Danio rerio

20 known processes

c3b

complement component c3b

(Aliases: C3-1,C3-2)

c3b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
activation of immune response GO:0002253 9 0.844
protein activation cascade GO:0072376 6 0.757
complement activation GO:0006956 3 0.721
positive regulation of immune system process GO:0002684 17 0.597
phagocytosis GO:0006909 3 0.493
positive regulation of immune response GO:0050778 11 0.401
regulation of cytokine production GO:0001817 3 0.380
regulation of immune system process GO:0002682 34 0.348
lipid storage GO:0019915 1 0.316
positive regulation of cytokine production GO:0001819 2 0.303
immune effector process GO:0002252 23 0.300
humoral immune response GO:0006959 5 0.285
immune system process GO:0002376 241 0.280
positive regulation of transport GO:0051050 2 0.272
maintenance of location GO:0051235 4 0.193
regulation of immune response GO:0050776 14 0.138
positive regulation of response to stimulus GO:0048584 80 0.133
g protein coupled receptor signaling pathway GO:0007186 74 0.132
immune response GO:0006955 28 0.126
signal transduction GO:0007165 455 0.115
cellular biosynthetic process GO:0044249 286 0.102
regulation of multicellular organismal process GO:0051239 277 0.101
regulation of response to stimulus GO:0048583 269 0.093
carbohydrate transport GO:0008643 13 0.092
establishment of localization GO:0051234 244 0.091
regulation of glucose transport GO:0010827 1 0.090
protein metabolic process GO:0019538 183 0.089
response to stress GO:0006950 263 0.089
single organism transport GO:0044765 206 0.086
regulation of vesicle mediated transport GO:0060627 9 0.079
defense response GO:0006952 47 0.077
cell surface receptor signaling pathway GO:0007166 325 0.076
regulation of gene expression GO:0010468 265 0.073
regulation of biosynthetic process GO:0009889 250 0.069
positive regulation of glucose transport GO:0010828 1 0.068
aging GO:0007568 2 0.067
positive regulation of biological process GO:0048518 253 0.062
regulation of primary metabolic process GO:0080090 311 0.059
biosynthetic process GO:0009058 294 0.058
transport GO:0006810 220 0.057
cellular macromolecule metabolic process GO:0044260 391 0.056
regulation of cellular biosynthetic process GO:0031326 245 0.055
regulation of metabolic process GO:0019222 359 0.055
organic substance biosynthetic process GO:1901576 289 0.054
larval development GO:0002164 2 0.053
single organism metabolic process GO:0044710 217 0.053
regulation of cellular metabolic process GO:0031323 320 0.050
regulation of endocytosis GO:0030100 7 0.050
protein modification process GO:0036211 100 0.050
regulation of macromolecule metabolic process GO:0060255 317 0.049
cellular response to external stimulus GO:0071496 2 0.048
regulation of signaling GO:0023051 235 0.046
glycerolipid biosynthetic process GO:0045017 1 0.044
multicellular organism growth GO:0035264 4 0.043
regulation of cell communication GO:0010646 232 0.041
immunoglobulin mediated immune response GO:0016064 3 0.041
regulation of signal transduction GO:0009966 225 0.040
apoptotic process GO:0006915 116 0.039
positive regulation of secretion by cell GO:1903532 1 0.036
regulation of multicellular organism growth GO:0040014 4 0.035
lipid biosynthetic process GO:0008610 22 0.035
regulation of protein transport GO:0051223 3 0.034
single organism nuclear import GO:1902593 3 0.034
positive regulation of cellular process GO:0048522 201 0.033
autophagy GO:0006914 4 0.033
positive regulation of multicellular organismal process GO:0051240 52 0.032
response to external biotic stimulus GO:0043207 97 0.032
nucleocytoplasmic transport GO:0006913 4 0.032
positive regulation of immune effector process GO:0002699 3 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.031
cellular response to extracellular stimulus GO:0031668 2 0.031
angiogenesis GO:0001525 158 0.030
blood vessel morphogenesis GO:0048514 216 0.030
positive regulation of cellular metabolic process GO:0031325 94 0.030
negative regulation of biological process GO:0048519 304 0.030
nuclear transport GO:0051169 4 0.030
response to monosaccharide GO:0034284 3 0.029
vasculature development GO:0001944 278 0.029
regulation of establishment of protein localization GO:0070201 4 0.029
multi organism process GO:0051704 134 0.029
cellular protein catabolic process GO:0044257 4 0.029
ameboidal type cell migration GO:0001667 143 0.029
response to carbohydrate GO:0009743 3 0.029
leukocyte mediated cytotoxicity GO:0001909 1 0.028
leukocyte proliferation GO:0070661 1 0.028
regulation of cellular component organization GO:0051128 86 0.028
regulation of developmental process GO:0050793 247 0.027
hexose transport GO:0008645 6 0.027
protein import into nucleus GO:0006606 3 0.027
regulation of inflammatory response GO:0050727 2 0.026
protein import GO:0017038 3 0.026
protein targeting to nucleus GO:0044744 3 0.026
nuclear import GO:0051170 3 0.026
establishment of protein localization to organelle GO:0072594 4 0.026
defense response to other organism GO:0098542 33 0.025
cellular response to starvation GO:0009267 1 0.025
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.025
blood vessel development GO:0001568 246 0.025
positive regulation of cell activation GO:0050867 1 0.025
programmed cell death GO:0012501 119 0.025
glucose transport GO:0015758 6 0.025
stem cell proliferation GO:0072089 4 0.024
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.024
digestive tract morphogenesis GO:0048546 231 0.024
cell motility GO:0048870 244 0.024
tube morphogenesis GO:0035239 349 0.024
cellular response to molecule of bacterial origin GO:0071219 3 0.024
hematopoietic or lymphoid organ development GO:0048534 191 0.024
cellular response to lipopolysaccharide GO:0071222 3 0.024
response to hexose GO:0009746 3 0.023
protein localization to nucleus GO:0034504 3 0.023
macromolecule modification GO:0043412 111 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
cellular lipid metabolic process GO:0044255 36 0.023
regulation of reactive oxygen species metabolic process GO:2000377 2 0.023
gastrulation GO:0007369 208 0.023
reactive oxygen species biosynthetic process GO:1903409 1 0.023
regulation of wound healing GO:0061041 2 0.023
regulation of leukocyte mediated immunity GO:0002703 1 0.022
regulation of cell activation GO:0050865 1 0.022
monosaccharide transport GO:0015749 6 0.022
cellular protein modification process GO:0006464 100 0.022
regulation of cellular protein metabolic process GO:0032268 52 0.022
amine metabolic process GO:0009308 2 0.022
transcription dna templated GO:0006351 181 0.022
heterocycle metabolic process GO:0046483 290 0.022
mesenchymal cell differentiation GO:0048762 87 0.022
regulation of biological quality GO:0065008 263 0.022
response to alkaloid GO:0043279 2 0.022
response to external stimulus GO:0009605 264 0.021
circadian sleep wake cycle GO:0042745 2 0.021
cellular protein metabolic process GO:0044267 129 0.021
wound healing GO:0042060 90 0.021
regulation of protein ubiquitination GO:0031396 3 0.021
positive regulation of inflammatory response GO:0050729 1 0.021
digestive system development GO:0055123 289 0.021
positive regulation of dna metabolic process GO:0051054 1 0.021
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.021
growth GO:0040007 174 0.021
cellular response to nutrient levels GO:0031669 2 0.021
regulation of localization GO:0032879 104 0.020
b cell mediated immunity GO:0019724 3 0.020
peptide transport GO:0015833 1 0.020
regulation of tube size GO:0035150 2 0.020
gtp metabolic process GO:0046039 4 0.020
modification dependent macromolecule catabolic process GO:0043632 3 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
modification dependent protein catabolic process GO:0019941 3 0.020
regulation of programmed cell death GO:0043067 101 0.020
sensory organ development GO:0007423 393 0.020
lipid metabolic process GO:0006629 52 0.020
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.020
ubiquitin dependent protein catabolic process GO:0006511 3 0.020
cell killing GO:0001906 2 0.020
aromatic compound biosynthetic process GO:0019438 217 0.020
response to glucose GO:0009749 3 0.020
interspecies interaction between organisms GO:0044419 4 0.020
guanosine containing compound catabolic process GO:1901069 2 0.019
defense response to bacterium GO:0042742 22 0.019
hemopoiesis GO:0030097 183 0.019
regulation of blood vessel size GO:0050880 2 0.019
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.019
positive regulation of protein metabolic process GO:0051247 23 0.019
negative regulation of protein phosphorylation GO:0001933 4 0.019
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.019
positive regulation of macromolecule metabolic process GO:0010604 93 0.019
mononuclear cell proliferation GO:0032943 1 0.019
glucose import GO:0046323 2 0.018
regulation of autophagy GO:0010506 3 0.018
lymphocyte proliferation GO:0046651 1 0.018
regulation of apoptotic process GO:0042981 98 0.018
proteasomal protein catabolic process GO:0010498 2 0.018
protein secretion GO:0009306 1 0.018
localization of cell GO:0051674 244 0.018
embryonic organ development GO:0048568 381 0.018
regulation of cell killing GO:0031341 2 0.018
positive regulation of secretion GO:0051047 1 0.018
response to wounding GO:0009611 116 0.018
gene expression GO:0010467 252 0.018
nucleic acid templated transcription GO:0097659 181 0.018
locomotion GO:0040011 313 0.018
cellular amine metabolic process GO:0044106 2 0.018
regulation of dna replication GO:0006275 3 0.018
rna metabolic process GO:0016070 219 0.017
cell migration GO:0016477 237 0.017
protein acetylation GO:0006473 2 0.017
response to other organism GO:0051707 97 0.017
regulation of protein complex assembly GO:0043254 3 0.017
organic cyclic compound biosynthetic process GO:1901362 223 0.017
positive regulation of map kinase activity GO:0043406 3 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
response to bacterium GO:0009617 58 0.017
mitochondrion organization GO:0007005 4 0.017
negative regulation of catabolic process GO:0009895 3 0.017
positive regulation of cell communication GO:0010647 56 0.017
organonitrogen compound metabolic process GO:1901564 74 0.017
nucleic acid metabolic process GO:0090304 244 0.017
cytokine production GO:0001816 4 0.017
positive regulation of signaling GO:0023056 56 0.016
nitric oxide metabolic process GO:0046209 2 0.016
regulation of protein metabolic process GO:0051246 56 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
sensory perception of chemical stimulus GO:0007606 3 0.016
inositol lipid mediated signaling GO:0048017 2 0.016
cell death GO:0008219 121 0.016
positive regulation of metabolic process GO:0009893 108 0.016
somatic muscle development GO:0007525 4 0.016
negative regulation of cellular catabolic process GO:0031330 3 0.016
cellular nitrogen compound metabolic process GO:0034641 290 0.016
pyruvate metabolic process GO:0006090 1 0.016
phosphorus metabolic process GO:0006793 109 0.016
positive regulation of signal transduction GO:0009967 56 0.016
neural crest cell migration GO:0001755 42 0.016
organic acid metabolic process GO:0006082 31 0.016
organism emergence from protective structure GO:0071684 4 0.016
regulation of protein import into nucleus GO:0042306 2 0.016
gtp catabolic process GO:0006184 2 0.016
regulation of protein catabolic process GO:0042176 1 0.016
cell migration involved in gastrulation GO:0042074 79 0.016
glucose homeostasis GO:0042593 1 0.016
regulation of binding GO:0051098 3 0.016
organic substance transport GO:0071702 58 0.016
regulation of cell death GO:0010941 103 0.016
regulation of circadian rhythm GO:0042752 4 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.016
mitotic dna damage checkpoint GO:0044773 4 0.016
positive regulation of leukocyte mediated immunity GO:0002705 1 0.015
response to glucocorticoid GO:0051384 1 0.015
cellular response to biotic stimulus GO:0071216 3 0.015
macromolecule biosynthetic process GO:0009059 227 0.015
regulation of protein targeting GO:1903533 2 0.015
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.015
b cell activation GO:0042113 2 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
neuron differentiation GO:0030182 353 0.015
phosphate containing compound metabolic process GO:0006796 108 0.015
neural crest cell differentiation GO:0014033 72 0.015
oxoacid metabolic process GO:0043436 31 0.015
cellular amide metabolic process GO:0043603 4 0.015
ear development GO:0043583 127 0.015
female sex differentiation GO:0046660 4 0.014
response to nutrient GO:0007584 3 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
regulation of nitrogen compound metabolic process GO:0051171 251 0.014
cellular nitrogen compound biosynthetic process GO:0044271 218 0.014
membrane invagination GO:0010324 1 0.014
neuron neuron synaptic transmission GO:0007270 1 0.014
negative regulation of defense response GO:0031348 2 0.014
macroautophagy GO:0016236 1 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
immune system development GO:0002520 191 0.014
regulation of reproductive process GO:2000241 4 0.014
single organism localization GO:1902578 225 0.014
peptidyl lysine acetylation GO:0018394 2 0.014
positive regulation of catabolic process GO:0009896 4 0.014
leukocyte mediated immunity GO:0002443 6 0.014
peptidyl serine phosphorylation GO:0018105 1 0.014
guanosine containing compound metabolic process GO:1901068 4 0.014
response to drug GO:0042493 3 0.014
cellular carbohydrate metabolic process GO:0044262 4 0.014
adult behavior GO:0030534 2 0.014
cellular component movement GO:0006928 335 0.014
mesenchyme development GO:0060485 127 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
meiotic cell cycle process GO:1903046 3 0.014
digestive tract development GO:0048565 265 0.014
multicellular organismal response to stress GO:0033555 2 0.014
positive regulation of cell cycle GO:0045787 3 0.014
protein acylation GO:0043543 3 0.014
response to vitamin GO:0033273 3 0.014
i kappab kinase nf kappab signaling GO:0007249 4 0.014
peptide metabolic process GO:0006518 1 0.014
regulation of phosphorus metabolic process GO:0051174 43 0.013
negative regulation of cytokine production GO:0001818 1 0.013
nitrogen compound metabolic process GO:0006807 319 0.013
positive regulation of cell killing GO:0031343 2 0.013
nucleobase containing compound biosynthetic process GO:0034654 205 0.013
hatching GO:0035188 4 0.013
brain development GO:0007420 293 0.013
innate immune response GO:0045087 13 0.013
cognition GO:0050890 1 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.013
protein polyubiquitination GO:0000209 4 0.013
antimicrobial humoral response GO:0019730 2 0.013
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.013
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
endosomal transport GO:0016197 2 0.013
stem cell division GO:0017145 1 0.013
phagocytosis engulfment GO:0006911 1 0.013
embryonic organ morphogenesis GO:0048562 274 0.013
dicarboxylic acid transport GO:0006835 1 0.013
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.013
regulation of synaptic plasticity GO:0048167 1 0.013
regulation of leukocyte mediated cytotoxicity GO:0001910 1 0.013
single fertilization GO:0007338 3 0.013
regulation of rna metabolic process GO:0051252 224 0.013
response to biotic stimulus GO:0009607 97 0.013
nucleobase containing compound metabolic process GO:0006139 274 0.013
toll like receptor signaling pathway GO:0002224 4 0.013
phosphatidylinositol mediated signaling GO:0048015 2 0.013
positive regulation of cellular component biogenesis GO:0044089 3 0.013
chordate embryonic development GO:0043009 271 0.013
sleep GO:0030431 1 0.013
regulation of ph GO:0006885 3 0.013
response to corticosteroid GO:0031960 1 0.013
heart development GO:0007507 313 0.013
positive regulation of myeloid cell differentiation GO:0045639 2 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
response to abiotic stimulus GO:0009628 122 0.013
inner ear development GO:0048839 126 0.013
developmental growth GO:0048589 166 0.013
death GO:0016265 121 0.013
cellular ketone metabolic process GO:0042180 11 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
regeneration GO:0031099 91 0.013
regulation of transport GO:0051049 45 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
regulation of protein maturation GO:1903317 10 0.012
internal protein amino acid acetylation GO:0006475 2 0.012
negative regulation of programmed cell death GO:0043069 58 0.012
regulation of jak stat cascade GO:0046425 3 0.012
small molecule metabolic process GO:0044281 77 0.012
circadian sleep wake cycle sleep GO:0050802 1 0.012
pericardium development GO:0060039 1 0.012
regulation of multicellular organismal development GO:2000026 223 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
cellular component disassembly GO:0022411 1 0.012
regulation of response to extracellular stimulus GO:0032104 1 0.012
natural killer cell mediated cytotoxicity GO:0042267 1 0.012
regulation of production of molecular mediator of immune response GO:0002700 1 0.012
cytokinesis GO:0000910 3 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
regulation of natural killer cell mediated immunity GO:0002715 1 0.012
tissue remodeling GO:0048771 4 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
carbohydrate homeostasis GO:0033500 1 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.012
morphogenesis of an epithelium GO:0002009 333 0.012
negative regulation of autophagy GO:0010507 1 0.012
development of primary female sexual characteristics GO:0046545 4 0.012
modification of morphology or physiology of other organism GO:0035821 4 0.012
protein phosphorylation GO:0006468 47 0.012
tissue regeneration GO:0042246 74 0.012
heterocycle biosynthetic process GO:0018130 215 0.012
nitric oxide biosynthetic process GO:0006809 2 0.012
regulation of hormone secretion GO:0046883 2 0.012
regulation of transporter activity GO:0032409 2 0.012
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.012
protein stabilization GO:0050821 2 0.012
peptidyl serine modification GO:0018209 2 0.012
regulation of circadian sleep wake cycle GO:0042749 1 0.012
liver development GO:0001889 96 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
somatic cell dna recombination GO:0016444 1 0.012
intracellular signal transduction GO:0035556 85 0.012
organic cyclic compound metabolic process GO:1901360 301 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
hormone secretion GO:0046879 2 0.011
skeletal system development GO:0001501 181 0.011
negative regulation of cellular process GO:0048523 283 0.011
regulation of protein binding GO:0043393 3 0.011
regulation of innate immune response GO:0045088 11 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
response to hydrogen peroxide GO:0042542 3 0.011
regulation of rna biosynthetic process GO:2001141 213 0.011
stem cell maintenance GO:0019827 4 0.011
central nervous system development GO:0007417 387 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
regulation of lipid biosynthetic process GO:0046890 8 0.011
positive regulation of wound healing GO:0090303 1 0.011
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
cellular aromatic compound metabolic process GO:0006725 295 0.011
negative regulation of multi organism process GO:0043901 3 0.011
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.011
neural crest cell development GO:0014032 62 0.011
hormone transport GO:0009914 2 0.011
response to virus GO:0009615 21 0.011
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
estrogen metabolic process GO:0008210 2 0.011
rna biosynthetic process GO:0032774 181 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
sulfur compound transport GO:0072348 3 0.011
determination of bilateral symmetry GO:0009855 204 0.011
spermatid development GO:0007286 2 0.011
spermatid differentiation GO:0048515 2 0.011
membrane repolarization GO:0086009 2 0.011
collagen metabolic process GO:0032963 2 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
sensory perception of pain GO:0019233 1 0.011
negative regulation of protein transport GO:0051224 3 0.011
meiotic nuclear division GO:0007126 4 0.011
regulation of stem cell proliferation GO:0072091 2 0.010
negative regulation of protein localization to nucleus GO:1900181 2 0.010
production of molecular mediator of immune response GO:0002440 2 0.010
homeostatic process GO:0042592 142 0.010
positive regulation of leukocyte differentiation GO:1902107 1 0.010
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
specification of symmetry GO:0009799 204 0.010
response to chemical GO:0042221 320 0.010
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.010
cellular respiration GO:0045333 3 0.010
negative regulation of cell death GO:0060548 60 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.010
regulation of response to external stimulus GO:0032101 31 0.010
positive regulation of blood circulation GO:1903524 2 0.010
positive regulation of stem cell proliferation GO:2000648 1 0.010
head development GO:0060322 303 0.010
neurotransmitter secretion GO:0007269 2 0.010
positive regulation of cell division GO:0051781 2 0.010
regulation of metal ion transport GO:0010959 4 0.010
dna templated transcription elongation GO:0006354 3 0.010
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.010

c3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.156
nervous system disease DOID:863 0 0.156
sensory system disease DOID:0050155 0 0.138
eye and adnexa disease DOID:1492 0 0.138
eye disease DOID:5614 0 0.138
immune system disease DOID:2914 0 0.076
hematopoietic system disease DOID:74 0 0.076
retinal disease DOID:5679 0 0.065
retinal degeneration DOID:8466 0 0.048
disease of metabolism DOID:0014667 0 0.019
anemia DOID:2355 0 0.016
inherited metabolic disorder DOID:655 0 0.013