Danio rerio

0 known processes

sigirr

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

(Aliases: sc:d148)

sigirr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.080
positive regulation of transport GO:0051050 2 0.053
maintenance of location GO:0051235 4 0.052
aging GO:0007568 2 0.047
cellular macromolecule metabolic process GO:0044260 391 0.046
Human
cellular aromatic compound metabolic process GO:0006725 295 0.045
Human
biosynthetic process GO:0009058 294 0.045
Human
central nervous system development GO:0007417 387 0.044
response to chemical GO:0042221 320 0.043
organic cyclic compound metabolic process GO:1901360 301 0.042
Human
negative regulation of biological process GO:0048519 304 0.041
Human
signal transduction GO:0007165 455 0.040
regulation of biological quality GO:0065008 263 0.040
autophagy GO:0006914 4 0.040
single organism metabolic process GO:0044710 217 0.038
cell migration GO:0016477 237 0.037
nitrogen compound metabolic process GO:0006807 319 0.036
Human
gtp catabolic process GO:0006184 2 0.036
lipid storage GO:0019915 1 0.036
response to drug GO:0042493 3 0.035
cellular component movement GO:0006928 335 0.035
regulation of establishment of protein localization GO:0070201 4 0.035
i kappab kinase nf kappab signaling GO:0007249 4 0.035
regulation of reproductive process GO:2000241 4 0.035
heterocycle metabolic process GO:0046483 290 0.035
Human
response to stress GO:0006950 263 0.035
cellular nitrogen compound biosynthetic process GO:0044271 218 0.034
Human
multicellular organism growth GO:0035264 4 0.034
morphogenesis of an epithelium GO:0002009 333 0.033
positive regulation of catabolic process GO:0009896 4 0.032
regulation of nucleoside metabolic process GO:0009118 2 0.032
organic substance biosynthetic process GO:1901576 289 0.032
Human
small molecule metabolic process GO:0044281 77 0.031
localization of cell GO:0051674 244 0.031
single fertilization GO:0007338 3 0.030
adult behavior GO:0030534 2 0.030
gene expression GO:0010467 252 0.030
Human
regulation of cytokine production GO:0001817 3 0.029
cognition GO:0050890 1 0.029
single organism organelle organization GO:1902589 199 0.029
exocytosis GO:0006887 1 0.029
ameboidal type cell migration GO:0001667 143 0.028
positive regulation of cellular catabolic process GO:0031331 3 0.028
meiotic cell cycle process GO:1903046 3 0.028
regulation of gene expression GO:0010468 265 0.028
Human
regulation of protein transport GO:0051223 3 0.028
regulation of multicellular organismal development GO:2000026 223 0.027
heart development GO:0007507 313 0.027
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.027
regulation of cellular metabolic process GO:0031323 320 0.027
Human
cellular nitrogen compound metabolic process GO:0034641 290 0.027
Human
embryonic organ development GO:0048568 381 0.027
meiotic nuclear division GO:0007126 4 0.027
stem cell proliferation GO:0072089 4 0.027
regulation of primary metabolic process GO:0080090 311 0.027
Human
fertilization GO:0009566 3 0.027
transport GO:0006810 220 0.027
regulation of nucleotide catabolic process GO:0030811 2 0.026
cell surface receptor signaling pathway GO:0007166 325 0.026
cellular biosynthetic process GO:0044249 286 0.026
Human
rna metabolic process GO:0016070 219 0.026
Human
generation of neurons GO:0048699 385 0.026
positive regulation of biological process GO:0048518 253 0.025
membrane fusion GO:0061025 2 0.025
cellular component disassembly GO:0022411 1 0.025
head development GO:0060322 303 0.024
cellular response to external stimulus GO:0071496 2 0.024
system process GO:0003008 185 0.024
gtp metabolic process GO:0046039 4 0.024
regulation of multicellular organism growth GO:0040014 4 0.024
nucleobase containing compound metabolic process GO:0006139 274 0.024
Human
guanosine containing compound metabolic process GO:1901068 4 0.023
cellular protein catabolic process GO:0044257 4 0.023
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.023
organelle fusion GO:0048284 3 0.023
cellular response to chemical stimulus GO:0070887 157 0.023
immune system process GO:0002376 241 0.023
regulation of synapse organization GO:0050807 3 0.023
nucleic acid metabolic process GO:0090304 244 0.023
Human
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.023
cellular response to oxygen levels GO:0071453 1 0.022
organonitrogen compound metabolic process GO:1901564 74 0.022
cell motility GO:0048870 244 0.022
growth GO:0040007 174 0.022
regulation of metabolic process GO:0019222 359 0.022
Human
brain development GO:0007420 293 0.022
embryonic organ morphogenesis GO:0048562 274 0.022
organic cyclic compound biosynthetic process GO:1901362 223 0.022
Human
guanosine containing compound catabolic process GO:1901069 2 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
Human
carboxylic acid catabolic process GO:0046395 3 0.022
cell death GO:0008219 121 0.022
nuclear migration GO:0007097 3 0.022
regulation of tube size GO:0035150 2 0.021
nucleic acid templated transcription GO:0097659 181 0.021
Human
rna biosynthetic process GO:0032774 181 0.021
Human
organic acid metabolic process GO:0006082 31 0.021
cellular response to decreased oxygen levels GO:0036294 1 0.021
amine metabolic process GO:0009308 2 0.021
modification dependent macromolecule catabolic process GO:0043632 3 0.021
regulation of multicellular organismal process GO:0051239 277 0.021
carboxylic acid metabolic process GO:0019752 22 0.021
oocyte anterior posterior axis specification GO:0007314 4 0.021
single organism membrane fusion GO:0044801 2 0.020
negative regulation of cellular process GO:0048523 283 0.020
homeostatic process GO:0042592 142 0.020
cellular ketone metabolic process GO:0042180 11 0.020
regulation of developmental process GO:0050793 247 0.020
mitochondrion organization GO:0007005 4 0.020
positive regulation of cytokine production GO:0001819 2 0.020
oxoacid metabolic process GO:0043436 31 0.020
single organism localization GO:1902578 225 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
regulation of macromolecule metabolic process GO:0060255 317 0.020
Human
heterocycle biosynthetic process GO:0018130 215 0.020
Human
chordate embryonic development GO:0043009 271 0.020
neuroblast proliferation GO:0007405 2 0.020
regulation of intracellular protein transport GO:0033157 3 0.020
response to external stimulus GO:0009605 264 0.020
actin polymerization or depolymerization GO:0008154 2 0.020
establishment of localization GO:0051234 244 0.020
cellular component assembly GO:0022607 170 0.020
modification dependent protein catabolic process GO:0019941 3 0.020
tube morphogenesis GO:0035239 349 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.020
cellular component morphogenesis GO:0032989 336 0.019
regulation of purine nucleotide catabolic process GO:0033121 2 0.019
ubiquitin dependent protein catabolic process GO:0006511 3 0.019
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.019
regulation of synapse assembly GO:0051963 3 0.019
regulation of signal transduction GO:0009966 225 0.019
nucleobase containing compound biosynthetic process GO:0034654 205 0.018
Human
regulation of protein catabolic process GO:0042176 1 0.018
death GO:0016265 121 0.018
embryo development ending in birth or egg hatching GO:0009792 271 0.018
cellular component biogenesis GO:0044085 178 0.018
digestive tract development GO:0048565 265 0.018
positive regulation of cellular component biogenesis GO:0044089 3 0.018
embryonic heart tube development GO:0035050 133 0.018
compound eye development GO:0048749 2 0.018
positive regulation of nucleoside metabolic process GO:0045979 1 0.018
positive regulation of cell cycle GO:0045787 3 0.018
hemopoiesis GO:0030097 183 0.018
response to monosaccharide GO:0034284 3 0.018
regulation of gtpase activity GO:0043087 2 0.018
digestive system development GO:0055123 289 0.018
digestive tract morphogenesis GO:0048546 231 0.018
regulation of macromolecule biosynthetic process GO:0010556 225 0.018
Human
organelle organization GO:0006996 227 0.017
single organism transport GO:0044765 206 0.017
proteasomal protein catabolic process GO:0010498 2 0.017
cellular amine metabolic process GO:0044106 2 0.017
spermatid development GO:0007286 2 0.017
rna localization GO:0006403 4 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
regulation of signaling GO:0023051 235 0.017
regulation of cellular biosynthetic process GO:0031326 245 0.017
Human
response to nutrient GO:0007584 3 0.017
aromatic compound biosynthetic process GO:0019438 217 0.017
Human
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.017
positive regulation of secretion GO:0051047 1 0.017
negative regulation of protein phosphorylation GO:0001933 4 0.017
intracellular signal transduction GO:0035556 85 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
apoptotic process GO:0006915 116 0.017
peptide transport GO:0015833 1 0.017
stem cell maintenance GO:0019827 4 0.017
regulation of synaptic plasticity GO:0048167 1 0.017
dorsal ventral pattern formation GO:0009953 125 0.017
epithelial tube morphogenesis GO:0060562 148 0.017
sensory organ development GO:0007423 393 0.016
muscle structure development GO:0061061 196 0.016
chemosensory behavior GO:0007635 1 0.016
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
developmental growth GO:0048589 166 0.016
positive regulation of secretion by cell GO:1903532 1 0.016
neuron development GO:0048666 262 0.016
cellular response to hypoxia GO:0071456 1 0.016
regulation of rna metabolic process GO:0051252 224 0.016
Human
spermatid differentiation GO:0048515 2 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.016
response to carbohydrate GO:0009743 3 0.016
monoamine transport GO:0015844 1 0.016
nuclear transport GO:0051169 4 0.016
cell projection organization GO:0030030 284 0.016
g protein coupled receptor signaling pathway GO:0007186 74 0.016
response to hexose GO:0009746 3 0.016
protein import into nucleus GO:0006606 3 0.016
eye development GO:0001654 277 0.016
transcription dna templated GO:0006351 181 0.016
Human
regulation of muscle contraction GO:0006937 3 0.015
meiosis i GO:0007127 1 0.015
protein localization to plasma membrane GO:0072659 1 0.015
maternal determination of anterior posterior axis embryo GO:0008358 4 0.015
cellular response to nutrient levels GO:0031669 2 0.015
regulation of cell death GO:0010941 103 0.015
protein localization to nucleus GO:0034504 3 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
positive regulation of immune effector process GO:0002699 3 0.015
cell part morphogenesis GO:0032990 246 0.015
protein metabolic process GO:0019538 183 0.015
positive regulation of blood circulation GO:1903524 2 0.015
regulation of biosynthetic process GO:0009889 250 0.015
Human
ion transport GO:0006811 114 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
regulation of response to stimulus GO:0048583 269 0.015
protein targeting to nucleus GO:0044744 3 0.015
protein complex disassembly GO:0043241 1 0.015
lipid homeostasis GO:0055088 3 0.015
regulation of binding GO:0051098 3 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.015
neuron neuron synaptic transmission GO:0007270 1 0.015
positive regulation of cell activation GO:0050867 1 0.015
cell morphogenesis GO:0000902 289 0.015
cytoplasm organization GO:0007028 4 0.015
antimicrobial humoral response GO:0019730 2 0.015
positive regulation of gtpase activity GO:0043547 1 0.014
g1 s transition of mitotic cell cycle GO:0000082 1 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
regulation of cell communication GO:0010646 232 0.014
regulation of cell activation GO:0050865 1 0.014
regulation of protein localization to nucleus GO:1900180 2 0.014
regulation of blood pressure GO:0008217 1 0.014
regulation of rna biosynthetic process GO:2001141 213 0.014
Human
cellular localization GO:0051641 97 0.014
neuron differentiation GO:0030182 353 0.014
regulation of metal ion transport GO:0010959 4 0.014
glial cell migration GO:0008347 3 0.014
cytokinesis GO:0000910 3 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
endosomal transport GO:0016197 2 0.014
determination of left right symmetry GO:0007368 179 0.014
specification of symmetry GO:0009799 204 0.014
protein import GO:0017038 3 0.014
regulation of dendrite development GO:0050773 3 0.014
neuron projection development GO:0031175 180 0.014
establishment of protein localization to organelle GO:0072594 4 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
Human
muscle cell development GO:0055001 115 0.014
adherens junction organization GO:0034332 4 0.014
small molecule catabolic process GO:0044282 3 0.014
regulation of blood vessel size GO:0050880 2 0.014
positive regulation of gtp catabolic process GO:0033126 1 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
blood vessel development GO:0001568 246 0.014
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.014
Human
dna templated transcription elongation GO:0006354 3 0.014
stem cell division GO:0017145 1 0.014
positive regulation of cellular process GO:0048522 201 0.014
single organism nuclear import GO:1902593 3 0.014
leukocyte proliferation GO:0070661 1 0.014
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
regulation of cell differentiation GO:0045595 142 0.014
cellular protein metabolic process GO:0044267 129 0.014
multi organism cellular process GO:0044764 2 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.014
medulla oblongata development GO:0021550 4 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.013
muscle organ development GO:0007517 101 0.013
secondary metabolic process GO:0019748 3 0.013
interspecies interaction between organisms GO:0044419 4 0.013
neurotransmitter transport GO:0006836 2 0.013
regulation of protein targeting GO:1903533 2 0.013
macromolecule modification GO:0043412 111 0.013
regulation of gtp catabolic process GO:0033124 2 0.013
negative regulation of mapk cascade GO:0043409 4 0.013
cell proliferation GO:0008283 80 0.013
cation transport GO:0006812 81 0.013
macromolecular complex disassembly GO:0032984 1 0.013
negative regulation of signaling GO:0023057 96 0.013
striated muscle cell differentiation GO:0051146 129 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
regulation of autophagy GO:0010506 3 0.013
response to glucocorticoid GO:0051384 1 0.013
response to corticosteroid GO:0031960 1 0.013
phagocytosis GO:0006909 3 0.013
cellular lipid catabolic process GO:0044242 3 0.013
cellular response to organic substance GO:0071310 105 0.013
regionalization GO:0003002 274 0.013
protein secretion GO:0009306 1 0.013
regulation of mrna processing GO:0050684 3 0.013
blood vessel morphogenesis GO:0048514 216 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
camera type eye development GO:0043010 222 0.013
regulation of programmed cell death GO:0043067 101 0.013
cellular macromolecule biosynthetic process GO:0034645 224 0.013
Human
nucleoside monophosphate catabolic process GO:0009125 4 0.013
vasculature development GO:0001944 278 0.013
immune system development GO:0002520 191 0.012
response to alkaloid GO:0043279 2 0.012
cell projection morphogenesis GO:0048858 244 0.012
protein polymerization GO:0051258 4 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
regulation of protein complex assembly GO:0043254 3 0.012
cytoskeleton organization GO:0007010 96 0.012
protein complex localization GO:0031503 1 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
angiogenesis GO:0001525 158 0.012
negative regulation of reproductive process GO:2000242 3 0.012
hematopoietic or lymphoid organ development GO:0048534 191 0.012
apoptotic process involved in morphogenesis GO:0060561 2 0.012
eye morphogenesis GO:0048592 144 0.012
negative regulation of protein transport GO:0051224 3 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
negative regulation of cytokine production GO:0001818 1 0.012
locomotion GO:0040011 313 0.012
regulation of neurotransmitter transport GO:0051588 1 0.012
regulation of oocyte development GO:0060281 3 0.012
regulation of response to biotic stimulus GO:0002831 2 0.012
positive regulation of protein complex assembly GO:0031334 2 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
negative regulation of catabolic process GO:0009895 3 0.012
retina development in camera type eye GO:0060041 146 0.012
synaptic vesicle localization GO:0097479 1 0.012
muscle cell differentiation GO:0042692 139 0.012
organelle assembly GO:0070925 110 0.012
regulation of protein polymerization GO:0032271 2 0.012
anterior posterior pattern specification GO:0009952 152 0.012
establishment of protein localization to plasma membrane GO:0090002 1 0.011
response to uv GO:0009411 3 0.011
response to wounding GO:0009611 116 0.011
negative regulation of map kinase activity GO:0043407 2 0.011
nuclear import GO:0051170 3 0.011
intracellular mrna localization GO:0008298 1 0.011
myeloid cell differentiation GO:0030099 86 0.011
organic acid catabolic process GO:0016054 3 0.011
response to glucose GO:0009749 3 0.011
rna 3 end processing GO:0031123 2 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
phagocytosis engulfment GO:0006911 1 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
response to transition metal nanoparticle GO:1990267 28 0.011
mononuclear cell proliferation GO:0032943 1 0.011
regulation of localization GO:0032879 104 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
membrane invagination GO:0010324 1 0.011
response to other organism GO:0051707 97 0.011
germ line stem cell maintenance GO:0030718 2 0.011
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
atp catabolic process GO:0006200 4 0.011
programmed cell death GO:0012501 119 0.011
striated muscle cell development GO:0055002 108 0.011
developmental programmed cell death GO:0010623 4 0.011
negative regulation of cell death GO:0060548 60 0.011
response to vitamin GO:0033273 3 0.011
regulation of cell shape GO:0008360 1 0.011
multi organism process GO:0051704 134 0.010
regulation of nucleic acid templated transcription GO:1903506 213 0.010
Human
protein polyubiquitination GO:0000209 4 0.010
regulation of fatty acid metabolic process GO:0019217 1 0.010
regulation of cell projection assembly GO:0060491 4 0.010
regulation of filopodium assembly GO:0051489 2 0.010
lymphocyte proliferation GO:0046651 1 0.010
production of molecular mediator of immune response GO:0002440 2 0.010
female meiotic division GO:0007143 2 0.010
cellular response to starvation GO:0009267 1 0.010
cell junction maintenance GO:0034331 2 0.010
skeletal system development GO:0001501 181 0.010
alpha amino acid metabolic process GO:1901605 3 0.010
regulation of protein localization to plasma membrane GO:1903076 1 0.010
viral process GO:0016032 1 0.010
catechol containing compound metabolic process GO:0009712 2 0.010
negative regulation of multi organism process GO:0043901 3 0.010
gastrulation GO:0007369 208 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
peptide metabolic process GO:0006518 1 0.010
determination of bilateral symmetry GO:0009855 204 0.010
response to biotic stimulus GO:0009607 97 0.010
neurological system process GO:0050877 62 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.010

sigirr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.048
musculoskeletal system disease DOID:17 0 0.020
immune system disease DOID:2914 0 0.016
nervous system disease DOID:863 0 0.014
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
muscular disease DOID:0080000 0 0.012
muscle tissue disease DOID:66 0 0.012
disease of metabolism DOID:0014667 0 0.011
cardiovascular system disease DOID:1287 0 0.011