Danio rerio

59 known processes

nr1h4

nuclear receptor subfamily 1, group H, member 4

(Aliases: zgc:110190,MGC110190,zgc:92742)

nr1h4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
maintenance of location GO:0051235 4 0.061
aging GO:0007568 2 0.052
larval development GO:0002164 2 0.048
single organism metabolic process GO:0044710 217 0.045
Human Mouse Rat
positive regulation of transport GO:0051050 2 0.045
multicellular organism growth GO:0035264 4 0.044
nitrogen compound metabolic process GO:0006807 319 0.041
hormone secretion GO:0046879 2 0.039
small molecule metabolic process GO:0044281 77 0.038
Human Mouse Rat
lipid storage GO:0019915 1 0.035
regulation of blood vessel size GO:0050880 2 0.034
guanosine containing compound metabolic process GO:1901068 4 0.031
guanosine containing compound catabolic process GO:1901069 2 0.031
liver development GO:0001889 96 0.031
hepaticobiliary system development GO:0061008 98 0.030
establishment of protein localization to organelle GO:0072594 4 0.030
regulation of tube size GO:0035150 2 0.029
stem cell proliferation GO:0072089 4 0.029
positive regulation of secretion GO:0051047 1 0.029
regulation of multicellular organism growth GO:0040014 4 0.029
regulation of hormone secretion GO:0046883 2 0.028
regulation of biological quality GO:0065008 263 0.027
Zebrafish
positive regulation of cellular component biogenesis GO:0044089 3 0.026
lipid catabolic process GO:0016042 4 0.026
oxoacid metabolic process GO:0043436 31 0.026
Human Mouse Rat
embryonic organ development GO:0048568 381 0.026
organic cyclic compound metabolic process GO:1901360 301 0.026
hormone transport GO:0009914 2 0.025
protein localization to nucleus GO:0034504 3 0.025
positive regulation of cell cycle GO:0045787 3 0.025
phagocytosis GO:0006909 3 0.025
adult behavior GO:0030534 2 0.025
regulation of blood pressure GO:0008217 1 0.025
gtp metabolic process GO:0046039 4 0.024
nucleobase containing compound metabolic process GO:0006139 274 0.024
cellular nitrogen compound metabolic process GO:0034641 290 0.024
alcohol biosynthetic process GO:0046165 2 0.024
positive regulation of secretion by cell GO:1903532 1 0.024
gtp catabolic process GO:0006184 2 0.024
cellular response to external stimulus GO:0071496 2 0.024
organic substance biosynthetic process GO:1901576 289 0.024
response to nutrient GO:0007584 3 0.023
amine metabolic process GO:0009308 2 0.023
Mouse
carboxylic acid metabolic process GO:0019752 22 0.023
Human Mouse Rat
regulation of systemic arterial blood pressure GO:0003073 1 0.023
gland development GO:0048732 143 0.023
gene expression GO:0010467 252 0.023
regulation of protein complex assembly GO:0043254 3 0.022
response to chemical GO:0042221 320 0.022
Zebrafish Mouse Rat
cellular response to extracellular stimulus GO:0031668 2 0.022
cellular component movement GO:0006928 335 0.022
response to vitamin GO:0033273 3 0.022
response to monosaccharide GO:0034284 3 0.022
Rat
organic acid metabolic process GO:0006082 31 0.022
Human Mouse Rat
organonitrogen compound metabolic process GO:1901564 74 0.022
Mouse
positive regulation of catabolic process GO:0009896 4 0.021
cellular response to nutrient levels GO:0031669 2 0.021
protein import GO:0017038 3 0.021
positive regulation of cellular catabolic process GO:0031331 3 0.021
protein targeting to nucleus GO:0044744 3 0.021
response to drug GO:0042493 3 0.021
regulation of cytokine production GO:0001817 3 0.021
cellular ketone metabolic process GO:0042180 11 0.021
Human Mouse
regulation of cytoplasmic transport GO:1903649 4 0.021
regulation of muscle contraction GO:0006937 3 0.021
mitochondrion organization GO:0007005 4 0.020
regulation of purine nucleotide catabolic process GO:0033121 2 0.020
meiotic cell cycle process GO:1903046 3 0.020
heart development GO:0007507 313 0.020
transport GO:0006810 220 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
cellular carbohydrate metabolic process GO:0044262 4 0.020
endosomal transport GO:0016197 2 0.020
cell substrate adhesion GO:0031589 4 0.020
digestive tract morphogenesis GO:0048546 231 0.020
positive regulation of immune effector process GO:0002699 3 0.020
peptide transport GO:0015833 1 0.020
eye development GO:0001654 277 0.020
cellular amine metabolic process GO:0044106 2 0.020
Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.020
positive regulation of biological process GO:0048518 253 0.019
Human Mouse Rat
membrane invagination GO:0010324 1 0.019
cellular macromolecule biosynthetic process GO:0034645 224 0.019
peptidyl lysine acetylation GO:0018394 2 0.019
protein import into nucleus GO:0006606 3 0.019
cellular nitrogen compound biosynthetic process GO:0044271 218 0.019
response to carbohydrate GO:0009743 3 0.019
Rat
system process GO:0003008 185 0.019
protein localization to plasma membrane GO:0072659 1 0.019
heterocycle metabolic process GO:0046483 290 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.019
Mouse
tube morphogenesis GO:0035239 349 0.019
small molecule catabolic process GO:0044282 3 0.019
stem cell maintenance GO:0019827 4 0.018
cell morphogenesis GO:0000902 289 0.018
neuroblast proliferation GO:0007405 2 0.018
establishment of protein localization to plasma membrane GO:0090002 1 0.018
single organism localization GO:1902578 225 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.018
Mouse
nucleic acid metabolic process GO:0090304 244 0.018
regulation of macromolecule metabolic process GO:0060255 317 0.018
regulation of establishment of protein localization GO:0070201 4 0.018
nuclear import GO:0051170 3 0.018
cellular lipid catabolic process GO:0044242 3 0.018
cognition GO:0050890 1 0.018
regulation of binding GO:0051098 3 0.018
xenobiotic metabolic process GO:0006805 4 0.018
meiotic nuclear division GO:0007126 4 0.018
establishment of localization GO:0051234 244 0.017
signal transduction GO:0007165 455 0.017
regulation of metabolic process GO:0019222 359 0.017
internal peptidyl lysine acetylation GO:0018393 2 0.017
nuclear transport GO:0051169 4 0.017
regulation of protein transport GO:0051223 3 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
circulatory system process GO:0003013 87 0.017
multicellular organismal response to stress GO:0033555 2 0.017
regulation of nucleotide catabolic process GO:0030811 2 0.017
regulation of macromolecule biosynthetic process GO:0010556 225 0.017
regulation of cell communication GO:0010646 232 0.017
vasculature development GO:0001944 278 0.017
cellular macromolecule metabolic process GO:0044260 391 0.017
camera type eye development GO:0043010 222 0.017
organelle organization GO:0006996 227 0.017
oxidation reduction process GO:0055114 41 0.017
sensory organ development GO:0007423 393 0.017
single organism nuclear import GO:1902593 3 0.017
sensory perception of chemical stimulus GO:0007606 3 0.017
glucose homeostasis GO:0042593 1 0.017
skeletal system development GO:0001501 181 0.017
regulation of circadian rhythm GO:0042752 4 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
locomotion GO:0040011 313 0.016
regulation of cellular metabolic process GO:0031323 320 0.016
regulation of transporter activity GO:0032409 2 0.016
generation of neurons GO:0048699 385 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
protein polymerization GO:0051258 4 0.016
regulation of reproductive process GO:2000241 4 0.016
regulation of nucleocytoplasmic transport GO:0046822 2 0.016
cellular amide metabolic process GO:0043603 4 0.016
Mouse
smooth muscle contraction GO:0006939 2 0.016
tissue remodeling GO:0048771 4 0.016
embryonic organ morphogenesis GO:0048562 274 0.016
secondary metabolic process GO:0019748 3 0.016
cellular component biogenesis GO:0044085 178 0.016
regulation of gene expression GO:0010468 265 0.016
regulation of gtpase activity GO:0043087 2 0.016
rna metabolic process GO:0016070 219 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
Mouse
carbohydrate homeostasis GO:0033500 1 0.016
regulation of cell activation GO:0050865 1 0.016
regulation of multicellular organismal process GO:0051239 277 0.016
determination of left right symmetry GO:0007368 179 0.016
heterocycle biosynthetic process GO:0018130 215 0.016
cellular component disassembly GO:0022411 1 0.016
digestive system development GO:0055123 289 0.015
Rat
single organism transport GO:0044765 206 0.015
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.015
morphogenesis of an epithelium GO:0002009 333 0.015
response to alkaloid GO:0043279 2 0.015
regulation of protein polymerization GO:0032271 2 0.015
positive regulation of cytoskeleton organization GO:0051495 3 0.015
aromatic compound biosynthetic process GO:0019438 217 0.015
determination of bilateral symmetry GO:0009855 204 0.015
regulation of signaling GO:0023051 235 0.015
regulation of stem cell proliferation GO:0072091 2 0.015
cellular response to lipopolysaccharide GO:0071222 3 0.015
protein stabilization GO:0050821 2 0.015
positive regulation of protein complex assembly GO:0031334 2 0.015
rna biosynthetic process GO:0032774 181 0.015
regulation of epithelial cell proliferation GO:0050678 3 0.015
regulation of endocrine process GO:0044060 2 0.015
response to external stimulus GO:0009605 264 0.015
Rat
regulation of gtp catabolic process GO:0033124 2 0.015
response to xenobiotic stimulus GO:0009410 45 0.015
lipid homeostasis GO:0055088 3 0.015
Zebrafish
neuron differentiation GO:0030182 353 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
sequestering of calcium ion GO:0051208 3 0.015
golgi vesicle transport GO:0048193 3 0.015
immune system development GO:0002520 191 0.015
phagocytosis engulfment GO:0006911 1 0.015
energy reserve metabolic process GO:0006112 2 0.015
regulation of protein targeting GO:1903533 2 0.014
regulation of metal ion transport GO:0010959 4 0.014
regulation of rna biosynthetic process GO:2001141 213 0.014
carboxylic acid catabolic process GO:0046395 3 0.014
negative regulation of biological process GO:0048519 304 0.014
Human Mouse Rat
inositol lipid mediated signaling GO:0048017 2 0.014
cellular component morphogenesis GO:0032989 336 0.014
negative regulation of protein kinase activity GO:0006469 4 0.014
endocrine process GO:0050886 2 0.014
sensory organ morphogenesis GO:0090596 200 0.014
actin polymerization or depolymerization GO:0008154 2 0.014
transcription from rna polymerase ii promoter GO:0006366 80 0.014
specification of symmetry GO:0009799 204 0.014
nucleobase containing compound biosynthetic process GO:0034654 205 0.014
regulation of response to stimulus GO:0048583 269 0.014
fatty acid oxidation GO:0019395 1 0.014
cellular response to biotic stimulus GO:0071216 3 0.014
rna localization GO:0006403 4 0.014
vacuolar transport GO:0007034 2 0.014
blood circulation GO:0008015 87 0.014
cell migration GO:0016477 237 0.014
cellular component assembly GO:0022607 170 0.014
regulation of developmental process GO:0050793 247 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.014
positive regulation of gtp catabolic process GO:0033126 1 0.014
gastrulation GO:0007369 208 0.014
nucleic acid templated transcription GO:0097659 181 0.014
positive regulation of blood circulation GO:1903524 2 0.014
regulation of inflammatory response GO:0050727 2 0.014
pancreas development GO:0031016 84 0.014
diterpenoid metabolic process GO:0016101 15 0.014
protein acetylation GO:0006473 2 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.014
cellular response to starvation GO:0009267 1 0.014
eye morphogenesis GO:0048592 144 0.014
acylglycerol homeostasis GO:0055090 2 0.014
Zebrafish
amino acid transport GO:0006865 2 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
production of molecular mediator of immune response GO:0002440 2 0.014
response to stress GO:0006950 263 0.014
cell projection morphogenesis GO:0048858 244 0.014
cellular aromatic compound metabolic process GO:0006725 295 0.014
regulation of synapse organization GO:0050807 3 0.014
fat soluble vitamin metabolic process GO:0006775 4 0.013
determination of heart left right asymmetry GO:0061371 117 0.013
epithelial cell differentiation GO:0030855 116 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
transmembrane transport GO:0055085 120 0.013
triglyceride homeostasis GO:0070328 2 0.013
Zebrafish
response to hydrogen peroxide GO:0042542 3 0.013
regulation of neural precursor cell proliferation GO:2000177 3 0.013
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.013
protein complex disassembly GO:0043241 1 0.013
positive regulation of cell activation GO:0050867 1 0.013
establishment of synaptic vesicle localization GO:0097480 1 0.013
neurotransmitter transport GO:0006836 2 0.013
synaptic vesicle localization GO:0097479 1 0.013
fin development GO:0033333 77 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
Human Mouse Rat
chemosensory behavior GO:0007635 1 0.013
negative regulation of sequestering of calcium ion GO:0051283 4 0.013
i kappab kinase nf kappab signaling GO:0007249 4 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
response to glucose GO:0009749 3 0.013
Rat
regulation of dendrite development GO:0050773 3 0.013
ion transport GO:0006811 114 0.013
neurotransmitter secretion GO:0007269 2 0.013
organic acid catabolic process GO:0016054 3 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
central nervous system development GO:0007417 387 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.013
striated muscle cell differentiation GO:0051146 129 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
hemopoiesis GO:0030097 183 0.013
negative regulation of catabolic process GO:0009895 3 0.013
cellular protein catabolic process GO:0044257 4 0.013
internal protein amino acid acetylation GO:0006475 2 0.012
regulation of protein catabolic process GO:0042176 1 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
cellular biosynthetic process GO:0044249 286 0.012
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
localization of cell GO:0051674 244 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
mitochondrial transport GO:0006839 2 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
biosynthetic process GO:0009058 294 0.012
negative regulation of intracellular protein transport GO:0090317 3 0.012
long chain fatty acid metabolic process GO:0001676 1 0.012
cell projection organization GO:0030030 284 0.012
growth GO:0040007 174 0.012
regulation of mrna splicing via spliceosome GO:0048024 3 0.012
regulation of signal transduction GO:0009966 225 0.012
germ line stem cell maintenance GO:0030718 2 0.012
positive regulation of stress activated mapk cascade GO:0032874 3 0.012
transcription dna templated GO:0006351 181 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
negative regulation of cytokine production GO:0001818 1 0.012
sequestering of metal ion GO:0051238 3 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
Mouse
regulation of protein depolymerization GO:1901879 1 0.012
phosphatidylinositol mediated signaling GO:0048015 2 0.012
mechanosensory behavior GO:0007638 2 0.012
blood vessel development GO:0001568 246 0.012
homeostatic process GO:0042592 142 0.012
Zebrafish
cellular response to molecule of bacterial origin GO:0071219 3 0.012
connective tissue development GO:0061448 99 0.012
interspecies interaction between organisms GO:0044419 4 0.012
b cell activation GO:0042113 2 0.012
regulation of transcription dna templated GO:0006355 213 0.012
regulation of biosynthetic process GO:0009889 250 0.012
leukocyte mediated cytotoxicity GO:0001909 1 0.012
response to topologically incorrect protein GO:0035966 2 0.012
lipid metabolic process GO:0006629 52 0.012
Human Mouse Rat
protein acylation GO:0043543 3 0.012
hematopoietic or lymphoid organ development GO:0048534 191 0.012
retinoid metabolic process GO:0001523 15 0.012
cellular localization GO:0051641 97 0.012
muscle cell differentiation GO:0042692 139 0.012
regulation of jak stat cascade GO:0046425 3 0.012
cartilage development GO:0051216 96 0.012
synaptic target recognition GO:0008039 1 0.012
actin filament polymerization GO:0030041 2 0.012
dicarboxylic acid transport GO:0006835 1 0.012
cell motility GO:0048870 244 0.012
positive regulation of gtpase activity GO:0043547 1 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
cellular response to xenobiotic stimulus GO:0071466 35 0.011
proteasomal protein catabolic process GO:0010498 2 0.011
synaptic vesicle transport GO:0048489 1 0.011
hormone biosynthetic process GO:0042446 3 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
Human Mouse
regulation of intracellular protein transport GO:0033157 3 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
regulation of cell shape GO:0008360 1 0.011
regulation of lipid transport GO:0032368 4 0.011
regulation of cellular biosynthetic process GO:0031326 245 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
regulation of meiotic cell cycle GO:0051445 1 0.011
leukocyte proliferation GO:0070661 1 0.011
lymphocyte proliferation GO:0046651 1 0.011
retina development in camera type eye GO:0060041 146 0.011
regulation of primary metabolic process GO:0080090 311 0.011
negative regulation of cellular process GO:0048523 283 0.011
Human Mouse Rat
heart looping GO:0001947 94 0.011
response to hexose GO:0009746 3 0.011
Rat
regulation of protein complex disassembly GO:0043244 1 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
response to organic substance GO:0010033 153 0.011
Zebrafish Mouse Rat
digestive tract development GO:0048565 265 0.011
Rat
positive regulation of protein polymerization GO:0032273 2 0.011
positive regulation of lipid metabolic process GO:0045834 1 0.011
anion transport GO:0006820 38 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
somatic muscle development GO:0007525 4 0.011
cell part morphogenesis GO:0032990 246 0.011
positive regulation of jnk cascade GO:0046330 3 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
negative regulation of defense response GO:0031348 2 0.011
positive regulation of cell adhesion GO:0045785 1 0.011
regulation of cell differentiation GO:0045595 142 0.011
regulation of synapse assembly GO:0051963 3 0.011
neuron development GO:0048666 262 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
atp catabolic process GO:0006200 4 0.011
regulation of nucleic acid templated transcription GO:1903506 213 0.011
mononuclear cell proliferation GO:0032943 1 0.011
ubiquitin dependent protein catabolic process GO:0006511 3 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
autophagy GO:0006914 4 0.011
membrane fusion GO:0061025 2 0.011
single organism organelle organization GO:1902589 199 0.011
compound eye development GO:0048749 2 0.011
exocytosis GO:0006887 1 0.011
cell matrix adhesion GO:0007160 4 0.011
antimicrobial humoral response GO:0019730 2 0.011
er nucleus signaling pathway GO:0006984 2 0.011
actin filament based movement GO:0030048 1 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.010
muscle structure development GO:0061061 196 0.010
action potential GO:0001508 19 0.010
cellular component assembly involved in morphogenesis GO:0010927 107 0.010
striated muscle cell development GO:0055002 108 0.010
immune system process GO:0002376 241 0.010
macromolecular complex disassembly GO:0032984 1 0.010
embryonic heart tube morphogenesis GO:0003143 108 0.010
cell surface receptor signaling pathway GO:0007166 325 0.010
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.010
positive regulation of metabolic process GO:0009893 108 0.010
Human Mouse Rat
negative regulation of protein transport GO:0051224 3 0.010
protein homooligomerization GO:0051260 3 0.010
regulation of protein import into nucleus GO:0042306 2 0.010
single organism membrane fusion GO:0044801 2 0.010
kidney development GO:0001822 92 0.010
cytokinesis GO:0000910 3 0.010
terpenoid metabolic process GO:0006721 15 0.010
negative regulation of multi organism process GO:0043901 3 0.010
protein secretion GO:0009306 1 0.010
regulation of neurotransmitter transport GO:0051588 1 0.010
negative regulation of epithelial cell proliferation GO:0050680 1 0.010
isoprenoid metabolic process GO:0006720 15 0.010
regulation of sequestering of calcium ion GO:0051282 4 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.010
regulation of carbohydrate metabolic process GO:0006109 4 0.010
Rat
post embryonic organ development GO:0048569 4 0.010
chemical homeostasis GO:0048878 49 0.010
Zebrafish
neuromuscular process controlling balance GO:0050885 3 0.010
renal system development GO:0072001 94 0.010

nr1h4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
disease of metabolism DOID:0014667 0 0.022
inherited metabolic disorder DOID:655 0 0.022
nervous system disease DOID:863 0 0.018
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.013
organ system cancer DOID:0050686 0 0.013
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
musculoskeletal system disease DOID:17 0 0.011