Danio rerio

0 known processes

spns1

spinster homolog 1 (Drosophila)

(Aliases: spinl,wu:fi37e11,MGC55239,nrs,etID64740.3,wu:fb95b12)

spns1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell surface receptor signaling pathway GO:0007166 325 0.154
Zebrafish Fly
larval development GO:0002164 2 0.110
Worm
autophagy GO:0006914 4 0.092
establishment of localization GO:0051234 244 0.086
Fly
establishment of protein localization to organelle GO:0072594 4 0.081
regulation of cell communication GO:0010646 232 0.075
Fly
meiotic nuclear division GO:0007126 4 0.074
regulation of response to stimulus GO:0048583 269 0.072
Fly
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.065
axon development GO:0061564 166 0.061
cellular protein catabolic process GO:0044257 4 0.060
cell part morphogenesis GO:0032990 246 0.057
aging GO:0007568 2 0.056
cell projection morphogenesis GO:0048858 244 0.053
signal transduction GO:0007165 455 0.051
Zebrafish Fly
regulation of metabolic process GO:0019222 359 0.050
modification dependent protein catabolic process GO:0019941 3 0.050
positive regulation of cellular catabolic process GO:0031331 3 0.049
immune system process GO:0002376 241 0.047
adult behavior GO:0030534 2 0.047
regulation of signal transduction GO:0009966 225 0.046
Fly
cellular response to nutrient levels GO:0031669 2 0.046
Fly
positive regulation of catabolic process GO:0009896 4 0.044
transport GO:0006810 220 0.044
Fly
regulation of autophagy GO:0010506 3 0.044
cell morphogenesis involved in differentiation GO:0000904 195 0.043
axonogenesis GO:0007409 152 0.043
macroautophagy GO:0016236 1 0.040
lipid storage GO:0019915 1 0.040
response to stress GO:0006950 263 0.040
Fly
cell projection organization GO:0030030 284 0.039
ubiquitin dependent protein catabolic process GO:0006511 3 0.037
maintenance of location GO:0051235 4 0.037
modification dependent macromolecule catabolic process GO:0043632 3 0.037
tube morphogenesis GO:0035239 349 0.037
Zebrafish
golgi vesicle transport GO:0048193 3 0.036
cellular response to extracellular stimulus GO:0031668 2 0.036
Fly
cellular response to starvation GO:0009267 1 0.036
Fly
regulation of multicellular organism growth GO:0040014 4 0.035
meiotic chromosome segregation GO:0045132 3 0.035
meiotic cell cycle process GO:1903046 3 0.035
tissue remodeling GO:0048771 4 0.034
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.033
extrinsic apoptotic signaling pathway GO:0097191 3 0.032
negative regulation of protein phosphorylation GO:0001933 4 0.032
regulation of synapse assembly GO:0051963 3 0.031
Fly
gastrulation GO:0007369 208 0.031
hematopoietic or lymphoid organ development GO:0048534 191 0.030
embryo development ending in birth or egg hatching GO:0009792 271 0.030
Zebrafish Worm
multicellular organism growth GO:0035264 4 0.030
stem cell proliferation GO:0072089 4 0.030
protein stabilization GO:0050821 2 0.030
cellular component morphogenesis GO:0032989 336 0.029
biosynthetic process GO:0009058 294 0.029
digestive tract development GO:0048565 265 0.029
cellular biosynthetic process GO:0044249 286 0.028
single organism membrane fusion GO:0044801 2 0.028
positive regulation of cellular component biogenesis GO:0044089 3 0.028
negative regulation of kinase activity GO:0033673 4 0.028
regulation of response to nutrient levels GO:0032107 1 0.028
cell migration GO:0016477 237 0.027
Zebrafish Worm Fly
single organism metabolic process GO:0044710 217 0.027
alpha amino acid metabolic process GO:1901605 3 0.027
negative regulation of protein kinase activity GO:0006469 4 0.027
gland development GO:0048732 143 0.027
proteasomal protein catabolic process GO:0010498 2 0.027
regulation of response to extracellular stimulus GO:0032104 1 0.027
neuron development GO:0048666 262 0.027
organic substance biosynthetic process GO:1901576 289 0.027
intracellular signal transduction GO:0035556 85 0.027
phosphate containing compound metabolic process GO:0006796 108 0.027
positive regulation of map kinase activity GO:0043406 3 0.026
organelle fusion GO:0048284 3 0.026
locomotion GO:0040011 313 0.026
Zebrafish Worm Fly
response to external biotic stimulus GO:0043207 97 0.026
response to abiotic stimulus GO:0009628 122 0.026
negative regulation of response to stimulus GO:0048585 104 0.026
Fly
regulation of signaling GO:0023051 235 0.026
Fly
positive regulation of transport GO:0051050 2 0.025
compound eye development GO:0048749 2 0.025
death GO:0016265 121 0.025
Fly
stem cell division GO:0017145 1 0.025
guanosine containing compound metabolic process GO:1901068 4 0.025
cellular transition metal ion homeostasis GO:0046916 3 0.025
neuron differentiation GO:0030182 353 0.025
generation of neurons GO:0048699 385 0.025
cellular component assembly GO:0022607 170 0.025
Fly
cellular response to external stimulus GO:0071496 2 0.025
Fly
localization of cell GO:0051674 244 0.024
Zebrafish Worm Fly
cellular ketone metabolic process GO:0042180 11 0.024
positive regulation of biological process GO:0048518 253 0.024
neuron projection development GO:0031175 180 0.024
digestive tract morphogenesis GO:0048546 231 0.024
mitochondrion organization GO:0007005 4 0.024
cellular amino acid metabolic process GO:0006520 7 0.023
phagocytosis GO:0006909 3 0.023
neuroblast proliferation GO:0007405 2 0.023
regulation of cell projection assembly GO:0060491 4 0.023
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.023
protein import into nucleus GO:0006606 3 0.023
neurotransmitter transport GO:0006836 2 0.023
cellular amino acid biosynthetic process GO:0008652 2 0.023
immune system development GO:0002520 191 0.023
single organism transport GO:0044765 206 0.023
Fly
cellular response to chemical stimulus GO:0070887 157 0.022
response to other organism GO:0051707 97 0.022
regulation of protein catabolic process GO:0042176 1 0.022
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.022
regulation of binding GO:0051098 3 0.022
gtp catabolic process GO:0006184 2 0.022
cell growth GO:0016049 57 0.022
developmental growth GO:0048589 166 0.022
Fly
negative regulation of cellular process GO:0048523 283 0.021
Fly
sensory organ development GO:0007423 393 0.021
transmembrane transport GO:0055085 120 0.021
regulation of protein transport GO:0051223 3 0.021
rna localization GO:0006403 4 0.021
axon ensheathment in central nervous system GO:0032291 2 0.021
organelle assembly GO:0070925 110 0.021
regulation of developmental process GO:0050793 247 0.021
Zebrafish Fly
protein homooligomerization GO:0051260 3 0.021
developmental cell growth GO:0048588 52 0.021
regulation of blood vessel size GO:0050880 2 0.021
negative regulation of signaling GO:0023057 96 0.020
Fly
peptidyl serine modification GO:0018209 2 0.020
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.020
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.020
Fly
positive regulation of cell cycle GO:0045787 3 0.020
cellular macromolecule metabolic process GO:0044260 391 0.020
nucleic acid transport GO:0050657 2 0.020
cellular component movement GO:0006928 335 0.020
Zebrafish Worm Fly
guanosine containing compound catabolic process GO:1901069 2 0.020
regulation of cytokine production GO:0001817 3 0.020
oxoacid metabolic process GO:0043436 31 0.020
protein localization to nucleus GO:0034504 3 0.020
cellular response to organic substance GO:0071310 105 0.020
membrane fusion GO:0061025 2 0.020
regulation of meiotic cell cycle GO:0051445 1 0.019
regulation of tube size GO:0035150 2 0.019
nitrogen compound metabolic process GO:0006807 319 0.019
digestive system development GO:0055123 289 0.019
regulation of synaptic plasticity GO:0048167 1 0.019
negative regulation of epithelial cell proliferation GO:0050680 1 0.019
female meiotic division GO:0007143 2 0.019
camera type eye development GO:0043010 222 0.019
positive regulation of apoptotic signaling pathway GO:2001235 1 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
gtp metabolic process GO:0046039 4 0.019
carboxylic acid catabolic process GO:0046395 3 0.019
negative regulation of signal transduction GO:0009968 94 0.019
Fly
response to hexose GO:0009746 3 0.018
protein metabolic process GO:0019538 183 0.018
actin filament polymerization GO:0030041 2 0.018
urogenital system development GO:0001655 97 0.018
regulation of protein targeting GO:1903533 2 0.018
response to uv GO:0009411 3 0.018
positive regulation of protein complex assembly GO:0031334 2 0.018
regulation of cellular metabolic process GO:0031323 320 0.018
neurotransmitter secretion GO:0007269 2 0.018
response to chemical GO:0042221 320 0.018
cognition GO:0050890 1 0.018
neuron projection morphogenesis GO:0048812 161 0.018
detection of stimulus GO:0051606 29 0.018
cellular carbohydrate metabolic process GO:0044262 4 0.018
synaptic target recognition GO:0008039 1 0.018
cellular protein metabolic process GO:0044267 129 0.018
heterocycle metabolic process GO:0046483 290 0.018
brain development GO:0007420 293 0.018
synaptic vesicle transport GO:0048489 1 0.017
Fly
response to monosaccharide GO:0034284 3 0.017
establishment of synaptic vesicle localization GO:0097480 1 0.017
Fly
synaptic growth at neuromuscular junction GO:0051124 2 0.017
Fly
regulation of cytoplasmic transport GO:1903649 4 0.017
membrane invagination GO:0010324 1 0.017
negative regulation of cell communication GO:0010648 96 0.017
Fly
cellular amine metabolic process GO:0044106 2 0.017
growth GO:0040007 174 0.017
Fly
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.017
blood vessel development GO:0001568 246 0.017
Zebrafish
regulation of protein complex assembly GO:0043254 3 0.017
cell aging GO:0007569 2 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
enzyme linked receptor protein signaling pathway GO:0007167 106 0.017
Fly
vacuolar transport GO:0007034 2 0.017
Fly
cation transmembrane transport GO:0098655 65 0.016
gene expression GO:0010467 252 0.016
regulation of cellular amine metabolic process GO:0033238 0 0.016
apoptotic process GO:0006915 116 0.016
Fly
cell cycle arrest GO:0007050 1 0.016
striated muscle tissue development GO:0014706 110 0.016
cell matrix adhesion GO:0007160 4 0.016
response to corticosteroid GO:0031960 1 0.016
regulation of synapse organization GO:0050807 3 0.016
Fly
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.016
post golgi vesicle mediated transport GO:0006892 1 0.016
regulation of skeletal muscle tissue development GO:0048641 4 0.016
single organism nuclear import GO:1902593 3 0.016
protein polymerization GO:0051258 4 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
activation of mapk activity GO:0000187 3 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.016
nucleobase containing compound metabolic process GO:0006139 274 0.016
erk1 and erk2 cascade GO:0070371 4 0.016
regulation of macromolecule metabolic process GO:0060255 317 0.016
lipid catabolic process GO:0016042 4 0.016
protein targeting to nucleus GO:0044744 3 0.016
cellular aromatic compound metabolic process GO:0006725 295 0.016
regeneration GO:0031099 91 0.016
organic acid metabolic process GO:0006082 31 0.016
cellular macromolecule biosynthetic process GO:0034645 224 0.016
regionalization GO:0003002 274 0.016
actin filament based movement GO:0030048 1 0.016
catabolic process GO:0009056 32 0.015
regulation of protein binding GO:0043393 3 0.015
regulation of production of molecular mediator of immune response GO:0002700 1 0.015
epithelial cell differentiation GO:0030855 116 0.015
vasculature development GO:0001944 278 0.015
Zebrafish
organonitrogen compound metabolic process GO:1901564 74 0.015
regulation of reactive oxygen species metabolic process GO:2000377 2 0.015
cell death GO:0008219 121 0.015
Fly
regulation of intracellular signal transduction GO:1902531 57 0.015
regulation of macromolecule biosynthetic process GO:0010556 225 0.015
nuclear transport GO:0051169 4 0.015
protein secretion GO:0009306 1 0.015
negative regulation of catabolic process GO:0009895 3 0.015
positive regulation of camp biosynthetic process GO:0030819 2 0.015
defense response to bacterium GO:0042742 22 0.015
synaptic vesicle localization GO:0097479 1 0.015
Fly
amine metabolic process GO:0009308 2 0.015
regulation of erk1 and erk2 cascade GO:0070372 4 0.015
macromolecule biosynthetic process GO:0009059 227 0.015
cellular component disassembly GO:0022411 1 0.015
iron ion homeostasis GO:0055072 4 0.015
regulation of cell activation GO:0050865 1 0.015
astrocyte differentiation GO:0048708 1 0.014
establishment of blood brain barrier GO:0060856 2 0.014
production of molecular mediator of immune response GO:0002440 2 0.014
embryonic limb morphogenesis GO:0030326 2 0.014
protein targeting to vacuole GO:0006623 1 0.014
defense response to other organism GO:0098542 33 0.014
defense response to gram negative bacterium GO:0050829 8 0.014
negative regulation of sequestering of calcium ion GO:0051283 4 0.014
stem cell maintenance GO:0019827 4 0.014
hepaticobiliary system development GO:0061008 98 0.014
neuron projection guidance GO:0097485 86 0.014
cytoplasm organization GO:0007028 4 0.014
locomotor rhythm GO:0045475 3 0.014
protein import GO:0017038 3 0.014
negative regulation of defense response GO:0031348 2 0.014
regulation of cell shape GO:0008360 1 0.014
cell substrate adhesion GO:0031589 4 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
regulation of neurotransmitter transport GO:0051588 1 0.014
mononuclear cell proliferation GO:0032943 1 0.014
post embryonic organ development GO:0048569 4 0.014
signal transduction in absence of ligand GO:0038034 1 0.014
synaptic transmission cholinergic GO:0007271 4 0.014
angiogenesis GO:0001525 158 0.013
Zebrafish
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
cellular respiration GO:0045333 3 0.013
multicellular organismal macromolecule metabolic process GO:0044259 2 0.013
regulation of establishment of protein localization GO:0070201 4 0.013
small molecule metabolic process GO:0044281 77 0.013
cellular response to reactive oxygen species GO:0034614 2 0.013
regulation of cellular component size GO:0032535 30 0.013
apoptotic process involved in development GO:1902742 2 0.013
Fly
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.013
establishment of protein localization to vacuole GO:0072666 1 0.013
nucleocytoplasmic transport GO:0006913 4 0.013
organelle organization GO:0006996 227 0.013
Fly
positive regulation of secretion by cell GO:1903532 1 0.013
hormone secretion GO:0046879 2 0.013
regulation of filopodium assembly GO:0051489 2 0.013
establishment of protein localization to plasma membrane GO:0090002 1 0.013
muscle cell migration GO:0014812 4 0.013
lymphocyte proliferation GO:0046651 1 0.013
regulation of reproductive process GO:2000241 4 0.013
Fly
peptidyl serine phosphorylation GO:0018105 1 0.013
regulation of carbohydrate metabolic process GO:0006109 4 0.013
blood vessel morphogenesis GO:0048514 216 0.013
Zebrafish
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.013
nucleobase containing compound transport GO:0015931 2 0.013
i kappab kinase nf kappab signaling GO:0007249 4 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
notch signaling pathway GO:0007219 35 0.013
cellular component biogenesis GO:0044085 178 0.013
Fly
inorganic cation transmembrane transport GO:0098662 50 0.013
regulation of organelle assembly GO:1902115 4 0.013
hemopoiesis GO:0030097 183 0.013
positive regulation of immune effector process GO:0002699 3 0.012
b cell activation GO:0042113 2 0.012
dicarboxylic acid transport GO:0006835 1 0.012
regulation of cellular component organization GO:0051128 86 0.012
Fly
eye development GO:0001654 277 0.012
regulation of inflammatory response GO:0050727 2 0.012
macromolecule modification GO:0043412 111 0.012
regulation of gtpase activity GO:0043087 2 0.012
positive regulation of secretion GO:0051047 1 0.012
aromatic compound biosynthetic process GO:0019438 217 0.012
secondary metabolic process GO:0019748 3 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
microtubule organizing center organization GO:0031023 1 0.012
atp catabolic process GO:0006200 4 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
response to decreased oxygen levels GO:0036293 25 0.012
nucleic acid templated transcription GO:0097659 181 0.012
lysosomal transport GO:0007041 2 0.012
Fly
actin polymerization or depolymerization GO:0008154 2 0.012
negative regulation of biological process GO:0048519 304 0.012
Fly
sensory perception of chemical stimulus GO:0007606 3 0.012
response to hydrogen peroxide GO:0042542 3 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
establishment of rna localization GO:0051236 3 0.012
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.012
regulation of multicellular organismal process GO:0051239 277 0.012
Zebrafish Fly
ion transmembrane transport GO:0034220 91 0.012
negative regulation of autophagy GO:0010507 1 0.012
positive regulation of protein polymerization GO:0032273 2 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
embryonic organ morphogenesis GO:0048562 274 0.011
Zebrafish
nuclear import GO:0051170 3 0.011
negative regulation of synapse assembly GO:0051964 2 0.011
heart development GO:0007507 313 0.011
Zebrafish
hormone biosynthetic process GO:0042446 3 0.011
single organism organelle organization GO:1902589 199 0.011
response to glucose GO:0009749 3 0.011
cellular modified amino acid metabolic process GO:0006575 3 0.011
positive regulation of gtpase activity GO:0043547 1 0.011
regulation of programmed cell death GO:0043067 101 0.011
Fly
response to topologically incorrect protein GO:0035966 2 0.011
regulation of neurotransmitter secretion GO:0046928 1 0.011
lateral inhibition GO:0046331 1 0.011
regulation of epithelial cell proliferation GO:0050678 3 0.011
morphogenesis of an epithelium GO:0002009 333 0.011
Zebrafish
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.011
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.011
odontogenesis of dentin containing tooth GO:0042475 1 0.011
cell morphogenesis GO:0000902 289 0.011
homeostasis of number of cells GO:0048872 62 0.011
chemosensory behavior GO:0007635 1 0.011
amino acid transport GO:0006865 2 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
negative chemotaxis GO:0050919 1 0.011
protein acylation GO:0043543 3 0.011
chemotaxis GO:0006935 104 0.011
transcription dna templated GO:0006351 181 0.011
regulation of organ growth GO:0046620 3 0.011
glial cell migration GO:0008347 3 0.011
Fly
developmental growth involved in morphogenesis GO:0060560 86 0.011
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.011
rna metabolic process GO:0016070 219 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
regulation of membrane potential GO:0042391 23 0.011
protein polyubiquitination GO:0000209 4 0.011
response to ph GO:0009268 2 0.011
pole plasm assembly GO:0007315 4 0.011
negative regulation of chemotaxis GO:0050922 4 0.011
embryonic organ development GO:0048568 381 0.011
Zebrafish
embryonic skeletal system morphogenesis GO:0048704 93 0.011
Zebrafish
response to light stimulus GO:0009416 46 0.011
single organism biosynthetic process GO:0044711 71 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
single organism localization GO:1902578 225 0.011
Fly
female sex differentiation GO:0046660 4 0.011
inorganic ion transmembrane transport GO:0098660 57 0.011
somatic muscle development GO:0007525 4 0.011
regulation of primary metabolic process GO:0080090 311 0.011
response to carbohydrate GO:0009743 3 0.011
regulation of circadian sleep wake cycle GO:0042749 1 0.010
kidney development GO:0001822 92 0.010
phosphorylation GO:0016310 69 0.010
negative regulation of multi organism process GO:0043901 3 0.010
response to organic substance GO:0010033 153 0.010
regulation of ph GO:0006885 3 0.010
ketone biosynthetic process GO:0042181 2 0.010
skeletal muscle organ development GO:0060538 78 0.010
embryonic skeletal system development GO:0048706 97 0.010
Zebrafish
negative regulation of cytokine production GO:0001818 1 0.010
transmission of nerve impulse GO:0019226 19 0.010
cellular response to decreased oxygen levels GO:0036294 1 0.010
g protein coupled receptor signaling pathway GO:0007186 74 0.010
Zebrafish
convergent extension GO:0060026 118 0.010
endosomal transport GO:0016197 2 0.010
Fly
establishment of epithelial cell polarity GO:0090162 2 0.010
regulation of protein import into nucleus GO:0042306 2 0.010
programmed cell death GO:0012501 119 0.010
Fly
regulation of gene expression GO:0010468 265 0.010
myeloid cell development GO:0061515 32 0.010

spns1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.059
inherited metabolic disorder DOID:655 0 0.059
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.016
cardiovascular system disease DOID:1287 0 0.015
lysosomal storage disease DOID:3211 0 0.010