Danio rerio

0 known processes

ppl

periplakin

(Aliases: im:7149519,cb180,sb:cb180,im:7140067)

ppl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
desmosome organization GO:0002934 3 0.277
growth GO:0040007 174 0.236
regulation of water loss via skin GO:0033561 1 0.219
keratinocyte differentiation GO:0030216 0 0.159
morphogenesis of an epithelium GO:0002009 333 0.152
gastrulation with mouth forming second GO:0001702 44 0.139
regulation of biological quality GO:0065008 263 0.128
neuron development GO:0048666 262 0.120
fin regeneration GO:0031101 51 0.119
hemopoiesis GO:0030097 183 0.113
convergent extension GO:0060026 118 0.107
system process GO:0003008 185 0.099
transport GO:0006810 220 0.097
inner ear receptor stereocilium organization GO:0060122 8 0.085
regulation of metabolic process GO:0019222 359 0.080
gene expression GO:0010467 252 0.077
immune system process GO:0002376 241 0.075
organelle organization GO:0006996 227 0.072
tube morphogenesis GO:0035239 349 0.071
regulation of gene expression GO:0010468 265 0.068
actomyosin structure organization GO:0031032 53 0.068
immune system development GO:0002520 191 0.066
organic acid metabolic process GO:0006082 31 0.065
cellular macromolecule metabolic process GO:0044260 391 0.065
hematopoietic or lymphoid organ development GO:0048534 191 0.062
positive regulation of cell cycle GO:0045787 3 0.062
regulation of macromolecule metabolic process GO:0060255 317 0.060
wound healing GO:0042060 90 0.059
regulation of inflammatory response GO:0050727 2 0.057
regulation of establishment of protein localization GO:0070201 4 0.056
developmental growth GO:0048589 166 0.054
gastrulation GO:0007369 208 0.053
regulation of epithelial cell proliferation GO:0050678 3 0.053
epidermal cell differentiation GO:0009913 36 0.051
regulation of multicellular organismal process GO:0051239 277 0.051
positive regulation of transport GO:0051050 2 0.050
multicellular organismal water homeostasis GO:0050891 1 0.049
regeneration GO:0031099 91 0.048
single organism organelle organization GO:1902589 199 0.047
striated muscle cell differentiation GO:0051146 129 0.046
oxoacid metabolic process GO:0043436 31 0.045
response to corticosteroid GO:0031960 1 0.044
stem cell maintenance GO:0019827 4 0.043
positive regulation of cellular process GO:0048522 201 0.043
epithelial cell differentiation GO:0030855 116 0.041
response to stress GO:0006950 263 0.041
muscle cell differentiation GO:0042692 139 0.040
cellular protein metabolic process GO:0044267 129 0.039
single organism transport GO:0044765 206 0.039
regulation of nitrogen compound metabolic process GO:0051171 251 0.038
cellular component morphogenesis GO:0032989 336 0.038
nucleic acid metabolic process GO:0090304 244 0.036
protein secretion GO:0009306 1 0.036
multi organism process GO:0051704 134 0.036
regulation of localization GO:0032879 104 0.035
negative regulation of cytokine production GO:0001818 1 0.035
tissue regeneration GO:0042246 74 0.034
regulation of cellular metabolic process GO:0031323 320 0.033
regulation of cytokine production GO:0001817 3 0.032
negative regulation of protein transport GO:0051224 3 0.032
cytoskeleton organization GO:0007010 96 0.031
heart looping GO:0001947 94 0.031
cellular component movement GO:0006928 335 0.031
protein metabolic process GO:0019538 183 0.031
behavior GO:0007610 74 0.030
generation of neurons GO:0048699 385 0.030
single organism localization GO:1902578 225 0.030
regulation of metal ion transport GO:0010959 4 0.030
cellular response to extracellular stimulus GO:0031668 2 0.030
negative regulation of epithelial cell proliferation GO:0050680 1 0.030
alpha amino acid metabolic process GO:1901605 3 0.030
kupffer s vesicle development GO:0070121 50 0.029
fatty acid biosynthetic process GO:0006633 4 0.029
phagocytosis GO:0006909 3 0.029
anion transport GO:0006820 38 0.029
complement activation GO:0006956 3 0.028
protein activation cascade GO:0072376 6 0.028
homeostatic process GO:0042592 142 0.028
striated muscle cell development GO:0055002 108 0.028
cell death GO:0008219 121 0.027
cellular component assembly GO:0022607 170 0.027
muscle cell development GO:0055001 115 0.026
establishment of localization GO:0051234 244 0.026
muscle structure development GO:0061061 196 0.026
erythrocyte maturation GO:0043249 8 0.026
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.026
phagocytosis engulfment GO:0006911 1 0.025
extrinsic apoptotic signaling pathway GO:0097191 3 0.025
cell morphogenesis GO:0000902 289 0.025
regulation of primary metabolic process GO:0080090 311 0.025
synaptic growth at neuromuscular junction GO:0051124 2 0.024
cell projection organization GO:0030030 284 0.024
nitrogen compound metabolic process GO:0006807 319 0.024
myofibril assembly GO:0030239 48 0.024
heart development GO:0007507 313 0.024
cellular nitrogen compound metabolic process GO:0034641 290 0.024
aging GO:0007568 2 0.023
regulation of epidermis development GO:0045682 2 0.023
female sex differentiation GO:0046660 4 0.023
autophagy GO:0006914 4 0.023
mesenchyme development GO:0060485 127 0.023
sensory organ development GO:0007423 393 0.023
liver development GO:0001889 96 0.022
response to endogenous stimulus GO:0009719 83 0.022
positive regulation of biological process GO:0048518 253 0.022
cell projection morphogenesis GO:0048858 244 0.022
regulation of sodium ion transport GO:0002028 2 0.022
cellular response to starvation GO:0009267 1 0.022
medial fin development GO:0033338 16 0.022
response to fluid shear stress GO:0034405 2 0.022
positive regulation of cell death GO:0010942 29 0.022
negative regulation of cellular process GO:0048523 283 0.021
signal transduction GO:0007165 455 0.021
response to wounding GO:0009611 116 0.021
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.021
protein modification process GO:0036211 100 0.021
adherens junction organization GO:0034332 4 0.021
desmosome assembly GO:0002159 2 0.021
single organism membrane fusion GO:0044801 2 0.021
water homeostasis GO:0030104 4 0.021
skin development GO:0043588 54 0.020
aromatic compound biosynthetic process GO:0019438 217 0.020
regulation of cell motility GO:2000145 46 0.020
cardiac conduction GO:0061337 3 0.020
calcium independent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016338 1 0.020
response to glucocorticoid GO:0051384 1 0.020
digestive tract development GO:0048565 265 0.020
plasma membrane repair GO:0001778 2 0.020
regulation of cellular biosynthetic process GO:0031326 245 0.020
cell proliferation GO:0008283 80 0.019
cellular response to external stimulus GO:0071496 2 0.019
death GO:0016265 121 0.019
determination of left right symmetry GO:0007368 179 0.019
regulation of nervous system development GO:0051960 90 0.019
fatty acid transport GO:0015908 1 0.019
neural crest cell differentiation GO:0014033 72 0.019
long chain fatty acid transport GO:0015909 1 0.019
regulation of eye photoreceptor cell development GO:0042478 2 0.019
cell cycle g1 s phase transition GO:0044843 1 0.019
digestive tract morphogenesis GO:0048546 231 0.019
organelle fusion GO:0048284 3 0.019
rna metabolic process GO:0016070 219 0.019
regulation of cellular component movement GO:0051270 55 0.018
response to organic substance GO:0010033 153 0.018
regulation of locomotion GO:0040012 55 0.018
negative regulation of defense response GO:0031348 2 0.018
neuron differentiation GO:0030182 353 0.018
cell surface receptor signaling pathway GO:0007166 325 0.018
apoptotic process GO:0006915 116 0.018
actin filament based movement GO:0030048 1 0.018
morphogenesis of an epithelial sheet GO:0002011 49 0.017
response to abiotic stimulus GO:0009628 122 0.017
negative regulation of secretion by cell GO:1903531 2 0.017
g1 s transition of mitotic cell cycle GO:0000082 1 0.017
membrane invagination GO:0010324 1 0.017
embryonic organ development GO:0048568 381 0.016
cellular macromolecule biosynthetic process GO:0034645 224 0.016
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.016
cognition GO:0050890 1 0.016
stem cell differentiation GO:0048863 117 0.016
locomotion GO:0040011 313 0.016
regulation of protein transport GO:0051223 3 0.016
establishment of endothelial barrier GO:0061028 3 0.016
reproductive process GO:0022414 40 0.016
tissue remodeling GO:0048771 4 0.016
positive regulation of macromolecule metabolic process GO:0010604 93 0.015
neuroblast differentiation GO:0014016 1 0.015
regulation of dna templated transcription in response to stress GO:0043620 0 0.015
heterocycle metabolic process GO:0046483 290 0.015
cell morphogenesis involved in differentiation GO:0000904 195 0.015
epidermis development GO:0008544 48 0.015
negative regulation of response to stimulus GO:0048585 104 0.015
glomerulus development GO:0032835 27 0.015
dna templated transcription elongation GO:0006354 3 0.015
cardiac muscle tissue development GO:0048738 48 0.015
regulation of cardiac muscle contraction GO:0055117 2 0.014
response to external stimulus GO:0009605 264 0.014
regulation of cell differentiation GO:0045595 142 0.014
response to lipid GO:0033993 60 0.014
membrane fusion GO:0061025 2 0.014
cellular aromatic compound metabolic process GO:0006725 295 0.014
regulation of rna metabolic process GO:0051252 224 0.014
cellular component biogenesis GO:0044085 178 0.014
rna biosynthetic process GO:0032774 181 0.014
regulation of response to external stimulus GO:0032101 31 0.014
cellular response to organic cyclic compound GO:0071407 38 0.013
small molecule metabolic process GO:0044281 77 0.013
regulation of cell activation GO:0050865 1 0.013
regulation of muscle contraction GO:0006937 3 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
response to organic cyclic compound GO:0014070 51 0.013
morphogenesis of an epithelial fold GO:0060571 1 0.013
cell cell adhesion involved in gastrulation GO:0070586 4 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
fin development GO:0033333 77 0.013
response to uv GO:0009411 3 0.013
myeloid cell homeostasis GO:0002262 56 0.013
positive regulation of cellular component biogenesis GO:0044089 3 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
lateral line system development GO:0048925 76 0.012
heart process GO:0003015 71 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
regulation of nucleic acid templated transcription GO:1903506 213 0.012
cellular localization GO:0051641 97 0.012
single organism metabolic process GO:0044710 217 0.012
skeletal system development GO:0001501 181 0.012
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.012
establishment of skin barrier GO:0061436 1 0.012
action potential GO:0001508 19 0.012
negative regulation of secretion GO:0051048 2 0.012
cellular biosynthetic process GO:0044249 286 0.012
multicellular organismal signaling GO:0035637 22 0.012
monoamine transport GO:0015844 1 0.012
hatching GO:0035188 4 0.012
heterocycle biosynthetic process GO:0018130 215 0.012
actin mediated cell contraction GO:0070252 1 0.012
organic cyclic compound metabolic process GO:1901360 301 0.012
cardiac cell fate commitment GO:0060911 1 0.012
epithelial tube morphogenesis GO:0060562 148 0.012
intestinal absorption GO:0050892 2 0.012
stem cell development GO:0048864 82 0.011
biosynthetic process GO:0009058 294 0.011
negative regulation of wnt signaling pathway involved in heart development GO:0003308 2 0.011
regulation of macromolecule biosynthetic process GO:0010556 225 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
negative regulation of biological process GO:0048519 304 0.011
neuroblast fate commitment GO:0014017 1 0.011
regulation of striated muscle contraction GO:0006942 2 0.011
cation transport GO:0006812 81 0.011
regulation of ectoderm development GO:2000383 2 0.011
regulation of biosynthetic process GO:0009889 250 0.011
regulation of organelle organization GO:0033043 29 0.011
cell motility GO:0048870 244 0.011
wnt signaling pathway GO:0016055 80 0.011
regulation of dna templated transcription elongation GO:0032784 3 0.011
regulation of rna biosynthetic process GO:2001141 213 0.011
cell cycle GO:0007049 93 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
actin cytoskeleton organization GO:0030036 63 0.011
macromolecule modification GO:0043412 111 0.011
single fertilization GO:0007338 3 0.011
multicellular organism growth GO:0035264 4 0.010
ectodermal cell fate specification GO:0001715 2 0.010
cellular nitrogen compound biosynthetic process GO:0044271 218 0.010
regulation of cell death GO:0010941 103 0.010
cellular protein modification process GO:0006464 100 0.010
neural crest cell development GO:0014032 62 0.010
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.010
regulation of response to stimulus GO:0048583 269 0.010
embryonic skeletal system development GO:0048706 97 0.010
regulation of epithelial to mesenchymal transition GO:0010717 3 0.010
cellular ketone metabolic process GO:0042180 11 0.010
positive regulation of dna templated transcription elongation GO:0032786 1 0.010
cartilage development GO:0051216 96 0.010
determination of heart left right asymmetry GO:0061371 117 0.010

ppl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.082
muscular disease DOID:0080000 0 0.082
heart disease DOID:114 0 0.082
cardiomyopathy DOID:0050700 0 0.082
disease of anatomical entity DOID:7 0 0.082
cardiovascular system disease DOID:1287 0 0.082
musculoskeletal system disease DOID:17 0 0.082
muscle tissue disease DOID:66 0 0.082
intrinsic cardiomyopathy DOID:0060036 0 0.055
integumentary system disease DOID:16 0 0.038