Danio rerio

13 known processes

chd8

chromodomain helicase DNA binding protein 8

(Aliases: fi45h08,wu:fi45h08,CHD-8,si:ch211-10e2.6)

chd8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nitrogen compound metabolic process GO:0006807 319 0.081
cellular macromolecule metabolic process GO:0044260 391 0.079
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.067
nucleobase containing compound biosynthetic process GO:0034654 205 0.064
nucleic acid metabolic process GO:0090304 244 0.059
regulation of transcription dna templated GO:0006355 213 0.056
signal transduction GO:0007165 455 0.055
cellular nitrogen compound biosynthetic process GO:0044271 218 0.055
organic cyclic compound metabolic process GO:1901360 301 0.048
oxoacid metabolic process GO:0043436 31 0.047
organic cyclic compound biosynthetic process GO:1901362 223 0.045
amine metabolic process GO:0009308 2 0.044
regulation of cellular amine metabolic process GO:0033238 0 0.044
heterocycle biosynthetic process GO:0018130 215 0.043
regulation of establishment of protein localization GO:0070201 4 0.042
organic acid metabolic process GO:0006082 31 0.042
gene expression GO:0010467 252 0.041
macromolecule biosynthetic process GO:0009059 227 0.040
rna biosynthetic process GO:0032774 181 0.040
rna metabolic process GO:0016070 219 0.040
regulation of protein transport GO:0051223 3 0.040
negative regulation of cellular process GO:0048523 283 0.040
immune system process GO:0002376 241 0.039
positive regulation of transport GO:0051050 2 0.039
regulation of multicellular organism growth GO:0040014 4 0.038
organic substance biosynthetic process GO:1901576 289 0.038
regulation of gene expression GO:0010468 265 0.038
eye development GO:0001654 277 0.038
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.036
nucleocytoplasmic transport GO:0006913 4 0.036
aging GO:0007568 2 0.036
cellular amine metabolic process GO:0044106 2 0.036
neuron development GO:0048666 262 0.035
purine nucleoside monophosphate catabolic process GO:0009128 4 0.035
regulation of response to stimulus GO:0048583 269 0.035
regulation of primary metabolic process GO:0080090 311 0.035
heterocycle metabolic process GO:0046483 290 0.033
positive regulation of cell cycle GO:0045787 3 0.033
cellular aromatic compound metabolic process GO:0006725 295 0.033
regulation of cellular amino acid metabolic process GO:0006521 0 0.033
regulation of biosynthetic process GO:0009889 250 0.032
negative regulation of biological process GO:0048519 304 0.032
glucose homeostasis GO:0042593 1 0.032
larval development GO:0002164 2 0.032
aromatic compound biosynthetic process GO:0019438 217 0.032
nucleobase containing compound metabolic process GO:0006139 274 0.032
cilium movement GO:0003341 26 0.031
regulation of nucleic acid templated transcription GO:1903506 213 0.031
peptidyl lysine acetylation GO:0018394 2 0.031
transcription dna templated GO:0006351 181 0.031
regulation of nitrogen compound metabolic process GO:0051171 251 0.030
nucleoside monophosphate catabolic process GO:0009125 4 0.030
nucleic acid templated transcription GO:0097659 181 0.030
cellular ketone metabolic process GO:0042180 11 0.030
cellular biosynthetic process GO:0044249 286 0.029
meiotic nuclear division GO:0007126 4 0.029
small molecule metabolic process GO:0044281 77 0.029
cell morphogenesis GO:0000902 289 0.029
cellular nitrogen compound metabolic process GO:0034641 290 0.028
head development GO:0060322 303 0.028
regulation of macromolecule biosynthetic process GO:0010556 225 0.028
regulation of macromolecule metabolic process GO:0060255 317 0.028
muscle fiber development GO:0048747 52 0.028
positive regulation of cytoskeleton organization GO:0051495 3 0.028
cell matrix adhesion GO:0007160 4 0.028
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.028
regulation of cellular ketone metabolic process GO:0010565 7 0.028
regulation of cytoplasmic transport GO:1903649 4 0.028
cellular amino acid metabolic process GO:0006520 7 0.027
multicellular organism growth GO:0035264 4 0.027
peptide transport GO:0015833 1 0.027
organonitrogen compound metabolic process GO:1901564 74 0.027
regulation of metabolic process GO:0019222 359 0.027
regulation of cellular metabolic process GO:0031323 320 0.026
protein acetylation GO:0006473 2 0.026
carboxylic acid metabolic process GO:0019752 22 0.026
positive regulation of biological process GO:0048518 253 0.026
regulation of rna metabolic process GO:0051252 224 0.026
ubiquitin dependent protein catabolic process GO:0006511 3 0.025
regulation of cell differentiation GO:0045595 142 0.025
regulation of signaling GO:0023051 235 0.025
regulation of dendrite development GO:0050773 3 0.025
ribonucleoside monophosphate catabolic process GO:0009158 4 0.025
central nervous system development GO:0007417 387 0.025
regulation of intracellular protein transport GO:0033157 3 0.024
establishment of protein localization to plasma membrane GO:0090002 1 0.024
exocytosis GO:0006887 1 0.024
atp catabolic process GO:0006200 4 0.024
embryonic organ development GO:0048568 381 0.024
nuclear export GO:0051168 1 0.024
biosynthetic process GO:0009058 294 0.024
digestive tract development GO:0048565 265 0.024
cell substrate adhesion GO:0031589 4 0.024
cell projection organization GO:0030030 284 0.024
protein acylation GO:0043543 3 0.023
regulation of rna biosynthetic process GO:2001141 213 0.023
organelle organization GO:0006996 227 0.023
vasculature development GO:0001944 278 0.023
morphogenesis of an epithelium GO:0002009 333 0.023
regulation of nucleoside metabolic process GO:0009118 2 0.023
guanosine containing compound metabolic process GO:1901068 4 0.023
cellular macromolecule biosynthetic process GO:0034645 224 0.022
single organism organelle organization GO:1902589 199 0.022
gtp catabolic process GO:0006184 2 0.022
sensory organ development GO:0007423 393 0.022
regulation of nucleocytoplasmic transport GO:0046822 2 0.022
muscle cell development GO:0055001 115 0.022
regulation of binding GO:0051098 3 0.022
regulation of cytokine production GO:0001817 3 0.022
response to stress GO:0006950 263 0.022
regulation of multicellular organismal process GO:0051239 277 0.022
internal protein amino acid acetylation GO:0006475 2 0.022
regulation of biological quality GO:0065008 263 0.022
gtp metabolic process GO:0046039 4 0.022
positive regulation of secretion by cell GO:1903532 1 0.022
nuclear migration GO:0007097 3 0.022
maintenance of location GO:0051235 4 0.022
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.022
regulation of apoptotic process GO:0042981 98 0.022
negative regulation of protein kinase activity GO:0006469 4 0.022
nuclear transport GO:0051169 4 0.021
regulation of dendrite morphogenesis GO:0048814 3 0.021
regulation of metal ion transport GO:0010959 4 0.021
protein metabolic process GO:0019538 183 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.021
cellular protein catabolic process GO:0044257 4 0.021
golgi vesicle transport GO:0048193 3 0.021
gastrulation GO:0007369 208 0.021
hormone transport GO:0009914 2 0.021
cell projection morphogenesis GO:0048858 244 0.021
response to chemical GO:0042221 320 0.021
amino acid transport GO:0006865 2 0.021
synaptic vesicle localization GO:0097479 1 0.021
regulation of multicellular organismal development GO:2000026 223 0.021
negative regulation of protein transport GO:0051224 3 0.020
regulation of cellular biosynthetic process GO:0031326 245 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
cognition GO:0050890 1 0.020
carbohydrate homeostasis GO:0033500 1 0.020
extrinsic apoptotic signaling pathway GO:0097191 3 0.020
regulation of synaptic plasticity GO:0048167 1 0.020
blood vessel morphogenesis GO:0048514 216 0.020
regulation of synapse organization GO:0050807 3 0.020
cellular component biogenesis GO:0044085 178 0.020
establishment of localization GO:0051234 244 0.020
regulation of mrna processing GO:0050684 3 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.020
modification dependent macromolecule catabolic process GO:0043632 3 0.020
rna localization GO:0006403 4 0.020
hemopoiesis GO:0030097 183 0.019
guanosine containing compound catabolic process GO:1901069 2 0.019
carbohydrate derivative biosynthetic process GO:1901137 43 0.019
hormone secretion GO:0046879 2 0.019
phagocytosis GO:0006909 3 0.019
internal peptidyl lysine acetylation GO:0018393 2 0.019
regulation of synapse assembly GO:0051963 3 0.019
protein import GO:0017038 3 0.019
protein localization to plasma membrane GO:0072659 1 0.019
carbohydrate biosynthetic process GO:0016051 1 0.019
neuron neuron synaptic transmission GO:0007270 1 0.019
cell surface receptor signaling pathway GO:0007166 325 0.019
single organism transport GO:0044765 206 0.019
macromolecule modification GO:0043412 111 0.019
single organism metabolic process GO:0044710 217 0.019
camera type eye development GO:0043010 222 0.019
stem cell maintenance GO:0019827 4 0.018
immune system development GO:0002520 191 0.018
positive regulation of cellular process GO:0048522 201 0.018
regulation of protein ubiquitination GO:0031396 3 0.018
single fertilization GO:0007338 3 0.018
brain development GO:0007420 293 0.018
protein dephosphorylation GO:0006470 3 0.018
lipid storage GO:0019915 1 0.018
cellular component movement GO:0006928 335 0.018
cellular protein metabolic process GO:0044267 129 0.018
anterior posterior pattern specification GO:0009952 152 0.018
regulation of cell death GO:0010941 103 0.018
regulation of inflammatory response GO:0050727 2 0.018
proteasomal protein catabolic process GO:0010498 2 0.018
striated muscle cell development GO:0055002 108 0.018
transcription from rna polymerase ii promoter GO:0006366 80 0.018
chordate embryonic development GO:0043009 271 0.018
transport GO:0006810 220 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
positive regulation of biosynthetic process GO:0009891 68 0.017
apoptotic process GO:0006915 116 0.017
compound eye development GO:0048749 2 0.017
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.017
positive regulation of cellular component biogenesis GO:0044089 3 0.017
regulation of hormone secretion GO:0046883 2 0.017
synaptic vesicle transport GO:0048489 1 0.017
small molecule catabolic process GO:0044282 3 0.017
fertilization GO:0009566 3 0.017
negative regulation of secretion GO:0051048 2 0.017
generation of neurons GO:0048699 385 0.017
erk1 and erk2 cascade GO:0070371 4 0.017
regulation of nucleotide catabolic process GO:0030811 2 0.017
neuron differentiation GO:0030182 353 0.017
negative regulation of protein phosphorylation GO:0001933 4 0.017
regulation of protein targeting GO:1903533 2 0.017
cellular response to external stimulus GO:0071496 2 0.017
heart development GO:0007507 313 0.017
negative regulation of kinase activity GO:0033673 4 0.017
pronuclear migration GO:0035046 1 0.017
tube morphogenesis GO:0035239 349 0.017
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.016
microtubule based movement GO:0007018 33 0.016
regulation of protein binding GO:0043393 3 0.016
embryonic hemopoiesis GO:0035162 53 0.016
stem cell differentiation GO:0048863 117 0.016
cilium morphogenesis GO:0060271 85 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
cell part morphogenesis GO:0032990 246 0.016
regulation of transmembrane transporter activity GO:0022898 2 0.016
negative regulation of macromolecule metabolic process GO:0010605 76 0.016
regulation of cell communication GO:0010646 232 0.016
calcium ion dependent exocytosis GO:0017156 1 0.016
mitochondrion organization GO:0007005 4 0.016
membrane fusion GO:0061025 2 0.016
determination of bilateral symmetry GO:0009855 204 0.016
developmental growth involved in morphogenesis GO:0060560 86 0.016
double strand break repair GO:0006302 3 0.016
peptidyl serine phosphorylation GO:0018105 1 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.015
positive regulation of cytokine production GO:0001819 2 0.015
regulation of protein import into nucleus GO:0042306 2 0.015
cilium organization GO:0044782 71 0.015
negative regulation of cytokine production GO:0001818 1 0.015
stem cell proliferation GO:0072089 4 0.015
cardiac atrium development GO:0003230 4 0.015
interspecies interaction between organisms GO:0044419 4 0.015
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.015
blood vessel development GO:0001568 246 0.015
specification of symmetry GO:0009799 204 0.015
positive regulation of catabolic process GO:0009896 4 0.015
meiotic cell cycle process GO:1903046 3 0.015
endosome organization GO:0007032 2 0.015
hematopoietic or lymphoid organ development GO:0048534 191 0.015
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.015
establishment of protein localization to organelle GO:0072594 4 0.015
regulation of cell shape GO:0008360 1 0.015
embryo development ending in birth or egg hatching GO:0009792 271 0.015
muscle structure development GO:0061061 196 0.015
post golgi vesicle mediated transport GO:0006892 1 0.015
retina development in camera type eye GO:0060041 146 0.014
determination of left right symmetry GO:0007368 179 0.014
programmed cell death GO:0012501 119 0.014
cell death GO:0008219 121 0.014
mechanosensory behavior GO:0007638 2 0.014
regulation of autophagy GO:0010506 3 0.014
response to glucocorticoid GO:0051384 1 0.014
peptide metabolic process GO:0006518 1 0.014
retina morphogenesis in camera type eye GO:0060042 79 0.014
regulation of receptor activity GO:0010469 2 0.014
monoamine transport GO:0015844 1 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
response to drug GO:0042493 3 0.014
antimicrobial humoral response GO:0019730 2 0.014
digestive tract morphogenesis GO:0048546 231 0.014
adult behavior GO:0030534 2 0.014
intracellular signal transduction GO:0035556 85 0.014
digestive system development GO:0055123 289 0.014
cellular component assembly involved in morphogenesis GO:0010927 107 0.014
regulation of protein complex disassembly GO:0043244 1 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.014
regulation of myotube differentiation GO:0010830 2 0.014
growth GO:0040007 174 0.014
protein localization to nucleus GO:0034504 3 0.014
synaptic growth at neuromuscular junction GO:0051124 2 0.014
positive regulation of cell division GO:0051781 2 0.013
cortical actin cytoskeleton organization GO:0030866 1 0.013
g protein coupled receptor signaling pathway GO:0007186 74 0.013
cellular response to lipopolysaccharide GO:0071222 3 0.013
regulation of exocytosis GO:0017157 1 0.013
negative regulation of ras protein signal transduction GO:0046580 1 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.013
cellular localization GO:0051641 97 0.013
positive regulation of translation GO:0045727 1 0.013
cellular response to hypoxia GO:0071456 1 0.013
protein complex disassembly GO:0043241 1 0.013
single organism localization GO:1902578 225 0.013
protein polymerization GO:0051258 4 0.013
carbon dioxide transport GO:0015670 3 0.013
mesenchyme development GO:0060485 127 0.013
cellular amide metabolic process GO:0043603 4 0.013
microtubule organizing center organization GO:0031023 1 0.013
death GO:0016265 121 0.013
protein homooligomerization GO:0051260 3 0.013
establishment of synaptic vesicle localization GO:0097480 1 0.013
regulation of organelle assembly GO:1902115 4 0.013
cellular response to oxygen levels GO:0071453 1 0.013
regulation of cell development GO:0060284 100 0.013
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.013
regulation of gtpase activity GO:0043087 2 0.013
multi organism cellular process GO:0044764 2 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
regulation of transporter activity GO:0032409 2 0.013
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
rna 3 end processing GO:0031123 2 0.012
myeloid cell homeostasis GO:0002262 56 0.012
regulation of blood pressure GO:0008217 1 0.012
negative regulation of cytoplasmic transport GO:1903650 2 0.012
system process GO:0003008 185 0.012
cellular protein modification process GO:0006464 100 0.012
nuclear import GO:0051170 3 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
regulation of biomineral tissue development GO:0070167 2 0.012
regulation of developmental process GO:0050793 247 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
cortical cytoskeleton organization GO:0030865 1 0.012
axonal defasciculation GO:0007414 2 0.012
negative regulation of apoptotic process GO:0043066 55 0.012
histone h3 k4 methylation GO:0051568 2 0.012
cellular component disassembly GO:0022411 1 0.012
skeletal system development GO:0001501 181 0.012
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
protein stabilization GO:0050821 2 0.012
cell substrate junction assembly GO:0007044 2 0.012
developmental growth GO:0048589 166 0.012
cellular response to radiation GO:0071478 4 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
i kappab kinase nf kappab signaling GO:0007249 4 0.012
positive regulation of secretion GO:0051047 1 0.012
cytoskeleton dependent cytokinesis GO:0061640 3 0.012
neuron projection development GO:0031175 180 0.012
cellular response to decreased oxygen levels GO:0036294 1 0.012
cellular component assembly GO:0022607 170 0.012
response to corticosteroid GO:0031960 1 0.012
adherens junction organization GO:0034332 4 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
centrosome organization GO:0051297 1 0.012
response to amine GO:0014075 1 0.012
specification of axis polarity GO:0065001 4 0.012
fat soluble vitamin metabolic process GO:0006775 4 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
positive regulation of neuron death GO:1901216 1 0.012
regulation of erythrocyte differentiation GO:0045646 2 0.012
autophagy GO:0006914 4 0.012
macromolecular complex disassembly GO:0032984 1 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
protein polyubiquitination GO:0000209 4 0.011
camera type eye morphogenesis GO:0048593 108 0.011
negative regulation of cell death GO:0060548 60 0.011
positive regulation of myeloid cell differentiation GO:0045639 2 0.011
actin filament based movement GO:0030048 1 0.011
regulation of cell activation GO:0050865 1 0.011
regulation of cell matrix adhesion GO:0001952 1 0.011
negative regulation of secretion by cell GO:1903531 2 0.011
regulation of programmed cell death GO:0043067 101 0.011
g2 m transition of mitotic cell cycle GO:0000086 4 0.011
muscle organ development GO:0007517 101 0.011
hepaticobiliary system development GO:0061008 98 0.011
protein secretion GO:0009306 1 0.011
regulation of rho protein signal transduction GO:0035023 2 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
oocyte maturation GO:0001556 4 0.011
response to organic substance GO:0010033 153 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
negative regulation of defense response GO:0031348 2 0.011
cell cycle g2 m phase transition GO:0044839 4 0.011
response to wounding GO:0009611 116 0.011
actin polymerization or depolymerization GO:0008154 2 0.011
muscle tissue development GO:0060537 110 0.011
single organism membrane fusion GO:0044801 2 0.011
striated muscle tissue development GO:0014706 110 0.011
locomotion GO:0040011 313 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
single organism nuclear import GO:1902593 3 0.011
determination of heart left right asymmetry GO:0061371 117 0.011
leukocyte proliferation GO:0070661 1 0.011
protein depolymerization GO:0051261 1 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
axon development GO:0061564 166 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
response to amphetamine GO:0001975 1 0.011
intracellular mrna localization GO:0008298 1 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
regulation of endocrine process GO:0044060 2 0.011
response to uv GO:0009411 3 0.011
regeneration GO:0031099 91 0.011
positive regulation of chromatin modification GO:1903310 1 0.010
angiogenesis GO:0001525 158 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.010
embryonic heart tube morphogenesis GO:0003143 108 0.010
response to external stimulus GO:0009605 264 0.010
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.010
positive regulation of immune effector process GO:0002699 3 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.010
neuron projection morphogenesis GO:0048812 161 0.010
cell cycle g1 s phase transition GO:0044843 1 0.010
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.010
regulation of erk1 and erk2 cascade GO:0070372 4 0.010
actin filament polymerization GO:0030041 2 0.010
neuroblast proliferation GO:0007405 2 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.010
striated muscle cell differentiation GO:0051146 129 0.010
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.010
viral process GO:0016032 1 0.010
phototransduction GO:0007602 2 0.010
protein import into nucleus GO:0006606 3 0.010
convergent extension GO:0060026 118 0.010
dicarboxylic acid transport GO:0006835 1 0.010
nephron tubule morphogenesis GO:0072078 1 0.010
ovulation cycle GO:0042698 2 0.010

chd8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
muscular disease DOID:0080000 0 0.021
musculoskeletal system disease DOID:17 0 0.021
immune system disease DOID:2914 0 0.019
myopathy DOID:423 0 0.017
muscle tissue disease DOID:66 0 0.017
nervous system disease DOID:863 0 0.016
cardiovascular system disease DOID:1287 0 0.015
disease of metabolism DOID:0014667 0 0.013
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
hematopoietic system disease DOID:74 0 0.010