Danio rerio

28 known processes

atp6ap1

ATPase, H+ transporting, lysosomal accessory protein 1

(Aliases: MGC103523,wu:fb33b05,bbl,zgc:103523,etID36826.23,fb33b05,atp6s1)

atp6ap1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response to bacterium GO:0042742 22 0.884
melanosome organization GO:0032438 4 0.882
larval development GO:0002164 2 0.845
Worm
lipid storage GO:0019915 1 0.808
pigment granule organization GO:0048753 4 0.799
cellular pigmentation GO:0033059 30 0.738
pigmentation GO:0043473 85 0.610
response to bacterium GO:0009617 58 0.560
eye pigmentation GO:0048069 4 0.556
retinal pigment epithelium development GO:0003406 8 0.451
cardiac conduction GO:0061337 3 0.380
rna transport GO:0050658 2 0.379
transport GO:0006810 220 0.373
Mouse Worm
maintenance of location GO:0051235 4 0.355
response to external stimulus GO:0009605 264 0.308
tube morphogenesis GO:0035239 349 0.287
regulation of cell communication GO:0010646 232 0.275
Mouse
eye development GO:0001654 277 0.264
organelle organization GO:0006996 227 0.252
camera type eye development GO:0043010 222 0.250
notochord cell development GO:0060035 9 0.246
regulation of autophagy GO:0010506 3 0.216
defense response to gram negative bacterium GO:0050829 8 0.200
aging GO:0007568 2 0.195
cellular protein catabolic process GO:0044257 4 0.193
sensory organ development GO:0007423 393 0.189
defense response to other organism GO:0098542 33 0.185
notochord cell vacuolation GO:0060036 7 0.183
cellular amine metabolic process GO:0044106 2 0.182
endosomal transport GO:0016197 2 0.152
developmental process involved in reproduction GO:0003006 27 0.147
cilium morphogenesis GO:0060271 85 0.146
regulation of cell shape GO:0008360 1 0.145
vesicle organization GO:0016050 6 0.138
response to nutrient GO:0007584 3 0.137
amine metabolic process GO:0009308 2 0.131
single organism organelle organization GO:1902589 199 0.128
nucleic acid transport GO:0050657 2 0.124
cell projection morphogenesis GO:0048858 244 0.122
epithelial tube morphogenesis GO:0060562 148 0.117
morphogenesis of an epithelium GO:0002009 333 0.111
response to biotic stimulus GO:0009607 97 0.109
autophagy GO:0006914 4 0.107
actin filament based movement GO:0030048 1 0.107
organophosphate metabolic process GO:0019637 37 0.106
ganglioside metabolic process GO:0001573 3 0.104
vacuole organization GO:0007033 9 0.103
organonitrogen compound metabolic process GO:1901564 74 0.100
cation transport GO:0006812 81 0.099
cellular amino acid metabolic process GO:0006520 7 0.095
cell projection assembly GO:0030031 64 0.094
pronephros development GO:0048793 69 0.094
response to external biotic stimulus GO:0043207 97 0.093
negative regulation of protein import into nucleus GO:0042308 2 0.088
embryonic heart tube morphogenesis GO:0003143 108 0.084
response to stress GO:0006950 263 0.083
determination of bilateral symmetry GO:0009855 204 0.083
regulation of biological quality GO:0065008 263 0.082
Mouse
glycoprotein metabolic process GO:0009100 23 0.082
purine nucleoside monophosphate catabolic process GO:0009128 4 0.080
cilium assembly GO:0042384 58 0.079
response to abiotic stimulus GO:0009628 122 0.079
regulation of metabolic process GO:0019222 359 0.077
Mouse
macromolecule localization GO:0033036 54 0.076
negative regulation of epithelial cell proliferation GO:0050680 1 0.073
locomotion GO:0040011 313 0.072
regulation of cellular amine metabolic process GO:0033238 0 0.070
cellular response to nutrient levels GO:0031669 2 0.070
lipid catabolic process GO:0016042 4 0.070
establishment of localization GO:0051234 244 0.067
Mouse Worm
determination of left right symmetry GO:0007368 179 0.065
cellular response to external stimulus GO:0071496 2 0.064
multi organism process GO:0051704 134 0.064
ribonucleotide metabolic process GO:0009259 27 0.062
determination of heart left right asymmetry GO:0061371 117 0.059
regulation of cardiac muscle cell contraction GO:0086004 1 0.059
guanosine containing compound catabolic process GO:1901069 2 0.058
cellular localization GO:0051641 97 0.058
Mouse
response to transition metal nanoparticle GO:1990267 28 0.057
pigment cell differentiation GO:0050931 38 0.056
phosphate containing compound metabolic process GO:0006796 108 0.055
Mouse
embryonic heart tube development GO:0035050 133 0.055
phagocytosis GO:0006909 3 0.054
regulation of signaling GO:0023051 235 0.054
Mouse
gtp metabolic process GO:0046039 4 0.053
retina development in camera type eye GO:0060041 146 0.052
response to chemical GO:0042221 320 0.052
cell morphogenesis GO:0000902 289 0.051
embryonic organ morphogenesis GO:0048562 274 0.050
gamete generation GO:0007276 33 0.049
defense response to gram positive bacterium GO:0050830 6 0.049
actin mediated cell contraction GO:0070252 1 0.049
cellular response to starvation GO:0009267 1 0.048
embryonic organ development GO:0048568 381 0.047
establishment of protein localization to organelle GO:0072594 4 0.047
response to copper ion GO:0046688 13 0.047
lateral line system development GO:0048925 76 0.047
regulation of gene expression GO:0010468 265 0.047
carbohydrate derivative metabolic process GO:1901135 61 0.045
epithelial cell differentiation GO:0030855 116 0.045
regulation of establishment of protein localization GO:0070201 4 0.045
heart looping GO:0001947 94 0.045
cellular component morphogenesis GO:0032989 336 0.045
neuron projection morphogenesis GO:0048812 161 0.044
modification dependent protein catabolic process GO:0019941 3 0.044
cell part morphogenesis GO:0032990 246 0.044
activation of mapkkk activity GO:0000185 1 0.043
regulation of actin filament based movement GO:1903115 1 0.043
nuclear transport GO:0051169 4 0.043
protein metabolic process GO:0019538 183 0.042
sialylation GO:0097503 4 0.042
protein targeting to nucleus GO:0044744 3 0.042
reproduction GO:0000003 40 0.041
Worm
regulation of developmental process GO:0050793 247 0.041
Mouse
single organism transport GO:0044765 206 0.041
Mouse
nucleoside monophosphate catabolic process GO:0009125 4 0.041
notochord development GO:0030903 54 0.041
response to glucose GO:0009749 3 0.040
inorganic cation transmembrane transport GO:0098662 50 0.039
regulation of protein metabolic process GO:0051246 56 0.039
inorganic ion transmembrane transport GO:0098660 57 0.039
regulation of myelination GO:0031641 1 0.038
nucleotide metabolic process GO:0009117 28 0.038
specification of symmetry GO:0009799 204 0.038
protein localization to plasma membrane GO:0072659 1 0.037
cellular macromolecule metabolic process GO:0044260 391 0.037
transmission of nerve impulse GO:0019226 19 0.037
heart morphogenesis GO:0003007 156 0.037
organic cyclic compound metabolic process GO:1901360 301 0.036
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.036
regulation of epithelial cell proliferation GO:0050678 3 0.035
peptide metabolic process GO:0006518 1 0.034
multicellular organismal signaling GO:0035637 22 0.034
establishment of protein localization to plasma membrane GO:0090002 1 0.034
protein localization GO:0008104 40 0.034
cell projection organization GO:0030030 284 0.034
action potential GO:0001508 19 0.034
regulation of organelle assembly GO:1902115 4 0.033
digestive system development GO:0055123 289 0.032
female gamete generation GO:0007292 14 0.032
system process GO:0003008 185 0.032
endocytosis GO:0006897 16 0.032
Worm
negative regulation of protein phosphorylation GO:0001933 4 0.031
vacuolar transport GO:0007034 2 0.031
cellular nitrogen compound metabolic process GO:0034641 290 0.031
morphogenesis of an epithelial fold GO:0060571 1 0.031
cardiac muscle cell contraction GO:0086003 1 0.031
germ cell development GO:0007281 22 0.031
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.030
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.030
cellular catabolic process GO:0044248 27 0.030
positive regulation of secretion by cell GO:1903532 1 0.030
Mouse
urogenital system development GO:0001655 97 0.029
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.029
positive regulation of transport GO:0051050 2 0.029
Mouse
regulation of multicellular organism growth GO:0040014 4 0.029
fatty acid transport GO:0015908 1 0.029
transmembrane transport GO:0055085 120 0.029
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
ubiquitin dependent protein catabolic process GO:0006511 3 0.028
positive regulation of cell cycle GO:0045787 3 0.028
cellular response to extracellular stimulus GO:0031668 2 0.028
epithelial cell proliferation involved in liver morphogenesis GO:0072575 2 0.028
meiotic cell cycle process GO:1903046 3 0.028
protein modification process GO:0036211 100 0.027
signal transduction GO:0007165 455 0.027
Mouse
cytokinesis GO:0000910 3 0.027
protein import GO:0017038 3 0.027
regulation of cellular ph GO:0030641 1 0.027
regulation of notch signaling pathway GO:0008593 16 0.027
positive regulation of cellular amine metabolic process GO:0033240 0 0.026
sensory system development GO:0048880 76 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.026
nucleoside phosphate metabolic process GO:0006753 28 0.026
wnt signaling pathway GO:0016055 80 0.025
response to organic substance GO:0010033 153 0.025
intrahepatic bile duct development GO:0035622 11 0.025
synaptic growth at neuromuscular junction GO:0051124 2 0.025
purine ribonucleotide metabolic process GO:0009150 27 0.025
swim bladder maturation GO:0048796 5 0.025
cation transmembrane transport GO:0098655 65 0.025
neuromast development GO:0048884 46 0.025
renal system development GO:0072001 94 0.024
response to carbohydrate GO:0009743 3 0.024
sensory organ morphogenesis GO:0090596 200 0.024
generation of neurons GO:0048699 385 0.024
positive regulation of catabolic process GO:0009896 4 0.024
negative regulation of protein transport GO:0051224 3 0.024
cellular component movement GO:0006928 335 0.024
neuronal action potential GO:0019228 18 0.024
gene expression GO:0010467 252 0.024
carboxylic acid metabolic process GO:0019752 22 0.024
cellular component assembly GO:0022607 170 0.024
cilium organization GO:0044782 71 0.023
response to other organism GO:0051707 97 0.023
rna localization GO:0006403 4 0.023
phagocytosis engulfment GO:0006911 1 0.023
nucleocytoplasmic transport GO:0006913 4 0.023
negative regulation of intracellular protein transport GO:0090317 3 0.023
establishment of rna localization GO:0051236 3 0.023
response to monosaccharide GO:0034284 3 0.023
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.023
regulation of striated muscle contraction GO:0006942 2 0.023
cellular protein metabolic process GO:0044267 129 0.023
regulation of cardiac muscle contraction GO:0055117 2 0.023
muscle structure development GO:0061061 196 0.022
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.022
eye morphogenesis GO:0048592 144 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.022
tissue homeostasis GO:0001894 25 0.022
Mouse
lytic vacuole organization GO:0080171 1 0.022
lysosomal transport GO:0007041 2 0.021
regulation of gtpase activity GO:0043087 2 0.021
cellular amide metabolic process GO:0043603 4 0.021
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.021
atp catabolic process GO:0006200 4 0.021
multi organism reproductive process GO:0044703 36 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.021
glial cell differentiation GO:0010001 42 0.021
heart development GO:0007507 313 0.020
protein localization to nucleus GO:0034504 3 0.020
regulation of response to stimulus GO:0048583 269 0.020
Mouse
immune system process GO:0002376 241 0.020
Mouse
negative regulation of autophagy GO:0010507 1 0.020
response to vitamin b3 GO:0033552 2 0.020
cell migration GO:0016477 237 0.020
regulation of cytokine production GO:0001817 3 0.020
regulation of ph GO:0006885 3 0.020
Mouse
oxoacid metabolic process GO:0043436 31 0.020
neuron differentiation GO:0030182 353 0.019
fertilization GO:0009566 3 0.019
embryonic limb morphogenesis GO:0030326 2 0.019
regulation of neutrophil extravasation GO:2000389 1 0.019
response to metal ion GO:0010038 34 0.019
regulation of metal ion transport GO:0010959 4 0.019
localization within membrane GO:0051668 1 0.019
cellular amino acid biosynthetic process GO:0008652 2 0.019
positive regulation of cell activation GO:0050867 1 0.019
modification dependent macromolecule catabolic process GO:0043632 3 0.019
defense response GO:0006952 47 0.019
spermatid differentiation GO:0048515 2 0.019
regulation of gtp catabolic process GO:0033124 2 0.019
regulation of leukocyte migration GO:0002685 8 0.019
single organism reproductive process GO:0044702 40 0.019
cellular protein localization GO:0034613 20 0.019
sulfur compound biosynthetic process GO:0044272 9 0.019
vesicle mediated transport GO:0016192 22 0.018
Mouse Worm
mechanosensory lateral line system development GO:0048881 49 0.018
glycerol transport GO:0015793 7 0.018
regulation of hormone secretion GO:0046883 2 0.018
regulation of cell morphogenesis GO:0022604 42 0.018
protein import into nucleus GO:0006606 3 0.018
death GO:0016265 121 0.018
Worm
negative regulation of cytoplasmic transport GO:1903650 2 0.018
cognition GO:0050890 1 0.018
carbohydrate homeostasis GO:0033500 1 0.018
notch signaling pathway GO:0007219 35 0.018
response to hexose GO:0009746 3 0.018
blood circulation GO:0008015 87 0.018
macromolecule glycosylation GO:0043413 9 0.018
response to xenobiotic stimulus GO:0009410 45 0.018
regulation of protein import into nucleus GO:0042306 2 0.017
homeostatic process GO:0042592 142 0.017
Mouse
epidermis morphogenesis GO:0048730 4 0.017
regulation of binding GO:0051098 3 0.017
adult behavior GO:0030534 2 0.017
multicellular organism growth GO:0035264 4 0.017
establishment of synaptic vesicle localization GO:0097480 1 0.016
multicellular organismal homeostasis GO:0048871 29 0.016
Mouse
gtp catabolic process GO:0006184 2 0.016
regulation of phosphate metabolic process GO:0019220 43 0.016
Mouse
regulation of catalytic activity GO:0050790 55 0.016
positive regulation of secretion GO:0051047 1 0.016
Mouse
smooth muscle contraction GO:0006939 2 0.016
regulation of cellular component organization GO:0051128 86 0.016
apical junction assembly GO:0043297 1 0.016
secondary metabolic process GO:0019748 3 0.016
negative regulation of metabolic process GO:0009892 86 0.016
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
nucleobase containing compound metabolic process GO:0006139 274 0.016
regulation of dendrite morphogenesis GO:0048814 3 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
protein acylation GO:0043543 3 0.016
myeloid leukocyte mediated immunity GO:0002444 1 0.016
multicellular organism reproduction GO:0032504 35 0.015
response to vitamin GO:0033273 3 0.015
embryo development ending in birth or egg hatching GO:0009792 271 0.015
purine ribonucleoside metabolic process GO:0046128 10 0.015
positive regulation of cellular metabolic process GO:0031325 94 0.015
Mouse
purine containing compound metabolic process GO:0072521 29 0.015
regulation of membrane potential GO:0042391 23 0.015
negative regulation of cellular process GO:0048523 283 0.015
nucleobase containing small molecule metabolic process GO:0055086 32 0.015
sympathetic nervous system development GO:0048485 3 0.015
neurotransmitter secretion GO:0007269 2 0.015
chemical homeostasis GO:0048878 49 0.015
Mouse
brain development GO:0007420 293 0.015
cell aging GO:0007569 2 0.015
regulation of dendrite development GO:0050773 3 0.015
guanosine containing compound metabolic process GO:1901068 4 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
endosome to lysosome transport GO:0008333 1 0.014
ion transmembrane transport GO:0034220 91 0.014
regulation of cell activation GO:0050865 1 0.014
regulation of response to extracellular stimulus GO:0032104 1 0.014
neurotransmitter transport GO:0006836 2 0.014
camera type eye morphogenesis GO:0048593 108 0.014
cellular cation homeostasis GO:0030003 17 0.014
regulation of ion transmembrane transport GO:0034765 18 0.014
kidney development GO:0001822 92 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
response to yeast GO:0001878 23 0.014
cellular biosynthetic process GO:0044249 286 0.014
response to extracellular stimulus GO:0009991 10 0.014
organic substance transport GO:0071702 58 0.014
type i interferon production GO:0032606 2 0.013
single organism intracellular transport GO:1902582 25 0.013
regulation of synapse organization GO:0050807 3 0.013
hair cell differentiation GO:0035315 32 0.013
regulation of epidermis development GO:0045682 2 0.013
protein targeting to vacuole GO:0006623 1 0.013
body morphogenesis GO:0010171 16 0.013
neuron development GO:0048666 262 0.013
response to light stimulus GO:0009416 46 0.013
digestive tract development GO:0048565 265 0.013
digestive tract morphogenesis GO:0048546 231 0.013
negative regulation of biological process GO:0048519 304 0.013
sexual reproduction GO:0019953 36 0.013
phosphorus metabolic process GO:0006793 109 0.013
Mouse
peptide transport GO:0015833 1 0.013
negative regulation of signaling GO:0023057 96 0.013
regulation of muscle contraction GO:0006937 3 0.013
regulation of signal transduction GO:0009966 225 0.013
Mouse
regulation of nucleotide catabolic process GO:0030811 2 0.013
nucleobase containing compound transport GO:0015931 2 0.013
developmental pigmentation GO:0048066 48 0.013
regulation of chromosome segregation GO:0051983 1 0.013
response to wounding GO:0009611 116 0.013
catabolic process GO:0009056 32 0.013
negative regulation of gene expression GO:0010629 65 0.013
central nervous system development GO:0007417 387 0.012
regulation of anatomical structure morphogenesis GO:0022603 130 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
skin development GO:0043588 54 0.012
ion homeostasis GO:0050801 41 0.012
Mouse
regulation of protein targeting GO:1903533 2 0.012
single organism carbohydrate metabolic process GO:0044723 12 0.012
oogenesis GO:0048477 14 0.012
ribose phosphate metabolic process GO:0019693 27 0.012
response to inorganic substance GO:0010035 38 0.012
chordate embryonic development GO:0043009 271 0.012
heterocycle metabolic process GO:0046483 290 0.012
aromatic compound catabolic process GO:0019439 15 0.012
cation homeostasis GO:0055080 33 0.012
Mouse
anatomical structure homeostasis GO:0060249 36 0.012
Mouse
neural retina development GO:0003407 49 0.011
organelle assembly GO:0070925 110 0.011
purine ribonucleoside biosynthetic process GO:0046129 2 0.011
organic acid metabolic process GO:0006082 31 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
protein phosphorylation GO:0006468 47 0.011
negative regulation of defense response GO:0031348 2 0.011
cellular component biogenesis GO:0044085 178 0.011
proteasomal protein catabolic process GO:0010498 2 0.011
neuroblast proliferation GO:0007405 2 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
positive regulation of wound healing GO:0090303 1 0.011
positive regulation of biological process GO:0048518 253 0.011
Mouse
rrna catabolic process GO:0016075 1 0.011
sphingolipid biosynthetic process GO:0030148 2 0.011
oxidoreduction coenzyme metabolic process GO:0006733 1 0.011
renal absorption GO:0070293 1 0.011
intracellular receptor signaling pathway GO:0030522 30 0.011
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.011
regulation of protein transport GO:0051223 3 0.011
heart contraction GO:0060047 71 0.011
regulation of establishment or maintenance of cell polarity GO:0032878 2 0.011
positive regulation of leukocyte migration GO:0002687 2 0.011
response to glucocorticoid GO:0051384 1 0.010
programmed cell death GO:0012501 119 0.010
Worm
axon development GO:0061564 166 0.010
regulation of nucleocytoplasmic transport GO:0046822 2 0.010
schwann cell differentiation GO:0014037 9 0.010
multicellular organismal water homeostasis GO:0050891 1 0.010
response to nutrient levels GO:0031667 10 0.010
long chain fatty acid transport GO:0015909 1 0.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.010
cellular homeostasis GO:0019725 26 0.010
head development GO:0060322 303 0.010
regulation of establishment of planar polarity GO:0090175 4 0.010
sequestering of metal ion GO:0051238 3 0.010
cellular response to unfolded protein GO:0034620 2 0.010
neuroblast differentiation GO:0014016 1 0.010
chloride transmembrane transport GO:1902476 4 0.010
single organism nuclear import GO:1902593 3 0.010
wound healing GO:0042060 90 0.010
positive regulation of notch signaling pathway GO:0045747 3 0.010
mitochondrion organization GO:0007005 4 0.010
neuron projection development GO:0031175 180 0.010
regulation of cellular ketone metabolic process GO:0010565 7 0.010
positive regulation of gtp catabolic process GO:0033126 1 0.010

atp6ap1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.062
musculoskeletal system disease DOID:17 0 0.025
integumentary system disease DOID:16 0 0.023
muscular disease DOID:0080000 0 0.023
muscle tissue disease DOID:66 0 0.023
myopathy DOID:423 0 0.022
disease of cellular proliferation DOID:14566 0 0.020
neuromuscular disease DOID:440 0 0.015
charcot marie tooth disease DOID:10595 0 0.015
nervous system disease DOID:863 0 0.015
neuropathy DOID:870 0 0.015
breast cancer DOID:1612 0 0.014
thoracic cancer DOID:5093 0 0.014
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.014
central nervous system disease DOID:331 0 0.014
brain disease DOID:936 0 0.014
endocrine gland cancer DOID:170 0 0.013
disease of metabolism DOID:0014667 0 0.013
lipid storage disease DOID:9455 0 0.013
lysosomal storage disease DOID:3211 0 0.013
inherited metabolic disorder DOID:655 0 0.013
colon carcinoma DOID:1520 0 0.011
large intestine cancer DOID:5672 0 0.011
colon cancer DOID:219 0 0.011
gastrointestinal system cancer DOID:3119 0 0.011
intestinal cancer DOID:10155 0 0.011
colorectal cancer DOID:9256 0 0.011
cell type cancer DOID:0050687 0 0.010