Danio rerio

0 known processes

wwp1

WW domain containing E3 ubiquitin protein ligase 1

(Aliases: Smurf1,wu:fb30b12,zgc:66401)

wwp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic organ development GO:0048568 381 0.132
heart development GO:0007507 313 0.111
larval development GO:0002164 2 0.107
ubiquitin dependent protein catabolic process GO:0006511 3 0.100
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.086
modification dependent protein catabolic process GO:0019941 3 0.084
meiotic nuclear division GO:0007126 4 0.083
locomotion GO:0040011 313 0.075
response to chemical GO:0042221 320 0.075
muscle cell development GO:0055001 115 0.072
regulation of metabolic process GO:0019222 359 0.070
regulation of primary metabolic process GO:0080090 311 0.069
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.066
cellular component movement GO:0006928 335 0.066
gtp metabolic process GO:0046039 4 0.065
aromatic compound biosynthetic process GO:0019438 217 0.064
regulation of protein catabolic process GO:0042176 1 0.064
cellular nitrogen compound biosynthetic process GO:0044271 218 0.063
modification dependent macromolecule catabolic process GO:0043632 3 0.062
meiotic cell cycle process GO:1903046 3 0.061
tube morphogenesis GO:0035239 349 0.061
negative regulation of biological process GO:0048519 304 0.060
Mouse
stem cell proliferation GO:0072089 4 0.059
peptidyl serine modification GO:0018209 2 0.059
signal transduction GO:0007165 455 0.057
specification of symmetry GO:0009799 204 0.055
cellular nitrogen compound metabolic process GO:0034641 290 0.055
cellular protein catabolic process GO:0044257 4 0.053
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.051
cellular macromolecule biosynthetic process GO:0034645 224 0.050
rna metabolic process GO:0016070 219 0.050
regulation of carbohydrate metabolic process GO:0006109 4 0.050
determination of left right symmetry GO:0007368 179 0.049
extrinsic apoptotic signaling pathway GO:0097191 3 0.049
organelle assembly GO:0070925 110 0.049
cell surface receptor signaling pathway GO:0007166 325 0.048
biosynthetic process GO:0009058 294 0.047
determination of bilateral symmetry GO:0009855 204 0.047
embryonic organ morphogenesis GO:0048562 274 0.046
regulation of biosynthetic process GO:0009889 250 0.045
negative regulation of cellular process GO:0048523 283 0.044
organelle organization GO:0006996 227 0.044
adult behavior GO:0030534 2 0.044
hematopoietic or lymphoid organ development GO:0048534 191 0.044
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.044
macromolecule modification GO:0043412 111 0.042
Mouse
proteasomal protein catabolic process GO:0010498 2 0.042
morphogenesis of an epithelium GO:0002009 333 0.041
embryo development ending in birth or egg hatching GO:0009792 271 0.041
cellular protein modification process GO:0006464 100 0.041
Mouse
organic substance biosynthetic process GO:1901576 289 0.040
protein metabolic process GO:0019538 183 0.040
Mouse
lipid storage GO:0019915 1 0.040
regulation of establishment of protein localization GO:0070201 4 0.039
regulation of response to stimulus GO:0048583 269 0.039
small molecule metabolic process GO:0044281 77 0.039
maintenance of location GO:0051235 4 0.038
regulation of macromolecule biosynthetic process GO:0010556 225 0.038
single organism organelle organization GO:1902589 199 0.038
guanosine containing compound catabolic process GO:1901069 2 0.038
negative regulation of metabolic process GO:0009892 86 0.037
macromolecule biosynthetic process GO:0009059 227 0.036
stem cell division GO:0017145 1 0.036
sensory organ morphogenesis GO:0090596 200 0.036
single organism biosynthetic process GO:0044711 71 0.035
positive regulation of catabolic process GO:0009896 4 0.035
gastrulation GO:0007369 208 0.035
gtp catabolic process GO:0006184 2 0.034
positive regulation of cellular component biogenesis GO:0044089 3 0.034
protein modification process GO:0036211 100 0.033
Mouse
striated muscle cell differentiation GO:0051146 129 0.033
nitrogen compound metabolic process GO:0006807 319 0.033
aging GO:0007568 2 0.033
regulation of purine nucleotide catabolic process GO:0033121 2 0.033
gene expression GO:0010467 252 0.032
cellular aromatic compound metabolic process GO:0006725 295 0.032
regulation of multicellular organism growth GO:0040014 4 0.032
cell part morphogenesis GO:0032990 246 0.032
protein localization to nucleus GO:0034504 3 0.032
negative regulation of signal transduction GO:0009968 94 0.032
striated muscle cell development GO:0055002 108 0.032
regulation of multicellular organismal process GO:0051239 277 0.032
Mouse
phosphate containing compound metabolic process GO:0006796 108 0.031
golgi vesicle transport GO:0048193 3 0.031
cellular ketone metabolic process GO:0042180 11 0.031
regulation of protein ubiquitination GO:0031396 3 0.031
peptidyl serine phosphorylation GO:0018105 1 0.031
transcription dna templated GO:0006351 181 0.031
regulation of reproductive process GO:2000241 4 0.031
regulation of carbohydrate biosynthetic process GO:0043255 1 0.030
negative regulation of response to stimulus GO:0048585 104 0.030
stem cell maintenance GO:0019827 4 0.030
regulation of stem cell proliferation GO:0072091 2 0.029
nucleic acid templated transcription GO:0097659 181 0.029
single organism metabolic process GO:0044710 217 0.029
chordate embryonic development GO:0043009 271 0.029
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.029
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.029
rna biosynthetic process GO:0032774 181 0.029
cell morphogenesis GO:0000902 289 0.028
regulation of filopodium assembly GO:0051489 2 0.028
regulation of gtp catabolic process GO:0033124 2 0.028
cellular biosynthetic process GO:0044249 286 0.028
cell projection morphogenesis GO:0048858 244 0.028
cellular component assembly GO:0022607 170 0.027
transcription from rna polymerase ii promoter GO:0006366 80 0.027
regulation of macromolecule metabolic process GO:0060255 317 0.027
regulation of nucleotide catabolic process GO:0030811 2 0.027
organic cyclic compound metabolic process GO:1901360 301 0.027
response to alkaloid GO:0043279 2 0.026
activation of jun kinase activity GO:0007257 2 0.026
neurotransmitter transport GO:0006836 2 0.026
regulation of nitrogen compound metabolic process GO:0051171 251 0.026
regulation of nucleoside metabolic process GO:0009118 2 0.026
regulation of signal transduction GO:0009966 225 0.026
carbohydrate biosynthetic process GO:0016051 1 0.026
chemotaxis GO:0006935 104 0.026
regulation of cellular biosynthetic process GO:0031326 245 0.026
negative regulation of cell communication GO:0010648 96 0.026
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.025
establishment of protein localization to organelle GO:0072594 4 0.025
cellular component biogenesis GO:0044085 178 0.025
heterocycle biosynthetic process GO:0018130 215 0.025
organic acid metabolic process GO:0006082 31 0.025
growth GO:0040007 174 0.025
male meiosis GO:0007140 2 0.024
phagocytosis GO:0006909 3 0.024
cellular protein metabolic process GO:0044267 129 0.024
Mouse
regulation of rna metabolic process GO:0051252 224 0.024
regionalization GO:0003002 274 0.024
regulation of nucleic acid templated transcription GO:1903506 213 0.024
programmed cell death GO:0012501 119 0.024
regulation of cell development GO:0060284 100 0.024
axonogenesis GO:0007409 152 0.024
cognition GO:0050890 1 0.024
protein dephosphorylation GO:0006470 3 0.024
nucleic acid metabolic process GO:0090304 244 0.024
multicellular organism growth GO:0035264 4 0.023
nucleobase containing compound biosynthetic process GO:0034654 205 0.023
protein targeting to nucleus GO:0044744 3 0.023
rna localization GO:0006403 4 0.023
digestive tract development GO:0048565 265 0.023
negative regulation of biosynthetic process GO:0009890 55 0.023
heterocycle metabolic process GO:0046483 290 0.023
ion transmembrane transport GO:0034220 91 0.023
response to hexose GO:0009746 3 0.023
sensory organ development GO:0007423 393 0.023
neurotransmitter secretion GO:0007269 2 0.023
production of molecular mediator of immune response GO:0002440 2 0.022
negative regulation of tor signaling GO:0032007 2 0.022
nuclear transport GO:0051169 4 0.022
nucleic acid transport GO:0050657 2 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.022
response to organic substance GO:0010033 153 0.022
regulation of cell projection assembly GO:0060491 4 0.022
nucleocytoplasmic transport GO:0006913 4 0.021
regulation of cell communication GO:0010646 232 0.021
negative regulation of kinase activity GO:0033673 4 0.021
regulation of developmental process GO:0050793 247 0.021
regulation of gene expression GO:0010468 265 0.021
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.021
cellular macromolecule metabolic process GO:0044260 391 0.021
Mouse
localization of cell GO:0051674 244 0.021
regulation of nucleocytoplasmic transport GO:0046822 2 0.021
determination of heart left right asymmetry GO:0061371 117 0.021
negative regulation of cellular metabolic process GO:0031324 77 0.021
regulation of gtpase activity GO:0043087 2 0.021
phosphorus metabolic process GO:0006793 109 0.021
skeletal system morphogenesis GO:0048705 102 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
meiosis i GO:0007127 1 0.020
embryonic skeletal system development GO:0048706 97 0.020
protein polyubiquitination GO:0000209 4 0.020
regulation of cellular metabolic process GO:0031323 320 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
transport GO:0006810 220 0.020
response to nutrient GO:0007584 3 0.020
positive regulation of transport GO:0051050 2 0.020
cellular response to oxygen levels GO:0071453 1 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
negative regulation of signaling GO:0023057 96 0.020
positive regulation of cell adhesion GO:0045785 1 0.019
muscle cell differentiation GO:0042692 139 0.019
oxidation reduction process GO:0055114 41 0.019
regulation of protein transport GO:0051223 3 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
cellular response to decreased oxygen levels GO:0036294 1 0.019
immune system process GO:0002376 241 0.019
muscle structure development GO:0061061 196 0.019
head development GO:0060322 303 0.019
single organism nuclear import GO:1902593 3 0.019
post golgi vesicle mediated transport GO:0006892 1 0.019
protein import into nucleus GO:0006606 3 0.019
neuroblast proliferation GO:0007405 2 0.019
organic cyclic compound biosynthetic process GO:1901362 223 0.019
negative regulation of macromolecule metabolic process GO:0010605 76 0.018
guanosine containing compound metabolic process GO:1901068 4 0.018
cellular component morphogenesis GO:0032989 336 0.018
heart looping GO:0001947 94 0.018
regulation of protein import into nucleus GO:0042306 2 0.018
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.018
cell substrate adhesion GO:0031589 4 0.018
vasculature development GO:0001944 278 0.018
cell fate commitment GO:0045165 99 0.018
eye morphogenesis GO:0048592 144 0.018
apoptotic process GO:0006915 116 0.018
skeletal system development GO:0001501 181 0.017
positive regulation of nucleoside metabolic process GO:0045979 1 0.017
protein import GO:0017038 3 0.017
compound eye development GO:0048749 2 0.017
signal transduction in absence of ligand GO:0038034 1 0.017
epithelial cell morphogenesis GO:0003382 2 0.017
liver development GO:0001889 96 0.017
developmental growth GO:0048589 166 0.017
camera type eye morphogenesis GO:0048593 108 0.017
energy reserve metabolic process GO:0006112 2 0.017
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.017
cilium assembly GO:0042384 58 0.017
regulation of multicellular organismal development GO:2000026 223 0.016
cell projection organization GO:0030030 284 0.016
mesenchyme development GO:0060485 127 0.016
central nervous system development GO:0007417 387 0.016
protein heterooligomerization GO:0051291 1 0.016
cell morphogenesis involved in differentiation GO:0000904 195 0.016
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.016
camera type eye development GO:0043010 222 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
regulation of biomineral tissue development GO:0070167 2 0.016
regulation of cell activation GO:0050865 1 0.016
segmentation GO:0035282 97 0.016
ear development GO:0043583 127 0.016
regulation of dendrite development GO:0050773 3 0.016
regulation of protein targeting GO:1903533 2 0.016
negative regulation of catabolic process GO:0009895 3 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
pyruvate metabolic process GO:0006090 1 0.016
renal tubule morphogenesis GO:0061333 1 0.016
oxoacid metabolic process GO:0043436 31 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
embryonic heart tube morphogenesis GO:0003143 108 0.016
digestive system development GO:0055123 289 0.016
regulation of synapse assembly GO:0051963 3 0.016
cellular response to hypoxia GO:0071456 1 0.016
regulation of receptor mediated endocytosis GO:0048259 4 0.016
regulation of neural precursor cell proliferation GO:2000177 3 0.016
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.015
embryonic heart tube development GO:0035050 133 0.015
regulation of protein complex assembly GO:0043254 3 0.015
negative regulation of mapk cascade GO:0043409 4 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.015
blood vessel development GO:0001568 246 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
cellular response to organic cyclic compound GO:0071407 38 0.015
nuclear import GO:0051170 3 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
cellular component disassembly GO:0022411 1 0.015
positive regulation of neural precursor cell proliferation GO:2000179 1 0.015
positive regulation of nucleotide catabolic process GO:0030813 1 0.015
hypothalamus cell differentiation GO:0021979 4 0.015
amino acid transport GO:0006865 2 0.015
response to carbohydrate GO:0009743 3 0.015
negative regulation of wnt signaling pathway GO:0030178 30 0.015
regulation of cytokine production GO:0001817 3 0.015
dna templated transcription elongation GO:0006354 3 0.015
synaptic growth at neuromuscular junction GO:0051124 2 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.014
cell matrix adhesion GO:0007160 4 0.014
negative regulation of defense response GO:0031348 2 0.014
regulation of circadian rhythm GO:0042752 4 0.014
death GO:0016265 121 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
positive regulation of gtpase activity GO:0043547 1 0.014
cytokinesis GO:0000910 3 0.014
inositol lipid mediated signaling GO:0048017 2 0.014
response to drug GO:0042493 3 0.014
positive regulation of cellular catabolic process GO:0031331 3 0.014
regulation of epithelial cell proliferation GO:0050678 3 0.013
meiotic spindle organization GO:0000212 1 0.013
response to monosaccharide GO:0034284 3 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
regulation of protein binding GO:0043393 3 0.013
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.013
cellular response to extracellular stimulus GO:0031668 2 0.013
positive regulation of gtp catabolic process GO:0033126 1 0.013
positive regulation of protein kinase b signaling GO:0051897 1 0.013
response to abiotic stimulus GO:0009628 122 0.013
neuron projection development GO:0031175 180 0.013
establishment of protein localization to plasma membrane GO:0090002 1 0.013
centrosome organization GO:0051297 1 0.013
synaptic vesicle transport GO:0048489 1 0.013
establishment of rna localization GO:0051236 3 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
cell migration GO:0016477 237 0.013
meiotic chromosome segregation GO:0045132 3 0.013
positive regulation of protein complex assembly GO:0031334 2 0.013
system process GO:0003008 185 0.013
regulation of cellular component organization GO:0051128 86 0.013
germ line stem cell maintenance GO:0030718 2 0.013
regulation of transcription dna templated GO:0006355 213 0.013
gland development GO:0048732 143 0.013
membrane invagination GO:0010324 1 0.013
microtubule based process GO:0007017 60 0.013
embryonic skeletal joint development GO:0072498 3 0.013
nucleobase containing compound transport GO:0015931 2 0.012
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.012
regulation of cell differentiation GO:0045595 142 0.012
muscle cell migration GO:0014812 4 0.012
positive regulation of cell substrate adhesion GO:0010811 1 0.012
primary neural tube formation GO:0014020 1 0.012
regulation of intracellular ph GO:0051453 1 0.012
post embryonic organ development GO:0048569 4 0.012
regulation of stem cell differentiation GO:2000736 4 0.012
regulation of signaling GO:0023051 235 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
regulation of response to nutrient levels GO:0032107 1 0.012
multi organism process GO:0051704 134 0.012
organonitrogen compound metabolic process GO:1901564 74 0.012
behavior GO:0007610 74 0.012
regulation of jak stat cascade GO:0046425 3 0.012
regulation of dna templated transcription elongation GO:0032784 3 0.012
regulation of organelle assembly GO:1902115 4 0.012
lymphocyte proliferation GO:0046651 1 0.012
response to stress GO:0006950 263 0.012
foregut morphogenesis GO:0007440 4 0.012
response to vitamin GO:0033273 3 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
positive regulation of response to stimulus GO:0048584 80 0.012
epithelial tube morphogenesis GO:0060562 148 0.012
regulation of synapse organization GO:0050807 3 0.012
establishment of synaptic vesicle localization GO:0097480 1 0.012
embryonic skeletal joint morphogenesis GO:0060272 3 0.012
regulation of bone mineralization GO:0030500 2 0.011
stem cell differentiation GO:0048863 117 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
carbohydrate derivative metabolic process GO:1901135 61 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of cell cycle GO:0045787 3 0.011
glucose homeostasis GO:0042593 1 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
gastrulation with mouth forming second GO:0001702 44 0.011
macromolecular complex assembly GO:0065003 35 0.011
chemosensory behavior GO:0007635 1 0.011
cartilage development GO:0051216 96 0.011
regulation of cell death GO:0010941 103 0.011
blood vessel morphogenesis GO:0048514 216 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
negative regulation of neural precursor cell proliferation GO:2000178 1 0.011
neuron differentiation GO:0030182 353 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.011
cellular response to starvation GO:0009267 1 0.011
hepaticobiliary system development GO:0061008 98 0.011
nuclear export GO:0051168 1 0.011
er to golgi vesicle mediated transport GO:0006888 1 0.010
somatic stem cell maintenance GO:0035019 1 0.010
spindle assembly GO:0051225 2 0.010
regulation of binding GO:0051098 3 0.010
negative regulation of protein complex assembly GO:0031333 1 0.010
cellular response to nutrient levels GO:0031669 2 0.010
embryonic skeletal system morphogenesis GO:0048704 93 0.010
positive regulation of cellular process GO:0048522 201 0.010
nuclear migration GO:0007097 3 0.010
regulation of embryonic development GO:0045995 47 0.010
pole plasm assembly GO:0007315 4 0.010
macromolecular complex disassembly GO:0032984 1 0.010
negative regulation of cytoplasmic transport GO:1903650 2 0.010
regulation of cellular protein catabolic process GO:1903362 1 0.010
osteoclast differentiation GO:0030316 1 0.010
generation of neurons GO:0048699 385 0.010
regulation of blood vessel size GO:0050880 2 0.010
regulation of programmed cell death GO:0043067 101 0.010
proximal distal pattern formation GO:0009954 1 0.010
microtubule organizing center organization GO:0031023 1 0.010
negative regulation of immune response GO:0050777 2 0.010
hormone secretion GO:0046879 2 0.010
regulation of skeletal muscle fiber development GO:0048742 2 0.010

wwp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
cardiovascular system disease DOID:1287 0 0.025
nervous system disease DOID:863 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
disease of metabolism DOID:0014667 0 0.012