Danio rerio

0 known processes

prpf18

PRP18 pre-mRNA processing factor 18 homolog (yeast)

(Aliases: zgc:91830)

prpf18 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.086
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.047
maintenance of location GO:0051235 4 0.047
multicellular organism growth GO:0035264 4 0.042
establishment of protein localization to organelle GO:0072594 4 0.040
signal transduction GO:0007165 455 0.039
phagocytosis GO:0006909 3 0.038
positive regulation of transport GO:0051050 2 0.037
modification dependent protein catabolic process GO:0019941 3 0.036
regulation of multicellular organism growth GO:0040014 4 0.036
aging GO:0007568 2 0.036
cellular protein catabolic process GO:0044257 4 0.035
cellular macromolecule metabolic process GO:0044260 391 0.035
ubiquitin dependent protein catabolic process GO:0006511 3 0.034
lipid storage GO:0019915 1 0.033
regulation of metabolic process GO:0019222 359 0.033
modification dependent macromolecule catabolic process GO:0043632 3 0.031
nuclear transport GO:0051169 4 0.031
regulation of establishment of protein localization GO:0070201 4 0.031
cellular nitrogen compound metabolic process GO:0034641 290 0.030
cellular amine metabolic process GO:0044106 2 0.029
nitrogen compound metabolic process GO:0006807 319 0.029
amine metabolic process GO:0009308 2 0.029
stem cell maintenance GO:0019827 4 0.028
organic substance biosynthetic process GO:1901576 289 0.028
nucleobase containing compound metabolic process GO:0006139 274 0.028
regulation of cytokine production GO:0001817 3 0.028
meiotic nuclear division GO:0007126 4 0.028
cellular biosynthetic process GO:0044249 286 0.028
single organism metabolic process GO:0044710 217 0.027
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.027
heterocycle metabolic process GO:0046483 290 0.027
biosynthetic process GO:0009058 294 0.027
regulation of protein transport GO:0051223 3 0.026
regulation of protein complex assembly GO:0043254 3 0.026
nucleic acid metabolic process GO:0090304 244 0.026
rna metabolic process GO:0016070 219 0.026
positive regulation of catabolic process GO:0009896 4 0.026
regulation of mrna processing GO:0050684 3 0.026
regulation of primary metabolic process GO:0080090 311 0.026
heterocycle biosynthetic process GO:0018130 215 0.025
regulation of protein catabolic process GO:0042176 1 0.025
regulation of cytoplasmic transport GO:1903649 4 0.025
golgi vesicle transport GO:0048193 3 0.025
aromatic compound biosynthetic process GO:0019438 217 0.025
positive regulation of cell cycle GO:0045787 3 0.024
negative regulation of protein phosphorylation GO:0001933 4 0.024
protein import GO:0017038 3 0.024
regulation of cell activation GO:0050865 1 0.024
regulation of signaling GO:0023051 235 0.024
regulation of macromolecule metabolic process GO:0060255 317 0.024
negative regulation of cellular process GO:0048523 283 0.024
membrane fusion GO:0061025 2 0.024
nucleobase containing compound biosynthetic process GO:0034654 205 0.024
cellular nitrogen compound biosynthetic process GO:0044271 218 0.024
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.023
negative regulation of biological process GO:0048519 304 0.023
organelle fusion GO:0048284 3 0.023
cell surface receptor signaling pathway GO:0007166 325 0.023
regulation of mrna splicing via spliceosome GO:0048024 3 0.023
gene expression GO:0010467 252 0.023
nuclear import GO:0051170 3 0.023
protein localization to plasma membrane GO:0072659 1 0.023
regulation of cellular metabolic process GO:0031323 320 0.023
centrosome organization GO:0051297 1 0.023
cytokinesis GO:0000910 3 0.023
cellular aromatic compound metabolic process GO:0006725 295 0.022
ribonucleoside monophosphate catabolic process GO:0009158 4 0.022
single organism nuclear import GO:1902593 3 0.022
organic cyclic compound metabolic process GO:1901360 301 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
positive regulation of cellular catabolic process GO:0031331 3 0.022
cellular response to lipopolysaccharide GO:0071222 3 0.022
regulation of biosynthetic process GO:0009889 250 0.022
guanosine containing compound metabolic process GO:1901068 4 0.022
single organism membrane fusion GO:0044801 2 0.022
mitochondrion organization GO:0007005 4 0.021
peptidyl lysine acetylation GO:0018394 2 0.021
guanosine containing compound catabolic process GO:1901069 2 0.021
regulation of gene expression GO:0010468 265 0.021
central nervous system development GO:0007417 387 0.021
transcription dna templated GO:0006351 181 0.021
proteasomal protein catabolic process GO:0010498 2 0.021
organic cyclic compound biosynthetic process GO:1901362 223 0.021
positive regulation of cellular component biogenesis GO:0044089 3 0.021
tube morphogenesis GO:0035239 349 0.021
protein import into nucleus GO:0006606 3 0.021
stem cell proliferation GO:0072089 4 0.021
regulation of intracellular protein transport GO:0033157 3 0.020
nucleoside monophosphate catabolic process GO:0009125 4 0.020
response to topologically incorrect protein GO:0035966 2 0.020
regulation of macromolecule biosynthetic process GO:0010556 225 0.020
regulation of organelle assembly GO:1902115 4 0.020
regulation of cell communication GO:0010646 232 0.020
regulation of signal transduction GO:0009966 225 0.020
cellular macromolecule biosynthetic process GO:0034645 224 0.020
rna biosynthetic process GO:0032774 181 0.020
regulation of meiotic cell cycle GO:0051445 1 0.020
gtp metabolic process GO:0046039 4 0.020
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.020
endosomal transport GO:0016197 2 0.020
cellular ketone metabolic process GO:0042180 11 0.020
gtp catabolic process GO:0006184 2 0.020
cellular component disassembly GO:0022411 1 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
positive regulation of cytokine production GO:0001819 2 0.019
macromolecule biosynthetic process GO:0009059 227 0.019
protein targeting to nucleus GO:0044744 3 0.019
regulation of multicellular organismal process GO:0051239 277 0.019
nucleocytoplasmic transport GO:0006913 4 0.019
cellular response to external stimulus GO:0071496 2 0.019
meiotic cell cycle process GO:1903046 3 0.019
protein acetylation GO:0006473 2 0.019
organelle organization GO:0006996 227 0.019
protein localization to nucleus GO:0034504 3 0.019
internal protein amino acid acetylation GO:0006475 2 0.019
exocytosis GO:0006887 1 0.019
regulation of cellular biosynthetic process GO:0031326 245 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.019
nucleic acid templated transcription GO:0097659 181 0.019
regulation of cell shape GO:0008360 1 0.019
rna localization GO:0006403 4 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
neuroblast proliferation GO:0007405 2 0.019
response to stress GO:0006950 263 0.019
protein secretion GO:0009306 1 0.019
response to uv GO:0009411 3 0.019
cell cycle g1 s phase transition GO:0044843 1 0.019
cellular respiration GO:0045333 3 0.019
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.019
transport GO:0006810 220 0.019
regulation of synaptic plasticity GO:0048167 1 0.019
regulation of response to stimulus GO:0048583 269 0.018
microtubule organizing center organization GO:0031023 1 0.018
autophagy GO:0006914 4 0.018
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.018
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
regulation of protein ubiquitination GO:0031396 3 0.018
oxoacid metabolic process GO:0043436 31 0.018
protein dephosphorylation GO:0006470 3 0.018
protein metabolic process GO:0019538 183 0.018
protein acylation GO:0043543 3 0.018
organic acid metabolic process GO:0006082 31 0.018
internal peptidyl lysine acetylation GO:0018393 2 0.018
cell morphogenesis GO:0000902 289 0.018
adult behavior GO:0030534 2 0.018
regulation of rna metabolic process GO:0051252 224 0.018
carboxylic acid metabolic process GO:0019752 22 0.017
positive regulation of protein complex assembly GO:0031334 2 0.017
extrinsic apoptotic signaling pathway GO:0097191 3 0.017
negative regulation of catabolic process GO:0009895 3 0.017
negative regulation of kinase activity GO:0033673 4 0.017
regulation of protein localization to nucleus GO:1900180 2 0.017
negative regulation of protein kinase activity GO:0006469 4 0.017
leukocyte proliferation GO:0070661 1 0.017
immune system process GO:0002376 241 0.017
g1 s transition of mitotic cell cycle GO:0000082 1 0.017
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
regulation of binding GO:0051098 3 0.017
cellular response to radiation GO:0071478 4 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
erk1 and erk2 cascade GO:0070371 4 0.017
response to chemical GO:0042221 320 0.017
establishment of localization GO:0051234 244 0.017
atp catabolic process GO:0006200 4 0.017
synaptic vesicle localization GO:0097479 1 0.017
cellular response to molecule of bacterial origin GO:0071219 3 0.017
cellular response to biotic stimulus GO:0071216 3 0.017
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.017
protein polymerization GO:0051258 4 0.017
protein complex disassembly GO:0043241 1 0.017
response to drug GO:0042493 3 0.017
phagocytosis engulfment GO:0006911 1 0.017
alternative mrna splicing via spliceosome GO:0000380 1 0.016
actin filament polymerization GO:0030041 2 0.016
sensory organ development GO:0007423 393 0.016
cell migration GO:0016477 237 0.016
i kappab kinase nf kappab signaling GO:0007249 4 0.016
stem cell division GO:0017145 1 0.016
positive regulation of cell activation GO:0050867 1 0.016
protein polyubiquitination GO:0000209 4 0.016
regulation of developmental process GO:0050793 247 0.016
positive regulation of translation GO:0045727 1 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
positive regulation of secretion GO:0051047 1 0.016
production of molecular mediator of immune response GO:0002440 2 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
nuclear export GO:0051168 1 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
regulation of inflammatory response GO:0050727 2 0.016
mononuclear cell proliferation GO:0032943 1 0.016
regulation of synapse organization GO:0050807 3 0.016
positive regulation of biological process GO:0048518 253 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
digestive system development GO:0055123 289 0.015
regulation of nucleic acid templated transcription GO:1903506 213 0.015
cellular component biogenesis GO:0044085 178 0.015
cellular component movement GO:0006928 335 0.015
actin polymerization or depolymerization GO:0008154 2 0.015
localization of cell GO:0051674 244 0.015
regulation of protein targeting GO:1903533 2 0.015
regulation of erk1 and erk2 cascade GO:0070372 4 0.015
regulation of transcription dna templated GO:0006355 213 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
small molecule metabolic process GO:0044281 77 0.015
regulation of cellular protein catabolic process GO:1903362 1 0.015
vasculature development GO:0001944 278 0.015
positive regulation of cytoskeleton organization GO:0051495 3 0.015
compound eye development GO:0048749 2 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
membrane invagination GO:0010324 1 0.015
single organism localization GO:1902578 225 0.015
regulation of neural precursor cell proliferation GO:2000177 3 0.015
purine nucleoside monophosphate catabolic process GO:0009128 4 0.015
carbohydrate homeostasis GO:0033500 1 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
regulation of purine nucleotide catabolic process GO:0033121 2 0.015
regulation of biological quality GO:0065008 263 0.015
system process GO:0003008 185 0.015
digestive tract morphogenesis GO:0048546 231 0.015
single organism transport GO:0044765 206 0.015
positive regulation of map kinase activity GO:0043406 3 0.015
synaptic growth at neuromuscular junction GO:0051124 2 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.015
positive regulation of immune effector process GO:0002699 3 0.015
b cell activation GO:0042113 2 0.014
er to golgi vesicle mediated transport GO:0006888 1 0.014
cellular component morphogenesis GO:0032989 336 0.014
cellular response to nutrient levels GO:0031669 2 0.014
regulation of dna replication GO:0006275 3 0.014
tissue remodeling GO:0048771 4 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
single fertilization GO:0007338 3 0.014
sequestering of metal ion GO:0051238 3 0.014
single organism organelle organization GO:1902589 199 0.014
cell substrate adhesion GO:0031589 4 0.014
cellular response to starvation GO:0009267 1 0.014
cell matrix adhesion GO:0007160 4 0.014
negative regulation of sequestering of calcium ion GO:0051283 4 0.014
locomotion GO:0040011 313 0.014
regulation of rna biosynthetic process GO:2001141 213 0.014
development of primary female sexual characteristics GO:0046545 4 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
cellular component assembly GO:0022607 170 0.014
sequestering of calcium ion GO:0051208 3 0.014
gastrulation GO:0007369 208 0.014
neurotransmitter transport GO:0006836 2 0.014
double strand break repair GO:0006302 3 0.014
establishment of protein localization to plasma membrane GO:0090002 1 0.014
lateral inhibition GO:0046331 1 0.014
macromolecular complex disassembly GO:0032984 1 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.014
protein stabilization GO:0050821 2 0.014
cognition GO:0050890 1 0.014
positive regulation of cell adhesion GO:0045785 1 0.014
regulation of autophagy GO:0010506 3 0.014
positive regulation of secretion by cell GO:1903532 1 0.014
regulation of protein polymerization GO:0032271 2 0.013
neuron differentiation GO:0030182 353 0.013
blood vessel development GO:0001568 246 0.013
regulation of multicellular organismal development GO:2000026 223 0.013
calcium ion transport into cytosol GO:0060402 3 0.013
regulation of reproductive process GO:2000241 4 0.013
regulation of circadian rhythm GO:0042752 4 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
head development GO:0060322 303 0.013
nucleic acid transport GO:0050657 2 0.013
establishment of synaptic vesicle localization GO:0097480 1 0.013
eye development GO:0001654 277 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
response to organic substance GO:0010033 153 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
regulation of metal ion transport GO:0010959 4 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
synaptic vesicle transport GO:0048489 1 0.013
positive regulation of apoptotic signaling pathway GO:2001235 1 0.013
cell part morphogenesis GO:0032990 246 0.013
vacuolar transport GO:0007034 2 0.013
response to carbohydrate GO:0009743 3 0.013
response to monosaccharide GO:0034284 3 0.013
cytosolic calcium ion transport GO:0060401 3 0.013
generation of neurons GO:0048699 385 0.013
cellular protein metabolic process GO:0044267 129 0.013
female sex differentiation GO:0046660 4 0.013
regulation of stem cell proliferation GO:0072091 2 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
negative regulation of protein complex assembly GO:0031333 1 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
embryonic organ development GO:0048568 381 0.013
spermatid development GO:0007286 2 0.013
positive regulation of leukocyte differentiation GO:1902107 1 0.013
brain development GO:0007420 293 0.013
spermatid differentiation GO:0048515 2 0.013
camera type eye development GO:0043010 222 0.013
regionalization GO:0003002 274 0.013
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.013
hemopoiesis GO:0030097 183 0.013
immune system development GO:0002520 191 0.013
heart development GO:0007507 313 0.013
intracellular signal transduction GO:0035556 85 0.013
germ line stem cell maintenance GO:0030718 2 0.013
peptidyl serine modification GO:0018209 2 0.013
negative regulation of cellular catabolic process GO:0031330 3 0.013
lipid catabolic process GO:0016042 4 0.013
mitochondrial transport GO:0006839 2 0.013
protein modification process GO:0036211 100 0.013
cellular response to topologically incorrect protein GO:0035967 2 0.013
secondary metabolic process GO:0019748 3 0.012
lymphocyte proliferation GO:0046651 1 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.012
somatic muscle development GO:0007525 4 0.012
interspecies interaction between organisms GO:0044419 4 0.012
antimicrobial humoral response GO:0019730 2 0.012
mitotic g2 m transition checkpoint GO:0044818 3 0.012
muscle structure development GO:0061061 196 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
meiotic chromosome segregation GO:0045132 3 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
mitotic dna integrity checkpoint GO:0044774 4 0.012
neuron development GO:0048666 262 0.012
regulation of gtpase activity GO:0043087 2 0.012
mitotic dna damage checkpoint GO:0044773 4 0.012
specification of symmetry GO:0009799 204 0.012
peptide transport GO:0015833 1 0.012
cellular response to light stimulus GO:0071482 4 0.012
locomotor rhythm GO:0045475 3 0.012
negative regulation of defense response GO:0031348 2 0.012
organic acid catabolic process GO:0016054 3 0.012
cortical cytoskeleton organization GO:0030865 1 0.012
cellular protein modification process GO:0006464 100 0.012
chemosensory behavior GO:0007635 1 0.012
rna export from nucleus GO:0006405 1 0.012
negative regulation of cytokine production GO:0001818 1 0.012
positive regulation of cellular process GO:0048522 201 0.012
digestive tract development GO:0048565 265 0.012
regulation of jak stat cascade GO:0046425 3 0.012
cell motility GO:0048870 244 0.012
alcohol biosynthetic process GO:0046165 2 0.012
positive regulation of stress activated mapk cascade GO:0032874 3 0.012
negative regulation of protein transport GO:0051224 3 0.012
mitotic cytokinesis GO:0000281 3 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
response to external stimulus GO:0009605 264 0.012
dna templated transcription elongation GO:0006354 3 0.012
blood vessel morphogenesis GO:0048514 216 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
response to hexose GO:0009746 3 0.011
nucleobase containing compound transport GO:0015931 2 0.011
post golgi vesicle mediated transport GO:0006892 1 0.011
activation of mapk activity GO:0000187 3 0.011
release of sequestered calcium ion into cytosol GO:0051209 3 0.011
cellular response to organic substance GO:0071310 105 0.011
positive regulation of chromosome organization GO:2001252 1 0.011
regulation of dna templated transcription elongation GO:0032784 3 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
multi organism cellular process GO:0044764 2 0.011
fertilization GO:0009566 3 0.011
macromolecule modification GO:0043412 111 0.011
regulation of response to biotic stimulus GO:0002831 2 0.011
regulation of transmembrane transporter activity GO:0022898 2 0.011
cell projection organization GO:0030030 284 0.011
multi organism process GO:0051704 134 0.011
mitotic cell cycle embryonic GO:0045448 2 0.011
regulation of synapse assembly GO:0051963 3 0.011
female gonad development GO:0008585 4 0.011
viral process GO:0016032 1 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
positive regulation of notch signaling pathway GO:0045747 3 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
cell projection morphogenesis GO:0048858 244 0.011
negative regulation of secretion GO:0051048 2 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
rna transport GO:0050658 2 0.011
response to nutrient GO:0007584 3 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
establishment of rna localization GO:0051236 3 0.011
g2 dna damage checkpoint GO:0031572 3 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
signal transduction in absence of ligand GO:0038034 1 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.011
centrosome cycle GO:0007098 1 0.011
regulation of protein binding GO:0043393 3 0.011
regulation of exocytosis GO:0017157 1 0.011
cortical actin cytoskeleton organization GO:0030866 1 0.011
cell substrate junction assembly GO:0007044 2 0.011
death GO:0016265 121 0.011
glucose homeostasis GO:0042593 1 0.011
post embryonic organ development GO:0048569 4 0.011
angiogenesis GO:0001525 158 0.011
lamellipodium assembly GO:0030032 1 0.011
regulation of organ growth GO:0046620 3 0.011
growth GO:0040007 174 0.011
lamellipodium organization GO:0097581 1 0.011
positive regulation of gtp catabolic process GO:0033126 1 0.010
macroautophagy GO:0016236 1 0.010
neuron neuron synaptic transmission GO:0007270 1 0.010
protein homooligomerization GO:0051260 3 0.010
lipid homeostasis GO:0055088 3 0.010
negative regulation of metabolic process GO:0009892 86 0.010
regulation of protein complex disassembly GO:0043244 1 0.010
negative regulation of intracellular transport GO:0032387 3 0.010
cell death GO:0008219 121 0.010
cytokinetic process GO:0032506 2 0.010
chordate embryonic development GO:0043009 271 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
regulation of blood pressure GO:0008217 1 0.010
forebrain cell migration GO:0021885 1 0.010
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.010
somatic stem cell maintenance GO:0035019 1 0.010
regulation of cell projection assembly GO:0060491 4 0.010
cellular localization GO:0051641 97 0.010
positive regulation of jnk cascade GO:0046330 3 0.010
hematopoietic or lymphoid organ development GO:0048534 191 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.010
cell morphogenesis involved in differentiation GO:0000904 195 0.010
response to unfolded protein GO:0006986 2 0.010
phosphorus metabolic process GO:0006793 109 0.010
negative regulation of secretion by cell GO:1903531 2 0.010

prpf18 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
nervous system disease DOID:863 0 0.022
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
disease of metabolism DOID:0014667 0 0.015
organ system cancer DOID:0050686 0 0.015
musculoskeletal system disease DOID:17 0 0.013
myopathy DOID:423 0 0.011
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011
sensory system disease DOID:0050155 0 0.011