Danio rerio

45 known processes

pcdh15a

protocadherin 15a

(Aliases: si:xx-bac7cse.1,si:bac7cse.1,PCDH15)

pcdh15a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
inner ear development GO:0048839 126 0.800
Mouse
dicarboxylic acid transport GO:0006835 1 0.738
detection of mechanical stimulus involved in sensory perception GO:0050974 11 0.705
reflex GO:0060004 2 0.649
Mouse
response to external stimulus GO:0009605 264 0.556
embryonic skeletal system morphogenesis GO:0048704 93 0.434
neuromuscular process controlling balance GO:0050885 3 0.397
Mouse
single organism localization GO:1902578 225 0.340
detection of mechanical stimulus GO:0050982 11 0.336
inner ear receptor cell differentiation GO:0060113 29 0.324
Mouse
ion transport GO:0006811 114 0.324
ear development GO:0043583 127 0.321
Mouse
inner ear morphogenesis GO:0042472 63 0.315
Mouse
regulation of biological quality GO:0065008 263 0.297
anion transport GO:0006820 38 0.295
cell projection organization GO:0030030 284 0.293
Mouse
equilibrioception GO:0050957 2 0.292
Mouse
transmembrane transport GO:0055085 120 0.278
sensory perception GO:0007600 39 0.266
detection of abiotic stimulus GO:0009582 24 0.259
regulation of developmental process GO:0050793 247 0.251
amino acid transport GO:0006865 2 0.240
sensory perception of mechanical stimulus GO:0050954 16 0.240
neurological system process GO:0050877 62 0.223
larval development GO:0002164 2 0.216
embryonic organ development GO:0048568 381 0.213
Mouse
response to abiotic stimulus GO:0009628 122 0.207
hair cell differentiation GO:0035315 32 0.201
single organism transport GO:0044765 206 0.181
negative regulation of multicellular organismal process GO:0051241 69 0.165
establishment of localization GO:0051234 244 0.165
vestibular reflex GO:0060005 2 0.157
system process GO:0003008 185 0.151
neuron projection development GO:0031175 180 0.145
monovalent inorganic cation transport GO:0015672 42 0.143
neuron development GO:0048666 262 0.132
Mouse
embryonic organ morphogenesis GO:0048562 274 0.130
Mouse
regulation of multicellular organismal process GO:0051239 277 0.126
fat soluble vitamin metabolic process GO:0006775 4 0.119
ear morphogenesis GO:0042471 64 0.115
Mouse
multi organism process GO:0051704 134 0.112
generation of neurons GO:0048699 385 0.112
hematopoietic or lymphoid organ development GO:0048534 191 0.110
epithelial cell differentiation GO:0030855 116 0.110
neuron neuron synaptic transmission GO:0007270 1 0.109
cognition GO:0050890 1 0.100
regulation of ion transmembrane transporter activity GO:0032412 2 0.099
transport GO:0006810 220 0.096
positive regulation of transport GO:0051050 2 0.095
dorsal ventral pattern formation GO:0009953 125 0.093
nucleobase containing compound metabolic process GO:0006139 274 0.092
detection of mechanical stimulus involved in sensory perception of sound GO:0050910 3 0.088
Mouse
toll like receptor signaling pathway GO:0002224 4 0.088
lateral line system development GO:0048925 76 0.085
multicellular organism growth GO:0035264 4 0.084
Mouse
lipid metabolic process GO:0006629 52 0.080
regulation of response to stimulus GO:0048583 269 0.078
carboxylic acid transport GO:0046942 8 0.077
response to salt stress GO:0009651 10 0.074
regulation of reproductive process GO:2000241 4 0.073
detection of external stimulus GO:0009581 24 0.073
ion transmembrane transport GO:0034220 91 0.073
specification of symmetry GO:0009799 204 0.072
determination of bilateral symmetry GO:0009855 204 0.069
regulation of signaling GO:0023051 235 0.067
organic substance transport GO:0071702 58 0.065
cell surface receptor signaling pathway GO:0007166 325 0.063
locomotion GO:0040011 313 0.063
regulation of multicellular organism growth GO:0040014 4 0.062
neuromuscular process GO:0050905 7 0.062
Mouse
organic substance biosynthetic process GO:1901576 289 0.061
regulation of synapse organization GO:0050807 3 0.058
organic anion transport GO:0015711 15 0.058
signal transduction GO:0007165 455 0.058
cellular macromolecule metabolic process GO:0044260 391 0.056
metal ion transport GO:0030001 58 0.056
regulation of multicellular organismal development GO:2000026 223 0.055
sensory organ development GO:0007423 393 0.055
eye development GO:0001654 277 0.054
Zebrafish
immune system process GO:0002376 241 0.053
regulation of biosynthetic process GO:0009889 250 0.053
regulation of cellular metabolic process GO:0031323 320 0.052
negative regulation of biological process GO:0048519 304 0.052
cellular biosynthetic process GO:0044249 286 0.051
cellular nitrogen compound metabolic process GO:0034641 290 0.049
inner ear receptor stereocilium organization GO:0060122 8 0.048
Mouse
cellular component disassembly GO:0022411 1 0.047
negative regulation of response to stimulus GO:0048585 104 0.047
embryonic cranial skeleton morphogenesis GO:0048701 90 0.047
cellular response to biotic stimulus GO:0071216 3 0.047
regulation of response to cytokine stimulus GO:0060759 3 0.047
positive regulation of cellular process GO:0048522 201 0.046
heterocycle metabolic process GO:0046483 290 0.045
inorganic ion transmembrane transport GO:0098660 57 0.045
protein localization to membrane GO:0072657 9 0.045
cation homeostasis GO:0055080 33 0.045
negative regulation of reproductive process GO:2000242 3 0.045
cellular localization GO:0051641 97 0.044
homeostatic process GO:0042592 142 0.044
camera type eye development GO:0043010 222 0.043
regulation of transmembrane transporter activity GO:0022898 2 0.043
positive regulation of secretion by cell GO:1903532 1 0.043
startle response GO:0001964 4 0.042
Mouse
macromolecule biosynthetic process GO:0009059 227 0.042
l amino acid transport GO:0015807 1 0.042
regulation of transporter activity GO:0032409 2 0.042
neuron differentiation GO:0030182 353 0.041
regulation of gene expression GO:0010468 265 0.041
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.041
immune system development GO:0002520 191 0.041
regulation of nitrogen compound metabolic process GO:0051171 251 0.041
protein complex disassembly GO:0043241 1 0.039
regulation of macromolecule biosynthetic process GO:0010556 225 0.039
spermatid development GO:0007286 2 0.039
cellular aromatic compound metabolic process GO:0006725 295 0.038
regulation of synapse assembly GO:0051963 3 0.038
synaptic vesicle recycling GO:0036465 1 0.038
regulation of cell communication GO:0010646 232 0.037
cell cell signaling GO:0007267 52 0.037
regionalization GO:0003002 274 0.036
single organism intracellular transport GO:1902582 25 0.036
g protein coupled receptor signaling pathway GO:0007186 74 0.035
positive regulation of secretion GO:0051047 1 0.035
erythrocyte homeostasis GO:0034101 55 0.035
synapse organization GO:0050808 21 0.035
organic acid transport GO:0015849 9 0.035
axon development GO:0061564 166 0.034
negative regulation of macromolecule metabolic process GO:0010605 76 0.034
regulation of transcription dna templated GO:0006355 213 0.034
cation transmembrane transport GO:0098655 65 0.034
regulation of rna metabolic process GO:0051252 224 0.034
determination of left right symmetry GO:0007368 179 0.034
inositol phosphate metabolic process GO:0043647 1 0.034
biosynthetic process GO:0009058 294 0.034
alcohol biosynthetic process GO:0046165 2 0.034
regulation of nucleic acid templated transcription GO:1903506 213 0.033
nitrogen compound metabolic process GO:0006807 319 0.033
organic cyclic compound metabolic process GO:1901360 301 0.033
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.033
neurotransmitter transport GO:0006836 2 0.032
regulation of neurogenesis GO:0050767 87 0.032
otic vesicle development GO:0071599 42 0.032
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.032
cation transport GO:0006812 81 0.032
lipid storage GO:0019915 1 0.032
maintenance of location GO:0051235 4 0.032
regulation of establishment of protein localization GO:0070201 4 0.031
aging GO:0007568 2 0.031
synaptic vesicle transport GO:0048489 1 0.030
cellular response to chemical stimulus GO:0070887 157 0.030
polyol metabolic process GO:0019751 1 0.030
cellular protein catabolic process GO:0044257 4 0.029
behavior GO:0007610 74 0.029
Mouse
small molecule metabolic process GO:0044281 77 0.029
membrane repolarization GO:0086009 2 0.029
cell morphogenesis GO:0000902 289 0.028
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.028
positive regulation of signal transduction GO:0009967 56 0.028
regulation of signal transduction GO:0009966 225 0.028
epithelial cell morphogenesis GO:0003382 2 0.028
exocytosis GO:0006887 1 0.028
regulation of epithelial cell proliferation GO:0050678 3 0.028
macromolecule modification GO:0043412 111 0.028
regulation of localization GO:0032879 104 0.027
homeostasis of number of cells within a tissue GO:0048873 4 0.027
transcription from rna polymerase ii promoter GO:0006366 80 0.027
protein metabolic process GO:0019538 183 0.027
negative regulation of cellular biosynthetic process GO:0031327 55 0.026
skin development GO:0043588 54 0.026
positive regulation of response to stimulus GO:0048584 80 0.026
sodium ion transport GO:0006814 24 0.025
cell morphogenesis involved in differentiation GO:0000904 195 0.025
Mouse
mechanoreceptor differentiation GO:0042490 37 0.025
Mouse
visual perception GO:0007601 17 0.025
Zebrafish Mouse
macromolecular complex disassembly GO:0032984 1 0.025
positive regulation of cellular catabolic process GO:0031331 3 0.025
single organism metabolic process GO:0044710 217 0.025
central nervous system development GO:0007417 387 0.025
regulation of alcohol biosynthetic process GO:1902930 1 0.024
sensory perception of light stimulus GO:0050953 19 0.024
Zebrafish Mouse
neural retina development GO:0003407 49 0.024
response to stress GO:0006950 263 0.024
myeloid cell homeostasis GO:0002262 56 0.024
regulation of cellular biosynthetic process GO:0031326 245 0.024
skeletal system development GO:0001501 181 0.024
regulation of metabolic process GO:0019222 359 0.024
cell death GO:0008219 121 0.023
axonogenesis GO:0007409 152 0.023
glial cell migration GO:0008347 3 0.023
nucleic acid metabolic process GO:0090304 244 0.023
heart development GO:0007507 313 0.023
retina development in camera type eye GO:0060041 146 0.023
regulation of sodium ion transmembrane transport GO:1902305 1 0.023
intracellular transport GO:0046907 32 0.023
cellular macromolecule biosynthetic process GO:0034645 224 0.023
fin development GO:0033333 77 0.023
inner ear receptor cell development GO:0060119 20 0.023
Mouse
regulation of retina development in camera type eye GO:1902866 2 0.023
negative regulation of behavior GO:0048521 6 0.022
cellular response to molecule of bacterial origin GO:0071219 3 0.022
phagocytosis GO:0006909 3 0.022
gene expression GO:0010467 252 0.022
cellular response to lipopolysaccharide GO:0071222 3 0.022
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.022
synaptic transmission cholinergic GO:0007271 4 0.022
regulation of macromolecule metabolic process GO:0060255 317 0.022
transcription dna templated GO:0006351 181 0.022
single organism organelle organization GO:1902589 199 0.022
Mouse
morphogenesis of an epithelium GO:0002009 333 0.022
Mouse
negative regulation of gene expression GO:0010629 65 0.021
reproductive process GO:0022414 40 0.021
cell migration GO:0016477 237 0.021
eye photoreceptor cell development GO:0042462 30 0.021
regulation of circadian rhythm GO:0042752 4 0.021
nucleobase containing compound biosynthetic process GO:0034654 205 0.021
organelle organization GO:0006996 227 0.021
Mouse
axon extension GO:0048675 45 0.021
negative regulation of metabolic process GO:0009892 86 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.021
homeostasis of number of cells GO:0048872 62 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.021
developmental maturation GO:0021700 34 0.021
regulation of metal ion transport GO:0010959 4 0.021
cellular carbohydrate metabolic process GO:0044262 4 0.020
aromatic compound biosynthetic process GO:0019438 217 0.020
camera type eye morphogenesis GO:0048593 108 0.020
spermatid differentiation GO:0048515 2 0.020
cell part morphogenesis GO:0032990 246 0.020
Mouse
chemical homeostasis GO:0048878 49 0.020
embryonic skeletal system development GO:0048706 97 0.020
negative regulation of neuron projection development GO:0010977 9 0.020
regulation of cellular component organization GO:0051128 86 0.020
rna metabolic process GO:0016070 219 0.020
digestive tract development GO:0048565 265 0.020
establishment of localization in cell GO:0051649 77 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.019
tube morphogenesis GO:0035239 349 0.019
fat soluble vitamin biosynthetic process GO:0042362 2 0.019
synaptic vesicle localization GO:0097479 1 0.019
modification dependent protein catabolic process GO:0019941 3 0.019
regulation of anatomical structure morphogenesis GO:0022603 130 0.019
negative regulation of developmental process GO:0051093 65 0.019
multicellular organism reproduction GO:0032504 35 0.019
nucleic acid templated transcription GO:0097659 181 0.019
appendage morphogenesis GO:0035107 56 0.019
ion homeostasis GO:0050801 41 0.019
negative regulation of cellular process GO:0048523 283 0.018
anion transmembrane transport GO:0098656 12 0.018
regulation of protein transport GO:0051223 3 0.018
post embryonic organ development GO:0048569 4 0.018
inorganic cation transmembrane transport GO:0098662 50 0.018
embryonic hemopoiesis GO:0035162 53 0.018
skeletal system morphogenesis GO:0048705 102 0.018
eye morphogenesis GO:0048592 144 0.018
cellular potassium ion transport GO:0071804 10 0.018
heart morphogenesis GO:0003007 156 0.017
response to external biotic stimulus GO:0043207 97 0.017
lamellipodium assembly GO:0030032 1 0.017
negative regulation of nervous system development GO:0051961 22 0.017
epidermis development GO:0008544 48 0.017
regulation of behavior GO:0050795 24 0.017
gtp metabolic process GO:0046039 4 0.017
regulation of nervous system development GO:0051960 90 0.017
rhythmic process GO:0048511 21 0.017
organonitrogen compound metabolic process GO:1901564 74 0.017
protein localization to plasma membrane GO:0072659 1 0.017
response to chemical GO:0042221 320 0.017
head development GO:0060322 303 0.017
endosomal transport GO:0016197 2 0.016
synaptic growth at neuromuscular junction GO:0051124 2 0.016
cellular protein modification process GO:0006464 100 0.016
cellular ion homeostasis GO:0006873 17 0.016
regulation of rna biosynthetic process GO:2001141 213 0.016
hemopoiesis GO:0030097 183 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
regulation of synapse structure and activity GO:0050803 5 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
Mouse
otolith development GO:0048840 32 0.016
nerve development GO:0021675 45 0.016
synaptic vesicle endocytosis GO:0048488 1 0.016
cytoskeleton organization GO:0007010 96 0.016
Mouse
sexual reproduction GO:0019953 36 0.016
cellular protein complex disassembly GO:0043624 1 0.016
regulation of wnt signaling pathway GO:0030111 53 0.016
cell projection morphogenesis GO:0048858 244 0.016
Mouse
positive regulation of signaling GO:0023056 56 0.016
multicellular organismal reproductive process GO:0048609 35 0.016
neuroblast proliferation GO:0007405 2 0.016
regulation of cytokine mediated signaling pathway GO:0001959 3 0.016
sensory organ morphogenesis GO:0090596 200 0.016
Mouse
sodium ion transmembrane transport GO:0035725 21 0.016
camera type eye photoreceptor cell differentiation GO:0060219 19 0.016
detection of stimulus involved in sensory perception GO:0050906 21 0.015
regulation of molecular function GO:0065009 70 0.015
membrane fusion GO:0061025 2 0.015
feeding behavior GO:0007631 5 0.015
multi organism reproductive process GO:0044703 36 0.015
sensory system development GO:0048880 76 0.015
regulation of system process GO:0044057 40 0.015
establishment of synaptic vesicle localization GO:0097480 1 0.015
protein dephosphorylation GO:0006470 3 0.015
protein depolymerization GO:0051261 1 0.015
positive regulation of cell communication GO:0010647 56 0.015
positive regulation of map kinase activity GO:0043406 3 0.014
synaptic transmission GO:0007268 35 0.014
action potential GO:0001508 19 0.014
cellular component movement GO:0006928 335 0.014
otic vesicle morphogenesis GO:0071600 34 0.014
retina morphogenesis in camera type eye GO:0060042 79 0.014
negative regulation of synapse assembly GO:0051964 2 0.014
positive regulation of nucleoside metabolic process GO:0045979 1 0.014
negative regulation of cell projection organization GO:0031345 9 0.014
positive regulation of catabolic process GO:0009896 4 0.014
embryo development ending in birth or egg hatching GO:0009792 271 0.013
golgi organization GO:0007030 1 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
protein targeting to membrane GO:0006612 1 0.013
lipid biosynthetic process GO:0008610 22 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.013
negative regulation of neurogenesis GO:0050768 20 0.013
diencephalon development GO:0021536 58 0.013
neuromast development GO:0048884 46 0.013
regulation of intracellular ph GO:0051453 1 0.013
regulation of sequestering of calcium ion GO:0051282 4 0.013
nitrogen compound transport GO:0071705 23 0.013
sequestering of calcium ion GO:0051208 3 0.013
response to monosaccharide GO:0034284 3 0.013
cellular amine metabolic process GO:0044106 2 0.013
regulation of protein complex disassembly GO:0043244 1 0.013
peripheral nervous system development GO:0007422 55 0.013
regulation of axon extension GO:0030516 24 0.013
negative regulation of rna biosynthetic process GO:1902679 45 0.013
nucleocytoplasmic transport GO:0006913 4 0.012
regulation of cellular ph GO:0030641 1 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
negative regulation of rna metabolic process GO:0051253 48 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
growth GO:0040007 174 0.012
Mouse
appendage development GO:0048736 80 0.012
lateral inhibition GO:0046331 1 0.012
post embryonic organ morphogenesis GO:0048563 1 0.012
positive regulation of biological process GO:0048518 253 0.012
cortical actin cytoskeleton organization GO:0030866 1 0.012
response to bacterium GO:0009617 58 0.012
regulation of membrane repolarization GO:0060306 1 0.012
small molecule catabolic process GO:0044282 3 0.012
cellular response to external stimulus GO:0071496 2 0.012
multicellular organismal signaling GO:0035637 22 0.012
negative regulation of multi organism process GO:0043901 3 0.012
neuron projection guidance GO:0097485 86 0.012
connective tissue development GO:0061448 99 0.012
regulation of cell projection organization GO:0031344 44 0.012
alcohol metabolic process GO:0006066 11 0.011
cell motility GO:0048870 244 0.011
cellular response to light stimulus GO:0071482 4 0.011
cellular response to starvation GO:0009267 1 0.011
cilium morphogenesis GO:0060271 85 0.011
Mouse
single organism biosynthetic process GO:0044711 71 0.011
chemotaxis GO:0006935 104 0.011
protein localization GO:0008104 40 0.011
metal ion homeostasis GO:0055065 26 0.011
regulation of blood circulation GO:1903522 32 0.011
proteasomal protein catabolic process GO:0010498 2 0.011
epidermal cell differentiation GO:0009913 36 0.011
melanocyte migration GO:0097324 4 0.011
central nervous system neuron differentiation GO:0021953 74 0.011
regulation of vasculature development GO:1901342 33 0.011
digestive system development GO:0055123 289 0.011
primitive hemopoiesis GO:0060215 27 0.011
organism emergence from protective structure GO:0071684 4 0.011
directional locomotion GO:0033058 1 0.011
organic acid metabolic process GO:0006082 31 0.011
auditory receptor cell differentiation GO:0042491 15 0.011
Mouse
vitamin biosynthetic process GO:0009110 2 0.011
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.011
membrane organization GO:0061024 21 0.011
forebrain development GO:0030900 96 0.011
muscle cell development GO:0055001 115 0.011
rna biosynthetic process GO:0032774 181 0.011
regulation of synaptic plasticity GO:0048167 1 0.010
pectoral fin development GO:0033339 50 0.010
liver development GO:0001889 96 0.010
chordate embryonic development GO:0043009 271 0.010
auditory receptor cell morphogenesis GO:0002093 4 0.010
Mouse
regulation of cell differentiation GO:0045595 142 0.010
epithelial cell development GO:0002064 42 0.010
Mouse
endoplasmic reticulum unfolded protein response GO:0030968 2 0.010
hormone secretion GO:0046879 2 0.010
neuron projection morphogenesis GO:0048812 161 0.010
negative regulation of nucleic acid templated transcription GO:1903507 45 0.010
pronephros development GO:0048793 69 0.010
autophagy GO:0006914 4 0.010
macromolecule localization GO:0033036 54 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.010
reproduction GO:0000003 40 0.010

pcdh15a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
auditory system disease DOID:2742 0 0.090
nonsyndromic deafness DOID:0050563 0 0.090
sensory system disease DOID:0050155 0 0.090
disease of anatomical entity DOID:7 0 0.090
nervous system disease DOID:863 0 0.090
immune system disease DOID:2914 0 0.054
hematopoietic system disease DOID:74 0 0.054
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.020
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014