner ear receptor cell fate commitment GO:0060120 4 0.086
specification of organ identity GO:0010092 2 0.085
cell proliferation involved in heart morphogenesis GO:0061323 2 0.085
neural plate pattern specification GO:0060896 12 0.083
neuron projection guidance GO:0097485 86 0.080
polarized epithelial cell differentiation GO:0030859 4 0.079
development of primary female sexual characteristics GO:0046545 4 0.079
cellular component assembly involved in morphogenesis GO:0010927 107 0.078
myotube differentiation GO:0014902 45 0.078
olfactory bulb axon guidance GO:0071678 3 0.077
auditory receptor cell fate commitment GO:0009912 4 0.076
negative regulation of cell communication GO:0010648 96 0.076
Zebrafish
negative regulation of nucleic acid templated transcription GO:1903507 45 0.074
heart looping GO:0001947 94 0.074
Zebrafish
cell differentiation in spinal cord GO:0021515 40 0.073
determination of left right symmetry GO:0007368 179 0.072
Zebrafish
heart development GO:0007507 313 0.071
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.071
behavior GO:0007610 74 0.071
single organismal cell cell adhesion GO:0016337 29 0.070
regulation of gene expression GO:0010468 265 0.070
regulation of epithelial to mesenchymal transition GO:0010717 3 0.070
regulation of macromolecule biosynthetic process GO:0010556 225 0.070
neuron development GO:0048666 262 0.069
embryonic digestive tract morphogenesis GO:0048557 3 0.069
regulation of cellular biosynthetic process GO:0031326 245 0.069
melanosome organization GO:0032438 4 0.069
negative regulation of axon extension GO:0030517 7 0.068
regulation of anterior head development GO:2000742 2 0.068
embryonic neurocranium morphogenesis GO:0048702 15 0.067
hematopoietic stem cell differentiation GO:0060218 20 0.066
morphogenesis of a branching epithelium GO:0061138 16 0.066
embryonic limb morphogenesis GO:0030326 2 0.066
embryonic viscerocranium morphogenesis GO:0048703 52 0.066
cellular amide metabolic process GO:0043603 4 0.065
reproduction GO:0000003 40 0.064
olfactory lobe development GO:0021988 4 0.063
embryonic camera type eye development GO:0031076 29 0.061
developmental growth GO:0048589 166 0.061
cell migration involved in gastrulation GO:0042074 79 0.060
regulation of nucleic acid templated transcription GO:1903506 213 0.060
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.059
camera type eye development GO:0043010 222 0.059
negative regulation of cell differentiation GO:0045596 46 0.059
organic cyclic compound metabolic process GO:1901360 301 0.059
mesodermal cell migration GO:0008078 12 0.058
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.057
single organism cell adhesion GO:0098602 29 0.057
skeletal muscle organ development GO:0060538 78 0.057
positive regulation of cellular metabolic process GO:0031325 94 0.056
neural crest cell differentiation GO:0014033 72 0.056
neuron projection development GO:0031175 180 0.055
cell part morphogenesis GO:0032990 246 0.055
positive regulation of transcription dna templated GO:0045893 57 0.054
hindbrain morphogenesis GO:0021575 22 0.054
endocardial cushion formation GO:0003272 2 0.054
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.054
renal tubule morphogenesis GO:0061333 1 0.053
central nervous system neuron axonogenesis GO:0021955 18 0.052
bmp signaling pathway involved in heart development GO:0061312 15 0.051
somatic stem cell maintenance GO:0035019 1 0.051
fin morphogenesis GO:0033334 53 0.051
gastrulation GO:0007369 208 0.051
Zebrafish
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.050
biological adhesion GO:0022610 40 0.050
multi organism process GO:0051704 134 0.050
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.050
cellular component assembly GO:0022607 170 0.050
limb bud formation GO:0060174 2 0.050
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.050
Zebrafish
regulation of neuron projection regeneration GO:0070570 7 0.050
digestive tract development GO:0048565 265 0.050
Zebrafish
positive regulation of neural precursor cell proliferation GO:2000179 1 0.050
floor plate development GO:0033504 15 0.049
immune system development GO:0002520 191 0.049
regulation of response to stress GO:0080134 36 0.049
stem cell maintenance GO:0019827 4 0.049
motor neuron axon guidance GO:0008045 23 0.048
cell growth GO:0016049 57 0.048
axon extension involved in axon guidance GO:0048846 10 0.048
regulation of cell growth GO:0001558 29 0.048
single organism metabolic process GO:0044710 217 0.048
developmental cell growth GO:0048588 52 0.047
anterior commissure morphogenesis GO:0021960 3 0.047
myeloid cell differentiation GO:0030099 86 0.046
response to organic cyclic compound GO:0014070 51 0.046
negative regulation of metabolic process GO:0009892 86 0.046
carboxylic acid metabolic process GO:0019752 22 0.046
autonomic nervous system development GO:0048483 19 0.045
sensory system development GO:0048880 76 0.045
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.044
regulation of cell differentiation GO:0045595 142 0.044
regulation of cell development GO:0060284 100 0.043
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 15 0.043
cellular response to external stimulus GO:0071496 2 0.043
phenol containing compound biosynthetic process GO:0046189 4 0.043
apoptotic process involved in morphogenesis GO:0060561 2 0.042
bmp signaling pathway involved in determination of left right symmetry GO:0003154 14 0.042
formation of primary germ layer GO:0001704 62 0.041
Zebrafish
anterior head development GO:0097065 2 0.041
synaptic target recognition GO:0008039 1 0.040
organonitrogen compound biosynthetic process GO:1901566 47 0.040
hematopoietic or lymphoid organ development GO:0048534 191 0.040
hepaticobiliary system development GO:0061008 98 0.040
negative regulation of embryonic development GO:0045992 11 0.040
connective tissue development GO:0061448 99 0.039
macromolecule localization GO:0033036 54 0.039
oxoacid metabolic process GO:0043436 31 0.039
wound healing GO:0042060 90 0.039
regulation of localization GO:0032879 104 0.039
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.039
system process GO:0003008 185 0.038
regulation of stem cell differentiation GO:2000736 4 0.038
negative regulation of signal transduction GO:0009968 94 0.038
Zebrafish
positive regulation of muscle tissue development GO:1901863 1 0.038
single organism localization GO:1902578 225 0.037
regulation of programmed cell death GO:0043067 101 0.037
cell projection organization GO:0030030 284 0.037
positive regulation of muscle organ development GO:0048636 1 0.037
gland development GO:0048732 143 0.037
optic nerve development GO:0021554 15 0.037
bone morphogenesis GO:0060349 11 0.037
hemopoiesis GO:0030097 183 0.037
alpha amino acid metabolic process GO:1901605 3 0.036
death GO:0016265 121 0.036
chemosensory behavior GO:0007635 1 0.036
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 2 0.036
tissue regeneration GO:0042246 74 0.036
regulation of response to external stimulus GO:0032101 31 0.036
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.036
negative regulation of epithelial cell migration GO:0010633 1 0.036
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.035
embryonic skeletal joint morphogenesis GO:0060272 3 0.035
cellular component morphogenesis GO:0032989 336 0.035
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.034
optic placode formation GO:0001743 4 0.034
regulation of wnt signaling pathway involved in digestive tract morphogenesis GO:2000056 2 0.034
negative regulation of biosynthetic process GO:0009890 55 0.034
striated muscle tissue development GO:0014706 110 0.034
sexual reproduction GO:0019953 36 0.034
regulation of cell projection organization GO:0031344 44 0.034
tube morphogenesis GO:0035239 349 0.034
Zebrafish
developmental programmed cell death GO:0010623 4 0.034
cell migration involved in vasculogenesis GO:0035441 1 0.034
positive regulation of developmental process GO:0051094 50 0.033
nephron development GO:0072006 31 0.033
digestive tract morphogenesis GO:0048546 231 0.033
Zebrafish
cell cell signaling involved in cell fate commitment GO:0045168 12 0.033
optic placode formation involved in camera type eye formation GO:0046619 3 0.033
positive regulation of macromolecule metabolic process GO:0010604 93 0.033
positive regulation of rna metabolic process GO:0051254 59 0.033
forebrain generation of neurons GO:0021872 14 0.033
neuron fate specification GO:0048665 20 0.032
cartilage morphogenesis GO:0060536 13 0.032
epithelial to mesenchymal transition GO:0001837 21 0.032
ectodermal placode development GO:0071696 37 0.032
cellular response to organic substance GO:0071310 105 0.032
negative regulation of mitosis GO:0045839 3 0.031
blood circulation GO:0008015 87 0.031
sex determination GO:0007530 1 0.031
mesodermal cell fate commitment GO:0001710 14 0.031
regulation of extent of cell growth GO:0061387 29 0.031
positive regulation of metabolic process GO:0009893 108 0.031
liver development GO:0001889 96 0.031
extrinsic apoptotic signaling pathway GO:0097191 3 0.031
cell fate specification GO:0001708 68 0.031
regulation of developmental growth GO:0048638 38 0.030
lipid storage GO:0019915 1 0.030
central nervous system projection neuron axonogenesis GO:0021952 15 0.030
negative regulation of mesodermal cell fate specification GO:0042662 3 0.030
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.030
cell recognition GO:0008037 19 0.030
cartilage development GO:0051216 96 0.030
apoptotic process GO:0006915 116 0.030
organic acid metabolic process GO:0006082 31 0.030
positive regulation of cell differentiation GO:0045597 30 0.029
positive regulation of embryonic development GO:0040019 3 0.029
pancreatic a cell development GO:0003322 2 0.029
regulation of heart morphogenesis GO:2000826 17 0.029
regulation of apoptotic process GO:0042981 98 0.029
endodermal cell fate specification GO:0001714 17 0.029
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.029
phagocytosis GO:0006909 3 0.028
nephric duct development GO:0072176 13 0.028
ganglion development GO:0061548 5 0.028
regulation of chemotaxis GO:0050920 18 0.028
regulation of neuron projection development GO:0010975 40 0.028
single organism biosynthetic process GO:0044711 71 0.027
convergent extension GO:0060026 118 0.027
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.026
negative regulation of nuclear division GO:0051784 3 0.026
determination of heart left right asymmetry GO:0061371 117 0.026
Zebrafish
tissue remodeling GO:0048771 4 0.026
negative regulation of cellular component organization GO:0051129 16 0.026
negative regulation of protein phosphorylation GO:0001933 4 0.026
negative regulation of gastrulation GO:2000542 11 0.026
septum transversum development GO:0003343 4 0.026
positive regulation of striated muscle tissue development GO:0045844 1 0.026
rna metabolic process GO:0016070 219 0.025
retinal rod cell development GO:0046548 4 0.025
catechol containing compound metabolic process GO:0009712 2 0.025
regulation of cell size GO:0008361 29 0.025
response to chemical GO:0042221 320 0.025
organelle organization GO:0006996 227 0.025
catechol containing compound biosynthetic process GO:0009713 2 0.025
maintenance of location GO:0051235 4 0.025
protein targeting to nucleus GO:0044744 3 0.024
proepicardium development GO:0003342 4 0.024
notochord development GO:0030903 54 0.024
nephric duct morphogenesis GO:0072178 7 0.024
heterocycle metabolic process GO:0046483 290 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.024
response to endogenous stimulus GO:0009719 83 0.024
protein secretion GO:0009306 1 0.024
bone development GO:0060348 14 0.024
epithelial cell differentiation GO:0030855 116 0.024
regulation of gastrulation GO:0010470 24 0.024
artery morphogenesis GO:0048844 14 0.024
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.024
cellular response to endogenous stimulus GO:0071495 68 0.023
heart morphogenesis GO:0003007 156 0.023
Zebrafish
growth GO:0040007 174 0.023
habenula development GO:0021986 9 0.023
cardiogenic plate morphogenesis GO:0003142 1 0.023
negative regulation of protein kinase activity GO:0006469 4 0.023
peripheral nervous system neuron development GO:0048935 22 0.023
organ formation GO:0048645 17 0.023
negative regulation of axon guidance GO:1902668 1 0.023
aging GO:0007568 2 0.023
regulation of cell fate commitment GO:0010453 22 0.023
axon extension GO:0048675 45 0.023
positive regulation of rna biosynthetic process GO:1902680 57 0.023
response to axon injury GO:0048678 14 0.023
cell proliferation in forebrain GO:0021846 3 0.023
anterior posterior pattern specification GO:0009952 152 0.023
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.023
negative regulation of stem cell differentiation GO:2000737 2 0.023
regulation of neuron migration GO:2001222 2 0.022
brain segmentation GO:0035284 6 0.022
positive regulation of signaling GO:0023056 56 0.022
glomerulus development GO:0032835 27 0.022
definitive hemopoiesis GO:0060216 18 0.022
negative regulation of cell death GO:0060548 60 0.022
negative regulation of kinase activity GO:0033673 4 0.022
regulation of signaling GO:0023051 235 0.022
Zebrafish
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.022
regulation of neuron differentiation GO:0045664 56 0.022
cellular response to growth factor stimulus GO:0071363 39 0.022
regulation of cell motility GO:2000145 46 0.021
regulation of bmp signaling pathway GO:0030510 39 0.021
sensory organ development GO:0007423 393 0.021
negative regulation of cell fate commitment GO:0010454 13 0.021
kidney vasculature development GO:0061440 2 0.021
cellular localization GO:0051641 97 0.021
otic vesicle development GO:0071599 42 0.021
forebrain cell migration GO:0021885 1 0.021
erythrocyte development GO:0048821 24 0.021
lipid digestion GO:0044241 3 0.021
pharyngeal muscle development GO:0043282 4 0.020
embryonic eye morphogenesis GO:0048048 30 0.020
protein localization GO:0008104 40 0.020
response to lipid GO:0033993 60 0.020
eye development GO:0001654 277 0.020
enzyme linked receptor protein signaling pathway GO:0007167 106 0.020
cardiac atrium morphogenesis GO:0003209 2 0.020
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.020
epidermal cell fate specification GO:0009957 4 0.020
nephron epithelium development GO:0072009 16 0.020
dopamine metabolic process GO:0042417 2 0.020
regulation of apoptotic signaling pathway GO:2001233 12 0.020
embryonic heart tube development GO:0035050 133 0.020
Zebrafish
muscle tissue development GO:0060537 110 0.020
homeostatic process GO:0042592 142 0.020
positive regulation of nucleic acid templated transcription GO:1903508 57 0.020
mesodermal cell differentiation GO:0048333 21 0.019
embryonic digestive tract development GO:0048566 4 0.019
pericardium development GO:0060039 1 0.019
endocardial cushion morphogenesis GO:0003203 3 0.019
central nervous system segmentation GO:0035283 6 0.019
morphogenesis of embryonic epithelium GO:0016331 30 0.019
positive regulation of gene expression GO:0010628 71 0.019
spemann organizer formation GO:0060061 10 0.019
negative regulation of cell development GO:0010721 26 0.019
positive regulation of smoothened signaling pathway GO:0045880 5 0.019
erythrocyte differentiation GO:0030218 54 0.019
glial cell proliferation GO:0014009 4 0.018
actomyosin structure organization GO:0031032 53 0.018
taxis GO:0042330 109 0.018
cellular component biogenesis GO:0044085 178 0.018
cardiac muscle cell development GO:0055013 20 0.018
intermediate mesoderm development GO:0048389 2 0.018
organic hydroxy compound metabolic process GO:1901615 16 0.018
regulation of axon extension involved in axon guidance GO:0048841 6 0.018
neuron recognition GO:0008038 18 0.018
cell surface receptor signaling pathway GO:0007166 325 0.018
regulation of response to biotic stimulus GO:0002831 2 0.018
protein metabolic process GO:0019538 183 0.018
positive regulation of multicellular organismal process GO:0051240 52 0.018
hepatic duct development GO:0061011 2 0.018
regulation of cellular component organization GO:0051128 86 0.018
regulation of cell death GO:0010941 103 0.018
somatic muscle development GO:0007525 4 0.018

grem2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.061
nervous system disease DOID:863 0 0.061
musculoskeletal system disease DOID:17 0 0.025
urinary system disease DOID:18 0 0.023
bone development disease DOID:0080006 0 0.021
bone disease DOID:0080001 0 0.021
connective tissue disease DOID:65 0 0.021