Danio rerio

0 known processes

smc4

structural maintenance of chromosomes 4

(Aliases: fb99b10,smc4l1,cb788,wu:fb99b10,chunp6901)

smc4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of nuclear division GO:0051784 3 0.941
meiotic nuclear division GO:0007126 4 0.726
Mouse
larval development GO:0002164 2 0.723
Worm
sister chromatid segregation GO:0000819 6 0.638
Human Yeast Worm
chromosome organization involved in meiosis GO:0070192 1 0.591
Mouse
meiosis i GO:0007127 1 0.562
nucleic acid metabolic process GO:0090304 244 0.509
Human Yeast Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.489
Worm
nitrogen compound metabolic process GO:0006807 319 0.486
Human Yeast Mouse
regulation of primary metabolic process GO:0080090 311 0.482
cellular macromolecule biosynthetic process GO:0034645 224 0.475
Yeast
regulation of meiotic cell cycle GO:0051445 1 0.456
chromosome organization GO:0051276 31 0.455
Human Yeast Mouse Worm
regulation of gene expression GO:0010468 265 0.455
Worm
negative regulation of cell division GO:0051782 4 0.453
heterocycle metabolic process GO:0046483 290 0.421
Human Yeast Mouse
microtubule based process GO:0007017 60 0.410
nucleobase containing compound metabolic process GO:0006139 274 0.378
Human Yeast Mouse
gene expression GO:0010467 252 0.377
Worm
mitotic sister chromatid segregation GO:0000070 6 0.373
Human Yeast Worm
negative regulation of cell cycle process GO:0010948 9 0.348
single organism localization GO:1902578 225 0.341
Yeast
regulation of cellular metabolic process GO:0031323 320 0.339
negative regulation of chromosome organization GO:2001251 1 0.298
mitotic cell cycle GO:0000278 64 0.294
Human Yeast Worm
mitotic cell cycle process GO:1903047 48 0.287
Human Yeast Worm
regulation of nitrogen compound metabolic process GO:0051171 251 0.277
cellular macromolecule metabolic process GO:0044260 391 0.276
Human Yeast Mouse
negative regulation of cellular process GO:0048523 283 0.275
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.275
single organism organelle organization GO:1902589 199 0.265
Human Yeast Mouse Worm
nuclear division GO:0000280 23 0.250
Human Yeast Mouse Worm
meiotic cell cycle process GO:1903046 3 0.249
Mouse
response to stress GO:0006950 263 0.241
positive regulation of biological process GO:0048518 253 0.241
negative regulation of biological process GO:0048519 304 0.235
cellular aromatic compound metabolic process GO:0006725 295 0.222
Human Yeast Mouse
aromatic compound biosynthetic process GO:0019438 217 0.209
embryo development ending in birth or egg hatching GO:0009792 271 0.204
Worm
negative regulation of macromolecule metabolic process GO:0010605 76 0.203
cellular nitrogen compound metabolic process GO:0034641 290 0.202
Human Yeast Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.202
modification dependent protein catabolic process GO:0019941 3 0.197
regulation of cellular biosynthetic process GO:0031326 245 0.193
negative regulation of cellular component organization GO:0051129 16 0.184
meiotic chromosome segregation GO:0045132 3 0.182
Mouse
regulation of biological quality GO:0065008 263 0.173
maintenance of location GO:0051235 4 0.173
single organism metabolic process GO:0044710 217 0.173
Human Yeast Mouse
organic cyclic compound metabolic process GO:1901360 301 0.171
Human Yeast Mouse
cytoskeleton organization GO:0007010 96 0.170
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.166
spindle assembly GO:0051225 2 0.164
heterocycle biosynthetic process GO:0018130 215 0.163
protein targeting to nucleus GO:0044744 3 0.163
regulation of nucleocytoplasmic transport GO:0046822 2 0.157
dna metabolic process GO:0006259 27 0.156
Human Yeast Mouse
mitotic nuclear division GO:0007067 18 0.155
Human Yeast Worm
positive regulation of metabolic process GO:0009893 108 0.154
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.153
negative regulation of mitosis GO:0045839 3 0.152
protein complex subunit organization GO:0071822 46 0.151
Mouse
spindle organization GO:0007051 5 0.147
rna metabolic process GO:0016070 219 0.145
organelle fission GO:0048285 23 0.144
Human Yeast Mouse Worm
cellular protein catabolic process GO:0044257 4 0.143
mitotic sister chromatid cohesion GO:0007064 2 0.143
positive regulation of catabolic process GO:0009896 4 0.142
spindle assembly involved in mitosis GO:0090307 1 0.133
astral microtubule organization GO:0030953 1 0.131
microtubule based movement GO:0007018 33 0.130
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.129
sister chromatid cohesion GO:0007062 2 0.129
organelle organization GO:0006996 227 0.128
Human Yeast Mouse Worm
male meiosis GO:0007140 2 0.127
negative regulation of cellular catabolic process GO:0031330 3 0.125
chromosome segregation GO:0007059 12 0.119
Human Yeast Mouse Worm
cellular component biogenesis GO:0044085 178 0.118
nucleic acid templated transcription GO:0097659 181 0.118
biosynthetic process GO:0009058 294 0.116
Yeast
cellular component movement GO:0006928 335 0.114
Worm
nucleobase containing compound biosynthetic process GO:0034654 205 0.113
localization of cell GO:0051674 244 0.110
Worm
negative regulation of cellular metabolic process GO:0031324 77 0.109
macromolecule biosynthetic process GO:0009059 227 0.107
Yeast
microtubule cytoskeleton organization GO:0000226 33 0.102
developmental growth GO:0048589 166 0.099
locomotion GO:0040011 313 0.094
Worm
regulation of metabolic process GO:0019222 359 0.093
Worm
camera type eye development GO:0043010 222 0.090
establishment of localization GO:0051234 244 0.090
regulation of protein import into nucleus GO:0042306 2 0.089
negative regulation of cellular biosynthetic process GO:0031327 55 0.089
single organism nuclear import GO:1902593 3 0.088
negative regulation of cell cycle GO:0045786 14 0.087
mitotic spindle organization GO:0007052 5 0.082
regulation of cell cycle GO:0051726 52 0.081
regulation of biosynthetic process GO:0009889 250 0.080
macromolecular complex subunit organization GO:0043933 74 0.079
Mouse
aging GO:0007568 2 0.079
cellular nitrogen compound biosynthetic process GO:0044271 218 0.078
death GO:0016265 121 0.078
protein import into nucleus GO:0006606 3 0.077
regulation of protein transport GO:0051223 3 0.077
ribonucleoside monophosphate catabolic process GO:0009158 4 0.077
Yeast
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.076
regulation of establishment of protein localization GO:0070201 4 0.075
multicellular organism growth GO:0035264 4 0.075
cellular component assembly GO:0022607 170 0.075
regulation of multicellular organism growth GO:0040014 4 0.075
cellular localization GO:0051641 97 0.074
Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.074
organic cyclic compound biosynthetic process GO:1901362 223 0.072
regulation of rna biosynthetic process GO:2001141 213 0.071
regulation of nuclear division GO:0051783 9 0.070
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.070
regulation of protein metabolic process GO:0051246 56 0.069
mitotic metaphase plate congression GO:0007080 1 0.069
eye development GO:0001654 277 0.069
proteasomal protein catabolic process GO:0010498 2 0.067
chordate embryonic development GO:0043009 271 0.067
signal transduction GO:0007165 455 0.066
oocyte maturation GO:0001556 4 0.066
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.066
mitotic cell cycle phase transition GO:0044772 9 0.065
macromolecular complex assembly GO:0065003 35 0.064
phosphorus metabolic process GO:0006793 109 0.063
Yeast
production of molecular mediator of immune response GO:0002440 2 0.063
retina development in camera type eye GO:0060041 146 0.063
negative regulation of metabolic process GO:0009892 86 0.061
reproduction GO:0000003 40 0.061
Mouse Worm
peptidyl serine modification GO:0018209 2 0.061
positive regulation of macromolecule metabolic process GO:0010604 93 0.061
negative regulation of mitotic cell cycle phase transition GO:1901991 5 0.061
regulation of nucleic acid templated transcription GO:1903506 213 0.061
stem cell maintenance GO:0019827 4 0.060
negative regulation of catabolic process GO:0009895 3 0.060
atp catabolic process GO:0006200 4 0.059
Yeast
protein import GO:0017038 3 0.058
cell cycle GO:0007049 93 0.058
Human Yeast Mouse Worm
homeostatic process GO:0042592 142 0.057
regulation of intracellular protein transport GO:0033157 3 0.056
regulation of rna metabolic process GO:0051252 224 0.056
nucleoside monophosphate catabolic process GO:0009125 4 0.054
Yeast
peptidyl serine phosphorylation GO:0018105 1 0.054
protein metabolic process GO:0019538 183 0.053
rna biosynthetic process GO:0032774 181 0.053
cellular biosynthetic process GO:0044249 286 0.052
Yeast
immune system development GO:0002520 191 0.052
organic substance biosynthetic process GO:1901576 289 0.052
Yeast
regulation of organelle organization GO:0033043 29 0.052
cytokinetic process GO:0032506 2 0.052
negative regulation of cell cycle phase transition GO:1901988 5 0.051
protein modification process GO:0036211 100 0.051
double strand break repair GO:0006302 3 0.050
response to biotic stimulus GO:0009607 97 0.049
establishment of protein localization to organelle GO:0072594 4 0.047
regulation of cytoplasmic transport GO:1903649 4 0.047
nucleocytoplasmic transport GO:0006913 4 0.047
positive regulation of cell cycle GO:0045787 3 0.046
positive regulation of cellular process GO:0048522 201 0.046
meiosis ii GO:0007135 1 0.045
negative regulation of biosynthetic process GO:0009890 55 0.045
macromolecule modification GO:0043412 111 0.045
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.045
nuclear transport GO:0051169 4 0.044
cell cycle process GO:0022402 53 0.044
Human Yeast Mouse Worm
cellular response to stress GO:0033554 62 0.044
cell migration GO:0016477 237 0.044
Worm
centrosome organization GO:0051297 1 0.043
transcription dna templated GO:0006351 181 0.043
regulation of cellular component organization GO:0051128 86 0.043
cell proliferation GO:0008283 80 0.042
modification dependent macromolecule catabolic process GO:0043632 3 0.042
sensory organ development GO:0007423 393 0.042
immune system process GO:0002376 241 0.042
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.041
Yeast
phosphorylation GO:0016310 69 0.041
regulation of organelle assembly GO:1902115 4 0.041
apoptotic process GO:0006915 116 0.041
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.040
regulation of protein catabolic process GO:0042176 1 0.040
organic substance catabolic process GO:1901575 28 0.040
Yeast
protein localization to nucleus GO:0034504 3 0.039
regulation of gene expression epigenetic GO:0040029 11 0.039
Worm
positive regulation of cellular metabolic process GO:0031325 94 0.038
positive regulation of cellular catabolic process GO:0031331 3 0.038
reproductive process GO:0022414 40 0.038
Worm
negative regulation of organelle organization GO:0010639 4 0.038
regulation of transcription dna templated GO:0006355 213 0.037
negative regulation of mitotic cell cycle GO:0045930 11 0.037
regulation of protein localization to nucleus GO:1900180 2 0.037
regulation of cellular protein metabolic process GO:0032268 52 0.037
regulation of apoptotic process GO:0042981 98 0.036
meiotic spindle organization GO:0000212 1 0.036
nuclear import GO:0051170 3 0.036
programmed cell death GO:0012501 119 0.036
growth GO:0040007 174 0.036
catabolic process GO:0009056 32 0.035
Yeast
digestive system development GO:0055123 289 0.035
single organism transport GO:0044765 206 0.035
organelle assembly GO:0070925 110 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.034
regulation of response to stimulus GO:0048583 269 0.034
actin filament based process GO:0030029 64 0.034
regulation of developmental process GO:0050793 247 0.034
cell morphogenesis GO:0000902 289 0.033
stem cell proliferation GO:0072089 4 0.033
regulation of protein targeting GO:1903533 2 0.033
cellular macromolecule catabolic process GO:0044265 12 0.033
microtubule organizing center organization GO:0031023 1 0.032
g2 dna damage checkpoint GO:0031572 3 0.031
cell motility GO:0048870 244 0.031
Worm
regulation of cellular protein catabolic process GO:1903362 1 0.031
regeneration GO:0031099 91 0.031
regulation of purine nucleotide catabolic process GO:0033121 2 0.030
lipid homeostasis GO:0055088 3 0.029
cellular response to chemical stimulus GO:0070887 157 0.029
cellular catabolic process GO:0044248 27 0.029
Yeast
cell fate commitment GO:0045165 99 0.028
negative regulation of protein import into nucleus GO:0042308 2 0.028
exocrine pancreas development GO:0031017 28 0.028
centrosome cycle GO:0007098 1 0.028
regulation of multicellular organismal process GO:0051239 277 0.028
regulation of cell cycle process GO:0010564 20 0.027
regulation of heart growth GO:0060420 2 0.027
immunoglobulin mediated immune response GO:0016064 3 0.027
negative regulation of cytoplasmic transport GO:1903650 2 0.027
protein phosphorylation GO:0006468 47 0.027
regulation of cell communication GO:0010646 232 0.027
dna methylation on cytosine GO:0032776 3 0.027
negative regulation of gene expression GO:0010629 65 0.027
cellular component morphogenesis GO:0032989 336 0.026
regulation of mitotic cell cycle GO:0007346 25 0.026
peptidyl threonine modification GO:0018210 1 0.026
transport GO:0006810 220 0.026
regulation of programmed cell death GO:0043067 101 0.026
negative regulation of protein localization to nucleus GO:1900181 2 0.026
regulation of catalytic activity GO:0050790 55 0.025
spindle assembly involved in meiosis GO:0090306 1 0.025
cellular protein modification process GO:0006464 100 0.025
digestive tract development GO:0048565 265 0.024
regulation of signaling GO:0023051 235 0.024
ubiquitin dependent protein catabolic process GO:0006511 3 0.023
regulation of proteolysis GO:0030162 24 0.023
phosphate containing compound metabolic process GO:0006796 108 0.023
Yeast
nucleic acid phosphodiester bond hydrolysis GO:0090305 6 0.023
chromosome localization GO:0050000 2 0.023
regulation of chromatin modification GO:1903308 5 0.023
small molecule metabolic process GO:0044281 77 0.022
Yeast
negative regulation of protein transport GO:0051224 3 0.022
negative regulation of nucleic acid templated transcription GO:1903507 45 0.022
cell division GO:0051301 20 0.022
hematopoietic or lymphoid organ development GO:0048534 191 0.022
regulation of phosphorylation GO:0042325 26 0.021
response to abiotic stimulus GO:0009628 122 0.021
female meiotic division GO:0007143 2 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.021
positive regulation of cell activation GO:0050867 1 0.021
regulation of cell division GO:0051302 12 0.021
negative regulation of meiotic cell cycle GO:0051447 1 0.021
regulation of cell differentiation GO:0045595 142 0.021
female meiosis chromosome segregation GO:0016321 1 0.021
multi organism process GO:0051704 134 0.021
Worm
protein complex assembly GO:0006461 30 0.020
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.020
response to endogenous stimulus GO:0009719 83 0.020
negative regulation of cell differentiation GO:0045596 46 0.020
cell cycle g2 m phase transition GO:0044839 4 0.020
dna biosynthetic process GO:0071897 3 0.020
guanosine containing compound metabolic process GO:1901068 4 0.020
purine nucleoside monophosphate catabolic process GO:0009128 4 0.020
Yeast
negative regulation of protein complex assembly GO:0031333 1 0.019
g1 s transition of mitotic cell cycle GO:0000082 1 0.019
fin regeneration GO:0031101 51 0.019
single organism reproductive process GO:0044702 40 0.019
Worm
somatic cell dna recombination GO:0016444 1 0.019
meiotic cell cycle GO:0051321 5 0.019
Mouse
cellular protein metabolic process GO:0044267 129 0.019
cytokinesis GO:0000910 3 0.019
transcription from rna polymerase ii promoter GO:0006366 80 0.019
response to organic substance GO:0010033 153 0.019
germ cell development GO:0007281 22 0.019
negative regulation of histone modification GO:0031057 1 0.019
regulation of chromosome segregation GO:0051983 1 0.018
small gtpase mediated signal transduction GO:0007264 8 0.018
mitotic cell cycle embryonic GO:0045448 2 0.018
regulation of phosphate metabolic process GO:0019220 43 0.018
regulation of transport GO:0051049 45 0.018
negative regulation of histone methylation GO:0031061 1 0.018
negative regulation of protein processing GO:0010955 10 0.018
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.018
vesicle mediated transport GO:0016192 22 0.018
reproductive system development GO:0061458 5 0.018
Worm
negative regulation of dna metabolic process GO:0051053 4 0.018
cell death GO:0008219 121 0.018
pyrimidine containing compound metabolic process GO:0072527 3 0.017
regulation of localization GO:0032879 104 0.017
negative regulation of apoptotic process GO:0043066 55 0.017
mitotic g2 m transition checkpoint GO:0044818 3 0.017
regulation of histone h3 k9 methylation GO:0051570 2 0.017
mitotic g2 dna damage checkpoint GO:0007095 3 0.017
tissue regeneration GO:0042246 74 0.017
intracellular signal transduction GO:0035556 85 0.017
microtubule polymerization GO:0046785 2 0.017
dna catabolic process GO:0006308 1 0.016
posttranscriptional regulation of gene expression GO:0010608 14 0.016
protein polymerization GO:0051258 4 0.016
regulation of dna catabolic process GO:1903624 1 0.016
cell cycle arrest GO:0007050 1 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
regulation of cell shape GO:0008360 1 0.016
retina morphogenesis in camera type eye GO:0060042 79 0.016
phagocytosis GO:0006909 3 0.016
neural retina development GO:0003407 49 0.016
response to uv GO:0009411 3 0.016
response to chemical GO:0042221 320 0.016
regulation of cell death GO:0010941 103 0.016
response to external stimulus GO:0009605 264 0.016
regulation of cell cycle phase transition GO:1901987 8 0.016
fertilization GO:0009566 3 0.016
peptidyl threonine phosphorylation GO:0018107 1 0.015
cleavage furrow formation GO:0036089 2 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
cilium morphogenesis GO:0060271 85 0.015
regulation of protein complex assembly GO:0043254 3 0.014
nitric oxide biosynthetic process GO:0006809 2 0.014
negative regulation of chromatin modification GO:1903309 1 0.014
regulation of stem cell proliferation GO:0072091 2 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
cellular component disassembly GO:0022411 1 0.014
mitotic cell cycle checkpoint GO:0007093 5 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
Yeast
cellular response to organic substance GO:0071310 105 0.014
negative regulation of cell death GO:0060548 60 0.013
establishment of localization in cell GO:0051649 77 0.013
response to external biotic stimulus GO:0043207 97 0.013
cellular macromolecular complex assembly GO:0034622 24 0.013
proteolysis GO:0006508 38 0.013
centrosome duplication GO:0051298 1 0.013
gland development GO:0048732 143 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
regulation of reproductive process GO:2000241 4 0.013
positive regulation of protein metabolic process GO:0051247 23 0.013
response to other organism GO:0051707 97 0.013
negative regulation of rna biosynthetic process GO:1902679 45 0.013
regulation of binding GO:0051098 3 0.013
cell substrate junction assembly GO:0007044 2 0.013
negative regulation of developmental process GO:0051093 65 0.012
organic substance transport GO:0071702 58 0.012
response to amino acid GO:0043200 2 0.012
g2 m transition of mitotic cell cycle GO:0000086 4 0.012
regulation of molecular function GO:0065009 70 0.012
protein complex biogenesis GO:0070271 30 0.012
single organism biosynthetic process GO:0044711 71 0.012
photoreceptor cell differentiation GO:0046530 55 0.012
myeloid cell homeostasis GO:0002262 56 0.012
regulation of mitosis GO:0007088 9 0.012
actin cytoskeleton organization GO:0030036 63 0.012
neuron development GO:0048666 262 0.012
Worm
response to drug GO:0042493 3 0.012
regulation of intracellular signal transduction GO:1902531 57 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
positive regulation of chromatin modification GO:1903310 1 0.011
regulation of cell proliferation GO:0042127 37 0.011
positive regulation of transport GO:0051050 2 0.011
cellular response to endogenous stimulus GO:0071495 68 0.011
protein localization GO:0008104 40 0.011
positive regulation of catalytic activity GO:0043085 25 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
cell part morphogenesis GO:0032990 246 0.011
regulation of protein processing GO:0070613 10 0.011
oxoacid metabolic process GO:0043436 31 0.011
embryonic skeletal system development GO:0048706 97 0.011
pharyngeal system development GO:0060037 18 0.011
pyrimidine containing compound biosynthetic process GO:0072528 2 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
gtp catabolic process GO:0006184 2 0.011
regulation of histone methylation GO:0031060 3 0.011
regulation of protein binding GO:0043393 3 0.011
mitotic dna damage checkpoint GO:0044773 4 0.010
mitotic dna integrity checkpoint GO:0044774 4 0.010
heart development GO:0007507 313 0.010
embryonic skeletal joint development GO:0072498 3 0.010
hatching GO:0035188 4 0.010
hepaticobiliary system development GO:0061008 98 0.010
negative regulation of intracellular protein transport GO:0090317 3 0.010
cell substrate adhesion GO:0031589 4 0.010

smc4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
gastrointestinal system cancer DOID:3119 0 0.028
cancer DOID:162 0 0.028
disease of cellular proliferation DOID:14566 0 0.028
organ system cancer DOID:0050686 0 0.028
large intestine cancer DOID:5672 0 0.021
intestinal cancer DOID:10155 0 0.021
disease of anatomical entity DOID:7 0 0.013
nervous system disease DOID:863 0 0.013
colorectal cancer DOID:9256 0 0.013
colon carcinoma DOID:1520 0 0.011
colon cancer DOID:219 0 0.011