Danio rerio

0 known processes

styx

serine/threonine/tyrosine interacting protein

(Aliases: im:6908851,si:dkey-119m7.5,zgc:110621)

styx biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.081
cellular protein catabolic process GO:0044257 4 0.054
modification dependent protein catabolic process GO:0019941 3 0.045
nitrogen compound metabolic process GO:0006807 319 0.043
aging GO:0007568 2 0.043
ubiquitin dependent protein catabolic process GO:0006511 3 0.043
maintenance of location GO:0051235 4 0.043
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.041
organic substance biosynthetic process GO:1901576 289 0.041
modification dependent macromolecule catabolic process GO:0043632 3 0.040
organic cyclic compound metabolic process GO:1901360 301 0.039
signal transduction GO:0007165 455 0.038
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.038
multicellular organism growth GO:0035264 4 0.038
proteasomal protein catabolic process GO:0010498 2 0.038
nucleobase containing compound metabolic process GO:0006139 274 0.038
establishment of protein localization to organelle GO:0072594 4 0.038
cellular nitrogen compound metabolic process GO:0034641 290 0.037
cellular macromolecule metabolic process GO:0044260 391 0.037
organic cyclic compound biosynthetic process GO:1901362 223 0.036
positive regulation of transport GO:0051050 2 0.035
regulation of metabolic process GO:0019222 359 0.034
nuclear transport GO:0051169 4 0.034
regulation of multicellular organism growth GO:0040014 4 0.033
nucleic acid metabolic process GO:0090304 244 0.033
cellular biosynthetic process GO:0044249 286 0.032
regulation of gene expression GO:0010468 265 0.032
rna metabolic process GO:0016070 219 0.031
gene expression GO:0010467 252 0.031
heterocycle metabolic process GO:0046483 290 0.031
aromatic compound biosynthetic process GO:0019438 217 0.031
regulation of biosynthetic process GO:0009889 250 0.031
cellular aromatic compound metabolic process GO:0006725 295 0.031
response to stress GO:0006950 263 0.030
regulation of establishment of protein localization GO:0070201 4 0.029
biosynthetic process GO:0009058 294 0.029
cellular nitrogen compound biosynthetic process GO:0044271 218 0.029
nucleocytoplasmic transport GO:0006913 4 0.029
phagocytosis GO:0006909 3 0.029
regulation of protein transport GO:0051223 3 0.029
amine metabolic process GO:0009308 2 0.029
meiotic nuclear division GO:0007126 4 0.029
lipid storage GO:0019915 1 0.028
mitochondrion organization GO:0007005 4 0.028
macromolecule biosynthetic process GO:0009059 227 0.028
stem cell maintenance GO:0019827 4 0.028
response to drug GO:0042493 3 0.028
cellular macromolecule biosynthetic process GO:0034645 224 0.028
regulation of cytokine production GO:0001817 3 0.028
regulation of protein complex assembly GO:0043254 3 0.028
regulation of primary metabolic process GO:0080090 311 0.027
protein localization to nucleus GO:0034504 3 0.027
regulation of nitrogen compound metabolic process GO:0051171 251 0.027
single organism membrane fusion GO:0044801 2 0.027
heterocycle biosynthetic process GO:0018130 215 0.027
positive regulation of cell cycle GO:0045787 3 0.027
cellular amine metabolic process GO:0044106 2 0.026
negative regulation of biological process GO:0048519 304 0.026
nucleic acid templated transcription GO:0097659 181 0.026
regulation of rna metabolic process GO:0051252 224 0.026
regulation of protein catabolic process GO:0042176 1 0.026
membrane fusion GO:0061025 2 0.026
autophagy GO:0006914 4 0.026
regulation of macromolecule metabolic process GO:0060255 317 0.026
immune system process GO:0002376 241 0.026
regulation of cellular biosynthetic process GO:0031326 245 0.026
cell surface receptor signaling pathway GO:0007166 325 0.026
regulation of cellular metabolic process GO:0031323 320 0.026
regulation of protein localization to nucleus GO:1900180 2 0.026
organelle fusion GO:0048284 3 0.026
rna biosynthetic process GO:0032774 181 0.025
protein import GO:0017038 3 0.025
positive regulation of catabolic process GO:0009896 4 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
regulation of nucleocytoplasmic transport GO:0046822 2 0.025
nucleobase containing compound biosynthetic process GO:0034654 205 0.025
protein import into nucleus GO:0006606 3 0.024
positive regulation of cellular component biogenesis GO:0044089 3 0.024
transcription dna templated GO:0006351 181 0.024
single organism metabolic process GO:0044710 217 0.024
single organism nuclear import GO:1902593 3 0.023
rna localization GO:0006403 4 0.023
regulation of cell activation GO:0050865 1 0.023
endosomal transport GO:0016197 2 0.023
regulation of cell shape GO:0008360 1 0.023
cellular ketone metabolic process GO:0042180 11 0.023
cytokinesis GO:0000910 3 0.023
regulation of protein import into nucleus GO:0042306 2 0.023
regulation of mrna processing GO:0050684 3 0.023
regulation of macromolecule biosynthetic process GO:0010556 225 0.022
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.022
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.022
regulation of cellular amine metabolic process GO:0033238 0 0.022
positive regulation of cellular process GO:0048522 201 0.022
cellular response to external stimulus GO:0071496 2 0.022
response to chemical GO:0042221 320 0.021
regulation of mrna splicing via spliceosome GO:0048024 3 0.021
cell cycle g1 s phase transition GO:0044843 1 0.021
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.021
nuclear import GO:0051170 3 0.021
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.021
regulation of intracellular protein transport GO:0033157 3 0.021
regulation of meiotic cell cycle GO:0051445 1 0.021
organelle organization GO:0006996 227 0.021
protein acetylation GO:0006473 2 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
sensory organ development GO:0007423 393 0.021
guanosine containing compound metabolic process GO:1901068 4 0.021
organonitrogen compound metabolic process GO:1901564 74 0.020
meiotic cell cycle process GO:1903046 3 0.020
negative regulation of cellular process GO:0048523 283 0.020
regulation of multicellular organismal process GO:0051239 277 0.020
protein localization to plasma membrane GO:0072659 1 0.020
regulation of transcription dna templated GO:0006355 213 0.020
regulation of nucleic acid templated transcription GO:1903506 213 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
positive regulation of translation GO:0045727 1 0.020
ribonucleoside monophosphate catabolic process GO:0009158 4 0.020
regulation of cell communication GO:0010646 232 0.020
small molecule metabolic process GO:0044281 77 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
establishment of localization GO:0051234 244 0.020
peptidyl lysine acetylation GO:0018394 2 0.020
g1 s transition of mitotic cell cycle GO:0000082 1 0.019
internal protein amino acid acetylation GO:0006475 2 0.019
cellular response to biotic stimulus GO:0071216 3 0.019
phagocytosis engulfment GO:0006911 1 0.019
cellular component disassembly GO:0022411 1 0.019
protein targeting to nucleus GO:0044744 3 0.019
leukocyte proliferation GO:0070661 1 0.019
protein metabolic process GO:0019538 183 0.019
cellular response to lipopolysaccharide GO:0071222 3 0.019
positive regulation of protein complex assembly GO:0031334 2 0.019
regulation of protein ubiquitination GO:0031396 3 0.019
regulation of signal transduction GO:0009966 225 0.019
protein polymerization GO:0051258 4 0.019
regulation of binding GO:0051098 3 0.019
protein acylation GO:0043543 3 0.019
regulation of protein targeting GO:1903533 2 0.019
regulation of signaling GO:0023051 235 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
cellular response to extracellular stimulus GO:0031668 2 0.019
transport GO:0006810 220 0.019
internal peptidyl lysine acetylation GO:0018393 2 0.019
regulation of rna biosynthetic process GO:2001141 213 0.018
cellular response to nutrient levels GO:0031669 2 0.018
gtp metabolic process GO:0046039 4 0.018
positive regulation of cytokine production GO:0001819 2 0.018
membrane invagination GO:0010324 1 0.018
gtp catabolic process GO:0006184 2 0.018
cellular protein metabolic process GO:0044267 129 0.018
negative regulation of catabolic process GO:0009895 3 0.018
nucleoside monophosphate catabolic process GO:0009125 4 0.018
response to uv GO:0009411 3 0.018
regulation of response to stimulus GO:0048583 269 0.018
production of molecular mediator of immune response GO:0002440 2 0.018
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.018
single organism organelle organization GO:1902589 199 0.018
eye development GO:0001654 277 0.018
positive regulation of cellular catabolic process GO:0031331 3 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
guanosine containing compound catabolic process GO:1901069 2 0.018
response to topologically incorrect protein GO:0035966 2 0.018
cellular response to chemical stimulus GO:0070887 157 0.017
i kappab kinase nf kappab signaling GO:0007249 4 0.017
positive regulation of biological process GO:0048518 253 0.017
mononuclear cell proliferation GO:0032943 1 0.017
protein secretion GO:0009306 1 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
cellular response to molecule of bacterial origin GO:0071219 3 0.017
development of primary female sexual characteristics GO:0046545 4 0.017
oxoacid metabolic process GO:0043436 31 0.017
regulation of erk1 and erk2 cascade GO:0070372 4 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.017
b cell activation GO:0042113 2 0.017
regulation of synapse organization GO:0050807 3 0.017
positive regulation of cell activation GO:0050867 1 0.017
cellular component biogenesis GO:0044085 178 0.017
organic acid metabolic process GO:0006082 31 0.017
erk1 and erk2 cascade GO:0070371 4 0.016
protein dephosphorylation GO:0006470 3 0.016
protein polyubiquitination GO:0000209 4 0.016
cellular response to starvation GO:0009267 1 0.016
regulation of neural precursor cell proliferation GO:2000177 3 0.016
central nervous system development GO:0007417 387 0.016
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.016
positive regulation of cell adhesion GO:0045785 1 0.016
actin filament polymerization GO:0030041 2 0.016
cellular component assembly GO:0022607 170 0.016
positive regulation of secretion GO:0051047 1 0.016
cellular respiration GO:0045333 3 0.016
meiotic chromosome segregation GO:0045132 3 0.016
regulation of autophagy GO:0010506 3 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
regulation of biological quality GO:0065008 263 0.016
cognition GO:0050890 1 0.016
locomotion GO:0040011 313 0.016
cytoskeleton dependent cytokinesis GO:0061640 3 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.016
golgi vesicle transport GO:0048193 3 0.016
tissue remodeling GO:0048771 4 0.016
positive regulation of immune effector process GO:0002699 3 0.015
spermatid development GO:0007286 2 0.015
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.015
cellular component morphogenesis GO:0032989 336 0.015
response to external stimulus GO:0009605 264 0.015
spindle assembly GO:0051225 2 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
negative regulation of kinase activity GO:0033673 4 0.015
regulation of reproductive process GO:2000241 4 0.015
locomotor rhythm GO:0045475 3 0.015
intracellular signal transduction GO:0035556 85 0.015
mitochondrial transport GO:0006839 2 0.015
atp catabolic process GO:0006200 4 0.015
hemopoiesis GO:0030097 183 0.015
microtubule organizing center organization GO:0031023 1 0.015
synaptic growth at neuromuscular junction GO:0051124 2 0.015
positive regulation of cytoskeleton organization GO:0051495 3 0.015
positive regulation of stress activated mapk cascade GO:0032874 3 0.015
camera type eye development GO:0043010 222 0.015
localization of cell GO:0051674 244 0.015
macromolecule modification GO:0043412 111 0.015
cellular component movement GO:0006928 335 0.015
dna templated transcription elongation GO:0006354 3 0.015
purine nucleoside monophosphate catabolic process GO:0009128 4 0.015
lymphocyte proliferation GO:0046651 1 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
immune system development GO:0002520 191 0.015
regulation of cellular protein catabolic process GO:1903362 1 0.015
antimicrobial humoral response GO:0019730 2 0.015
peptide transport GO:0015833 1 0.015
rna modification GO:0009451 2 0.014
protein complex disassembly GO:0043241 1 0.014
regulation of circadian rhythm GO:0042752 4 0.014
interspecies interaction between organisms GO:0044419 4 0.014
regulation of multicellular organismal development GO:2000026 223 0.014
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.014
centrosome organization GO:0051297 1 0.014
cellular amide metabolic process GO:0043603 4 0.014
adult behavior GO:0030534 2 0.014
negative regulation of protein transport GO:0051224 3 0.014
regulation of protein polymerization GO:0032271 2 0.014
cell migration GO:0016477 237 0.014
single organism localization GO:1902578 225 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
regulation of synapse assembly GO:0051963 3 0.014
compound eye development GO:0048749 2 0.014
negative regulation of protein localization to nucleus GO:1900181 2 0.014
negative regulation of metabolic process GO:0009892 86 0.014
transcription from rna polymerase ii promoter GO:0006366 80 0.014
exocytosis GO:0006887 1 0.014
growth GO:0040007 174 0.014
macromolecular complex disassembly GO:0032984 1 0.014
digestive system development GO:0055123 289 0.014
protein stabilization GO:0050821 2 0.014
positive regulation of myeloid cell differentiation GO:0045639 2 0.014
spermatid differentiation GO:0048515 2 0.013
system process GO:0003008 185 0.013
cell part morphogenesis GO:0032990 246 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
cellular response to radiation GO:0071478 4 0.013
cell morphogenesis GO:0000902 289 0.013
protein modification process GO:0036211 100 0.013
secondary metabolic process GO:0019748 3 0.013
stem cell division GO:0017145 1 0.013
regulation of developmental process GO:0050793 247 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
regulation of production of molecular mediator of immune response GO:0002700 1 0.013
peptidyl serine modification GO:0018209 2 0.013
double strand break repair GO:0006302 3 0.013
female sex differentiation GO:0046660 4 0.013
vasculature development GO:0001944 278 0.013
cell matrix adhesion GO:0007160 4 0.013
neuron differentiation GO:0030182 353 0.013
multi organism cellular process GO:0044764 2 0.013
stem cell proliferation GO:0072089 4 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
cellular response to organic substance GO:0071310 105 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
positive regulation of apoptotic signaling pathway GO:2001235 1 0.013
cellular response to light stimulus GO:0071482 4 0.013
tube morphogenesis GO:0035239 349 0.013
specification of symmetry GO:0009799 204 0.013
regulation of inflammatory response GO:0050727 2 0.012
hematopoietic or lymphoid organ development GO:0048534 191 0.012
sequestering of calcium ion GO:0051208 3 0.012
regulation of dna templated transcription elongation GO:0032784 3 0.012
germ line stem cell maintenance GO:0030718 2 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
brain development GO:0007420 293 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
cell projection organization GO:0030030 284 0.012
mitotic dna damage checkpoint GO:0044773 4 0.012
single organism transport GO:0044765 206 0.012
centrosome cycle GO:0007098 1 0.012
regulation of nucleoside metabolic process GO:0009118 2 0.012
viral process GO:0016032 1 0.012
somatic stem cell maintenance GO:0035019 1 0.012
positive regulation of jnk cascade GO:0046330 3 0.012
response to biotic stimulus GO:0009607 97 0.012
nucleobase containing compound transport GO:0015931 2 0.012
response to hexose GO:0009746 3 0.012
response to organic substance GO:0010033 153 0.012
negative regulation of sequestering of calcium ion GO:0051283 4 0.012
developmental growth GO:0048589 166 0.012
vacuolar transport GO:0007034 2 0.012
single fertilization GO:0007338 3 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.012
peptidyl serine phosphorylation GO:0018105 1 0.012
mitotic dna integrity checkpoint GO:0044774 4 0.012
response to external biotic stimulus GO:0043207 97 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
adherens junction organization GO:0034332 4 0.012
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.012
establishment of rna localization GO:0051236 3 0.012
regulation of stem cell proliferation GO:0072091 2 0.012
nuclear export GO:0051168 1 0.012
sequestering of metal ion GO:0051238 3 0.012
regulation of protein binding GO:0043393 3 0.012
actin polymerization or depolymerization GO:0008154 2 0.012
meiosis i GO:0007127 1 0.012
digestive tract morphogenesis GO:0048546 231 0.012
regulation of response to biotic stimulus GO:0002831 2 0.012
response to monosaccharide GO:0034284 3 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
regulation of blood pressure GO:0008217 1 0.011
alternative mrna splicing via spliceosome GO:0000380 1 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
response to carbohydrate GO:0009743 3 0.011
response to abiotic stimulus GO:0009628 122 0.011
embryonic organ development GO:0048568 381 0.011
digestive tract development GO:0048565 265 0.011
regulation of organ growth GO:0046620 3 0.011
lamellipodium assembly GO:0030032 1 0.011
rna export from nucleus GO:0006405 1 0.011
positive regulation of chromosome organization GO:2001252 1 0.011
negative regulation of nuclear division GO:0051784 3 0.011
signal transduction in absence of ligand GO:0038034 1 0.011
negative regulation of cytokine production GO:0001818 1 0.011
blood vessel development GO:0001568 246 0.011
response to hydrogen peroxide GO:0042542 3 0.011
carbohydrate homeostasis GO:0033500 1 0.011
neuroblast proliferation GO:0007405 2 0.011
response to corticosteroid GO:0031960 1 0.011
regulation of jak stat cascade GO:0046425 3 0.011
phosphorus metabolic process GO:0006793 109 0.011
retina development in camera type eye GO:0060041 146 0.011
glial cell migration GO:0008347 3 0.011
head development GO:0060322 303 0.011
neuron development GO:0048666 262 0.011
regulation of gtpase activity GO:0043087 2 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
regulation of organelle assembly GO:1902115 4 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
cell substrate adhesion GO:0031589 4 0.011
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.011
positive regulation of leukocyte differentiation GO:1902107 1 0.011
cellular response to topologically incorrect protein GO:0035967 2 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
negative regulation of defense response GO:0031348 2 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
positive regulation of multi organism process GO:0043902 3 0.011
positive regulation of gtp catabolic process GO:0033126 1 0.011
response to unfolded protein GO:0006986 2 0.011
cellular response to stress GO:0033554 62 0.011
positive regulation of metabolic process GO:0009893 108 0.011
lipid homeostasis GO:0055088 3 0.011
cortical cytoskeleton organization GO:0030865 1 0.011
fertilization GO:0009566 3 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.011
mitotic cytokinesis GO:0000281 3 0.011
cell projection morphogenesis GO:0048858 244 0.011
cellular protein modification process GO:0006464 100 0.011
cell cycle GO:0007049 93 0.011
forebrain cell migration GO:0021885 1 0.011
cell death GO:0008219 121 0.010
protein homooligomerization GO:0051260 3 0.010
negative regulation of multi organism process GO:0043901 3 0.010
response to nutrient GO:0007584 3 0.010
regulation of chromosome segregation GO:0051983 1 0.010
regulation of nucleotide catabolic process GO:0030811 2 0.010
developmental programmed cell death GO:0010623 4 0.010
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
negative regulation of macromolecule metabolic process GO:0010605 76 0.010
heart development GO:0007507 313 0.010
gastrulation GO:0007369 208 0.010
regionalization GO:0003002 274 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
nucleic acid transport GO:0050657 2 0.010
phosphate containing compound metabolic process GO:0006796 108 0.010
regulation of cell projection assembly GO:0060491 4 0.010
organelle assembly GO:0070925 110 0.010
cytokinetic process GO:0032506 2 0.010
female gonad development GO:0008585 4 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.010
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.010
negative regulation of intracellular transport GO:0032387 3 0.010
mitotic g2 m transition checkpoint GO:0044818 3 0.010
regulation of programmed cell death GO:0043067 101 0.010
positive regulation of chromatin modification GO:1903310 1 0.010
chemosensory behavior GO:0007635 1 0.010

styx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
nervous system disease DOID:863 0 0.025
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.015
disease of metabolism DOID:0014667 0 0.014
inherited metabolic disorder DOID:655 0 0.014
musculoskeletal system disease DOID:17 0 0.014
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013
eye disease DOID:5614 0 0.011