Danio rerio

15 known processes

dact1

dapper homolog 1, antagonist of beta-catenin (xenopus)

(Aliases: frd1,dapper1,frodo1,MGC152821,dpr1)

dact1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular process GO:0048523 283 0.921
Human Zebrafish Mouse
signal transduction GO:0007165 455 0.907
hematopoietic progenitor cell differentiation GO:0002244 23 0.890
regulation of rna metabolic process GO:0051252 224 0.875
Human
cell morphogenesis involved in differentiation GO:0000904 195 0.813
Mouse
regulation of signaling GO:0023051 235 0.776
Human Zebrafish Mouse
eye morphogenesis GO:0048592 144 0.771
chordate embryonic development GO:0043009 271 0.755
regulation of cell proliferation GO:0042127 37 0.650
regulation of gene expression GO:0010468 265 0.622
Human
bmp signaling pathway GO:0030509 52 0.617
regulation of rna biosynthetic process GO:2001141 213 0.604
Human
head development GO:0060322 303 0.596
regulation of signal transduction GO:0009966 225 0.582
Human Zebrafish Mouse
regulation of bmp signaling pathway GO:0030510 39 0.523
neuron differentiation GO:0030182 353 0.522
Mouse
skeletal system morphogenesis GO:0048705 102 0.517
striated muscle cell differentiation GO:0051146 129 0.508
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.489
Zebrafish
organic cyclic compound metabolic process GO:1901360 301 0.479
Human
neuron fate commitment GO:0048663 26 0.476
regulation of wnt signaling pathway involved in digestive tract morphogenesis GO:2000056 2 0.466
skeletal system development GO:0001501 181 0.455
regulation of multicellular organismal process GO:0051239 277 0.436
Mouse
transcription dna templated GO:0006351 181 0.432
Human
sensory organ morphogenesis GO:0090596 200 0.431
cellular biosynthetic process GO:0044249 286 0.409
Human
regulation of primary metabolic process GO:0080090 311 0.379
Human
somite development GO:0061053 96 0.373
immune system process GO:0002376 241 0.373
negative regulation of nodal signaling pathway GO:1900108 4 0.368
Zebrafish
organic substance biosynthetic process GO:1901576 289 0.359
Human
regulation of biological quality GO:0065008 263 0.342
Human
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.336
Zebrafish
negative regulation of collateral sprouting of intact axon in response to injury GO:0048685 2 0.308
determination of bilateral symmetry GO:0009855 204 0.307
embryonic organ development GO:0048568 381 0.304
negative regulation of cell communication GO:0010648 96 0.296
Human Zebrafish Mouse
wnt signaling pathway involved in somitogenesis GO:0090244 2 0.287
tube closure GO:0060606 1 0.280
regulation of cellular metabolic process GO:0031323 320 0.277
Human Mouse
neural crest cell differentiation GO:0014033 72 0.272
mesenchymal cell development GO:0014031 78 0.267
rna metabolic process GO:0016070 219 0.266
Human
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.266
regulation of macromolecule metabolic process GO:0060255 317 0.265
Human
digestive system development GO:0055123 289 0.261
Mouse
determination of left right asymmetry in diencephalon GO:0035462 4 0.251
regulation of nitrogen compound metabolic process GO:0051171 251 0.250
Human
regulation of cell communication GO:0010646 232 0.250
Human Zebrafish Mouse
appendage development GO:0048736 80 0.249
embryonic heart tube left right pattern formation GO:0060971 5 0.241
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.240
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.235
Human
specification of symmetry GO:0009799 204 0.227
camera type eye development GO:0043010 222 0.224
negative regulation of biological process GO:0048519 304 0.223
Human Zebrafish Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.217
Human
striated muscle tissue development GO:0014706 110 0.204
response to chemical GO:0042221 320 0.203
regulation of skeletal muscle tissue development GO:0048641 4 0.202
convergent extension GO:0060026 118 0.200
regulation of epithelial cell proliferation GO:0050678 3 0.200
regulation of multicellular organismal development GO:2000026 223 0.197
Mouse
negative regulation of signal transduction GO:0009968 94 0.194
Human Zebrafish Mouse
spemann organizer formation GO:0060061 10 0.193
neural plate regionalization GO:0060897 10 0.189
notochord development GO:0030903 54 0.187
axial mesoderm development GO:0048318 10 0.186
camera type eye morphogenesis GO:0048593 108 0.185
retina morphogenesis in camera type eye GO:0060042 79 0.184
regulation of reproductive process GO:2000241 4 0.177
negative regulation of multicellular organismal process GO:0051241 69 0.177
collateral sprouting of intact axon in response to injury GO:0048673 2 0.172
appendage morphogenesis GO:0035107 56 0.170
muscle structure development GO:0061061 196 0.168
cell fate commitment GO:0045165 99 0.165
rna biosynthetic process GO:0032774 181 0.164
Human
gene expression GO:0010467 252 0.163
Human
heterocycle biosynthetic process GO:0018130 215 0.162
Human
brain development GO:0007420 293 0.161
axis elongation GO:0003401 31 0.161
atrial ventricular junction remodeling GO:0003294 2 0.160
cellular aldehyde metabolic process GO:0006081 4 0.158
hematopoietic stem cell differentiation GO:0060218 20 0.157
primary neural tube formation GO:0014020 1 0.156
water homeostasis GO:0030104 4 0.156
nodal signaling pathway GO:0038092 7 0.155
Zebrafish
determination of dorsal ventral asymmetry GO:0048262 34 0.151
negative regulation of response to stimulus GO:0048585 104 0.151
Human Zebrafish Mouse
negative regulation of bmp signaling pathway GO:0030514 13 0.151
growth GO:0040007 174 0.147
regulation of macromolecule biosynthetic process GO:0010556 225 0.143
Human
response to stress GO:0006950 263 0.140
Human Mouse
diterpenoid metabolic process GO:0016101 15 0.139
aromatic compound biosynthetic process GO:0019438 217 0.138
Human
retinal cone cell development GO:0046549 8 0.138
left right pattern formation GO:0060972 19 0.138
mesenchymal cell differentiation GO:0048762 87 0.137
biological adhesion GO:0022610 40 0.134
diencephalon development GO:0021536 58 0.129
optic nerve development GO:0021554 15 0.129
neuron fate specification GO:0048665 20 0.128
skeletal muscle organ development GO:0060538 78 0.128
intracellular receptor signaling pathway GO:0030522 30 0.128
heart looping GO:0001947 94 0.126
determination of left right symmetry GO:0007368 179 0.124
multicellular organism growth GO:0035264 4 0.123
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway GO:0022002 1 0.122
cellular macromolecule biosynthetic process GO:0034645 224 0.122
Human
developmental growth GO:0048589 166 0.121
embryonic organ morphogenesis GO:0048562 274 0.120
cell cell signaling involved in cell fate commitment GO:0045168 12 0.118
skeletal muscle tissue development GO:0007519 67 0.117
immune system development GO:0002520 191 0.117
negative regulation of wnt signaling pathway GO:0030178 30 0.116
Human Mouse
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.115
cell motility GO:0048870 244 0.114
sexual reproduction GO:0019953 36 0.113
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.111
Human
optic placode formation GO:0001743 4 0.111
fin development GO:0033333 77 0.110
central nervous system myelination GO:0022010 2 0.109
forebrain development GO:0030900 96 0.109
morphogenesis of an epithelial fold GO:0060571 1 0.107
positive regulation of biological process GO:0048518 253 0.107
Human Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.105
regulation of vascular permeability GO:0043114 5 0.103
regulation of cardiac muscle tissue development GO:0055024 1 0.099
limb bud formation GO:0060174 2 0.098
cranial ganglion development GO:0061550 3 0.098
cranial nerve development GO:0021545 42 0.097
negative regulation of gastrulation GO:2000542 11 0.096
positive regulation of striated muscle cell differentiation GO:0051155 1 0.092
muscle tissue development GO:0060537 110 0.092
positive regulation of rna metabolic process GO:0051254 59 0.091
regulation of collateral sprouting of intact axon in response to injury GO:0048683 2 0.090
spinal cord anterior posterior patterning GO:0021512 1 0.090
regulation of response to stimulus GO:0048583 269 0.090
Human Zebrafish Mouse
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.090
cellular response to retinoic acid GO:0071300 1 0.087
negative regulation of apoptotic process GO:0043066 55 0.086
epithelial tube formation GO:0072175 19 0.083
camera type eye photoreceptor cell differentiation GO:0060219 19 0.080
embryonic cranial skeleton morphogenesis GO:0048701 90 0.080
determination of dorsal identity GO:0048263 13 0.078
neuron development GO:0048666 262 0.078
Mouse
multicellular organismal signaling GO:0035637 22 0.076
regulation of cardiac muscle cell differentiation GO:2000725 1 0.076
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.074
regulation of metabolic process GO:0019222 359 0.074
Human Mouse
embryonic camera type eye development GO:0031076 29 0.073
larval development GO:0002164 2 0.072
central nervous system myelin formation GO:0032289 1 0.071
cell surface receptor signaling pathway GO:0007166 325 0.071
embryonic eye morphogenesis GO:0048048 30 0.070
negative regulation of signaling GO:0023057 96 0.068
Human Zebrafish Mouse
photoreceptor cell fate commitment GO:0046552 1 0.068
wnt signaling pathway GO:0016055 80 0.067
ameboidal type cell migration GO:0001667 143 0.067
pericardium morphogenesis GO:0003344 1 0.067
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.067
Zebrafish
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.066
activin receptor signaling pathway GO:0032924 8 0.065
Zebrafish
embryonic heart tube morphogenesis GO:0003143 108 0.064
nuclear transport GO:0051169 4 0.064
Human
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.064
enzyme linked receptor protein signaling pathway GO:0007167 106 0.063
Zebrafish
muscle organ development GO:0007517 101 0.062
mesenchymal cell proliferation GO:0010463 1 0.061
nucleobase containing compound metabolic process GO:0006139 274 0.061
Human
organic cyclic compound biosynthetic process GO:1901362 223 0.060
Human
negative regulation of mesodermal cell fate specification GO:0042662 3 0.060
response to vitamin b3 GO:0033552 2 0.060
lateral line ganglion development GO:0048890 2 0.059
mesendoderm development GO:0048382 10 0.059
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.058
intestinal epithelial cell differentiation GO:0060575 3 0.056
production of molecular mediator of immune response GO:0002440 2 0.056
hematopoietic or lymphoid organ development GO:0048534 191 0.055
nerve development GO:0021675 45 0.054
embryonic viscerocranium morphogenesis GO:0048703 52 0.054
nucleic acid templated transcription GO:0097659 181 0.054
Human
fourth ventricle development GO:0021592 8 0.053
bone morphogenesis GO:0060349 11 0.053
nose development GO:0043584 3 0.053
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.052
Human
positive regulation of rna biosynthetic process GO:1902680 57 0.052
developmental induction GO:0031128 10 0.051
embryonic skeletal system morphogenesis GO:0048704 93 0.051
regulation of ectoderm development GO:2000383 2 0.051
transmission of nerve impulse GO:0019226 19 0.050
cell proliferation in forebrain GO:0021846 3 0.050
regulation of organ morphogenesis GO:2000027 35 0.050
Mouse
nephron morphogenesis GO:0072028 2 0.050
nephric duct morphogenesis GO:0072178 7 0.050
regulation of ectodermal cell fate specification GO:0042665 2 0.049
establishment of protein localization to organelle GO:0072594 4 0.049
Human
cartilage development involved in endochondral bone morphogenesis GO:0060351 8 0.049
determination of left right asymmetry in nervous system GO:0035545 4 0.049
localization of cell GO:0051674 244 0.049
positive regulation of muscle tissue development GO:1901863 1 0.049
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.049
Human
positive regulation of nucleic acid templated transcription GO:1903508 57 0.049
mammillary body development GO:0021767 4 0.048
positive regulation of muscle cell differentiation GO:0051149 1 0.048
cell death GO:0008219 121 0.048
hatching gland development GO:0048785 3 0.048
positive regulation of jnk cascade GO:0046330 3 0.046
regulation of cellular biosynthetic process GO:0031326 245 0.046
Human
ectodermal placode morphogenesis GO:0071697 32 0.045
death GO:0016265 121 0.045
positive regulation of cellular process GO:0048522 201 0.045
Human Mouse
negative regulation of activin receptor signaling pathway GO:0032926 5 0.045
Zebrafish
regulation of mesenchymal cell proliferation GO:0010464 1 0.045
hepatic duct development GO:0061011 2 0.044
neural crest cell development GO:0014032 62 0.044
optic placode formation involved in camera type eye formation GO:0046619 3 0.044
detection of temperature stimulus involved in sensory perception GO:0050961 0 0.044
endocardial cushion formation GO:0003272 2 0.043
regulation of myotube differentiation GO:0010830 2 0.042
growth plate cartilage development GO:0003417 2 0.042
generation of neurons GO:0048699 385 0.041
Mouse
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.041
negative regulation of neuron projection regeneration GO:0070571 4 0.040
dorsal ventral pattern formation GO:0009953 125 0.040
single organism nuclear import GO:1902593 3 0.040
Human
neural plate pattern specification GO:0060896 12 0.040
pectoral fin development GO:0033339 50 0.040
positive regulation of gene expression GO:0010628 71 0.040
regulation of molecular function GO:0065009 70 0.040
regulation of nucleic acid templated transcription GO:1903506 213 0.039
Human
positive regulation of jun kinase activity GO:0043507 2 0.039
formation of primary germ layer GO:0001704 62 0.039
single organism localization GO:1902578 225 0.039
Human
cell adhesion GO:0007155 40 0.038
regulation of activin receptor signaling pathway GO:0032925 5 0.038
Zebrafish
regulation of nodal signaling pathway GO:1900107 4 0.038
Zebrafish
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.038
lipid storage GO:0019915 1 0.038
nucleobase containing compound biosynthetic process GO:0034654 205 0.037
Human
nephron epithelium morphogenesis GO:0072088 1 0.037
regulation of biosynthetic process GO:0009889 250 0.037
Human
non canonical wnt signaling pathway involved in heart development GO:0061341 2 0.037
regulation of phosphate metabolic process GO:0019220 43 0.037
Human Mouse
nitrogen compound metabolic process GO:0006807 319 0.037
Human
single organism organelle organization GO:1902589 199 0.037
proximal distal pattern formation GO:0009954 1 0.037
intermediate mesoderm development GO:0048389 2 0.036
muscle cell differentiation GO:0042692 139 0.036
regulation of developmental process GO:0050793 247 0.036
Mouse
embryonic camera type eye morphogenesis GO:0048596 19 0.036
formation of anatomical boundary GO:0048859 14 0.036
cellular nitrogen compound biosynthetic process GO:0044271 218 0.036
Human
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.035
proximal tubule development GO:0072014 3 0.035
wnt signaling pathway involved in digestive tract morphogenesis GO:0044333 4 0.035
regulation of calcium dependent cell cell adhesion GO:0046586 1 0.035
negative regulation of metabolic process GO:0009892 86 0.035
Human Mouse
proepicardium development GO:0003342 4 0.035
mesodermal cell fate specification GO:0007501 12 0.035
negative regulation of biosynthetic process GO:0009890 55 0.035
Human
negative regulation of collateral sprouting GO:0048671 2 0.035
stem cell differentiation GO:0048863 117 0.035
cell migration GO:0016477 237 0.034
regulation of muscle organ development GO:0048634 9 0.034
nucleic acid metabolic process GO:0090304 244 0.034
Human
positive regulation of cell differentiation GO:0045597 30 0.033
Mouse
regulation of histone deacetylation GO:0031063 2 0.033
developmental growth involved in morphogenesis GO:0060560 86 0.033
heart development GO:0007507 313 0.033
sulfur compound metabolic process GO:0006790 13 0.033
regulation of collateral sprouting GO:0048670 7 0.032
oxoacid metabolic process GO:0043436 31 0.032
embryonic limb morphogenesis GO:0030326 2 0.032
endochondral bone growth GO:0003416 2 0.032
heart morphogenesis GO:0003007 156 0.032
myotube cell development GO:0014904 35 0.032
regulation of cell differentiation GO:0045595 142 0.031
Mouse
immunoglobulin mediated immune response GO:0016064 3 0.031
myotube differentiation GO:0014902 45 0.031
cellular component morphogenesis GO:0032989 336 0.031
Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.031
Human
embryonic foregut morphogenesis GO:0048617 1 0.031
protein import into nucleus GO:0006606 3 0.031
Human
regulation of stem cell proliferation GO:0072091 2 0.031
stem cell maintenance GO:0019827 4 0.031
positive regulation of neuron projection development GO:0010976 9 0.030
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 4 0.030
retinal ganglion cell axon guidance GO:0031290 35 0.030
morphogenesis of embryonic epithelium GO:0016331 30 0.030
positive regulation of muscle organ development GO:0048636 1 0.030
axon ensheathment in central nervous system GO:0032291 2 0.030
protein localization to nucleus GO:0034504 3 0.029
Human
myelination GO:0042552 18 0.029
limb development GO:0060173 8 0.029
nuclear import GO:0051170 3 0.029
Human
regulation of cell fate commitment GO:0010453 22 0.029
neuronal action potential GO:0019228 18 0.029
positive regulation of catabolic process GO:0009896 4 0.029
Human
regulation of anatomical structure morphogenesis GO:0022603 130 0.029
Mouse
negative regulation of axon regeneration GO:0048681 4 0.029
renal system development GO:0072001 94 0.029
lens development in camera type eye GO:0002088 22 0.028
ventricular system development GO:0021591 12 0.028
atrioventricular valve formation GO:0003190 3 0.028
retina development in camera type eye GO:0060041 146 0.028
astrocyte differentiation GO:0048708 1 0.027
endocardial cushion morphogenesis GO:0003203 3 0.027
programmed cell death GO:0012501 119 0.027
vasculature development GO:0001944 278 0.026
myelin assembly GO:0032288 1 0.026
retinoid metabolic process GO:0001523 15 0.026
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.026
Human
epithelial cell development GO:0002064 42 0.026
epithalamus development GO:0021538 10 0.026
canonical wnt signaling pathway GO:0060070 48 0.026
Mouse
terpenoid metabolic process GO:0006721 15 0.025
development of primary female sexual characteristics GO:0046545 4 0.025
regulation of canonical wnt signaling pathway GO:0060828 34 0.025
Mouse
positive regulation of nervous system development GO:0051962 25 0.025
sensory organ development GO:0007423 393 0.025
cellular response to extracellular stimulus GO:0031668 2 0.025
urogenital system development GO:0001655 97 0.025
positive regulation of stem cell proliferation GO:2000648 1 0.025
ectoderm formation GO:0001705 2 0.024
cell proliferation in hindbrain GO:0021534 4 0.024
tissue remodeling GO:0048771 4 0.024
multi organism process GO:0051704 134 0.024
endodermal cell fate determination GO:0007493 2 0.024
heterocycle metabolic process GO:0046483 290 0.024
Human
cellular aromatic compound metabolic process GO:0006725 295 0.023
Human
carboxylic acid metabolic process GO:0019752 22 0.023
neural plate anterior posterior regionalization GO:0021999 8 0.023
phosphate containing compound metabolic process GO:0006796 108 0.023
Human Mouse
stem cell division GO:0017145 1 0.023
developmental process involved in reproduction GO:0003006 27 0.023
regulation of transcription involved in cell fate commitment GO:0060850 1 0.023
axial mesoderm formation GO:0048320 4 0.023
cartilage development GO:0051216 96 0.023
ventral spinal cord development GO:0021517 35 0.022
cell morphogenesis GO:0000902 289 0.022
Mouse
positive regulation of immune effector process GO:0002699 3 0.022
negative regulation of reproductive process GO:2000242 3 0.022
retinal metabolic process GO:0042574 3 0.022
mesodermal cell fate commitment GO:0001710 14 0.022
diterpenoid biosynthetic process GO:0016102 7 0.022
establishment of localization GO:0051234 244 0.022
Human
mesenchyme development GO:0060485 127 0.022
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.022
ensheathment of neurons GO:0007272 18 0.021
regulation of blood vessel size GO:0050880 2 0.021
maintenance of location GO:0051235 4 0.021
septum transversum development GO:0003343 4 0.021
small molecule metabolic process GO:0044281 77 0.021
negative regulation of embryonic development GO:0045992 11 0.021
negative regulation of cell death GO:0060548 60 0.021
vitamin biosynthetic process GO:0009110 2 0.021
neurological system process GO:0050877 62 0.021
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.021
Mouse
negative regulation of epithelial cell proliferation GO:0050680 1 0.021
retinal cone cell differentiation GO:0042670 12 0.021
somatic stem cell maintenance GO:0035019 1 0.021
locomotion GO:0040011 313 0.020
negative regulation of locomotion GO:0040013 18 0.020
negative regulation of cell adhesion GO:0007162 6 0.020
eye photoreceptor cell development GO:0042462 30 0.020
paraxial mesoderm development GO:0048339 8 0.020
regulation of phosphorus metabolic process GO:0051174 43 0.020
Human Mouse
fin morphogenesis GO:0033334 53 0.020
cellular response to organic substance GO:0071310 105 0.020
nucleocytoplasmic transport GO:0006913 4 0.020
Human
negative regulation of endodermal cell fate specification GO:0042664 8 0.019
cell cell recognition GO:0009988 1 0.019
lateral mesoderm development GO:0048368 23 0.019
specification of axis polarity GO:0065001 4 0.019
otic vesicle development GO:0071599 42 0.019
specification of organ position GO:0010159 3 0.019
positive regulation of biosynthetic process GO:0009891 68 0.019
peripheral nervous system development GO:0007422 55 0.019
cellular response to chemical stimulus GO:0070887 157 0.019
response to glucocorticoid GO:0051384 1 0.019
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.019
ectodermal placode formation GO:0060788 26 0.019
negative regulation of cellular metabolic process GO:0031324 77 0.019
Human Mouse
nephric duct development GO:0072176 13 0.018
heart field specification GO:0003128 1 0.018
outflow tract morphogenesis GO:0003151 1 0.018
retinoic acid receptor signaling pathway GO:0048384 16 0.018
lymphatic endothelial cell fate commitment GO:0060838 1 0.018
regulation of intracellular signal transduction GO:1902531 57 0.018
Human Mouse
steroid hormone mediated signaling pathway GO:0043401 9 0.018
cell migration involved in gastrulation GO:0042074 79 0.018
positive regulation of stress activated mapk cascade GO:0032874 3 0.018
epithelial tube morphogenesis GO:0060562 148 0.018
regulation of neutrophil migration GO:1902622 6 0.018
regulation of myelination GO:0031641 1 0.018
spinal cord motor neuron differentiation GO:0021522 26 0.018
hemopoiesis GO:0030097 183 0.017
action potential GO:0001508 19 0.017
regulation of establishment of planar polarity GO:0090175 4 0.017
Mouse
anterior head development GO:0097065 2 0.017
regulation of jun kinase activity GO:0043506 3 0.017
regulation of alcohol biosynthetic process GO:1902930 1 0.017
bone development GO:0060348 14 0.017
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 1 0.017
negative regulation of cellular component movement GO:0051271 18 0.017
positive regulation of bmp signaling pathway GO:0030513 10 0.017
response to organic substance GO:0010033 153 0.017
cardiocyte differentiation GO:0035051 44 0.016
aging GO:0007568 2 0.016
angioblast cell migration GO:0035476 9 0.016
axonogenesis GO:0007409 152 0.016
muscle cell development GO:0055001 115 0.016
organic acid metabolic process GO:0006082 31 0.016
ectodermal cell fate specification GO:0001715 2 0.016
regulation of cell death GO:0010941 103 0.016
positive regulation of epithelial cell proliferation GO:0050679 1 0.016
pronephric glomerulus morphogenesis GO:0035775 6 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
Human
negative regulation of muscle tissue development GO:1901862 2 0.016
blood vessel morphogenesis GO:0048514 216 0.016
regulation of jnk cascade GO:0046328 5 0.016
Human Mouse
sensory perception of chemical stimulus GO:0007606 3 0.016
ear morphogenesis GO:0042471 64 0.016
central nervous system formation GO:0021556 1 0.016
pectoral fin morphogenesis GO:0035138 29 0.015
epithelial cell proliferation GO:0050673 17 0.015
regulation of somitogenesis GO:0014807 1 0.015
positive regulation of striated muscle tissue development GO:0045844 1 0.015
myeloid leukocyte migration GO:0097529 12 0.015
positive regulation of cellular metabolic process GO:0031325 94 0.015
positive regulation of transcription dna templated GO:0045893 57 0.015
wnt signaling pathway involved in dorsal ventral axis specification GO:0044332 5 0.015
multicellular organismal macromolecule metabolic process GO:0044259 2 0.015
single organism metabolic process GO:0044710 217 0.014
Human Mouse
positive regulation of embryonic development GO:0040019 3 0.014
skin development GO:0043588 54 0.014
epidermis development GO:0008544 48 0.014
isoprenoid metabolic process GO:0006720 15 0.014
kidney development GO:0001822 92 0.014
lens morphogenesis in camera type eye GO:0002089 7 0.014
intracellular signal transduction GO:0035556 85 0.014
Human Mouse
neural retina development GO:0003407 49 0.014
cellular response to external stimulus GO:0071496 2 0.014
pharyngeal system development GO:0060037 18 0.014
organ formation GO:0048645 17 0.014
regulation of wnt signaling pathway GO:0030111 53 0.014
Human Mouse
regulation of wnt signaling pathway involved in dorsal ventral axis specification GO:2000053 5 0.014
positive regulation of developmental process GO:0051094 50 0.014
Mouse
habenula development GO:0021986 9 0.014
negative regulation of gene expression GO:0010629 65 0.014
Human
positive regulation of gastrulation GO:2000543 2 0.014
regulation of striated muscle cell differentiation GO:0051153 6 0.013
otic vesicle formation GO:0030916 27 0.013
regulation of cytokine production GO:0001817 3 0.013
muscle fiber development GO:0048747 52 0.013
invagination involved in gastrulation with mouth forming second GO:0055109 1 0.013
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.013
positive regulation of cell communication GO:0010647 56 0.013
Human
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.013
Human
regulation of developmental growth GO:0048638 38 0.013
positive regulation of response to stimulus GO:0048584 80 0.013
Human
cytoskeleton organization GO:0007010 96 0.013
axon ensheathment GO:0008366 18 0.013
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.013
Mouse
protein import GO:0017038 3 0.013
Human
negative regulation of developmental process GO:0051093 65 0.013
atrioventricular valve morphogenesis GO:0003181 6 0.013
positive regulation of jak stat cascade GO:0046427 2 0.013
mesenchyme morphogenesis GO:0072132 5 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
selective angioblast sprouting GO:0035474 5 0.013
regulation of neurogenesis GO:0050767 87 0.013
axial mesoderm morphogenesis GO:0048319 8 0.013
regulation of locomotion GO:0040012 55 0.012
foregut morphogenesis GO:0007440 4 0.012
protein metabolic process GO:0019538 183 0.012
Human
spinal cord development GO:0021510 46 0.012
thalamus development GO:0021794 6 0.012
midbrain development GO:0030901 28 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
Human
response to fluid shear stress GO:0034405 2 0.012
regulation of cell adhesion GO:0030155 15 0.012
endoderm formation GO:0001706 29 0.012
neural crest cell migration GO:0001755 42 0.012
response to lipid GO:0033993 60 0.012

dact1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.139
bone disease DOID:0080001 0 0.139
disease of anatomical entity DOID:7 0 0.139
dysostosis DOID:1934 0 0.139
musculoskeletal system disease DOID:17 0 0.139
connective tissue disease DOID:65 0 0.139
reproductive organ cancer DOID:193 0 0.017
female reproductive organ cancer DOID:120 0 0.017
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
reproductive system disease DOID:15 0 0.013