Danio rerio

6 known processes

LOC554173

abnormal spindles

LOC554173 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ribonucleoside monophosphate catabolic process GO:0009158 4 0.201
positive regulation of biological process GO:0048518 253 0.188
hematopoietic or lymphoid organ development GO:0048534 191 0.176
regulation of multicellular organism growth GO:0040014 4 0.160
embryonic cleavage GO:0040016 3 0.145
sister chromatid cohesion GO:0007062 2 0.133
mitotic sister chromatid cohesion GO:0007064 2 0.124
embryonic organ morphogenesis GO:0048562 274 0.120
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.119
angiogenesis GO:0001525 158 0.115
chordate embryonic development GO:0043009 271 0.112
sensory organ development GO:0007423 393 0.105
regulation of protein transport GO:0051223 3 0.104
neural crest cell differentiation GO:0014033 72 0.104
negative regulation of biological process GO:0048519 304 0.103
protein complex localization GO:0031503 1 0.103
regulation of apoptotic process GO:0042981 98 0.102
cellular response to endogenous stimulus GO:0071495 68 0.101
embryonic organ development GO:0048568 381 0.099
negative regulation of cellular process GO:0048523 283 0.095
regulation of primary metabolic process GO:0080090 311 0.095
regulation of cell death GO:0010941 103 0.093
head development GO:0060322 303 0.091
single organism organelle organization GO:1902589 199 0.090
regulation of developmental process GO:0050793 247 0.088
cellular macromolecule metabolic process GO:0044260 391 0.087
cilium morphogenesis GO:0060271 85 0.083
cellular aromatic compound metabolic process GO:0006725 295 0.082
meiotic nuclear division GO:0007126 4 0.082
immune system process GO:0002376 241 0.079
response to chemical GO:0042221 320 0.078
neuron differentiation GO:0030182 353 0.077
positive regulation of catabolic process GO:0009896 4 0.076
eye development GO:0001654 277 0.075
immune system development GO:0002520 191 0.071
cell migration GO:0016477 237 0.071
tube morphogenesis GO:0035239 349 0.071
atp catabolic process GO:0006200 4 0.068
regulation of establishment of protein localization GO:0070201 4 0.067
digestive system development GO:0055123 289 0.066
meiosis i GO:0007127 1 0.066
camera type eye morphogenesis GO:0048593 108 0.064
positive regulation of cellular catabolic process GO:0031331 3 0.064
somitogenesis GO:0001756 87 0.064
regulation of programmed cell death GO:0043067 101 0.063
mesenchymal cell differentiation GO:0048762 87 0.063
regulation of cellular metabolic process GO:0031323 320 0.062
hemopoiesis GO:0030097 183 0.062
chromosome organization involved in meiosis GO:0070192 1 0.061
mesenchyme development GO:0060485 127 0.061
microtubule depolymerization GO:0007019 1 0.060
camera type eye development GO:0043010 222 0.058
biosynthetic process GO:0009058 294 0.057
neural crest cell development GO:0014032 62 0.056
morphogenesis of an epithelium GO:0002009 333 0.056
regulation of signaling GO:0023051 235 0.056
embryonic heart tube morphogenesis GO:0003143 108 0.055
cellular protein modification process GO:0006464 100 0.055
negative regulation of apoptotic process GO:0043066 55 0.053
reciprocal dna recombination GO:0035825 1 0.053
embryonic skeletal system development GO:0048706 97 0.053
negative regulation of kinase activity GO:0033673 4 0.052
signal transduction GO:0007165 455 0.052
extrinsic apoptotic signaling pathway GO:0097191 3 0.051
death GO:0016265 121 0.051
positive regulation of nuclease activity GO:0032075 1 0.050
regulation of multicellular organismal development GO:2000026 223 0.050
centrosome duplication GO:0051298 1 0.050
neuroblast proliferation GO:0007405 2 0.050
somite development GO:0061053 96 0.050
multicellular organism growth GO:0035264 4 0.050
digestive tract morphogenesis GO:0048546 231 0.049
negative regulation of programmed cell death GO:0043069 58 0.049
aging GO:0007568 2 0.049
centrosome cycle GO:0007098 1 0.048
regulation of metabolic process GO:0019222 359 0.048
meiotic cell cycle process GO:1903046 3 0.048
negative regulation of protein kinase activity GO:0006469 4 0.048
meiosis ii GO:0007135 1 0.048
regulation of response to stimulus GO:0048583 269 0.048
positive regulation of dna metabolic process GO:0051054 1 0.048
specification of symmetry GO:0009799 204 0.046
organic cyclic compound metabolic process GO:1901360 301 0.045
stem cell differentiation GO:0048863 117 0.045
response to xenobiotic stimulus GO:0009410 45 0.045
apoptotic process GO:0006915 116 0.045
neuron projection development GO:0031175 180 0.045
stem cell maintenance GO:0019827 4 0.044
cellular component movement GO:0006928 335 0.044
b cell differentiation GO:0030183 1 0.044
regulation of cell differentiation GO:0045595 142 0.043
cell surface receptor signaling pathway GO:0007166 325 0.043
cellular macromolecule biosynthetic process GO:0034645 224 0.042
positive regulation of protein complex assembly GO:0031334 2 0.042
positive regulation of cellular process GO:0048522 201 0.042
organelle organization GO:0006996 227 0.042
developmental growth GO:0048589 166 0.041
programmed cell death GO:0012501 119 0.041
blood vessel development GO:0001568 246 0.041
sensory organ morphogenesis GO:0090596 200 0.040
cellular protein metabolic process GO:0044267 129 0.040
negative regulation of signaling GO:0023057 96 0.040
stem cell development GO:0048864 82 0.039
embryonic cranial skeleton morphogenesis GO:0048701 90 0.039
phagocytosis GO:0006909 3 0.039
response to external biotic stimulus GO:0043207 97 0.039
retina layer formation GO:0010842 24 0.038
regulation of cell cycle GO:0051726 52 0.038
cellular component disassembly GO:0022411 1 0.038
cellular component morphogenesis GO:0032989 336 0.037
retina morphogenesis in camera type eye GO:0060042 79 0.037
hematopoietic progenitor cell differentiation GO:0002244 23 0.037
oocyte maturation GO:0001556 4 0.037
single organism metabolic process GO:0044710 217 0.037
hepaticobiliary system development GO:0061008 98 0.036
regulation of epithelial cell proliferation GO:0050678 3 0.036
cellular carbohydrate metabolic process GO:0044262 4 0.035
extracellular structure organization GO:0043062 27 0.035
nucleic acid metabolic process GO:0090304 244 0.035
cytoskeleton dependent cytokinesis GO:0061640 3 0.035
response to oxygen containing compound GO:1901700 55 0.034
stem cell proliferation GO:0072089 4 0.034
protein secretion GO:0009306 1 0.033
generation of neurons GO:0048699 385 0.033
somatic muscle development GO:0007525 4 0.033
cognition GO:0050890 1 0.032
larval development GO:0002164 2 0.032
regulation of cell communication GO:0010646 232 0.032
negative regulation of protein transport GO:0051224 3 0.031
regulation of protein import into nucleus GO:0042306 2 0.031
neuron development GO:0048666 262 0.031
response to abiotic stimulus GO:0009628 122 0.031
protein targeting to nucleus GO:0044744 3 0.030
negative regulation of protein complex assembly GO:0031333 1 0.030
central nervous system development GO:0007417 387 0.030
nucleus organization GO:0006997 7 0.030
cell substrate adhesion GO:0031589 4 0.029
gene expression GO:0010467 252 0.029
negative regulation of meiotic cell cycle GO:0051447 1 0.029
negative regulation of response to stimulus GO:0048585 104 0.029
negative regulation of cellular metabolic process GO:0031324 77 0.028
cell projection organization GO:0030030 284 0.028
regulation of macromolecule metabolic process GO:0060255 317 0.028
mesenchymal cell development GO:0014031 78 0.028
localization of cell GO:0051674 244 0.028
negative regulation of cell communication GO:0010648 96 0.028
centrosome organization GO:0051297 1 0.028
microtubule organizing center organization GO:0031023 1 0.027
nucleoside monophosphate catabolic process GO:0009125 4 0.027
negative regulation of cell death GO:0060548 60 0.026
positive regulation of myeloid cell differentiation GO:0045639 2 0.026
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.026
neural retina development GO:0003407 49 0.026
cell part morphogenesis GO:0032990 246 0.026
nitrogen compound metabolic process GO:0006807 319 0.026
regulation of cellular component organization GO:0051128 86 0.026
blood vessel morphogenesis GO:0048514 216 0.025
response to other organism GO:0051707 97 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
reciprocal meiotic recombination GO:0007131 1 0.025
negative regulation of oocyte development GO:0060283 2 0.025
cellular nitrogen compound metabolic process GO:0034641 290 0.025
positive regulation of epithelial cell proliferation GO:0050679 1 0.024
protein import GO:0017038 3 0.024
regulation of meiotic cell cycle GO:0051445 1 0.024
macromolecule modification GO:0043412 111 0.024
spindle assembly involved in mitosis GO:0090307 1 0.024
negative regulation of histone modification GO:0031057 1 0.024
regulation of catalytic activity GO:0050790 55 0.024
vasculature development GO:0001944 278 0.024
regulation of cell activation GO:0050865 1 0.023
organic substance biosynthetic process GO:1901576 289 0.023
ectodermal placode morphogenesis GO:0071697 32 0.023
digestive tract development GO:0048565 265 0.023
carboxylic acid metabolic process GO:0019752 22 0.023
regulation of multicellular organismal process GO:0051239 277 0.023
response to biotic stimulus GO:0009607 97 0.023
cellular ketone metabolic process GO:0042180 11 0.023
organ regeneration GO:0031100 1 0.023
dna catabolic process GO:0006308 1 0.022
gastrulation GO:0007369 208 0.022
regulation of gene silencing GO:0060968 1 0.022
establishment of protein localization to organelle GO:0072594 4 0.022
single organism nuclear import GO:1902593 3 0.022
double strand break repair via homologous recombination GO:0000724 1 0.022
brain development GO:0007420 293 0.022
myeloid cell differentiation GO:0030099 86 0.022
neural crest cell migration GO:0001755 42 0.022
cell death GO:0008219 121 0.022
embryonic heart tube development GO:0035050 133 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
regulation of endothelial cell proliferation GO:0001936 1 0.021
response to organic substance GO:0010033 153 0.021
dna methylation on cytosine GO:0032776 3 0.021
embryonic skeletal system morphogenesis GO:0048704 93 0.020
cell proliferation in forebrain GO:0021846 3 0.020
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.020
cell death in response to oxidative stress GO:0036473 2 0.020
regulation of intracellular protein transport GO:0033157 3 0.020
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.020
positive regulation of immune system process GO:0002684 17 0.020
regulation of binding GO:0051098 3 0.020
organic substance transport GO:0071702 58 0.020
rna metabolic process GO:0016070 219 0.020
negative regulation of chromosome organization GO:2001251 1 0.019
erythrocyte differentiation GO:0030218 54 0.019
purine nucleoside monophosphate catabolic process GO:0009128 4 0.019
negative regulation of histone methylation GO:0031061 1 0.019
regulation of synaptic plasticity GO:0048167 1 0.019
single organism localization GO:1902578 225 0.019
regulation of protein targeting GO:1903533 2 0.019
negative regulation of protein import into nucleus GO:0042308 2 0.019
regionalization GO:0003002 274 0.019
female meiotic division GO:0007143 2 0.019
spindle assembly involved in meiosis GO:0090306 1 0.019
skeletal system development GO:0001501 181 0.019
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.019
positive regulation of cellular metabolic process GO:0031325 94 0.019
protein localization to nucleus GO:0034504 3 0.019
b cell activation GO:0042113 2 0.019
response to topologically incorrect protein GO:0035966 2 0.019
positive regulation of response to stimulus GO:0048584 80 0.018
regulation of dna replication GO:0006275 3 0.018
macromolecule biosynthetic process GO:0009059 227 0.018
meiotic chromosome segregation GO:0045132 3 0.018
auditory receptor cell fate commitment GO:0009912 4 0.018
regulation of embryonic development GO:0045995 47 0.018
positive regulation of transport GO:0051050 2 0.018
meiotic spindle organization GO:0000212 1 0.018
regulation of molecular function GO:0065009 70 0.018
negative regulation of dna metabolic process GO:0051053 4 0.018
ameboidal type cell migration GO:0001667 143 0.018
cell motility GO:0048870 244 0.018
segmentation GO:0035282 97 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
eye morphogenesis GO:0048592 144 0.017
cranial nerve development GO:0021545 42 0.017
regulation of protein complex assembly GO:0043254 3 0.017
methylation GO:0032259 22 0.017
positive regulation of chromosome organization GO:2001252 1 0.017
positive regulation of cell cycle GO:0045787 3 0.017
positive regulation of immune effector process GO:0002699 3 0.017
maintenance of location GO:0051235 4 0.016
astral microtubule organization GO:0030953 1 0.016
negative regulation of intracellular transport GO:0032387 3 0.016
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.016
negative regulation of developmental process GO:0051093 65 0.016
inner ear receptor cell fate commitment GO:0060120 4 0.016
cellular response to estradiol stimulus GO:0071392 1 0.016
nuclear import GO:0051170 3 0.016
regulation of mitotic cell cycle GO:0007346 25 0.016
cellular response to chemical stimulus GO:0070887 157 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.016
exocrine pancreas development GO:0031017 28 0.016
cell migration involved in gastrulation GO:0042074 79 0.016
nucleobase containing compound biosynthetic process GO:0034654 205 0.016
homeostasis of number of cells GO:0048872 62 0.016
nephron morphogenesis GO:0072028 2 0.016
negative regulation of protein localization to nucleus GO:1900181 2 0.015
compound eye development GO:0048749 2 0.015
system process GO:0003008 185 0.015
positive regulation of chromatin modification GO:1903310 1 0.015
protein import into nucleus GO:0006606 3 0.015
regulation of microtubule cytoskeleton organization GO:0070507 3 0.015
skeletal system morphogenesis GO:0048705 102 0.015
spermatid differentiation GO:0048515 2 0.015
cellular component assembly involved in morphogenesis GO:0010927 107 0.015
positive regulation of macromolecule metabolic process GO:0010604 93 0.015
positive regulation of nucleotide catabolic process GO:0030813 1 0.015
spermatid development GO:0007286 2 0.015
zinc ion homeostasis GO:0055069 1 0.015
response to endogenous stimulus GO:0009719 83 0.015
regulation of heart growth GO:0060420 2 0.015
regulation of oocyte development GO:0060281 3 0.015
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.015
energy reserve metabolic process GO:0006112 2 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.015
single organism transport GO:0044765 206 0.015
myeloid cell homeostasis GO:0002262 56 0.015
negative regulation of macromolecule metabolic process GO:0010605 76 0.015
heterocycle metabolic process GO:0046483 290 0.015
negative regulation of intracellular protein transport GO:0090317 3 0.014
microtubule based movement GO:0007018 33 0.014
amine metabolic process GO:0009308 2 0.014
positive regulation of catalytic activity GO:0043085 25 0.014
positive regulation of cell communication GO:0010647 56 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
response to stress GO:0006950 263 0.014
endothelial cell proliferation GO:0001935 11 0.014
intracellular signal transduction GO:0035556 85 0.014
cell division GO:0051301 20 0.014
mitotic cell cycle GO:0000278 64 0.014
oxidation reduction process GO:0055114 41 0.014
neuron fate determination GO:0048664 2 0.014
protein modification process GO:0036211 100 0.014
heart development GO:0007507 313 0.014
nuclear transport GO:0051169 4 0.014
exocrine system development GO:0035272 28 0.014
cell projection morphogenesis GO:0048858 244 0.014
axon development GO:0061564 166 0.014
sensory system development GO:0048880 76 0.013
megakaryocyte differentiation GO:0030219 1 0.013
positive regulation of developmental process GO:0051094 50 0.013
striated muscle tissue development GO:0014706 110 0.013
muscle organ development GO:0007517 101 0.013
positive regulation of endothelial cell proliferation GO:0001938 1 0.013
microtubule bundle formation GO:0001578 9 0.013
heterocycle biosynthetic process GO:0018130 215 0.013
cellular response to organic substance GO:0071310 105 0.013
regulation of stem cell proliferation GO:0072091 2 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
regulation of nuclease activity GO:0032069 1 0.013
floor plate development GO:0033504 15 0.013
positive regulation of carbohydrate metabolic process GO:0045913 1 0.013
regulation of myeloid cell differentiation GO:0045637 8 0.013
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.013
positive regulation of cell division GO:0051781 2 0.013
aromatic compound biosynthetic process GO:0019438 217 0.013
dorsal ventral neural tube patterning GO:0021904 1 0.013
positive regulation of stem cell proliferation GO:2000648 1 0.013
positive regulation of signaling GO:0023056 56 0.013
regeneration GO:0031099 91 0.013
positive regulation of multi organism process GO:0043902 3 0.013
lateral line system development GO:0048925 76 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.012
intracellular transport GO:0046907 32 0.012
epithelial cell differentiation GO:0030855 116 0.012
lipid storage GO:0019915 1 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.012
phosphorylation GO:0016310 69 0.012
nuclear envelope organization GO:0006998 2 0.012
cytokinesis GO:0000910 3 0.012
cellular response to extracellular stimulus GO:0031668 2 0.012
small gtpase mediated signal transduction GO:0007264 8 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.012
positive regulation of ras protein signal transduction GO:0046579 1 0.012
regulation of gene expression GO:0010468 265 0.012
regulation of phospholipase activity GO:0010517 2 0.012
epithelial cell morphogenesis GO:0003382 2 0.012
regulation of reproductive process GO:2000241 4 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
locomotion GO:0040011 313 0.012
spindle organization GO:0007051 5 0.012
cleavage furrow formation GO:0036089 2 0.012
stem cell division GO:0017145 1 0.012
deoxyribonucleotide biosynthetic process GO:0009263 1 0.012
response to amino acid GO:0043200 2 0.012
regulation of establishment of planar polarity GO:0090175 4 0.012
actomyosin structure organization GO:0031032 53 0.012
cellular component biogenesis GO:0044085 178 0.012
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.012
peptidyl serine modification GO:0018209 2 0.012
regulation of intracellular signal transduction GO:1902531 57 0.012
pancreas development GO:0031016 84 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
regulation of lipase activity GO:0060191 2 0.011
positive regulation of signal transduction GO:0009967 56 0.011
regulation of localization GO:0032879 104 0.011
positive regulation of neuron apoptotic process GO:0043525 1 0.011
cellular response to external stimulus GO:0071496 2 0.011
heart looping GO:0001947 94 0.011
negative regulation of cytoplasmic transport GO:1903650 2 0.011
cell cycle arrest GO:0007050 1 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
spindle assembly GO:0051225 2 0.011
neural tube development GO:0021915 62 0.011
nuclear migration GO:0007097 3 0.011
regulation of locomotion GO:0040012 55 0.011
positive regulation of molecular function GO:0044093 33 0.011
negative regulation of nucleic acid templated transcription GO:1903507 45 0.011
developmental growth involved in morphogenesis GO:0060560 86 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
nucleus localization GO:0051647 8 0.011
cell proliferation GO:0008283 80 0.011
neuron death GO:0070997 21 0.011
striated muscle cell development GO:0055002 108 0.011
response to lipid GO:0033993 60 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
i kappab kinase nf kappab signaling GO:0007249 4 0.011
regulation of wnt signaling pathway GO:0030111 53 0.011
mitotic cell cycle process GO:1903047 48 0.011
negative regulation of rna metabolic process GO:0051253 48 0.011
olfactory bulb development GO:0021772 4 0.010
response to organic cyclic compound GO:0014070 51 0.010
mesenchymal cell proliferation GO:0010463 1 0.010
response to corticosteroid GO:0031960 1 0.010
regulation of protein depolymerization GO:1901879 1 0.010
organic acid metabolic process GO:0006082 31 0.010
positive regulation of muscle organ development GO:0048636 1 0.010
retina development in camera type eye GO:0060041 146 0.010
cell morphogenesis GO:0000902 289 0.010
embryonic skeletal joint development GO:0072498 3 0.010
negative regulation of catabolic process GO:0009895 3 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.010
lipid catabolic process GO:0016042 4 0.010
cellular amine metabolic process GO:0044106 2 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010
positive regulation of map kinase activity GO:0043406 3 0.010
positive regulation of striated muscle tissue development GO:0045844 1 0.010
protein metabolic process GO:0019538 183 0.010
regulation of signal transduction GO:0009966 225 0.010
response to external stimulus GO:0009605 264 0.010
regulation of erythrocyte differentiation GO:0045646 2 0.010
regulation of organ growth GO:0046620 3 0.010
modification dependent macromolecule catabolic process GO:0043632 3 0.010
anterior posterior pattern specification GO:0009952 152 0.010
mitotic dna damage checkpoint GO:0044773 4 0.010

LOC554173 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 0 0.018
disease of anatomical entity DOID:7 0 0.018
musculoskeletal system disease DOID:17 0 0.018
connective tissue disease DOID:65 0 0.018