Danio rerio

64 known processes

bhlhe41

basic helix-loop-helix family, member e41

(Aliases: dec2,bhlhb3l,si:ch211-154h20.6)

bhlhe41 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
optic placode formation GO:0001743 4 0.380
cell morphogenesis involved in differentiation GO:0000904 195 0.370
digestive tract morphogenesis GO:0048546 231 0.335
gastrulation GO:0007369 208 0.300
vasculature development GO:0001944 278 0.261
response to external stimulus GO:0009605 264 0.260
regulation of cellular metabolic process GO:0031323 320 0.257
angiogenesis GO:0001525 158 0.255
morphogenesis of an epithelium GO:0002009 333 0.250
neuron projection development GO:0031175 180 0.246
cell migration GO:0016477 237 0.226
negative regulation of cellular process GO:0048523 283 0.224
formation of primary germ layer GO:0001704 62 0.220
regeneration GO:0031099 91 0.205
single organism cell adhesion GO:0098602 29 0.201
cellular component morphogenesis GO:0032989 336 0.191
localization of cell GO:0051674 244 0.190
locomotion GO:0040011 313 0.185
cellular component movement GO:0006928 335 0.180
embryonic skeletal joint development GO:0072498 3 0.180
regulation of proteolysis GO:0030162 24 0.178
axon guidance GO:0007411 86 0.177
regulation of neurological system process GO:0031644 2 0.170
regulation of biosynthetic process GO:0009889 250 0.157
cell morphogenesis GO:0000902 289 0.150
response to wounding GO:0009611 116 0.149
nitrogen compound metabolic process GO:0006807 319 0.148
digestive tract development GO:0048565 265 0.143
cell motility GO:0048870 244 0.139
immune system development GO:0002520 191 0.132
blood vessel morphogenesis GO:0048514 216 0.125
axonogenesis GO:0007409 152 0.122
neuron projection guidance GO:0097485 86 0.121
establishment of localization GO:0051234 244 0.121
forebrain development GO:0030900 96 0.119
heart jogging GO:0003146 40 0.114
protein complex subunit organization GO:0071822 46 0.113
immune system process GO:0002376 241 0.111
regulation of wnt signaling pathway involved in digestive tract morphogenesis GO:2000056 2 0.109
regulation of metabolic process GO:0019222 359 0.107
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.105
organic cyclic compound metabolic process GO:1901360 301 0.103
phagocytosis engulfment GO:0006911 1 0.102
cellular protein modification process GO:0006464 100 0.102
wnt signaling pathway GO:0016055 80 0.101
cell part morphogenesis GO:0032990 246 0.094
response to stress GO:0006950 263 0.093
tissue remodeling GO:0048771 4 0.093
organic acid metabolic process GO:0006082 31 0.091
cerebellar granular layer formation GO:0021684 3 0.089
cardiac atrium development GO:0003230 4 0.089
epithelial cell morphogenesis GO:0003382 2 0.088
central nervous system development GO:0007417 387 0.088
collagen metabolic process GO:0032963 2 0.083
regulation of biological quality GO:0065008 263 0.083
negative regulation of secretion GO:0051048 2 0.083
protein secretion GO:0009306 1 0.079
embryonic organ development GO:0048568 381 0.079
aromatic compound biosynthetic process GO:0019438 217 0.078
single organism transport GO:0044765 206 0.078
response to fluid shear stress GO:0034405 2 0.075
cell fate specification GO:0001708 68 0.075
determination of left right asymmetry in diencephalon GO:0035462 4 0.074
anterior head development GO:0097065 2 0.074
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.074
neuron projection morphogenesis GO:0048812 161 0.073
phosphate containing compound metabolic process GO:0006796 108 0.071
cellular macromolecule metabolic process GO:0044260 391 0.068
neurological system process GO:0050877 62 0.068
negative regulation of biological process GO:0048519 304 0.067
convergent extension GO:0060026 118 0.067
neuron differentiation GO:0030182 353 0.066
hepaticobiliary system development GO:0061008 98 0.065
signal transduction GO:0007165 455 0.065
regulation of response to stimulus GO:0048583 269 0.062
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.062
cell surface receptor signaling pathway GO:0007166 325 0.062
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.061
response to organic substance GO:0010033 153 0.061
regulation of primary metabolic process GO:0080090 311 0.060
mesenchymal cell development GO:0014031 78 0.059
programmed cell death GO:0012501 119 0.059
wound healing GO:0042060 90 0.059
regulation of organ growth GO:0046620 3 0.058
cellular response to extracellular stimulus GO:0031668 2 0.056
regulation of nitrogen compound metabolic process GO:0051171 251 0.056
endoderm development GO:0007492 49 0.055
ectoderm formation GO:0001705 2 0.054
single organism metabolic process GO:0044710 217 0.054
cellular ketone metabolic process GO:0042180 11 0.054
cell projection organization GO:0030030 284 0.054
multicellular organismal macromolecule metabolic process GO:0044259 2 0.053
specification of organ identity GO:0010092 2 0.053
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.053
single organismal cell cell adhesion GO:0016337 29 0.051
cell growth GO:0016049 57 0.051
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.050
positive regulation of transport GO:0051050 2 0.049
larval development GO:0002164 2 0.048
ameboidal type cell migration GO:0001667 143 0.047
tissue migration GO:0090130 37 0.047
taxis GO:0042330 109 0.047
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.047
positive regulation of cellular process GO:0048522 201 0.047
proteasomal protein catabolic process GO:0010498 2 0.047
thrombocyte differentiation GO:0002574 4 0.046
cellular response to starvation GO:0009267 1 0.046
intracellular signal transduction GO:0035556 85 0.046
cell differentiation in hindbrain GO:0021533 5 0.045
mediolateral intercalation GO:0060031 3 0.044
smooth muscle tissue development GO:0048745 1 0.044
positive regulation of epithelial cell proliferation GO:0050679 1 0.044
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.043
cell projection morphogenesis GO:0048858 244 0.043
cellular protein metabolic process GO:0044267 129 0.043
organelle localization GO:0051640 49 0.043
regulation of cell communication GO:0010646 232 0.043
growth GO:0040007 174 0.043
cellular protein catabolic process GO:0044257 4 0.042
heart development GO:0007507 313 0.042
regulation of programmed cell death GO:0043067 101 0.042
organelle assembly GO:0070925 110 0.041
mesoderm development GO:0007498 88 0.041
heart looping GO:0001947 94 0.040
cellular macromolecule biosynthetic process GO:0034645 224 0.040
positive regulation of muscle tissue development GO:1901863 1 0.040
negative regulation of apoptotic process GO:0043066 55 0.039
regulation of signaling GO:0023051 235 0.039
blood vessel development GO:0001568 246 0.039
positive regulation of biological process GO:0048518 253 0.039
head development GO:0060322 303 0.039
mesenchyme development GO:0060485 127 0.039
ubiquitin dependent protein catabolic process GO:0006511 3 0.039
aging GO:0007568 2 0.038
convergent extension involved in gastrulation GO:0060027 71 0.038
diencephalon development GO:0021536 58 0.038
synaptic growth at neuromuscular junction GO:0051124 2 0.038
regulation of cellular component organization GO:0051128 86 0.038
axon development GO:0061564 166 0.038
cellular amine metabolic process GO:0044106 2 0.037
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.037
nucleocytoplasmic transport GO:0006913 4 0.037
i kappab kinase nf kappab signaling GO:0007249 4 0.037
determination of left right asymmetry in nervous system GO:0035545 4 0.037
small molecule metabolic process GO:0044281 77 0.037
striated muscle tissue development GO:0014706 110 0.037
establishment of spindle localization GO:0051293 12 0.036
establishment of organelle localization GO:0051656 45 0.036
embryo development ending in birth or egg hatching GO:0009792 271 0.036
digestive system development GO:0055123 289 0.036
positive regulation of rna biosynthetic process GO:1902680 57 0.036
regulation of signal transduction GO:0009966 225 0.036
tissue regeneration GO:0042246 74 0.036
phosphorus metabolic process GO:0006793 109 0.035
optic placode formation involved in camera type eye formation GO:0046619 3 0.035
regulation of heart growth GO:0060420 2 0.035
hepatocyte proliferation GO:0072574 2 0.035
hepatic duct development GO:0061011 2 0.035
transcription dna templated GO:0006351 181 0.035
stem cell differentiation GO:0048863 117 0.035
determination of dorsal ventral asymmetry GO:0048262 34 0.034
regulation of multicellular organismal process GO:0051239 277 0.034
epithelial cell differentiation GO:0030855 116 0.034
regulation of establishment of protein localization GO:0070201 4 0.034
hematopoietic stem cell differentiation GO:0060218 20 0.034
regulation of cytokine production GO:0001817 3 0.034
synaptic target recognition GO:0008039 1 0.033
neuron development GO:0048666 262 0.033
regulation of hydrolase activity GO:0051336 28 0.032
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.032
gene expression GO:0010467 252 0.032
notochord development GO:0030903 54 0.032
neuron projection extension GO:1990138 45 0.032
cellular nitrogen compound metabolic process GO:0034641 290 0.032
cellular response to nutrient levels GO:0031669 2 0.032
regulation of jun kinase activity GO:0043506 3 0.032
mitochondrion organization GO:0007005 4 0.031
protein modification process GO:0036211 100 0.031
regulation of blood vessel size GO:0050880 2 0.031
phagocytosis GO:0006909 3 0.031
inner ear development GO:0048839 126 0.031
regulation of epithelial to mesenchymal transition GO:0010717 3 0.031
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.031
regulation of tube size GO:0035150 2 0.030
macromolecular complex subunit organization GO:0043933 74 0.030
cellular response to external stimulus GO:0071496 2 0.030
regulation of apoptotic process GO:0042981 98 0.030
ear morphogenesis GO:0042471 64 0.029
macromolecule modification GO:0043412 111 0.029
generation of neurons GO:0048699 385 0.029
dna biosynthetic process GO:0071897 3 0.029
regulation of biomineral tissue development GO:0070167 2 0.028
brain development GO:0007420 293 0.028
multi organism process GO:0051704 134 0.028
biological adhesion GO:0022610 40 0.028
fin regeneration GO:0031101 51 0.028
single organism organelle organization GO:1902589 199 0.028
embryonic heart tube morphogenesis GO:0003143 108 0.028
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.028
system process GO:0003008 185 0.028
heterocycle metabolic process GO:0046483 290 0.028
regulation of anterior head development GO:2000742 2 0.027
establishment of protein localization to organelle GO:0072594 4 0.027
wnt signaling pathway involved in digestive tract morphogenesis GO:0044333 4 0.026
positive regulation of gastrulation GO:2000543 2 0.026
regulation of microtubule cytoskeleton organization GO:0070507 3 0.026
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.026
negative chemotaxis GO:0050919 1 0.026
regulation of intracellular signal transduction GO:1902531 57 0.026
morphogenesis of an epithelial fold GO:0060571 1 0.025
negative regulation of cell death GO:0060548 60 0.025
regulation of epithelial cell proliferation GO:0050678 3 0.025
mesenchymal cell differentiation GO:0048762 87 0.025
fin morphogenesis GO:0033334 53 0.025
multicellular organismal metabolic process GO:0044236 2 0.025
negative regulation of programmed cell death GO:0043069 58 0.025
cellular component assembly GO:0022607 170 0.025
endoderm formation GO:0001706 29 0.025
hemopoiesis GO:0030097 183 0.024
spinal cord development GO:0021510 46 0.024
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.024
regulation of cardiac muscle tissue development GO:0055024 1 0.024
regulation of metal ion transport GO:0010959 4 0.024
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.024
collagen biosynthetic process GO:0032964 2 0.024
regulation of response to stress GO:0080134 36 0.023
sensory epithelium regeneration GO:0070654 14 0.023
autophagy GO:0006914 4 0.023
muscle structure development GO:0061061 196 0.023
Mouse
embryonic heart tube development GO:0035050 133 0.023
determination of bilateral symmetry GO:0009855 204 0.022
protein metabolic process GO:0019538 183 0.022
appendage development GO:0048736 80 0.022
regulation of multicellular organismal development GO:2000026 223 0.022
response to oxygen levels GO:0070482 25 0.022
developmental growth involved in morphogenesis GO:0060560 86 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.022
chemosensory behavior GO:0007635 1 0.022
chemotaxis GO:0006935 104 0.022
embryonic camera type eye formation GO:0060900 10 0.022
regulation of locomotion GO:0040012 55 0.022
modification dependent macromolecule catabolic process GO:0043632 3 0.022
regulation of cellular amine metabolic process GO:0033238 0 0.021
regulation of bone mineralization GO:0030500 2 0.021
non canonical wnt signaling pathway GO:0035567 13 0.021
positive regulation of neural precursor cell proliferation GO:2000179 1 0.021
protein localization to nucleus GO:0034504 3 0.021
detection of mechanical stimulus involved in sensory perception of sound GO:0050910 3 0.021
regulation of endocrine process GO:0044060 2 0.021
transport GO:0006810 220 0.020
dorsal convergence GO:0060030 14 0.020
oxoacid metabolic process GO:0043436 31 0.020
regulation of nucleic acid templated transcription GO:1903506 213 0.020
modification dependent protein catabolic process GO:0019941 3 0.020
regulation of localization GO:0032879 104 0.020
cellular response to growth factor stimulus GO:0071363 39 0.020
response to growth factor GO:0070848 39 0.020
macromolecule localization GO:0033036 54 0.020
lymphocyte proliferation GO:0046651 1 0.020
regulation of cytokine biosynthetic process GO:0042035 1 0.019
leukocyte proliferation GO:0070661 1 0.019
regulation of cardiac muscle cell differentiation GO:2000725 1 0.019
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.019
protein localization GO:0008104 40 0.019
regulation of molecular function GO:0065009 70 0.019
pyruvate metabolic process GO:0006090 1 0.019
response to lipid GO:0033993 60 0.018
cell migration involved in gastrulation GO:0042074 79 0.018
cerebellar granular layer development GO:0021681 3 0.018
regulation of developmental process GO:0050793 247 0.018
Mouse
regulation of calcium ion transport GO:0051924 2 0.018
regulation of mitochondrion organization GO:0010821 1 0.018
embryonic digestive tract morphogenesis GO:0048557 3 0.018
positive regulation of locomotion GO:0040017 14 0.018
sequestering of calcium ion GO:0051208 3 0.017
protein import GO:0017038 3 0.017
regulation of protein transport GO:0051223 3 0.017
negative regulation of cell communication GO:0010648 96 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
gall bladder development GO:0061010 1 0.017
protein import into nucleus GO:0006606 3 0.017
cellular nitrogen compound biosynthetic process GO:0044271 218 0.017
bmp signaling pathway GO:0030509 52 0.017
regulation of protein catabolic process GO:0042176 1 0.017
protein targeting to nucleus GO:0044744 3 0.017
cell adhesion GO:0007155 40 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
negative regulation of sequestering of calcium ion GO:0051283 4 0.017
ion transport GO:0006811 114 0.017
cell proliferation involved in heart morphogenesis GO:0061323 2 0.016
death GO:0016265 121 0.016
phosphorylation GO:0016310 69 0.016
negative regulation of secretion by cell GO:1903531 2 0.016
response to molecule of bacterial origin GO:0002237 14 0.016
regulation of cellular response to growth factor stimulus GO:0090287 35 0.016
regulation of neuron projection development GO:0010975 40 0.016
positive regulation of jun kinase activity GO:0043507 2 0.016
chondrocyte development GO:0002063 4 0.016
heart field specification GO:0003128 1 0.016
epiboly GO:0090504 41 0.016
cerebellar cortex morphogenesis GO:0021696 5 0.016
response to chemical GO:0042221 320 0.016
regulation of calcium mediated signaling GO:0050848 1 0.016
embryonic limb morphogenesis GO:0030326 2 0.016
odontogenesis of dentin containing tooth GO:0042475 1 0.015
embryonic appendage morphogenesis GO:0035113 30 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
determination of heart left right asymmetry GO:0061371 117 0.015
regulation of cysteine type endopeptidase activity GO:2000116 21 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.015
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.015
regulation of endocytosis GO:0030100 7 0.015
nuclear transport GO:0051169 4 0.015
regulation of cytoskeleton organization GO:0051493 11 0.015
regulation of mitotic cell cycle GO:0007346 25 0.015
cellular component biogenesis GO:0044085 178 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
response to decreased oxygen levels GO:0036293 25 0.015
cation transport GO:0006812 81 0.015
dorsal ventral pattern formation GO:0009953 125 0.015
proteolysis GO:0006508 38 0.015
regulation of developmental pigmentation GO:0048070 6 0.014
activation of mapk activity GO:0000187 3 0.014
neuromuscular process controlling balance GO:0050885 3 0.014
regulation of angiogenesis GO:0045765 26 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.014
epithelium regeneration GO:1990399 14 0.014
positive regulation of rho protein signal transduction GO:0035025 0 0.014
mononuclear cell proliferation GO:0032943 1 0.014
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.014
response to hypoxia GO:0001666 25 0.014
regulation of ectodermal cell fate specification GO:0042665 2 0.014
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 1 0.014
regulation of protein ubiquitination GO:0031396 3 0.014
organelle organization GO:0006996 227 0.014
regulation of cell migration GO:0030334 40 0.014
synapse organization GO:0050808 21 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.014
chondrocyte differentiation GO:0002062 7 0.013
positive regulation of striated muscle tissue development GO:0045844 1 0.013
organic cyclic compound biosynthetic process GO:1901362 223 0.013
sensory perception of pain GO:0019233 1 0.013
cellular response to organic substance GO:0071310 105 0.013
negative regulation of epithelial cell proliferation GO:0050680 1 0.013
negative regulation of gastrulation GO:2000542 11 0.013
positive regulation of embryonic development GO:0040019 3 0.013
sensory perception GO:0007600 39 0.013
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
regulation of cell motility GO:2000145 46 0.013
ribosomal small subunit biogenesis GO:0042274 2 0.013
embryonic skeletal joint morphogenesis GO:0060272 3 0.013
macroautophagy GO:0016236 1 0.013
cytoskeleton organization GO:0007010 96 0.013
protein phosphorylation GO:0006468 47 0.013
cell fate commitment involved in pattern specification GO:0060581 6 0.013
positive regulation of synapse assembly GO:0051965 1 0.013
cerebellum development GO:0021549 17 0.013
regulation of cellular biosynthetic process GO:0031326 245 0.013
cell differentiation in spinal cord GO:0021515 40 0.013
regulation of wnt signaling pathway calcium modulating pathway GO:0008591 3 0.013
determination of dorsal identity GO:0048263 13 0.012
negative regulation of stem cell differentiation GO:2000737 2 0.012
auditory receptor cell morphogenesis GO:0002093 4 0.012
membrane invagination GO:0010324 1 0.012
positive regulation of stress activated mapk cascade GO:0032874 3 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
positive regulation of cellular protein metabolic process GO:0032270 22 0.012
regulation of cellular protein metabolic process GO:0032268 52 0.012
cellular component disassembly GO:0022411 1 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.012
neural plate development GO:0001840 10 0.012
positive regulation of jnk cascade GO:0046330 3 0.012
positive regulation of translation GO:0045727 1 0.012
cerebellar cortex formation GO:0021697 5 0.012
cellular response to endogenous stimulus GO:0071495 68 0.012
positive regulation of nucleic acid templated transcription GO:1903508 57 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.012
spinal cord radial glial cell differentiation GO:0021531 2 0.011
nucleic acid templated transcription GO:0097659 181 0.011
divalent inorganic cation transport GO:0072511 21 0.011
protein complex assembly GO:0006461 30 0.011
muscle tissue development GO:0060537 110 0.011
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
protein complex biogenesis GO:0070271 30 0.011
intestinal epithelial cell differentiation GO:0060575 3 0.011
axon extension involved in axon guidance GO:0048846 10 0.011
negative regulation of defense response GO:0031348 2 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.011
multi organism reproductive process GO:0044703 36 0.011
positive regulation of muscle organ development GO:0048636 1 0.011
spinal cord anterior posterior patterning GO:0021512 1 0.011
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.011
apoptotic process GO:0006915 116 0.011
receptor internalization GO:0031623 2 0.011
cerebellar granule cell differentiation GO:0021707 3 0.011
regulation of cell development GO:0060284 100 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
determination of left right symmetry GO:0007368 179 0.011
mesendoderm development GO:0048382 10 0.010
negative regulation of mitosis GO:0045839 3 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
growth plate cartilage development GO:0003417 2 0.010
protein maturation GO:0051604 12 0.010
wnt signaling pathway involved in dorsal ventral axis specification GO:0044332 5 0.010
regulation of rna metabolic process GO:0051252 224 0.010
positive regulation of cellular metabolic process GO:0031325 94 0.010

bhlhe41 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.068
disease of metabolism DOID:0014667 0 0.014
lysosomal storage disease DOID:3211 0 0.014
inherited metabolic disorder DOID:655 0 0.014