Danio rerio

0 known processes

lasp1

LIM and SH3 protein 1

(Aliases: wu:fb92f05,zgc:77542,fb92f05)

lasp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.442
phagocytosis GO:0006909 3 0.331
cortical cytoskeleton organization GO:0030865 1 0.303
embryo development ending in birth or egg hatching GO:0009792 271 0.270
positive regulation of cellular process GO:0048522 201 0.259
Fly
transport GO:0006810 220 0.259
Rat
positive regulation of biological process GO:0048518 253 0.226
Fly
regulation of biological quality GO:0065008 263 0.206
Fly
single organism organelle organization GO:1902589 199 0.205
Fly
localization of cell GO:0051674 244 0.199
actin polymerization or depolymerization GO:0008154 2 0.174
positive regulation of protein complex assembly GO:0031334 2 0.167
cortical actin cytoskeleton organization GO:0030866 1 0.164
actin filament based process GO:0030029 64 0.159
Fly
cytoskeleton organization GO:0007010 96 0.159
Fly
regulation of protein polymerization GO:0032271 2 0.159
meiotic nuclear division GO:0007126 4 0.153
actin cytoskeleton organization GO:0030036 63 0.150
Fly
single organism localization GO:1902578 225 0.146
Rat Fly
regulation of cell shape GO:0008360 1 0.140
regulation of protein complex assembly GO:0043254 3 0.137
positive regulation of cellular component biogenesis GO:0044089 3 0.136
Fly
organelle organization GO:0006996 227 0.128
Fly
single organism transport GO:0044765 206 0.127
Rat
phagocytosis engulfment GO:0006911 1 0.126
ameboidal type cell migration GO:0001667 143 0.113
regulation of metabolic process GO:0019222 359 0.109
aging GO:0007568 2 0.108
heterocycle metabolic process GO:0046483 290 0.106
regulation of signal transduction GO:0009966 225 0.101
morphogenesis of an epithelium GO:0002009 333 0.096
cellular component morphogenesis GO:0032989 336 0.095
Fly
cellular component movement GO:0006928 335 0.095
cellular component biogenesis GO:0044085 178 0.091
Fly
cell surface receptor signaling pathway GO:0007166 325 0.089
regulation of filopodium assembly GO:0051489 2 0.084
regulation of multicellular organismal development GO:2000026 223 0.083
Fly
regulation of cell morphogenesis GO:0022604 42 0.082
actin filament polymerization GO:0030041 2 0.081
protein polymerization GO:0051258 4 0.079
positive regulation of protein polymerization GO:0032273 2 0.078
organic cyclic compound metabolic process GO:1901360 301 0.072
maintenance of location GO:0051235 4 0.072
regulation of anatomical structure morphogenesis GO:0022603 130 0.070
locomotion GO:0040011 313 0.069
cell migration GO:0016477 237 0.068
regionalization GO:0003002 274 0.067
Fly
chordate embryonic development GO:0043009 271 0.067
meiotic chromosome segregation GO:0045132 3 0.067
establishment of localization GO:0051234 244 0.064
Rat
regulation of erk1 and erk2 cascade GO:0070372 4 0.063
fertilization GO:0009566 3 0.062
cellular nitrogen compound metabolic process GO:0034641 290 0.062
cell morphogenesis GO:0000902 289 0.062
membrane invagination GO:0010324 1 0.060
meiotic cell cycle process GO:1903046 3 0.060
erk1 and erk2 cascade GO:0070371 4 0.059
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.058
cell motility GO:0048870 244 0.057
regulation of establishment of protein localization GO:0070201 4 0.056
neuroblast proliferation GO:0007405 2 0.055
cytoskeleton dependent cytokinesis GO:0061640 3 0.054
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.051
cellular aromatic compound metabolic process GO:0006725 295 0.051
regulation of signaling GO:0023051 235 0.050
peptidyl serine phosphorylation GO:0018105 1 0.049
nitrogen compound metabolic process GO:0006807 319 0.049
stem cell proliferation GO:0072089 4 0.049
protein complex biogenesis GO:0070271 30 0.048
regulation of multicellular organismal process GO:0051239 277 0.048
Fly
generation of neurons GO:0048699 385 0.047
positive regulation of signaling GO:0023056 56 0.047
response to nutrient GO:0007584 3 0.046
epithelium migration GO:0090132 25 0.046
negative regulation of nuclear division GO:0051784 3 0.045
regulation of protein transport GO:0051223 3 0.045
regulation of developmental process GO:0050793 247 0.044
Fly
cellular component assembly GO:0022607 170 0.042
Fly
gtp metabolic process GO:0046039 4 0.041
signal transduction GO:0007165 455 0.041
guanosine containing compound metabolic process GO:1901068 4 0.040
endocytosis GO:0006897 16 0.039
regulation of synapse assembly GO:0051963 3 0.039
head development GO:0060322 303 0.039
regulation of cellular component organization GO:0051128 86 0.038
Fly
cell cycle GO:0007049 93 0.038
positive regulation of transport GO:0051050 2 0.038
single fertilization GO:0007338 3 0.037
cell projection organization GO:0030030 284 0.037
multi organism process GO:0051704 134 0.037
Fly
biological adhesion GO:0022610 40 0.037
protein complex subunit organization GO:0071822 46 0.037
Fly
positive regulation of cytoskeleton organization GO:0051495 3 0.035
response to chemical GO:0042221 320 0.035
vesicle mediated transport GO:0016192 22 0.035
adherens junction organization GO:0034332 4 0.035
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.035
guanosine containing compound catabolic process GO:1901069 2 0.034
sequestering of calcium ion GO:0051208 3 0.034
nucleocytoplasmic transport GO:0006913 4 0.034
regulation of intracellular protein transport GO:0033157 3 0.033
positive regulation of secretion by cell GO:1903532 1 0.032
cell substrate adhesion GO:0031589 4 0.032
regulation of meiotic cell cycle GO:0051445 1 0.032
multicellular organism growth GO:0035264 4 0.031
cell adhesion GO:0007155 40 0.031
tissue migration GO:0090130 37 0.031
negative regulation of cytoplasmic transport GO:1903650 2 0.031
negative regulation of protein complex assembly GO:0031333 1 0.031
positive regulation of cell communication GO:0010647 56 0.031
digestive system development GO:0055123 289 0.031
regulation of wound healing GO:0061041 2 0.031
regulation of synaptic vesicle transport GO:1902803 1 0.030
protein import into nucleus GO:0006606 3 0.030
regulation of gtp catabolic process GO:0033124 2 0.030
positive regulation of neuron death GO:1901216 1 0.030
synaptic growth at neuromuscular junction GO:0051124 2 0.030
macromolecular complex subunit organization GO:0043933 74 0.030
Fly
response to stress GO:0006950 263 0.030
secondary metabolic process GO:0019748 3 0.030
nuclear transport GO:0051169 4 0.030
positive regulation of neuron apoptotic process GO:0043525 1 0.030
germ line stem cell maintenance GO:0030718 2 0.030
regulation of response to stimulus GO:0048583 269 0.029
positive regulation of catabolic process GO:0009896 4 0.029
cell projection morphogenesis GO:0048858 244 0.029
establishment of protein localization to organelle GO:0072594 4 0.029
positive regulation of cellular amine metabolic process GO:0033240 0 0.029
regulation of organelle organization GO:0033043 29 0.028
epithelial cell migration GO:0010631 25 0.028
axonogenesis GO:0007409 152 0.028
vasculature development GO:0001944 278 0.028
single organism membrane fusion GO:0044801 2 0.027
segmentation GO:0035282 97 0.027
Fly
heart development GO:0007507 313 0.027
gene expression GO:0010467 252 0.027
protein targeting to nucleus GO:0044744 3 0.027
regulation of anatomical structure size GO:0090066 33 0.027
Fly
organelle fusion GO:0048284 3 0.027
positive regulation of cell division GO:0051781 2 0.026
organic cyclic compound biosynthetic process GO:1901362 223 0.026
cytokinesis GO:0000910 3 0.026
regulation of multicellular organism growth GO:0040014 4 0.026
stem cell division GO:0017145 1 0.025
regulation of cell communication GO:0010646 232 0.025
nucleoside phosphate biosynthetic process GO:1901293 21 0.025
regulation of gene expression GO:0010468 265 0.025
regulation of synapse organization GO:0050807 3 0.025
amine metabolic process GO:0009308 2 0.025
glial cell migration GO:0008347 3 0.025
regulation of cytoplasmic transport GO:1903649 4 0.025
neuron differentiation GO:0030182 353 0.025
nuclear division GO:0000280 23 0.024
regulation of cell differentiation GO:0045595 142 0.024
Fly
regulation of binding GO:0051098 3 0.024
nuclear import GO:0051170 3 0.024
protein import GO:0017038 3 0.024
purine nucleoside monophosphate catabolic process GO:0009128 4 0.024
maternal determination of anterior posterior axis embryo GO:0008358 4 0.024
Fly
response to wounding GO:0009611 116 0.024
spermatid differentiation GO:0048515 2 0.024
Fly
anterior posterior pattern specification GO:0009952 152 0.023
Fly
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
negative regulation of protein kinase activity GO:0006469 4 0.023
cell division GO:0051301 20 0.023
regulation of catalytic activity GO:0050790 55 0.023
actin filament organization GO:0007015 15 0.023
Fly
transcription dna templated GO:0006351 181 0.022
protein complex assembly GO:0006461 30 0.022
regulation of neurotransmitter transport GO:0051588 1 0.022
leukocyte proliferation GO:0070661 1 0.022
organic substance biosynthetic process GO:1901576 289 0.022
regulation of cellular amine metabolic process GO:0033238 0 0.022
pronuclear migration GO:0035046 1 0.022
nuclear migration GO:0007097 3 0.022
regulation of nucleotide catabolic process GO:0030811 2 0.022
positive regulation of notch signaling pathway GO:0045747 3 0.022
cognition GO:0050890 1 0.022
exocytosis GO:0006887 1 0.021
nucleoside monophosphate catabolic process GO:0009125 4 0.021
lipid storage GO:0019915 1 0.021
carbohydrate homeostasis GO:0033500 1 0.021
peptidyl lysine acetylation GO:0018394 2 0.021
negative regulation of intracellular transport GO:0032387 3 0.021
intracellular signal transduction GO:0035556 85 0.021
regulation of macromolecule biosynthetic process GO:0010556 225 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
regulation of neurotransmitter secretion GO:0046928 1 0.021
positive regulation of dna metabolic process GO:0051054 1 0.021
single organism nuclear import GO:1902593 3 0.021
positive regulation of wound healing GO:0090303 1 0.021
wound healing GO:0042060 90 0.021
organelle fission GO:0048285 23 0.021
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.021
mitotic cell cycle process GO:1903047 48 0.021
macromolecule localization GO:0033036 54 0.021
Fly
ribonucleoside monophosphate catabolic process GO:0009158 4 0.021
aromatic compound biosynthetic process GO:0019438 217 0.021
neuron projection morphogenesis GO:0048812 161 0.021
central nervous system development GO:0007417 387 0.020
immune system process GO:0002376 241 0.020
regulation of primary metabolic process GO:0080090 311 0.020
regulation of localization GO:0032879 104 0.020
Fly
regulation of cell projection assembly GO:0060491 4 0.020
rna localization GO:0006403 4 0.020
Fly
cell adhesion mediated by integrin GO:0033627 1 0.020
regulation of gtpase activity GO:0043087 2 0.020
regulation of nitrogen compound metabolic process GO:0051171 251 0.020
reproduction GO:0000003 40 0.020
Fly
sensory perception of chemical stimulus GO:0007606 3 0.020
positive regulation of secretion GO:0051047 1 0.020
atp catabolic process GO:0006200 4 0.019
gtp catabolic process GO:0006184 2 0.019
cellular biosynthetic process GO:0044249 286 0.019
microtubule based movement GO:0007018 33 0.019
germ line stem cell division GO:0042078 1 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
positive regulation of gtpase activity GO:0043547 1 0.019
protein localization to nucleus GO:0034504 3 0.019
stem cell maintenance GO:0019827 4 0.019
embryonic heart tube development GO:0035050 133 0.018
mitotic cell cycle GO:0000278 64 0.018
cellular response to external stimulus GO:0071496 2 0.018
cellular amine metabolic process GO:0044106 2 0.018
peptidyl serine modification GO:0018209 2 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.018
negative regulation of protein localization to nucleus GO:1900181 2 0.018
regulation of nucleic acid templated transcription GO:1903506 213 0.018
establishment or maintenance of bipolar cell polarity GO:0061245 12 0.018
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.018
endosomal transport GO:0016197 2 0.018
lymphocyte proliferation GO:0046651 1 0.018
single organism metabolic process GO:0044710 217 0.018
regulation of cellular biosynthetic process GO:0031326 245 0.018
blood vessel morphogenesis GO:0048514 216 0.018
establishment of localization in cell GO:0051649 77 0.018
phagosome maturation GO:0090382 1 0.018
regulation of axonogenesis GO:0050770 32 0.018
nephron epithelium morphogenesis GO:0072088 1 0.018
signal transduction in absence of ligand GO:0038034 1 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
regulation of ion transmembrane transporter activity GO:0032412 2 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.017
negative regulation of blood circulation GO:1903523 2 0.017
establishment or maintenance of cell polarity GO:0007163 29 0.017
regulation of cytoskeleton organization GO:0051493 11 0.017
cell aging GO:0007569 2 0.017
mononuclear cell proliferation GO:0032943 1 0.017
cell part morphogenesis GO:0032990 246 0.017
programmed cell death GO:0012501 119 0.017
regulation of cell division GO:0051302 12 0.017
regulation of protein targeting GO:1903533 2 0.017
epithelial cell differentiation GO:0030855 116 0.017
membrane fusion GO:0061025 2 0.017
sprouting angiogenesis GO:0002040 53 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
growth GO:0040007 174 0.016
regulation of hormone secretion GO:0046883 2 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
regulation of lyase activity GO:0051339 12 0.016
convergent extension GO:0060026 118 0.016
regulation of nervous system development GO:0051960 90 0.016
positive regulation of gtp catabolic process GO:0033126 1 0.016
morphogenesis of embryonic epithelium GO:0016331 30 0.016
autophagy GO:0006914 4 0.016
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.016
cell death GO:0008219 121 0.016
negative regulation of sequestering of calcium ion GO:0051283 4 0.016
cellular protein complex assembly GO:0043623 19 0.016
neuron development GO:0048666 262 0.016
membrane organization GO:0061024 21 0.016
positive regulation of cell adhesion GO:0045785 1 0.016
regulation of phosphate metabolic process GO:0019220 43 0.016
urogenital system development GO:0001655 97 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.016
neuronal action potential GO:0019228 18 0.015
cellular amino acid metabolic process GO:0006520 7 0.015
regulation of neurogenesis GO:0050767 87 0.015
small gtpase mediated signal transduction GO:0007264 8 0.015
lamellipodium assembly GO:0030032 1 0.015
interspecies interaction between organisms GO:0044419 4 0.015
regulation of dendrite morphogenesis GO:0048814 3 0.015
regulation of dna replication GO:0006275 3 0.015
protein stabilization GO:0050821 2 0.015
regulation of metal ion transport GO:0010959 4 0.015
rna biosynthetic process GO:0032774 181 0.015
reflex GO:0060004 2 0.015
phosphorylation GO:0016310 69 0.015
regulation of macromolecule metabolic process GO:0060255 317 0.015
cell fate commitment GO:0045165 99 0.015
neutrophil extravasation GO:0072672 1 0.015
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.015
homeostatic process GO:0042592 142 0.015
regulation of chromosome segregation GO:0051983 1 0.015
cellular nitrogen compound biosynthetic process GO:0044271 218 0.014
muscle structure development GO:0061061 196 0.014
Zebrafish Fly
organic acid metabolic process GO:0006082 31 0.014
cell growth GO:0016049 57 0.014
circulatory system process GO:0003013 87 0.014
gland development GO:0048732 143 0.014
cellular macromolecule biosynthetic process GO:0034645 224 0.014
hormone secretion GO:0046879 2 0.014
regulation of nuclear division GO:0051783 9 0.014
sequestering of metal ion GO:0051238 3 0.014
positive regulation of biosynthetic process GO:0009891 68 0.014
spindle assembly GO:0051225 2 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
cellular response to biotic stimulus GO:0071216 3 0.014
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.014
regulation of cell development GO:0060284 100 0.014
Fly
axon development GO:0061564 166 0.014
behavior GO:0007610 74 0.014
hatching GO:0035188 4 0.014
regulation of cell cycle GO:0051726 52 0.014
ras protein signal transduction GO:0007265 7 0.013
canonical wnt signaling pathway GO:0060070 48 0.013
regulation of transporter activity GO:0032409 2 0.013
release of sequestered calcium ion into cytosol GO:0051209 3 0.013
regulation of transcription dna templated GO:0006355 213 0.013
pole plasm assembly GO:0007315 4 0.013
Fly
positive regulation of molecular function GO:0044093 33 0.013
nucleic acid templated transcription GO:0097659 181 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
pancreas development GO:0031016 84 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
phosphorus metabolic process GO:0006793 109 0.013
regulation of rna metabolic process GO:0051252 224 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
oocyte anterior posterior axis specification GO:0007314 4 0.013
Fly
peptide transport GO:0015833 1 0.013
ovulation cycle GO:0042698 2 0.013
system process GO:0003008 185 0.013
Fly
intracellular mrna localization GO:0008298 1 0.013
Fly
positive regulation of response to stimulus GO:0048584 80 0.013
determination of left right symmetry GO:0007368 179 0.013
digestive tract development GO:0048565 265 0.013
neurotransmitter transport GO:0006836 2 0.013
cellular macromolecule metabolic process GO:0044260 391 0.013
regulation of calcium ion transport GO:0051924 2 0.013
nephron morphogenesis GO:0072028 2 0.013
determination of bilateral symmetry GO:0009855 204 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
regulation of dendrite development GO:0050773 3 0.012
macromolecular complex assembly GO:0065003 35 0.012
renal tubule morphogenesis GO:0061333 1 0.012
positive regulation of cell cycle GO:0045787 3 0.012
heart process GO:0003015 71 0.012
somitogenesis GO:0001756 87 0.012
cytoplasm organization GO:0007028 4 0.012
Fly
regulation of nucleoside metabolic process GO:0009118 2 0.012
angiogenesis GO:0001525 158 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
cellular ketone metabolic process GO:0042180 11 0.012
chemosensory behavior GO:0007635 1 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
small molecule metabolic process GO:0044281 77 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
mitotic cytokinesis GO:0000281 3 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
positive regulation of camp metabolic process GO:0030816 2 0.012
oxoacid metabolic process GO:0043436 31 0.012
positive regulation of synapse assembly GO:0051965 1 0.012
maintenance of cell polarity GO:0030011 5 0.012
heterocycle biosynthetic process GO:0018130 215 0.012
cellular localization GO:0051641 97 0.012
Fly
positive regulation of metabolic process GO:0009893 108 0.012
multicellular organismal signaling GO:0035637 22 0.012
positive regulation of camp biosynthetic process GO:0030819 2 0.012
organism emergence from protective structure GO:0071684 4 0.012
regulation of mitochondrion organization GO:0010821 1 0.011
neuron projection development GO:0031175 180 0.011
superoxide metabolic process GO:0006801 2 0.011
nephron tubule morphogenesis GO:0072078 1 0.011
response to monosaccharide GO:0034284 3 0.011
cell cycle process GO:0022402 53 0.011
mitochondrion organization GO:0007005 4 0.011
tube morphogenesis GO:0035239 349 0.011
exocrine system development GO:0035272 28 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
cellular response to nutrient levels GO:0031669 2 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
negative regulation of mitosis GO:0045839 3 0.011
regulation of locomotion GO:0040012 55 0.011
cell proliferation GO:0008283 80 0.011
regulation of oxidative stress induced cell death GO:1903201 2 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
negative regulation of chromosome organization GO:2001251 1 0.011
midbrain development GO:0030901 28 0.011
muscle tissue development GO:0060537 110 0.011
lamellipodium organization GO:0097581 1 0.011
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.011
neuron projection guidance GO:0097485 86 0.011
specification of symmetry GO:0009799 204 0.011
thermosensory behavior GO:0040040 1 0.011
action potential GO:0001508 19 0.011
blood vessel development GO:0001568 246 0.011
regulation of cellular metabolic process GO:0031323 320 0.011
sensory organ morphogenesis GO:0090596 200 0.011
negative regulation of biological process GO:0048519 304 0.011
g protein coupled receptor signaling pathway GO:0007186 74 0.011
regulation of exocytosis GO:0017157 1 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
mitotic cell cycle embryonic GO:0045448 2 0.011
regulation of cell activation GO:0050865 1 0.011
cellular response to extracellular stimulus GO:0031668 2 0.010
nuclear export GO:0051168 1 0.010
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.010
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
er to golgi vesicle mediated transport GO:0006888 1 0.010
multi organism cellular process GO:0044764 2 0.010
positive regulation of signal transduction GO:0009967 56 0.010
purine ribonucleotide biosynthetic process GO:0009152 20 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
cellular component disassembly GO:0022411 1 0.010
positive regulation of cellular catabolic process GO:0031331 3 0.010
tissue remodeling GO:0048771 4 0.010
regulation of stem cell differentiation GO:2000736 4 0.010
regulation of biosynthetic process GO:0009889 250 0.010
embryonic axis specification GO:0000578 12 0.010
Fly
apoptotic process GO:0006915 116 0.010
regulation of receptor mediated endocytosis GO:0048259 4 0.010
female sex differentiation GO:0046660 4 0.010
regulation of autophagy GO:0010506 3 0.010
muscle cell development GO:0055001 115 0.010
Zebrafish Fly
positive regulation of ras protein signal transduction GO:0046579 1 0.010

lasp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.057
nervous system disease DOID:863 0 0.024
musculoskeletal system disease DOID:17 0 0.015
connective tissue disease DOID:65 0 0.015
immune system disease DOID:2914 0 0.012