Danio rerio

62 known processes

pdgfb

platelet derived growth factor, B polypeptide

(Aliases: si:dkey-261d11.1,si:ch211-79m20.1)

pdgfb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
vasculature development GO:0001944 278 0.164
regulation of cellular metabolic process GO:0031323 320 0.127
signal transduction GO:0007165 455 0.095
organic substance biosynthetic process GO:1901576 289 0.088
cell surface receptor signaling pathway GO:0007166 325 0.085
blood vessel morphogenesis GO:0048514 216 0.080
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.079
sprouting angiogenesis GO:0002040 53 0.079
cellular nitrogen compound biosynthetic process GO:0044271 218 0.078
regulation of biosynthetic process GO:0009889 250 0.074
response to stress GO:0006950 263 0.073
heterocycle metabolic process GO:0046483 290 0.069
sensory organ development GO:0007423 393 0.069
heart morphogenesis GO:0003007 156 0.068
modification dependent protein catabolic process GO:0019941 3 0.067
cellular component movement GO:0006928 335 0.067
ubiquitin dependent protein catabolic process GO:0006511 3 0.062
blood vessel development GO:0001568 246 0.062
positive regulation of map kinase activity GO:0043406 3 0.062
nucleobase containing compound biosynthetic process GO:0034654 205 0.060
eye development GO:0001654 277 0.058
nucleic acid metabolic process GO:0090304 244 0.056
response to external stimulus GO:0009605 264 0.056
morphogenesis of an epithelium GO:0002009 333 0.056
organic cyclic compound metabolic process GO:1901360 301 0.056
proteasomal protein catabolic process GO:0010498 2 0.053
small molecule metabolic process GO:0044281 77 0.051
biosynthetic process GO:0009058 294 0.048
heterocycle biosynthetic process GO:0018130 215 0.048
angiogenesis GO:0001525 158 0.046
single organism metabolic process GO:0044710 217 0.046
nitrogen compound metabolic process GO:0006807 319 0.046
rna biosynthetic process GO:0032774 181 0.045
positive regulation of metabolic process GO:0009893 108 0.045
cell motility GO:0048870 244 0.045
regulation of gene expression GO:0010468 265 0.044
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.043
regulation of macromolecule metabolic process GO:0060255 317 0.043
blood circulation GO:0008015 87 0.043
tube morphogenesis GO:0035239 349 0.043
locomotion GO:0040011 313 0.042
amine metabolic process GO:0009308 2 0.041
camera type eye development GO:0043010 222 0.040
organic cyclic compound biosynthetic process GO:1901362 223 0.040
positive regulation of transport GO:0051050 2 0.040
localization of cell GO:0051674 244 0.040
nucleic acid templated transcription GO:0097659 181 0.040
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.039
phagocytosis GO:0006909 3 0.038
regulation of cellular biosynthetic process GO:0031326 245 0.038
embryonic organ development GO:0048568 381 0.038
hemopoiesis GO:0030097 183 0.037
cellular protein catabolic process GO:0044257 4 0.037
regulation of protein complex assembly GO:0043254 3 0.037
response to chemical GO:0042221 320 0.037
regulation of reactive oxygen species metabolic process GO:2000377 2 0.037
stem cell maintenance GO:0019827 4 0.036
regulation of rna biosynthetic process GO:2001141 213 0.035
regulation of neural precursor cell proliferation GO:2000177 3 0.034
regulation of transcription dna templated GO:0006355 213 0.034
positive regulation of phospholipase c activity GO:0010863 1 0.034
cell substrate adhesion GO:0031589 4 0.033
aging GO:0007568 2 0.033
cell migration GO:0016477 237 0.033
brain development GO:0007420 293 0.033
stem cell proliferation GO:0072089 4 0.033
rna metabolic process GO:0016070 219 0.032
regulation of primary metabolic process GO:0080090 311 0.032
hematopoietic or lymphoid organ development GO:0048534 191 0.032
positive regulation of inflammatory response GO:0050729 1 0.032
response to drug GO:0042493 3 0.032
cellular amino acid metabolic process GO:0006520 7 0.031
cellular protein metabolic process GO:0044267 129 0.031
cell morphogenesis involved in differentiation GO:0000904 195 0.031
regulation of blood vessel size GO:0050880 2 0.031
response to decreased oxygen levels GO:0036293 25 0.030
regulation of metabolic process GO:0019222 359 0.030
cellular response to chemical stimulus GO:0070887 157 0.029
regulation of nucleic acid templated transcription GO:1903506 213 0.029
cellular component morphogenesis GO:0032989 336 0.029
digestive system development GO:0055123 289 0.029
cellular aromatic compound metabolic process GO:0006725 295 0.029
positive regulation of protein kinase b signaling GO:0051897 1 0.029
positive regulation of cellular catabolic process GO:0031331 3 0.028
regulation of nitrogen compound metabolic process GO:0051171 251 0.028
head development GO:0060322 303 0.027
regulation of cytokine production GO:0001817 3 0.027
heart development GO:0007507 313 0.027
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.027
epithelium migration GO:0090132 25 0.027
regulation of heart contraction GO:0008016 32 0.027
nucleobase containing compound metabolic process GO:0006139 274 0.026
organic acid metabolic process GO:0006082 31 0.026
positive regulation of cell cycle GO:0045787 3 0.026
positive regulation of cell matrix adhesion GO:0001954 1 0.026
larval development GO:0002164 2 0.025
embryonic organ morphogenesis GO:0048562 274 0.025
regulation of tube size GO:0035150 2 0.025
protein localization to nucleus GO:0034504 3 0.025
central nervous system development GO:0007417 387 0.025
regulation of autophagy GO:0010506 3 0.024
positive regulation of signal transduction GO:0009967 56 0.024
regulation of binding GO:0051098 3 0.024
positive regulation of cell adhesion GO:0045785 1 0.024
regulation of epithelial cell proliferation GO:0050678 3 0.024
positive regulation of catabolic process GO:0009896 4 0.024
regulation of cell death GO:0010941 103 0.024
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
transcription dna templated GO:0006351 181 0.023
oxoacid metabolic process GO:0043436 31 0.023
regulation of inflammatory response GO:0050727 2 0.023
regionalization GO:0003002 274 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
positive regulation of biological process GO:0048518 253 0.023
cognition GO:0050890 1 0.023
regulation of rna metabolic process GO:0051252 224 0.023
epithelial tube morphogenesis GO:0060562 148 0.023
circulatory system process GO:0003013 87 0.023
cellular macromolecule metabolic process GO:0044260 391 0.022
positive regulation of nucleic acid templated transcription GO:1903508 57 0.022
immune system process GO:0002376 241 0.022
ameboidal type cell migration GO:0001667 143 0.022
reactive nitrogen species metabolic process GO:2001057 0 0.022
intracellular signal transduction GO:0035556 85 0.022
mitochondrion organization GO:0007005 4 0.022
cell morphogenesis GO:0000902 289 0.022
taxis GO:0042330 109 0.022
system process GO:0003008 185 0.022
cellular amine metabolic process GO:0044106 2 0.022
maintenance of location GO:0051235 4 0.021
cellular macromolecule biosynthetic process GO:0034645 224 0.021
establishment of protein localization to organelle GO:0072594 4 0.021
cellular ketone metabolic process GO:0042180 11 0.021
neuron projection morphogenesis GO:0048812 161 0.021
carboxylic acid metabolic process GO:0019752 22 0.021
response to external biotic stimulus GO:0043207 97 0.021
regulation of cell substrate adhesion GO:0010810 1 0.021
meiotic nuclear division GO:0007126 4 0.021
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.020
regulation of erk1 and erk2 cascade GO:0070372 4 0.020
extrinsic apoptotic signaling pathway GO:0097191 3 0.020
cell projection morphogenesis GO:0048858 244 0.020
regulation of signaling GO:0023051 235 0.020
neuroblast proliferation GO:0007405 2 0.020
cellular response to external stimulus GO:0071496 2 0.020
regulation of multicellular organismal development GO:2000026 223 0.020
gland development GO:0048732 143 0.020
cellular lipid metabolic process GO:0044255 36 0.020
embryonic heart tube development GO:0035050 133 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
regulation of cell shape GO:0008360 1 0.019
heart contraction GO:0060047 71 0.019
response to biotic stimulus GO:0009607 97 0.019
regulation of stem cell proliferation GO:0072091 2 0.019
phosphate containing compound metabolic process GO:0006796 108 0.019
cell projection organization GO:0030030 284 0.019
cellular biosynthetic process GO:0044249 286 0.019
modification dependent macromolecule catabolic process GO:0043632 3 0.019
ovulation cycle GO:0042698 2 0.018
regulation of protein catabolic process GO:0042176 1 0.018
cell fate specification GO:0001708 68 0.018
regulation of developmental process GO:0050793 247 0.018
skeletal system morphogenesis GO:0048705 102 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.018
positive regulation of cytokine production GO:0001819 2 0.018
negative regulation of biosynthetic process GO:0009890 55 0.018
lymphangiogenesis GO:0001946 25 0.018
stem cell differentiation GO:0048863 117 0.018
regulation of macromolecule biosynthetic process GO:0010556 225 0.018
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.018
aromatic compound biosynthetic process GO:0019438 217 0.018
regulation of production of molecular mediator of immune response GO:0002700 1 0.018
regulation of multicellular organismal process GO:0051239 277 0.017
multicellular organism growth GO:0035264 4 0.017
regulation of cell communication GO:0010646 232 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
negative regulation of biological process GO:0048519 304 0.017
heart process GO:0003015 71 0.017
regulation of anatomical structure morphogenesis GO:0022603 130 0.017
regulation of phospholipase c activity GO:1900274 1 0.017
protein import into nucleus GO:0006606 3 0.017
nephron epithelium morphogenesis GO:0072088 1 0.017
enzyme linked receptor protein signaling pathway GO:0007167 106 0.017
ribonucleotide biosynthetic process GO:0009260 20 0.017
regulation of signal transduction GO:0009966 225 0.017
lymph vessel development GO:0001945 27 0.017
organelle organization GO:0006996 227 0.017
sensory perception of chemical stimulus GO:0007606 3 0.017
multi organism process GO:0051704 134 0.017
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.017
cellular response to nutrient levels GO:0031669 2 0.017
reactive oxygen species biosynthetic process GO:1903409 1 0.016
positive regulation of muscle cell differentiation GO:0051149 1 0.016
protein acetylation GO:0006473 2 0.016
defense response GO:0006952 47 0.016
protein import GO:0017038 3 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.016
nucleocytoplasmic transport GO:0006913 4 0.016
germ line stem cell maintenance GO:0030718 2 0.016
positive regulation of epithelial cell migration GO:0010634 2 0.016
reactive oxygen species metabolic process GO:0072593 6 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.016
positive regulation of immune effector process GO:0002699 3 0.016
lymphocyte proliferation GO:0046651 1 0.016
regulation of nucleocytoplasmic transport GO:0046822 2 0.016
regulation of muscle contraction GO:0006937 3 0.016
lymph vessel morphogenesis GO:0036303 25 0.016
transcription from rna polymerase ii promoter GO:0006366 80 0.016
vasculogenesis GO:0001570 41 0.016
positive regulation of cellular component biogenesis GO:0044089 3 0.016
g protein coupled receptor signaling pathway GO:0007186 74 0.016
axonogenesis GO:0007409 152 0.016
erk1 and erk2 cascade GO:0070371 4 0.016
cellular nitrogen compound metabolic process GO:0034641 290 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
cellular response to molecule of bacterial origin GO:0071219 3 0.015
autophagy GO:0006914 4 0.015
retina development in camera type eye GO:0060041 146 0.015
pericardium morphogenesis GO:0003344 1 0.015
cell matrix adhesion GO:0007160 4 0.015
inositol lipid mediated signaling GO:0048017 2 0.015
positive regulation of blood circulation GO:1903524 2 0.015
skeletal muscle organ development GO:0060538 78 0.015
female gonad development GO:0008585 4 0.015
tissue remodeling GO:0048771 4 0.015
positive regulation of apoptotic signaling pathway GO:2001235 1 0.015
single organism organelle organization GO:1902589 199 0.015
response to abiotic stimulus GO:0009628 122 0.015
negative regulation of metabolic process GO:0009892 86 0.015
neural retina development GO:0003407 49 0.015
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.015
protein metabolic process GO:0019538 183 0.015
positive regulation of neural precursor cell proliferation GO:2000179 1 0.015
positive regulation of stress activated mapk cascade GO:0032874 3 0.015
gene expression GO:0010467 252 0.015
cell part morphogenesis GO:0032990 246 0.015
renal tubule morphogenesis GO:0061333 1 0.015
urogenital system development GO:0001655 97 0.015
axon development GO:0061564 166 0.015
positive regulation of secretion GO:0051047 1 0.014
ovulation cycle process GO:0022602 2 0.014
neurological system process GO:0050877 62 0.014
inner ear development GO:0048839 126 0.014
positive regulation of multicellular organismal process GO:0051240 52 0.014
regulation of response to stimulus GO:0048583 269 0.014
myeloid cell differentiation GO:0030099 86 0.014
single organism nuclear import GO:1902593 3 0.014
response to other organism GO:0051707 97 0.014
regulation of protein ubiquitination GO:0031396 3 0.014
protein secretion GO:0009306 1 0.014
trabecula morphogenesis GO:0061383 2 0.014
positive regulation of cell activation GO:0050867 1 0.014
antimicrobial humoral response GO:0019730 2 0.014
response to growth factor GO:0070848 39 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.014
cellular response to starvation GO:0009267 1 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.014
protein modification process GO:0036211 100 0.014
positive regulation of biosynthetic process GO:0009891 68 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
connective tissue development GO:0061448 99 0.014
regulation of locomotion GO:0040012 55 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.014
regulation of carbohydrate metabolic process GO:0006109 4 0.014
regulation of cell matrix adhesion GO:0001952 1 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.014
cellular response to radiation GO:0071478 4 0.014
hematopoietic progenitor cell differentiation GO:0002244 23 0.014
negative regulation of programmed cell death GO:0043069 58 0.014
nuclear transport GO:0051169 4 0.014
generation of neurons GO:0048699 385 0.014
signal transduction in absence of ligand GO:0038034 1 0.013
mesenchymal cell differentiation GO:0048762 87 0.013
positive regulation of cell substrate adhesion GO:0010811 1 0.013
small molecule catabolic process GO:0044282 3 0.013
regulation of multicellular organism growth GO:0040014 4 0.013
negative regulation of protein complex assembly GO:0031333 1 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
mesenchymal cell proliferation GO:0010463 1 0.013
nitric oxide metabolic process GO:0046209 2 0.013
ear development GO:0043583 127 0.013
kidney development GO:0001822 92 0.013
regulation of skeletal muscle tissue development GO:0048641 4 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
patterning of blood vessels GO:0001569 15 0.013
compound eye development GO:0048749 2 0.013
membrane invagination GO:0010324 1 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
response to bacterium GO:0009617 58 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
protein acylation GO:0043543 3 0.013
ventricular cardiac muscle tissue development GO:0003229 3 0.013
interspecies interaction between organisms GO:0044419 4 0.013
internal protein amino acid acetylation GO:0006475 2 0.013
gastrulation GO:0007369 208 0.013
eye morphogenesis GO:0048592 144 0.013
positive regulation of leukocyte migration GO:0002687 2 0.013
cellular response to growth factor stimulus GO:0071363 39 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
negative regulation of rna biosynthetic process GO:1902679 45 0.012
chemotaxis GO:0006935 104 0.012
peptide transport GO:0015833 1 0.012
regulation of protein targeting GO:1903533 2 0.012
regulation of biological quality GO:0065008 263 0.012
chordate embryonic development GO:0043009 271 0.012
sensory perception of smell GO:0007608 2 0.012
response to nutrient GO:0007584 3 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
positive regulation of lipid metabolic process GO:0045834 1 0.012
regulation of cell differentiation GO:0045595 142 0.012
regulation of cell activation GO:0050865 1 0.012
hormone transport GO:0009914 2 0.012
mesenchymal cell development GO:0014031 78 0.012
embryonic skeletal system development GO:0048706 97 0.012
lipid catabolic process GO:0016042 4 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
regulation of cell motility GO:2000145 46 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
tissue migration GO:0090130 37 0.012
cardiac atrium morphogenesis GO:0003209 2 0.012
cellular response to extracellular stimulus GO:0031668 2 0.012
positive regulation of gene expression GO:0010628 71 0.011
internal peptidyl lysine acetylation GO:0018393 2 0.011
regulation of cellular component movement GO:0051270 55 0.011
notch signaling pathway GO:0007219 35 0.011
cell death GO:0008219 121 0.011
regulation of programmed cell death GO:0043067 101 0.011
epidermal cell differentiation GO:0009913 36 0.011
hepaticobiliary system development GO:0061008 98 0.011
regulation of growth rate GO:0040009 1 0.011
regulation of reproductive process GO:2000241 4 0.011
protein targeting to nucleus GO:0044744 3 0.011
cellular response to vascular endothelial growth factor stimulus GO:0035924 3 0.011
regulation of organ growth GO:0046620 3 0.011
endothelial cell proliferation GO:0001935 11 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
muscle structure development GO:0061061 196 0.011
negative regulation of neural precursor cell proliferation GO:2000178 1 0.011
nitric oxide biosynthetic process GO:0006809 2 0.011
apoptotic process GO:0006915 116 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
response to corticosteroid GO:0031960 1 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
response to hypoxia GO:0001666 25 0.011
neuromast development GO:0048884 46 0.011
mononuclear cell proliferation GO:0032943 1 0.011
muscle cell differentiation GO:0042692 139 0.011
determination of bilateral symmetry GO:0009855 204 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
negative regulation of multicellular organismal process GO:0051241 69 0.011
muscle organ development GO:0007517 101 0.011
regulation of organelle assembly GO:1902115 4 0.011
cell proliferation GO:0008283 80 0.011
catechol containing compound metabolic process GO:0009712 2 0.011
negative regulation of transcription dna templated GO:0045892 45 0.011
positive regulation of stem cell proliferation GO:2000648 1 0.011
carboxylic acid catabolic process GO:0046395 3 0.011
cellular response to organic substance GO:0071310 105 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.010
pericardium development GO:0060039 1 0.010
response to carbohydrate GO:0009743 3 0.010
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.010
chemosensory behavior GO:0007635 1 0.010
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.010
membrane fusion GO:0061025 2 0.010
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.010
phosphorus metabolic process GO:0006793 109 0.010
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.010
positive regulation of secretion by cell GO:1903532 1 0.010
regulation of lipase activity GO:0060191 2 0.010
regulation of mesenchymal cell proliferation GO:0010464 1 0.010
regulation of circadian rhythm GO:0042752 4 0.010
nuclear import GO:0051170 3 0.010
neuron differentiation GO:0030182 353 0.010
cell substrate junction assembly GO:0007044 2 0.010
negative regulation of cellular process GO:0048523 283 0.010
phagocytosis engulfment GO:0006911 1 0.010
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.010
homeostatic process GO:0042592 142 0.010
regulation of catalytic activity GO:0050790 55 0.010
regulation of intracellular signal transduction GO:1902531 57 0.010

pdgfb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
musculoskeletal system disease DOID:17 0 0.025
disease of cellular proliferation DOID:14566 0 0.014
nervous system disease DOID:863 0 0.012
disease of metabolism DOID:0014667 0 0.010