Danio rerio

0 known processes

me3

malic enzyme 3, NADP(+)-dependent, mitochondrial

(Aliases: zgc:163117,im:7151680,wu:fi43b04)

me3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.178
cell projection organization GO:0030030 284 0.163
larval development GO:0002164 2 0.154
single organism transport GO:0044765 206 0.138
organelle organization GO:0006996 227 0.126
response to chemical GO:0042221 320 0.118
lipid storage GO:0019915 1 0.109
response to organic substance GO:0010033 153 0.105
organic cyclic compound metabolic process GO:1901360 301 0.098
cellular response to chemical stimulus GO:0070887 157 0.093
maintenance of location GO:0051235 4 0.092
establishment of localization GO:0051234 244 0.091
embryo development ending in birth or egg hatching GO:0009792 271 0.087
cellular component movement GO:0006928 335 0.084
autophagy GO:0006914 4 0.084
signal transduction GO:0007165 455 0.083
locomotion GO:0040011 313 0.081
meiotic nuclear division GO:0007126 4 0.077
central nervous system development GO:0007417 387 0.076
brain development GO:0007420 293 0.074
immune system process GO:0002376 241 0.072
response to external stimulus GO:0009605 264 0.071
positive regulation of transport GO:0051050 2 0.071
microtubule based process GO:0007017 60 0.066
meiotic cell cycle process GO:1903046 3 0.062
nitrogen compound metabolic process GO:0006807 319 0.060
negative regulation of biological process GO:0048519 304 0.060
single organism organelle organization GO:1902589 199 0.059
positive regulation of biological process GO:0048518 253 0.057
cellular response to organic substance GO:0071310 105 0.057
transmembrane transport GO:0055085 120 0.057
organic acid metabolic process GO:0006082 31 0.057
negative regulation of cellular process GO:0048523 283 0.057
cell cycle GO:0007049 93 0.057
oxoacid metabolic process GO:0043436 31 0.056
cell surface receptor signaling pathway GO:0007166 325 0.054
regulation of gene expression GO:0010468 265 0.054
generation of neurons GO:0048699 385 0.054
immune system development GO:0002520 191 0.053
organic substance biosynthetic process GO:1901576 289 0.051
apoptotic process GO:0006915 116 0.050
regulation of metabolic process GO:0019222 359 0.050
nucleic acid metabolic process GO:0090304 244 0.049
regulation of biological quality GO:0065008 263 0.049
aging GO:0007568 2 0.048
heterocycle metabolic process GO:0046483 290 0.047
cellular response to extracellular stimulus GO:0031668 2 0.047
nucleobase containing compound metabolic process GO:0006139 274 0.047
regulation of cell projection assembly GO:0060491 4 0.047
single organism localization GO:1902578 225 0.046
cell migration GO:0016477 237 0.046
negative regulation of sequestering of calcium ion GO:0051283 4 0.045
cellular amino acid metabolic process GO:0006520 7 0.045
response to amino acid GO:0043200 2 0.045
small molecule metabolic process GO:0044281 77 0.045
cellular macromolecule metabolic process GO:0044260 391 0.045
cytoskeleton organization GO:0007010 96 0.045
regulation of primary metabolic process GO:0080090 311 0.045
regulation of nitrogen compound metabolic process GO:0051171 251 0.044
single organism metabolic process GO:0044710 217 0.043
nucleobase containing compound biosynthetic process GO:0034654 205 0.042
regulation of macromolecule metabolic process GO:0060255 317 0.041
positive regulation of cellular process GO:0048522 201 0.041
transcription dna templated GO:0006351 181 0.041
macromolecular complex subunit organization GO:0043933 74 0.041
regulation of cell communication GO:0010646 232 0.041
nuclear migration GO:0007097 3 0.040
adult behavior GO:0030534 2 0.040
positive regulation of cellular component biogenesis GO:0044089 3 0.040
aromatic compound biosynthetic process GO:0019438 217 0.040
biosynthetic process GO:0009058 294 0.040
localization of cell GO:0051674 244 0.039
small molecule catabolic process GO:0044282 3 0.039
hematopoietic or lymphoid organ development GO:0048534 191 0.039
homeostatic process GO:0042592 142 0.039
response to monosaccharide GO:0034284 3 0.038
response to endogenous stimulus GO:0009719 83 0.038
cell cycle process GO:0022402 53 0.038
extrinsic apoptotic signaling pathway GO:0097191 3 0.038
regulation of cellular biosynthetic process GO:0031326 245 0.038
embryonic hemopoiesis GO:0035162 53 0.038
regulation of biosynthetic process GO:0009889 250 0.037
cellular component biogenesis GO:0044085 178 0.036
establishment of localization in cell GO:0051649 77 0.036
transport GO:0006810 220 0.036
blood vessel development GO:0001568 246 0.036
regulation of filopodium assembly GO:0051489 2 0.036
programmed cell death GO:0012501 119 0.036
intracellular signal transduction GO:0035556 85 0.036
rna biosynthetic process GO:0032774 181 0.035
cellular biosynthetic process GO:0044249 286 0.035
establishment of protein localization to organelle GO:0072594 4 0.035
cellular component assembly GO:0022607 170 0.035
phagocytosis GO:0006909 3 0.035
cellular nitrogen compound metabolic process GO:0034641 290 0.035
regulation of signaling GO:0023051 235 0.034
carboxylic acid metabolic process GO:0019752 22 0.034
cellular response to nutrient levels GO:0031669 2 0.034
carboxylic acid catabolic process GO:0046395 3 0.034
cellular response to external stimulus GO:0071496 2 0.033
cellular response to hormone stimulus GO:0032870 39 0.033
organonitrogen compound metabolic process GO:1901564 74 0.033
cell motility GO:0048870 244 0.033
membrane invagination GO:0010324 1 0.033
actin filament polymerization GO:0030041 2 0.032
protein polymerization GO:0051258 4 0.032
response to hormone GO:0009725 48 0.032
chordate embryonic development GO:0043009 271 0.031
vasculature development GO:0001944 278 0.031
response to stress GO:0006950 263 0.031
head development GO:0060322 303 0.031
gland development GO:0048732 143 0.031
actin polymerization or depolymerization GO:0008154 2 0.030
macromolecule biosynthetic process GO:0009059 227 0.029
regulation of ion transmembrane transporter activity GO:0032412 2 0.029
protein import GO:0017038 3 0.029
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
myeloid cell differentiation GO:0030099 86 0.028
cellular response to endogenous stimulus GO:0071495 68 0.028
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.028
connective tissue development GO:0061448 99 0.028
cellular nitrogen compound biosynthetic process GO:0044271 218 0.028
urogenital system development GO:0001655 97 0.027
gene expression GO:0010467 252 0.027
negative regulation of kinase activity GO:0033673 4 0.027
negative regulation of protein phosphorylation GO:0001933 4 0.027
system process GO:0003008 185 0.027
female meiotic division GO:0007143 2 0.026
gtp catabolic process GO:0006184 2 0.026
multi organism process GO:0051704 134 0.026
death GO:0016265 121 0.026
negative regulation of protein kinase activity GO:0006469 4 0.026
regulation of cell death GO:0010941 103 0.026
organelle localization GO:0051640 49 0.026
stem cell proliferation GO:0072089 4 0.026
regulation of multicellular organism growth GO:0040014 4 0.026
positive regulation of catabolic process GO:0009896 4 0.026
ion transport GO:0006811 114 0.025
response to carbohydrate GO:0009743 3 0.025
gtp metabolic process GO:0046039 4 0.025
angiogenesis GO:0001525 158 0.025
neuron differentiation GO:0030182 353 0.025
muscle structure development GO:0061061 196 0.025
regulation of rna metabolic process GO:0051252 224 0.025
regulation of rna biosynthetic process GO:2001141 213 0.025
heart development GO:0007507 313 0.025
response to glucose GO:0009749 3 0.025
nucleic acid templated transcription GO:0097659 181 0.025
regulation of multicellular organismal process GO:0051239 277 0.024
lipid catabolic process GO:0016042 4 0.024
rna metabolic process GO:0016070 219 0.024
protein metabolic process GO:0019538 183 0.024
regeneration GO:0031099 91 0.023
endosomal transport GO:0016197 2 0.023
ameboidal type cell migration GO:0001667 143 0.023
protein localization to nucleus GO:0034504 3 0.023
macroautophagy GO:0016236 1 0.023
response to hexose GO:0009746 3 0.023
nucleocytoplasmic transport GO:0006913 4 0.023
regulation of binding GO:0051098 3 0.023
response to oxygen containing compound GO:1901700 55 0.023
guanosine containing compound metabolic process GO:1901068 4 0.023
negative regulation of response to stimulus GO:0048585 104 0.022
ribonucleoside monophosphate catabolic process GO:0009158 4 0.022
positive regulation of apoptotic signaling pathway GO:2001235 1 0.022
regulation of programmed cell death GO:0043067 101 0.022
protein import into nucleus GO:0006606 3 0.022
heterocycle biosynthetic process GO:0018130 215 0.022
regulation of transporter activity GO:0032409 2 0.022
protein targeting to nucleus GO:0044744 3 0.022
camera type eye development GO:0043010 222 0.022
cell morphogenesis GO:0000902 289 0.022
mitotic cell cycle GO:0000278 64 0.022
neuron projection development GO:0031175 180 0.021
establishment of spindle localization GO:0051293 12 0.021
positive regulation of secretion GO:0051047 1 0.021
regulation of molecular function GO:0065009 70 0.021
regulation of signal transduction GO:0009966 225 0.021
hepaticobiliary system development GO:0061008 98 0.021
nucleoside monophosphate catabolic process GO:0009125 4 0.021
inorganic ion transmembrane transport GO:0098660 57 0.021
regulation of cellular amine metabolic process GO:0033238 0 0.021
mononuclear cell proliferation GO:0032943 1 0.021
regulation of response to stimulus GO:0048583 269 0.021
mitochondrion organization GO:0007005 4 0.021
cell death GO:0008219 121 0.020
regulation of cellular component organization GO:0051128 86 0.020
positive regulation of map kinase activity GO:0043406 3 0.020
regulation of protein polymerization GO:0032271 2 0.020
vesicle localization GO:0051648 27 0.020
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.020
single organism cellular localization GO:1902580 46 0.020
cell part morphogenesis GO:0032990 246 0.020
release of sequestered calcium ion into cytosol GO:0051209 3 0.020
regulation of apoptotic process GO:0042981 98 0.020
cytokinesis GO:0000910 3 0.020
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.019
stem cell maintenance GO:0019827 4 0.019
organic cyclic compound biosynthetic process GO:1901362 223 0.019
inner ear development GO:0048839 126 0.019
nuclear import GO:0051170 3 0.019
neurotransmitter transport GO:0006836 2 0.019
response to nutrient GO:0007584 3 0.019
nuclear transport GO:0051169 4 0.019
positive regulation of secretion by cell GO:1903532 1 0.019
spermatid development GO:0007286 2 0.019
enzyme linked receptor protein signaling pathway GO:0007167 106 0.019
negative regulation of signal transduction GO:0009968 94 0.019
regulation of blood pressure GO:0008217 1 0.019
response to drug GO:0042493 3 0.018
positive regulation of cytoskeleton organization GO:0051495 3 0.018
alpha amino acid metabolic process GO:1901605 3 0.018
hormone secretion GO:0046879 2 0.018
cellular protein metabolic process GO:0044267 129 0.018
response to lipid GO:0033993 60 0.018
cellular response to stress GO:0033554 62 0.018
regulation of sequestering of calcium ion GO:0051282 4 0.018
catabolic process GO:0009056 32 0.018
actin filament based movement GO:0030048 1 0.018
digestive system development GO:0055123 289 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
positive regulation of nucleotide catabolic process GO:0030813 1 0.018
carbohydrate homeostasis GO:0033500 1 0.018
lymphocyte proliferation GO:0046651 1 0.018
microtubule cytoskeleton organization GO:0000226 33 0.017
single organism nuclear import GO:1902593 3 0.017
positive regulation of cellular metabolic process GO:0031325 94 0.017
smooth muscle contraction GO:0006939 2 0.017
stem cell division GO:0017145 1 0.017
signal transduction in absence of ligand GO:0038034 1 0.017
negative regulation of signaling GO:0023057 96 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
cellular ketone metabolic process GO:0042180 11 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.017
sensory organ morphogenesis GO:0090596 200 0.017
negative regulation of macromolecule metabolic process GO:0010605 76 0.017
digestive tract morphogenesis GO:0048546 231 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
cellular aromatic compound metabolic process GO:0006725 295 0.017
muscle fiber development GO:0048747 52 0.016
regulation of protein complex assembly GO:0043254 3 0.016
regulation of macromolecule biosynthetic process GO:0010556 225 0.016
retina development in camera type eye GO:0060041 146 0.016
cellular catabolic process GO:0044248 27 0.016
notch signaling pathway GO:0007219 35 0.016
regulation of synapse organization GO:0050807 3 0.016
regulation of gtp catabolic process GO:0033124 2 0.016
amine metabolic process GO:0009308 2 0.016
superoxide metabolic process GO:0006801 2 0.016
regulation of hormone secretion GO:0046883 2 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
establishment of organelle localization GO:0051656 45 0.016
regulation of cellular metabolic process GO:0031323 320 0.016
sequestering of metal ion GO:0051238 3 0.016
atp catabolic process GO:0006200 4 0.016
regulation of erk1 and erk2 cascade GO:0070372 4 0.016
neuron development GO:0048666 262 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.015
growth GO:0040007 174 0.015
establishment of mitotic spindle orientation GO:0000132 10 0.015
regulation of rho protein signal transduction GO:0035023 2 0.015
establishment of synaptic vesicle localization GO:0097480 1 0.015
carbohydrate derivative metabolic process GO:1901135 61 0.015
regulation of metal ion transport GO:0010959 4 0.015
cation transmembrane transport GO:0098655 65 0.015
protein dephosphorylation GO:0006470 3 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.015
cilium assembly GO:0042384 58 0.015
embryonic organ development GO:0048568 381 0.015
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.015
synaptic vesicle transport GO:0048489 1 0.015
er to golgi vesicle mediated transport GO:0006888 1 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
protein localization to vacuole GO:0072665 1 0.015
regulation of blood vessel size GO:0050880 2 0.015
multicellular organismal metabolic process GO:0044236 2 0.015
tube morphogenesis GO:0035239 349 0.015
cellular response to starvation GO:0009267 1 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
cell projection assembly GO:0030031 64 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.015
negative regulation of cellular metabolic process GO:0031324 77 0.015
response to uv GO:0009411 3 0.014
regulation of purine nucleotide catabolic process GO:0033121 2 0.014
medulla oblongata development GO:0021550 4 0.014
hemopoiesis GO:0030097 183 0.014
determination of left right symmetry GO:0007368 179 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
blood vessel morphogenesis GO:0048514 216 0.014
homeostasis of number of cells GO:0048872 62 0.014
phagocytosis engulfment GO:0006911 1 0.014
positive regulation of cellular biosynthetic process GO:0031328 68 0.014
negative regulation of catalytic activity GO:0043086 21 0.014
renal system development GO:0072001 94 0.014
regulation of transmembrane transport GO:0034762 18 0.014
organic acid catabolic process GO:0016054 3 0.014
b cell activation GO:0042113 2 0.014
sensory organ development GO:0007423 393 0.014
phosphatidylinositol mediated signaling GO:0048015 2 0.014
calcium ion transport into cytosol GO:0060402 3 0.013
regulation of cell shape GO:0008360 1 0.013
peptide transport GO:0015833 1 0.013
glial cell migration GO:0008347 3 0.013
circulatory system process GO:0003013 87 0.013
neuroblast proliferation GO:0007405 2 0.013
multicellular organism growth GO:0035264 4 0.013
protein modification process GO:0036211 100 0.013
eye development GO:0001654 277 0.013
erythrocyte differentiation GO:0030218 54 0.013
phosphorus metabolic process GO:0006793 109 0.013
oxidation reduction process GO:0055114 41 0.013
spermatid differentiation GO:0048515 2 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
regulation of reproductive process GO:2000241 4 0.013
digestive tract mesoderm development GO:0007502 1 0.013
negative regulation of mapk cascade GO:0043409 4 0.013
mitotic cell cycle process GO:1903047 48 0.013
skeletal system development GO:0001501 181 0.013
wound healing GO:0042060 90 0.013
regulation of cellular component movement GO:0051270 55 0.013
cellular amide metabolic process GO:0043603 4 0.013
cell aging GO:0007569 2 0.013
inositol lipid mediated signaling GO:0048017 2 0.013
anion transport GO:0006820 38 0.013
specification of symmetry GO:0009799 204 0.013
regulation of calcium ion transport GO:0051924 2 0.013
b cell mediated immunity GO:0019724 3 0.013
negative regulation of intracellular transport GO:0032387 3 0.013
establishment of vesicle localization GO:0051650 24 0.013
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
regulation of protein localization to nucleus GO:1900180 2 0.013
neurological system process GO:0050877 62 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.013
golgi vesicle transport GO:0048193 3 0.013
regulation of cell motility GO:2000145 46 0.013
purine nucleoside monophosphate catabolic process GO:0009128 4 0.012
response to organic cyclic compound GO:0014070 51 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
collagen metabolic process GO:0032963 2 0.012
myeloid cell homeostasis GO:0002262 56 0.012
cellular response to oxygen levels GO:0071453 1 0.012
leukocyte proliferation GO:0070661 1 0.012
regulation of synapse assembly GO:0051963 3 0.012
regulation of systemic arterial blood pressure GO:0003073 1 0.012
membrane fusion GO:0061025 2 0.012
cytosolic calcium ion transport GO:0060401 3 0.012
cellular amine metabolic process GO:0044106 2 0.012
axonogenesis GO:0007409 152 0.012
regulation of epithelial cell proliferation GO:0050678 3 0.012
cellular amino acid biosynthetic process GO:0008652 2 0.012
negative regulation of metabolic process GO:0009892 86 0.012
regulation of tube size GO:0035150 2 0.012
protein acetylation GO:0006473 2 0.012
cellular localization GO:0051641 97 0.012
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.012
regulation of neurotransmitter secretion GO:0046928 1 0.012
cilium organization GO:0044782 71 0.012
establishment of protein localization to plasma membrane GO:0090002 1 0.012
embryonic organ morphogenesis GO:0048562 274 0.012
pigmentation GO:0043473 85 0.012
macromolecule localization GO:0033036 54 0.012
regulation of inflammatory response GO:0050727 2 0.012
exocytosis GO:0006887 1 0.012
intestinal absorption GO:0050892 2 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
lipid homeostasis GO:0055088 3 0.012
cellular response to hypoxia GO:0071456 1 0.012
negative regulation of multicellular organismal process GO:0051241 69 0.012
meiotic spindle organization GO:0000212 1 0.011
regulation of dendrite development GO:0050773 3 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
ion transmembrane transport GO:0034220 91 0.011
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.011
organic substance catabolic process GO:1901575 28 0.011
negative regulation of biosynthetic process GO:0009890 55 0.011
multicellular organismal macromolecule metabolic process GO:0044259 2 0.011
positive regulation of striated muscle cell differentiation GO:0051155 1 0.011
negative regulation of catabolic process GO:0009895 3 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
cartilage development GO:0051216 96 0.011
axon development GO:0061564 166 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.011
positive regulation of signal transduction GO:0009967 56 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.011
sequestering of calcium ion GO:0051208 3 0.011
cellular response to retinoic acid GO:0071300 1 0.011
ear development GO:0043583 127 0.011
response to hydrogen peroxide GO:0042542 3 0.011
cellular response to oxygen containing compound GO:1901701 20 0.011
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.011
hormone transport GO:0009914 2 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
microtubule based movement GO:0007018 33 0.011
vacuolar transport GO:0007034 2 0.011
erk1 and erk2 cascade GO:0070371 4 0.011
negative regulation of cell communication GO:0010648 96 0.011
nucleus localization GO:0051647 8 0.011
response to abiotic stimulus GO:0009628 122 0.011
cell cycle arrest GO:0007050 1 0.011
response to alcohol GO:0097305 14 0.011
actin filament based process GO:0030029 64 0.011
cellular component disassembly GO:0022411 1 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.010
cognition GO:0050890 1 0.010
transcription from rna polymerase ii promoter GO:0006366 80 0.010
actin cytoskeleton organization GO:0030036 63 0.010
negative regulation of map kinase activity GO:0043407 2 0.010
pronuclear migration GO:0035046 1 0.010
germ line stem cell maintenance GO:0030718 2 0.010
cellular protein modification process GO:0006464 100 0.010
erythrocyte homeostasis GO:0034101 55 0.010
multicellular organismal response to stress GO:0033555 2 0.010
rna 3 end processing GO:0031123 2 0.010
determination of bilateral symmetry GO:0009855 204 0.010
response to wounding GO:0009611 116 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
gastrulation GO:0007369 208 0.010
axon guidance GO:0007411 86 0.010
striated muscle cell development GO:0055002 108 0.010

me3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
disease of metabolism DOID:0014667 0 0.015
inherited metabolic disorder DOID:655 0 0.015
nervous system disease DOID:863 0 0.012