Danio rerio

66 known processes

mitfb

microphthalmia-associated transcription factor b

mitfb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular pigmentation GO:0033059 30 0.501
pigmentation GO:0043473 85 0.396
developmental pigmentation GO:0048066 48 0.309
melanocyte differentiation GO:0030318 26 0.173
neuroepithelial cell differentiation GO:0060563 26 0.151
pigment granule localization GO:0051875 25 0.111
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.098
chordate embryonic development GO:0043009 271 0.081
establishment of pigment granule localization GO:0051905 22 0.076
cellular macromolecule biosynthetic process GO:0034645 224 0.074
single organism localization GO:1902578 225 0.072
melanosome localization GO:0032400 21 0.071
regulation of macromolecule biosynthetic process GO:0010556 225 0.066
organic substance biosynthetic process GO:1901576 289 0.065
secondary metabolic process GO:0019748 3 0.055
nitrogen compound metabolic process GO:0006807 319 0.054
tissue remodeling GO:0048771 4 0.050
Mouse
retina development in camera type eye GO:0060041 146 0.047
camera type eye development GO:0043010 222 0.047
Mouse
sensory organ development GO:0007423 393 0.046
Mouse
negative regulation of cellular process GO:0048523 283 0.045
Human Mouse
macromolecule biosynthetic process GO:0009059 227 0.043
positive regulation of catabolic process GO:0009896 4 0.043
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.042
regulation of cell shape GO:0008360 1 0.041
rna metabolic process GO:0016070 219 0.041
regulation of protein transport GO:0051223 3 0.041
nucleobase containing compound biosynthetic process GO:0034654 205 0.040
positive regulation of cellular catabolic process GO:0031331 3 0.039
biosynthetic process GO:0009058 294 0.038
single organism transport GO:0044765 206 0.038
generation of neurons GO:0048699 385 0.037
morphogenesis of an epithelium GO:0002009 333 0.037
epithelial cell differentiation GO:0030855 116 0.037
growth GO:0040007 174 0.036
cell morphogenesis GO:0000902 289 0.036
larval development GO:0002164 2 0.035
vesicle localization GO:0051648 27 0.035
cellular component morphogenesis GO:0032989 336 0.035
regulation of biosynthetic process GO:0009889 250 0.035
regulation of multicellular organism growth GO:0040014 4 0.035
cellular localization GO:0051641 97 0.034
transport GO:0006810 220 0.034
regulation of primary metabolic process GO:0080090 311 0.034
neuron differentiation GO:0030182 353 0.034
regulation of cellular amine metabolic process GO:0033238 0 0.033
regulation of establishment of protein localization GO:0070201 4 0.033
cellular component movement GO:0006928 335 0.032
aging GO:0007568 2 0.032
cellular biosynthetic process GO:0044249 286 0.032
multicellular organism growth GO:0035264 4 0.032
cell part morphogenesis GO:0032990 246 0.032
establishment of localization GO:0051234 244 0.032
melanin biosynthetic process GO:0042438 1 0.031
regulation of nitrogen compound metabolic process GO:0051171 251 0.031
maintenance of location GO:0051235 4 0.031
cellular aromatic compound metabolic process GO:0006725 295 0.031
organic cyclic compound biosynthetic process GO:1901362 223 0.031
cellular amine metabolic process GO:0044106 2 0.030
establishment of vesicle localization GO:0051650 24 0.030
single organism organelle organization GO:1902589 199 0.029
regulation of purine nucleotide catabolic process GO:0033121 2 0.029
embryonic skeletal system morphogenesis GO:0048704 93 0.029
amine metabolic process GO:0009308 2 0.029
organelle organization GO:0006996 227 0.028
embryonic organ morphogenesis GO:0048562 274 0.028
specification of symmetry GO:0009799 204 0.028
regulation of nucleotide catabolic process GO:0030811 2 0.027
mesenchyme development GO:0060485 127 0.027
embryonic skeletal joint morphogenesis GO:0060272 3 0.026
carboxylic acid metabolic process GO:0019752 22 0.026
nucleic acid templated transcription GO:0097659 181 0.026
organic cyclic compound metabolic process GO:1901360 301 0.026
cilium morphogenesis GO:0060271 85 0.025
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.025
heart development GO:0007507 313 0.025
gene expression GO:0010467 252 0.025
inner ear development GO:0048839 126 0.025
oxoacid metabolic process GO:0043436 31 0.025
regulation of blood pressure GO:0008217 1 0.025
regulation of muscle contraction GO:0006937 3 0.025
sensory organ morphogenesis GO:0090596 200 0.025
cellular macromolecule metabolic process GO:0044260 391 0.025
melanin metabolic process GO:0006582 2 0.025
regulation of gtp catabolic process GO:0033124 2 0.024
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.024
protein secretion GO:0009306 1 0.024
guanosine containing compound catabolic process GO:1901069 2 0.024
skeletal system morphogenesis GO:0048705 102 0.023
regulation of endocrine process GO:0044060 2 0.023
regulation of systemic arterial blood pressure GO:0003073 1 0.023
ion transmembrane transport GO:0034220 91 0.023
developmental growth GO:0048589 166 0.023
ear development GO:0043583 127 0.023
regulation of cellular biosynthetic process GO:0031326 245 0.023
establishment of organelle localization GO:0051656 45 0.023
establishment of localization in cell GO:0051649 77 0.023
proteasomal protein catabolic process GO:0010498 2 0.023
striated muscle cell differentiation GO:0051146 129 0.023
gtp metabolic process GO:0046039 4 0.023
urogenital system development GO:0001655 97 0.023
guanosine containing compound metabolic process GO:1901068 4 0.022
organelle localization GO:0051640 49 0.022
positive regulation of nucleoside metabolic process GO:0045979 1 0.022
lipid storage GO:0019915 1 0.022
cellular component assembly GO:0022607 170 0.022
Human
purine nucleoside monophosphate catabolic process GO:0009128 4 0.022
cognition GO:0050890 1 0.021
digestive system development GO:0055123 289 0.021
muscle structure development GO:0061061 196 0.021
ribonucleoside monophosphate catabolic process GO:0009158 4 0.021
protein localization GO:0008104 40 0.021
cellular component assembly involved in morphogenesis GO:0010927 107 0.021
positive regulation of epithelial cell proliferation GO:0050679 1 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
extrinsic apoptotic signaling pathway GO:0097191 3 0.021
cilium organization GO:0044782 71 0.020
cardiac muscle tissue development GO:0048738 48 0.020
positive regulation of translation GO:0045727 1 0.020
skeletal system development GO:0001501 181 0.020
cardiac atrium development GO:0003230 4 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
regulation of rna metabolic process GO:0051252 224 0.020
actin filament based movement GO:0030048 1 0.020
regulation of nucleoside metabolic process GO:0009118 2 0.020
cellular amino acid metabolic process GO:0006520 7 0.020
hemopoiesis GO:0030097 183 0.020
Mouse
heterocycle metabolic process GO:0046483 290 0.020
stem cell maintenance GO:0019827 4 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
transcription dna templated GO:0006351 181 0.020
otic vesicle morphogenesis GO:0071600 34 0.020
regulation of rna biosynthetic process GO:2001141 213 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.019
Human Mouse
positive regulation of biological process GO:0048518 253 0.019
Human Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.019
circulatory system process GO:0003013 87 0.019
small molecule metabolic process GO:0044281 77 0.019
regulation of actin filament based movement GO:1903115 1 0.019
renal tubule morphogenesis GO:0061333 1 0.019
brain development GO:0007420 293 0.019
cellular protein catabolic process GO:0044257 4 0.019
organelle assembly GO:0070925 110 0.019
regulation of cell activation GO:0050865 1 0.019
pigment granule organization GO:0048753 4 0.019
regulation of synapse organization GO:0050807 3 0.018
mitochondrion organization GO:0007005 4 0.018
organic substance transport GO:0071702 58 0.018
cell projection organization GO:0030030 284 0.018
fin development GO:0033333 77 0.018
negative regulation of protein kinase activity GO:0006469 4 0.018
adult behavior GO:0030534 2 0.018
eye development GO:0001654 277 0.018
Mouse
stem cell proliferation GO:0072089 4 0.018
kupffer s vesicle development GO:0070121 50 0.018
transmembrane transport GO:0055085 120 0.018
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.018
regulation of epithelial cell proliferation GO:0050678 3 0.018
cell surface receptor signaling pathway GO:0007166 325 0.018
Mouse
regulation of protein catabolic process GO:0042176 1 0.018
cellular response to external stimulus GO:0071496 2 0.018
regulation of cellular ketone metabolic process GO:0010565 7 0.017
phagocytosis GO:0006909 3 0.017
cell migration GO:0016477 237 0.017
regulation of metabolic process GO:0019222 359 0.017
determination of bilateral symmetry GO:0009855 204 0.017
camera type eye morphogenesis GO:0048593 108 0.017
positive regulation of transport GO:0051050 2 0.017
positive regulation of nucleotide catabolic process GO:0030813 1 0.017
nucleoside monophosphate catabolic process GO:0009125 4 0.017
regulation of cytokine production GO:0001817 3 0.017
digestive tract development GO:0048565 265 0.017
kidney development GO:0001822 92 0.017
head development GO:0060322 303 0.016
determination of left right symmetry GO:0007368 179 0.016
embryonic hemopoiesis GO:0035162 53 0.016
neural crest cell development GO:0014032 62 0.016
alpha amino acid metabolic process GO:1901605 3 0.016
endocrine process GO:0050886 2 0.016
ribosomal small subunit biogenesis GO:0042274 2 0.016
positive regulation of rna metabolic process GO:0051254 59 0.016
Human Mouse
activation of mapk activity GO:0000187 3 0.016
cellular amide metabolic process GO:0043603 4 0.016
response to drug GO:0042493 3 0.016
negative regulation of response to stimulus GO:0048585 104 0.016
gtp catabolic process GO:0006184 2 0.016
cell projection morphogenesis GO:0048858 244 0.016
osteoclast differentiation GO:0030316 1 0.016
Mouse
nucleic acid metabolic process GO:0090304 244 0.016
developmental programmed cell death GO:0010623 4 0.016
muscle cell differentiation GO:0042692 139 0.016
regulation of synapse assembly GO:0051963 3 0.016
regulation of gtpase activity GO:0043087 2 0.015
negative regulation of protein phosphorylation GO:0001933 4 0.015
regulation of tube size GO:0035150 2 0.015
cellular protein modification process GO:0006464 100 0.015
positive regulation of gtpase activity GO:0043547 1 0.015
regulation of response to stimulus GO:0048583 269 0.015
regulation of developmental process GO:0050793 247 0.015
Mouse
regulation of rho protein signal transduction GO:0035023 2 0.015
action potential GO:0001508 19 0.015
positive regulation of cellular biosynthetic process GO:0031328 68 0.015
Human Mouse
renal system development GO:0072001 94 0.015
compound eye development GO:0048749 2 0.015
regulation of transcription dna templated GO:0006355 213 0.015
centrosome organization GO:0051297 1 0.015
regulation of cardiac muscle contraction GO:0055117 2 0.015
melanocyte migration GO:0097324 4 0.015
negative regulation of signal transduction GO:0009968 94 0.015
antimicrobial humoral response GO:0019730 2 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
leukocyte proliferation GO:0070661 1 0.015
tube morphogenesis GO:0035239 349 0.014
cilium assembly GO:0042384 58 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
regulation of gene expression GO:0010468 265 0.014
cellular response to biotic stimulus GO:0071216 3 0.014
positive regulation of gtp catabolic process GO:0033126 1 0.014
single organism metabolic process GO:0044710 217 0.014
embryonic skeletal joint development GO:0072498 3 0.014
cellular protein metabolic process GO:0044267 129 0.014
digestive tract morphogenesis GO:0048546 231 0.014
nucleocytoplasmic transport GO:0006913 4 0.014
regulation of neural retina development GO:0061074 2 0.014
regulation of retina development in camera type eye GO:1902866 2 0.014
cell morphogenesis involved in differentiation GO:0000904 195 0.014
endosomal transport GO:0016197 2 0.014
regulation of jak stat cascade GO:0046425 3 0.014
embryonic cranial skeleton morphogenesis GO:0048701 90 0.014
cardiac muscle contraction GO:0060048 6 0.014
negative regulation of signaling GO:0023057 96 0.014
embryonic skeletal system development GO:0048706 97 0.014
embryonic organ development GO:0048568 381 0.014
meiotic cell cycle process GO:1903046 3 0.014
catechol containing compound metabolic process GO:0009712 2 0.014
protein localization to nucleus GO:0034504 3 0.013
cardiac atrium morphogenesis GO:0003209 2 0.013
ubiquitin dependent protein catabolic process GO:0006511 3 0.013
phenol containing compound biosynthetic process GO:0046189 4 0.013
autophagy GO:0006914 4 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
cellular ketone metabolic process GO:0042180 11 0.013
neural crest cell differentiation GO:0014033 72 0.013
cellular response to lipopolysaccharide GO:0071222 3 0.013
signal transduction in absence of ligand GO:0038034 1 0.013
negative regulation of cytokine production GO:0001818 1 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
positive regulation of jak stat cascade GO:0046427 2 0.013
cardiocyte differentiation GO:0035051 44 0.013
protein complex disassembly GO:0043241 1 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
striated muscle tissue development GO:0014706 110 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
cellular component disassembly GO:0022411 1 0.012
neuroblast proliferation GO:0007405 2 0.012
cartilage development GO:0051216 96 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
ovulation cycle GO:0042698 2 0.012
meiotic nuclear division GO:0007126 4 0.012
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.012
pigment cell differentiation GO:0050931 38 0.012
negative regulation of biological process GO:0048519 304 0.012
Human Mouse
alcohol biosynthetic process GO:0046165 2 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
catecholamine biosynthetic process GO:0042423 2 0.012
regulation of protein targeting GO:1903533 2 0.012
rna biosynthetic process GO:0032774 181 0.012
membrane fusion GO:0061025 2 0.012
lateral inhibition GO:0046331 1 0.012
protein targeting to nucleus GO:0044744 3 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
eye morphogenesis GO:0048592 144 0.012
lamellipodium assembly GO:0030032 1 0.012
cellular response to extracellular stimulus GO:0031668 2 0.012
vasculature development GO:0001944 278 0.012
exocytosis GO:0006887 1 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
protein import GO:0017038 3 0.012
cell fate commitment GO:0045165 99 0.012
Mouse
peptide metabolic process GO:0006518 1 0.012
germ line stem cell maintenance GO:0030718 2 0.012
cellular nitrogen compound metabolic process GO:0034641 290 0.012
convergent extension GO:0060026 118 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.012
blood vessel development GO:0001568 246 0.012
nuclear import GO:0051170 3 0.012
regulation of anatomical structure morphogenesis GO:0022603 130 0.012
actin mediated cell contraction GO:0070252 1 0.012
regulation of reproductive process GO:2000241 4 0.012
establishment of protein localization to organelle GO:0072594 4 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
Human Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.011
response to external stimulus GO:0009605 264 0.011
positive regulation of stress activated mapk cascade GO:0032874 3 0.011
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.011
retina morphogenesis in camera type eye GO:0060042 79 0.011
cellular response to starvation GO:0009267 1 0.011
centrosome cycle GO:0007098 1 0.011
response to carbohydrate GO:0009743 3 0.011
microtubule organizing center organization GO:0031023 1 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
rna modification GO:0009451 2 0.011
regulation of intracellular protein transport GO:0033157 3 0.011
regulation of autophagy GO:0010506 3 0.011
localization of cell GO:0051674 244 0.011
regulation of signal transduction GO:0009966 225 0.011
intracellular transport GO:0046907 32 0.011
negative regulation of reproductive process GO:2000242 3 0.011
atp catabolic process GO:0006200 4 0.011
startle response GO:0001964 4 0.011
regulation of striated muscle contraction GO:0006942 2 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
regulation of cell differentiation GO:0045595 142 0.011
Mouse
central nervous system development GO:0007417 387 0.011
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.011
embryonic heart tube development GO:0035050 133 0.011
homeostatic process GO:0042592 142 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
Mouse
regulation of stem cell proliferation GO:0072091 2 0.011
regulation of oxidative stress induced cell death GO:1903201 2 0.011
synaptic growth at neuromuscular junction GO:0051124 2 0.011
cilium movement GO:0003341 26 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.011
striated muscle cell development GO:0055002 108 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
regulation of protein complex assembly GO:0043254 3 0.010
neural retina development GO:0003407 49 0.010
toll like receptor signaling pathway GO:0002224 4 0.010
regulation of cellular metabolic process GO:0031323 320 0.010
small gtpase mediated signal transduction GO:0007264 8 0.010
pigment granule transport GO:0051904 19 0.010
negative regulation of biosynthetic process GO:0009890 55 0.010
Human
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.010
synaptic target recognition GO:0008039 1 0.010
production of molecular mediator of immune response GO:0002440 2 0.010
negative regulation of multi organism process GO:0043901 3 0.010
response to stress GO:0006950 263 0.010
liver development GO:0001889 96 0.010
regulation of system process GO:0044057 40 0.010
macromolecule modification GO:0043412 111 0.010
positive regulation of cell cycle GO:0045787 3 0.010
caudal fin morphogenesis GO:0035143 7 0.010
intracellular signal transduction GO:0035556 85 0.010
carbohydrate homeostasis GO:0033500 1 0.010
dopamine metabolic process GO:0042417 2 0.010
cardiac muscle cell development GO:0055013 20 0.010
enzyme linked receptor protein signaling pathway GO:0007167 106 0.010
mesenchymal cell differentiation GO:0048762 87 0.010
rna localization GO:0006403 4 0.010
positive regulation of cell adhesion GO:0045785 1 0.010

mitfb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
immune system disease DOID:2914 0 0.023
musculoskeletal system disease DOID:17 0 0.017
connective tissue disease DOID:65 0 0.017
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.013
organ system cancer DOID:0050686 0 0.013
nervous system disease DOID:863 0 0.012