Danio rerio

0 known processes

me2

malic enzyme 2, NAD(+)-dependent, mitochondrial

(Aliases: zgc:100941)

me2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.378
muscle cell differentiation GO:0042692 139 0.304
generation of neurons GO:0048699 385 0.235
actin polymerization or depolymerization GO:0008154 2 0.196
aging GO:0007568 2 0.196
actin filament polymerization GO:0030041 2 0.184
regulation of cell projection assembly GO:0060491 4 0.181
neuron differentiation GO:0030182 353 0.173
muscle structure development GO:0061061 196 0.166
maintenance of location GO:0051235 4 0.153
cytokinesis GO:0000910 3 0.150
digestive tract development GO:0048565 265 0.147
cell morphogenesis GO:0000902 289 0.140
cell projection assembly GO:0030031 64 0.136
lamellipodium organization GO:0097581 1 0.134
heart contraction GO:0060047 71 0.131
regulation of biological quality GO:0065008 263 0.121
heart process GO:0003015 71 0.117
muscle tissue development GO:0060537 110 0.114
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.112
regulation of protein polymerization GO:0032271 2 0.110
lipid storage GO:0019915 1 0.105
protein polymerization GO:0051258 4 0.104
cellular component morphogenesis GO:0032989 336 0.103
regulation of muscle contraction GO:0006937 3 0.103
regulation of protein depolymerization GO:1901879 1 0.097
muscle cell development GO:0055001 115 0.096
regulation of macromolecule metabolic process GO:0060255 317 0.096
actomyosin structure organization GO:0031032 53 0.095
organic substance biosynthetic process GO:1901576 289 0.091
regulation of nucleotide catabolic process GO:0030811 2 0.083
cellular component disassembly GO:0022411 1 0.082
regulation of metabolic process GO:0019222 359 0.078
cellular aromatic compound metabolic process GO:0006725 295 0.078
muscle system process GO:0003012 20 0.077
negative regulation of cellular process GO:0048523 283 0.077
neuron development GO:0048666 262 0.077
blood circulation GO:0008015 87 0.076
cellular macromolecule metabolic process GO:0044260 391 0.075
circulatory system process GO:0003013 87 0.074
positive regulation of biological process GO:0048518 253 0.073
striated muscle contraction GO:0006941 12 0.073
positive regulation of transport GO:0051050 2 0.072
protein localization to plasma membrane GO:0072659 1 0.070
intracellular mrna localization GO:0008298 1 0.070
positive regulation of cellular component biogenesis GO:0044089 3 0.069
positive regulation of cellular catabolic process GO:0031331 3 0.069
cell cycle g1 s phase transition GO:0044843 1 0.069
myofibril assembly GO:0030239 48 0.068
regulation of cell projection organization GO:0031344 44 0.068
cellular component assembly GO:0022607 170 0.067
striated muscle cell differentiation GO:0051146 129 0.066
lamellipodium assembly GO:0030032 1 0.066
cell projection organization GO:0030030 284 0.066
regulation of cellular metabolic process GO:0031323 320 0.065
nucleoside monophosphate catabolic process GO:0009125 4 0.064
heart development GO:0007507 313 0.064
macromolecule biosynthetic process GO:0009059 227 0.063
regulation of nucleoside metabolic process GO:0009118 2 0.061
negative regulation of biological process GO:0048519 304 0.060
cytoskeleton organization GO:0007010 96 0.060
cardiac muscle cell development GO:0055013 20 0.060
regulation of cell shape GO:0008360 1 0.059
actin filament based process GO:0030029 64 0.058
cellular component assembly involved in morphogenesis GO:0010927 107 0.057
sequestering of metal ion GO:0051238 3 0.057
cellular nitrogen compound metabolic process GO:0034641 290 0.056
regulation of multicellular organismal process GO:0051239 277 0.054
organic cyclic compound metabolic process GO:1901360 301 0.053
regulation of cellular component organization GO:0051128 86 0.053
protein complex disassembly GO:0043241 1 0.053
somatic muscle development GO:0007525 4 0.053
establishment of protein localization to plasma membrane GO:0090002 1 0.052
regulation of primary metabolic process GO:0080090 311 0.052
muscle contraction GO:0006936 18 0.052
cellular macromolecule biosynthetic process GO:0034645 224 0.051
ribonucleoside monophosphate catabolic process GO:0009158 4 0.051
cellular component biogenesis GO:0044085 178 0.051
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.050
digestive system development GO:0055123 289 0.049
single organism organelle organization GO:1902589 199 0.047
striated muscle cell development GO:0055002 108 0.046
actin filament organization GO:0007015 15 0.046
nitrogen compound metabolic process GO:0006807 319 0.046
system process GO:0003008 185 0.045
regionalization GO:0003002 274 0.044
organelle organization GO:0006996 227 0.044
aromatic compound biosynthetic process GO:0019438 217 0.044
eye development GO:0001654 277 0.043
regulation of binding GO:0051098 3 0.043
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.043
positive regulation of gtp catabolic process GO:0033126 1 0.043
locomotion GO:0040011 313 0.042
embryo development ending in birth or egg hatching GO:0009792 271 0.041
positive regulation of muscle cell differentiation GO:0051149 1 0.041
regulation of gtp catabolic process GO:0033124 2 0.041
nucleic acid metabolic process GO:0090304 244 0.041
rna localization GO:0006403 4 0.040
g1 s transition of mitotic cell cycle GO:0000082 1 0.040
cardiac muscle cell differentiation GO:0055007 30 0.040
regulation of multicellular organismal development GO:2000026 223 0.039
cardiocyte differentiation GO:0035051 44 0.039
regulation of developmental process GO:0050793 247 0.039
regulation of filopodium assembly GO:0051489 2 0.039
organelle assembly GO:0070925 110 0.038
growth GO:0040007 174 0.038
segmentation GO:0035282 97 0.038
striated muscle tissue development GO:0014706 110 0.037
regulation of metal ion transport GO:0010959 4 0.037
macromolecular complex disassembly GO:0032984 1 0.036
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.036
regulation of protein complex assembly GO:0043254 3 0.036
carboxylic acid catabolic process GO:0046395 3 0.035
regulation of protein complex disassembly GO:0043244 1 0.035
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.035
cellular macromolecular complex assembly GO:0034622 24 0.035
macromolecular complex subunit organization GO:0043933 74 0.035
purine nucleotide metabolic process GO:0006163 27 0.035
cardiac muscle tissue development GO:0048738 48 0.035
response to chemical GO:0042221 320 0.034
cardiac myofibril assembly GO:0055003 9 0.034
regulation of purine nucleotide catabolic process GO:0033121 2 0.034
positive regulation of cellular process GO:0048522 201 0.033
regulation of nitrogen compound metabolic process GO:0051171 251 0.033
single organism localization GO:1902578 225 0.033
oocyte anterior posterior axis specification GO:0007314 4 0.033
heterocycle metabolic process GO:0046483 290 0.033
single organism transport GO:0044765 206 0.032
sequestering of calcium ion GO:0051208 3 0.032
positive regulation of catabolic process GO:0009896 4 0.032
g2 m transition of mitotic cell cycle GO:0000086 4 0.032
actin cytoskeleton organization GO:0030036 63 0.032
regulation of heart contraction GO:0008016 32 0.032
cardiac cell development GO:0055006 21 0.031
regulation of gene expression GO:0010468 265 0.031
regulation of organelle assembly GO:1902115 4 0.031
atp catabolic process GO:0006200 4 0.031
protein depolymerization GO:0051261 1 0.030
blood vessel development GO:0001568 246 0.030
nucleobase containing compound metabolic process GO:0006139 274 0.030
fatty acid beta oxidation GO:0006635 1 0.030
establishment of localization GO:0051234 244 0.030
central nervous system development GO:0007417 387 0.030
regulation of rna biosynthetic process GO:2001141 213 0.030
cell morphogenesis involved in differentiation GO:0000904 195 0.030
negative regulation of sequestering of calcium ion GO:0051283 4 0.030
regulation of protein binding GO:0043393 3 0.030
cellular biosynthetic process GO:0044249 286 0.029
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.029
regulation of cellular biosynthetic process GO:0031326 245 0.029
regulation of anatomical structure morphogenesis GO:0022603 130 0.029
cell projection morphogenesis GO:0048858 244 0.029
regulation of cell substrate adhesion GO:0010810 1 0.028
regulation of gtpase activity GO:0043087 2 0.028
regulation of molecular function GO:0065009 70 0.028
brain development GO:0007420 293 0.028
response to abiotic stimulus GO:0009628 122 0.028
heart morphogenesis GO:0003007 156 0.027
cardiac muscle contraction GO:0060048 6 0.027
positive regulation of nucleoside metabolic process GO:0045979 1 0.027
positive regulation of cell substrate adhesion GO:0010811 1 0.027
nucleobase containing compound biosynthetic process GO:0034654 205 0.027
regulation of cell differentiation GO:0045595 142 0.027
organonitrogen compound metabolic process GO:1901564 74 0.027
cell cycle GO:0007049 93 0.026
positive regulation of cell adhesion GO:0045785 1 0.026
modification dependent protein catabolic process GO:0019941 3 0.026
positive regulation of cell matrix adhesion GO:0001954 1 0.026
single organism metabolic process GO:0044710 217 0.025
regulation of dendrite development GO:0050773 3 0.025
cellular protein complex assembly GO:0043623 19 0.025
regulation of sequestering of calcium ion GO:0051282 4 0.025
purine nucleoside monophosphate catabolic process GO:0009128 4 0.025
regulation of cytoskeleton organization GO:0051493 11 0.025
cell motility GO:0048870 244 0.024
fatty acid catabolic process GO:0009062 1 0.024
cell part morphogenesis GO:0032990 246 0.024
transport GO:0006810 220 0.024
biosynthetic process GO:0009058 294 0.024
cellular component movement GO:0006928 335 0.024
transcription dna templated GO:0006351 181 0.024
regulation of cell morphogenesis GO:0022604 42 0.024
embryonic pattern specification GO:0009880 44 0.024
regulation of catalytic activity GO:0050790 55 0.024
cardiac chamber development GO:0003205 19 0.024
regulation of bone mineralization GO:0030500 2 0.023
ubiquitin dependent protein catabolic process GO:0006511 3 0.023
small molecule metabolic process GO:0044281 77 0.023
protein metabolic process GO:0019538 183 0.023
regulation of rna metabolic process GO:0051252 224 0.022
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.022
neuron projection development GO:0031175 180 0.022
cell cycle process GO:0022402 53 0.022
cytoplasm organization GO:0007028 4 0.022
guanosine containing compound metabolic process GO:1901068 4 0.022
fatty acid transport GO:0015908 1 0.022
cellular response to extracellular stimulus GO:0031668 2 0.022
regulation of cellular component size GO:0032535 30 0.022
regulation of ion transmembrane transporter activity GO:0032412 2 0.021
adult behavior GO:0030534 2 0.021
carbohydrate derivative metabolic process GO:1901135 61 0.021
negative regulation of macromolecule metabolic process GO:0010605 76 0.021
negative regulation of blood circulation GO:1903523 2 0.021
response to drug GO:0042493 3 0.021
multi organism process GO:0051704 134 0.021
gtp metabolic process GO:0046039 4 0.021
regulation of actin filament based process GO:0032970 9 0.021
rna biosynthetic process GO:0032774 181 0.021
heterocycle biosynthetic process GO:0018130 215 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.021
catabolic process GO:0009056 32 0.020
regulation of multicellular organism growth GO:0040014 4 0.020
gene expression GO:0010467 252 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
modification dependent macromolecule catabolic process GO:0043632 3 0.020
protein complex subunit organization GO:0071822 46 0.020
protein targeting to membrane GO:0006612 1 0.020
response to stress GO:0006950 263 0.020
regulation of cell development GO:0060284 100 0.020
circadian sleep wake cycle sleep GO:0050802 1 0.020
cellular carbohydrate metabolic process GO:0044262 4 0.020
cellular protein metabolic process GO:0044267 129 0.020
cation transmembrane transport GO:0098655 65 0.019
negative regulation of protein phosphorylation GO:0001933 4 0.019
localization of cell GO:0051674 244 0.019
gtp catabolic process GO:0006184 2 0.019
macromolecule localization GO:0033036 54 0.019
head development GO:0060322 303 0.019
macromolecular complex assembly GO:0065003 35 0.019
positive regulation of nucleotide catabolic process GO:0030813 1 0.019
regulation of anatomical structure size GO:0090066 33 0.019
positive regulation of macromolecule metabolic process GO:0010604 93 0.019
nuclear import GO:0051170 3 0.019
inositol lipid mediated signaling GO:0048017 2 0.019
sarcomere organization GO:0045214 26 0.019
guanosine containing compound catabolic process GO:1901069 2 0.018
programmed cell death GO:0012501 119 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
cellular response to nutrient levels GO:0031669 2 0.018
organic acid metabolic process GO:0006082 31 0.018
negative regulation of heart contraction GO:0045822 2 0.018
cellular protein complex disassembly GO:0043624 1 0.018
phosphorus metabolic process GO:0006793 109 0.018
regulation of reproductive process GO:2000241 4 0.018
multicellular organism growth GO:0035264 4 0.018
positive regulation of cytoskeleton organization GO:0051495 3 0.018
regulation of sarcomere organization GO:0060297 2 0.018
ameboidal type cell migration GO:0001667 143 0.018
cellular lipid catabolic process GO:0044242 3 0.017
positive regulation of map kinase activity GO:0043406 3 0.017
signal transduction GO:0007165 455 0.017
regulation of nucleotide metabolic process GO:0006140 17 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
regulation of circadian rhythm GO:0042752 4 0.017
axis specification GO:0009798 43 0.017
positive regulation of gtpase activity GO:0043547 1 0.017
regulation of system process GO:0044057 40 0.017
lipid homeostasis GO:0055088 3 0.017
cell substrate adhesion GO:0031589 4 0.017
cellular response to external stimulus GO:0071496 2 0.017
cellular amine metabolic process GO:0044106 2 0.017
long chain fatty acid transport GO:0015909 1 0.017
morphogenesis of an epithelium GO:0002009 333 0.017
cell surface receptor signaling pathway GO:0007166 325 0.017
amine metabolic process GO:0009308 2 0.016
enzyme linked receptor protein signaling pathway GO:0007167 106 0.016
cellular response to starvation GO:0009267 1 0.016
single organism cellular localization GO:1902580 46 0.016
anterior posterior pattern specification GO:0009952 152 0.016
release of sequestered calcium ion into cytosol GO:0051209 3 0.016
regulation of macromolecule biosynthetic process GO:0010556 225 0.016
regulation of protein transport GO:0051223 3 0.016
neuron projection morphogenesis GO:0048812 161 0.016
regulation of biosynthetic process GO:0009889 250 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
cellular response to chemical stimulus GO:0070887 157 0.016
action potential GO:0001508 19 0.016
vasculature development GO:0001944 278 0.016
protein import GO:0017038 3 0.016
inorganic ion transmembrane transport GO:0098660 57 0.016
macromolecule modification GO:0043412 111 0.016
adherens junction assembly GO:0034333 1 0.016
regulation of transmembrane transporter activity GO:0022898 2 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
regulation of transporter activity GO:0032409 2 0.015
regulation of neuron differentiation GO:0045664 56 0.015
oxoacid metabolic process GO:0043436 31 0.015
homeostatic process GO:0042592 142 0.015
spermatid differentiation GO:0048515 2 0.015
regulation of establishment of protein localization GO:0070201 4 0.015
cell division GO:0051301 20 0.015
ion transmembrane transport GO:0034220 91 0.015
negative regulation of cytokine production GO:0001818 1 0.015
membrane invagination GO:0010324 1 0.015
cellular response to endogenous stimulus GO:0071495 68 0.015
protein complex biogenesis GO:0070271 30 0.015
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.015
blood vessel morphogenesis GO:0048514 216 0.015
regulation of synapse assembly GO:0051963 3 0.015
protein complex assembly GO:0006461 30 0.015
regulation of transcription dna templated GO:0006355 213 0.015
regulation of neurogenesis GO:0050767 87 0.015
cellular nitrogen compound biosynthetic process GO:0044271 218 0.015
negative regulation of cyclic nucleotide metabolic process GO:0030800 7 0.015
regulation of protein metabolic process GO:0051246 56 0.015
gastrulation GO:0007369 208 0.015
adherens junction organization GO:0034332 4 0.015
embryonic organ development GO:0048568 381 0.014
regulation of rho protein signal transduction GO:0035023 2 0.014
musculoskeletal movement GO:0050881 8 0.014
axon development GO:0061564 166 0.014
regulation of synapse organization GO:0050807 3 0.014
skeletal muscle tissue development GO:0007519 67 0.014
oocyte development GO:0048599 14 0.014
cognition GO:0050890 1 0.014
response to endogenous stimulus GO:0009719 83 0.014
nucleobase containing compound transport GO:0015931 2 0.014
regeneration GO:0031099 91 0.014
positive regulation of cell cycle GO:0045787 3 0.014
response to external stimulus GO:0009605 264 0.014
negative regulation of protein kinase activity GO:0006469 4 0.014
negative regulation of cellular component organization GO:0051129 16 0.014
hormone transport GO:0009914 2 0.014
organic cyclic compound biosynthetic process GO:1901362 223 0.013
autophagy GO:0006914 4 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
regulation of circadian sleep wake cycle GO:0042749 1 0.013
chordate embryonic development GO:0043009 271 0.013
dna templated transcription elongation GO:0006354 3 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
angiogenesis GO:0001525 158 0.013
apoptotic process GO:0006915 116 0.013
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.013
regulation of membrane potential GO:0042391 23 0.013
response to organic substance GO:0010033 153 0.013
regulation of autophagy GO:0010506 3 0.013
heart trabecula morphogenesis GO:0061384 2 0.013
lipid catabolic process GO:0016042 4 0.013
epithelial cell morphogenesis GO:0003382 2 0.013
lipid oxidation GO:0034440 1 0.013
somitogenesis GO:0001756 87 0.013
death GO:0016265 121 0.013
circadian sleep wake cycle GO:0042745 2 0.013
body morphogenesis GO:0010171 16 0.013
regulation of production of molecular mediator of immune response GO:0002700 1 0.013
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.013
startle response GO:0001964 4 0.012
regulation of cardiac muscle contraction GO:0055117 2 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
cell cycle arrest GO:0007050 1 0.012
protein localization to nucleus GO:0034504 3 0.012
cytoskeleton dependent cytokinesis GO:0061640 3 0.012
skeletal muscle organ development GO:0060538 78 0.012
regulation of hydrolase activity GO:0051336 28 0.012
regulation of cell communication GO:0010646 232 0.012
meiotic nuclear division GO:0007126 4 0.012
regulation of striated muscle contraction GO:0006942 2 0.012
cytokinetic process GO:0032506 2 0.012
regulation of localization GO:0032879 104 0.012
response to corticosteroid GO:0031960 1 0.012
mononuclear cell proliferation GO:0032943 1 0.012
catecholamine metabolic process GO:0006584 2 0.012
dendrite development GO:0016358 9 0.012
positive regulation of secretion GO:0051047 1 0.012
catechol containing compound biosynthetic process GO:0009713 2 0.011
cell cycle g2 m phase transition GO:0044839 4 0.011
regulation of cell activation GO:0050865 1 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
spermatid development GO:0007286 2 0.011
immune system process GO:0002376 241 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
lymphocyte proliferation GO:0046651 1 0.011
pharynx development GO:0060465 5 0.011
cell substrate junction assembly GO:0007044 2 0.011
regulation of mrna processing GO:0050684 3 0.011
cardiac atrium morphogenesis GO:0003209 2 0.011
organonitrogen compound biosynthetic process GO:1901566 47 0.011
regulation of cellular protein metabolic process GO:0032268 52 0.011
ventricular cardiac muscle cell development GO:0055015 5 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
rna metabolic process GO:0016070 219 0.011
regulation of cell matrix adhesion GO:0001952 1 0.011
specification of symmetry GO:0009799 204 0.011
oogenesis GO:0048477 14 0.011
locomotor rhythm GO:0045475 3 0.011
protein targeting to nucleus GO:0044744 3 0.011
germ cell development GO:0007281 22 0.011
compound eye development GO:0048749 2 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
protein import into nucleus GO:0006606 3 0.011
positive regulation of developmental process GO:0051094 50 0.011
positive regulation of striated muscle cell differentiation GO:0051155 1 0.011
cellular localization GO:0051641 97 0.011
protein stabilization GO:0050821 2 0.011
oocyte differentiation GO:0009994 14 0.011
digestive tract morphogenesis GO:0048546 231 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
single organism nuclear import GO:1902593 3 0.011
mitochondrial transport GO:0006839 2 0.010
regulation of cellular component biogenesis GO:0044087 12 0.010
determination of bilateral symmetry GO:0009855 204 0.010
transcription from rna polymerase ii promoter GO:0006366 80 0.010
developmental maturation GO:0021700 34 0.010
actin filament based movement GO:0030048 1 0.010
regulation of stem cell differentiation GO:2000736 4 0.010
cell death GO:0008219 121 0.010
regulation of neuron projection development GO:0010975 40 0.010
purine ribonucleotide metabolic process GO:0009150 27 0.010
protein secretion GO:0009306 1 0.010
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.010
phagocytosis engulfment GO:0006911 1 0.010
female sex differentiation GO:0046660 4 0.010
establishment of protein localization to organelle GO:0072594 4 0.010
negative regulation of synapse assembly GO:0051964 2 0.010
larval heart development GO:0007508 2 0.010
regulation of protein localization to nucleus GO:1900180 2 0.010
chemosensory behavior GO:0007635 1 0.010
monocarboxylic acid catabolic process GO:0072329 3 0.010

me2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.168
muscular disease DOID:0080000 0 0.164
musculoskeletal system disease DOID:17 0 0.164
myopathy DOID:423 0 0.109
muscle tissue disease DOID:66 0 0.109
cardiovascular system disease DOID:1287 0 0.027
disease of metabolism DOID:0014667 0 0.015
nervous system disease DOID:863 0 0.012
heart disease DOID:114 0 0.011
cardiomyopathy DOID:0050700 0 0.011