Danio rerio

259 known processes

smo

smoothened homolog (Drosophila)

(Aliases: wu:fb70b01,wu:fc39h03,smoh,CHUNP6862)

smo biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sensory organ morphogenesis GO:0090596 200 0.988
macromolecule biosynthetic process GO:0009059 227 0.982
Mouse
determination of heart left right asymmetry GO:0061371 117 0.981
cellular macromolecule metabolic process GO:0044260 391 0.981
Mouse
central nervous system development GO:0007417 387 0.975
negative regulation of cellular process GO:0048523 283 0.967
Mouse Fly
retinal ganglion cell axon guidance GO:0031290 35 0.963
axonogenesis GO:0007409 152 0.950
digestive system development GO:0055123 289 0.949
proteoglycan biosynthetic process GO:0030166 12 0.942
determination of left right symmetry GO:0007368 179 0.937
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.920
embryonic organ development GO:0048568 381 0.917
organic substance biosynthetic process GO:1901576 289 0.902
Mouse
gene expression GO:0010467 252 0.901
Mouse
embryonic heart tube morphogenesis GO:0003143 108 0.891
digestive tract development GO:0048565 265 0.889
cellular component morphogenesis GO:0032989 336 0.886
heart jogging GO:0003146 40 0.877
gland development GO:0048732 143 0.874
regulation of cellular biosynthetic process GO:0031326 245 0.874
Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.873
Mouse
cell surface receptor signaling pathway GO:0007166 325 0.867
anterior posterior axon guidance GO:0033564 5 0.831
hypophysis morphogenesis GO:0048850 5 0.827
cellular nitrogen compound metabolic process GO:0034641 290 0.813
Mouse
neuron projection development GO:0031175 180 0.798
regulation of metabolic process GO:0019222 359 0.778
Mouse
specification of axis polarity GO:0065001 4 0.777
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.774
Mouse
multicellular organism reproduction GO:0032504 35 0.772
Rat Fly
heart looping GO:0001947 94 0.770
regulation of cellular metabolic process GO:0031323 320 0.766
Mouse
diencephalon morphogenesis GO:0048852 5 0.761
floor plate morphogenesis GO:0033505 12 0.750
response to external stimulus GO:0009605 264 0.747
digestive tract morphogenesis GO:0048546 231 0.740
regionalization GO:0003002 274 0.733
regulation of primary metabolic process GO:0080090 311 0.729
Mouse
wnt signaling pathway GO:0016055 80 0.729
biosynthetic process GO:0009058 294 0.723
Mouse
chordate embryonic development GO:0043009 271 0.713
neuron projection morphogenesis GO:0048812 161 0.705
heart development GO:0007507 313 0.705
inner ear development GO:0048839 126 0.702
axial mesoderm formation GO:0048320 4 0.700
morphogenesis of an epithelium GO:0002009 333 0.680
odontogenesis of dentin containing tooth GO:0042475 1 0.679
Mouse
floor plate formation GO:0021508 12 0.677
signal transduction GO:0007165 455 0.673
muscle organ development GO:0007517 101 0.672
cellular nitrogen compound biosynthetic process GO:0044271 218 0.671
Mouse
cellular component movement GO:0006928 335 0.661
cell part morphogenesis GO:0032990 246 0.656
regulation of developmental process GO:0050793 247 0.655
Mouse Fly
neural tube development GO:0021915 62 0.652
specification of symmetry GO:0009799 204 0.638
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.631
notochord morphogenesis GO:0048570 17 0.624
neuron projection guidance GO:0097485 86 0.613
chemotaxis GO:0006935 104 0.609
embryonic organ morphogenesis GO:0048562 274 0.602
taxis GO:0042330 109 0.602
neuroblast proliferation GO:0007405 2 0.595
Mouse
regulation of synapse organization GO:0050807 3 0.591
regulation of wnt signaling pathway GO:0030111 53 0.581
heterocycle biosynthetic process GO:0018130 215 0.580
Mouse
response to chemical GO:0042221 320 0.573
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.569
Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.566
regulation of signaling GO:0023051 235 0.561
segmentation GO:0035282 97 0.560
Fly
regulation of heart morphogenesis GO:2000826 17 0.557
Mouse
neuron development GO:0048666 262 0.557
nucleic acid metabolic process GO:0090304 244 0.553
Mouse
ear development GO:0043583 127 0.552
regulation of signal transduction GO:0009966 225 0.546
axon guidance GO:0007411 86 0.534
segment polarity determination GO:0007367 1 0.530
cellular biosynthetic process GO:0044249 286 0.528
Mouse
rna biosynthetic process GO:0032774 181 0.528
Mouse
locomotion GO:0040011 313 0.525
regulation of macromolecule metabolic process GO:0060255 317 0.523
Mouse
aminoglycan biosynthetic process GO:0006023 8 0.517
smoothened signaling pathway GO:0007224 30 0.509
regulation of neurogenesis GO:0050767 87 0.506
Mouse
epithelial tube morphogenesis GO:0060562 148 0.483
axon development GO:0061564 166 0.452
cell projection morphogenesis GO:0048858 244 0.447
morphogenesis of an epithelial fold GO:0060571 1 0.444
renal system development GO:0072001 94 0.442
Human Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.436
regulation of synapse assembly GO:0051963 3 0.430
bmp signaling pathway GO:0030509 52 0.430
striated muscle cell differentiation GO:0051146 129 0.428
embryonic digestive tract development GO:0048566 4 0.427
negative regulation of macromolecule metabolic process GO:0010605 76 0.418
Mouse
diencephalon development GO:0021536 58 0.414
nitrogen compound metabolic process GO:0006807 319 0.414
Mouse
regulation of cell communication GO:0010646 232 0.406
regulation of cell proliferation GO:0042127 37 0.403
Mouse
brain development GO:0007420 293 0.402
muscle cell development GO:0055001 115 0.398
regulation of macromolecule biosynthetic process GO:0010556 225 0.397
Mouse
regulation of multicellular organismal development GO:2000026 223 0.391
Mouse
muscle structure development GO:0061061 196 0.384
determination of bilateral symmetry GO:0009855 204 0.376
positive regulation of cell cycle GO:0045787 3 0.375
developmental process involved in reproduction GO:0003006 27 0.373
Fly
negative regulation of biological process GO:0048519 304 0.361
Mouse Fly
positive regulation of biological process GO:0048518 253 0.357
vasculature development GO:0001944 278 0.354
reproduction GO:0000003 40 0.352
Rat Fly
nucleic acid templated transcription GO:0097659 181 0.349
Mouse
regulation of biological quality GO:0065008 263 0.344
Mouse
embryonic limb morphogenesis GO:0030326 2 0.341
neuron differentiation GO:0030182 353 0.337
generation of neurons GO:0048699 385 0.330
positive regulation of cellular biosynthetic process GO:0031328 68 0.324
Mouse
regulation of meiotic cell cycle GO:0051445 1 0.316
spinal cord dorsal ventral patterning GO:0021513 5 0.316
Mouse
left right pattern formation GO:0060972 19 0.316
bmp signaling pathway involved in heart development GO:0061312 15 0.313
regulation of multicellular organism growth GO:0040014 4 0.311
skeletal system development GO:0001501 181 0.311
cardiac atrium morphogenesis GO:0003209 2 0.294
Mouse
embryonic digestive tract morphogenesis GO:0048557 3 0.290
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.287
Mouse
regulation of anatomical structure morphogenesis GO:0022603 130 0.285
Mouse
proximal distal pattern formation GO:0009954 1 0.281
regulation of apoptotic process GO:0042981 98 0.281
Mouse Fly
blood vessel morphogenesis GO:0048514 216 0.279
determination of left right asymmetry in diencephalon GO:0035462 4 0.278
tube morphogenesis GO:0035239 349 0.278
cell proliferation GO:0008283 80 0.275
Mouse Rat
ventral spinal cord interneuron specification GO:0021521 3 0.273
wnt signaling pathway involved in somitogenesis GO:0090244 2 0.273
meiotic nuclear division GO:0007126 4 0.273
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.271
somite development GO:0061053 96 0.270
Mouse
branching morphogenesis of an epithelial tube GO:0048754 15 0.269
Mouse
establishment of protein localization to organelle GO:0072594 4 0.266
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.263
Mouse
rna metabolic process GO:0016070 219 0.259
Mouse
regulation of cell development GO:0060284 100 0.251
Mouse
ossification GO:0001503 23 0.251
Mouse Rat
sexual reproduction GO:0019953 36 0.249
Rat Fly
sensory organ development GO:0007423 393 0.248
anterior posterior pattern specification GO:0009952 152 0.248
regulation of nervous system development GO:0051960 90 0.244
Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.241
Mouse
cell migration involved in gastrulation GO:0042074 79 0.241
developmental growth involved in morphogenesis GO:0060560 86 0.240
Rat
negative regulation of gene expression GO:0010629 65 0.236
Mouse
primary neural tube formation GO:0014020 1 0.235
nucleobase containing compound biosynthetic process GO:0034654 205 0.232
Mouse
cell cycle g1 s phase transition GO:0044843 1 0.232
Fly
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.230
multi organism reproductive process GO:0044703 36 0.227
Rat Fly
gastrulation GO:0007369 208 0.223
regulation of bmp signaling pathway GO:0030510 39 0.221
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.220
forebrain morphogenesis GO:0048853 6 0.217
Mouse
embryonic pectoral fin morphogenesis GO:0035118 24 0.216
single organism reproductive process GO:0044702 40 0.216
Rat Fly
patterning of blood vessels GO:0001569 15 0.215
positive regulation of cellular process GO:0048522 201 0.215
connective tissue development GO:0061448 99 0.214
negative regulation of metabolic process GO:0009892 86 0.213
Mouse
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.212
regulation of neuron differentiation GO:0045664 56 0.212
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.212
Mouse
determination of left right asymmetry in nervous system GO:0035545 4 0.211
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 15 0.209
cell fate commitment GO:0045165 99 0.206
growth GO:0040007 174 0.203
Mouse Rat
notochord development GO:0030903 54 0.203
stem cell maintenance GO:0019827 4 0.199
Mouse Fly
stem cell proliferation GO:0072089 4 0.198
Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.198
regulation of cell morphogenesis GO:0022604 42 0.198
positive regulation of epithelial cell proliferation GO:0050679 1 0.194
Mouse
embryonic heart tube development GO:0035050 133 0.194
skeletal muscle tissue development GO:0007519 67 0.194
bmp signaling pathway involved in heart jogging GO:0003303 14 0.192
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.184
positive regulation of oocyte development GO:0060282 1 0.183
multi organism process GO:0051704 134 0.182
Rat Fly
invagination involved in gastrulation with mouth forming second GO:0055109 1 0.177
smoothened signaling pathway involved in dorsal ventral neural tube patterning GO:0060831 1 0.177
determination of ventral identity GO:0048264 21 0.174
somitogenesis GO:0001756 87 0.174
sulfur compound biosynthetic process GO:0044272 9 0.170
negative regulation of cellular biosynthetic process GO:0031327 55 0.169
Mouse
regulation of cell projection assembly GO:0060491 4 0.169
positive regulation of skeletal muscle tissue development GO:0048643 1 0.168
organelle organization GO:0006996 227 0.168
localization of cell GO:0051674 244 0.167
positive regulation of catabolic process GO:0009896 4 0.166
cell morphogenesis GO:0000902 289 0.166
vagus nerve development GO:0021564 2 0.166
heart morphogenesis GO:0003007 156 0.165
convergent extension involved in gastrulation GO:0060027 71 0.163
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.163
positive regulation of rna biosynthetic process GO:1902680 57 0.162
Mouse
regulation of protein import into nucleus GO:0042306 2 0.162
Mouse
regulation of muscle organ development GO:0048634 9 0.162
cellular component assembly involved in morphogenesis GO:0010927 107 0.161
mesodermal cell fate commitment GO:0001710 14 0.160
cell proliferation in dorsal spinal cord GO:0010456 2 0.159
regulation of skeletal muscle tissue development GO:0048641 4 0.158
tube closure GO:0060606 1 0.156
optic nerve morphogenesis GO:0021631 6 0.156
regulation of epithelial cell proliferation GO:0050678 3 0.155
Mouse
protein complex subunit organization GO:0071822 46 0.151
regulation of response to stimulus GO:0048583 269 0.147
tissue migration GO:0090130 37 0.146
eye development GO:0001654 277 0.146
nuclear import GO:0051170 3 0.145
Mouse
regulation of protein localization to nucleus GO:1900180 2 0.143
Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.143
Mouse
multicellular organism growth GO:0035264 4 0.140
Mouse
negative regulation of signaling GO:0023057 96 0.140
Fly
protein metabolic process GO:0019538 183 0.139
regulation of cytoplasmic transport GO:1903649 4 0.138
Mouse
regulation of multicellular organismal process GO:0051239 277 0.138
Mouse
mesodermal cell fate specification GO:0007501 12 0.135
fin morphogenesis GO:0033334 53 0.134
cell fate specification GO:0001708 68 0.134
single organism cellular localization GO:1902580 46 0.133
embryonic appendage morphogenesis GO:0035113 30 0.132
embryonic pattern specification GO:0009880 44 0.131
cellular protein modification process GO:0006464 100 0.131
intracellular transport GO:0046907 32 0.130
Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.129
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.127
Mouse
canonical wnt signaling pathway GO:0060070 48 0.125
embryonic cranial skeleton morphogenesis GO:0048701 90 0.124
heart rudiment formation GO:0003315 5 0.124
single organism localization GO:1902578 225 0.121
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.119
gamete generation GO:0007276 33 0.119
Rat Fly
myotube cell development GO:0014904 35 0.118
synaptic growth at neuromuscular junction GO:0051124 2 0.117
reproductive process GO:0022414 40 0.117
Rat Fly
regulation of canonical wnt signaling pathway GO:0060828 34 0.116
floor plate development GO:0033504 15 0.115
muscle fiber development GO:0048747 52 0.115
endocardial cushion formation GO:0003272 2 0.113
negative regulation of multicellular organismal process GO:0051241 69 0.113
Mouse
positive regulation of rna metabolic process GO:0051254 59 0.113
Mouse
appendage morphogenesis GO:0035107 56 0.111
regulation of programmed cell death GO:0043067 101 0.110
Mouse Fly
microtubule based process GO:0007017 60 0.110
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.110
glycosaminoglycan biosynthetic process GO:0006024 8 0.110
positive regulation of metabolic process GO:0009893 108 0.110
Mouse
atrial ventricular junction remodeling GO:0003294 2 0.110
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 9 0.109
cell motility GO:0048870 244 0.109
pericardium morphogenesis GO:0003344 1 0.108
neuron projection extension GO:1990138 45 0.106
Rat
organic acid metabolic process GO:0006082 31 0.105
regulation of synapse structure and activity GO:0050803 5 0.104
negative regulation of axon guidance GO:1902668 1 0.104
camera type eye development GO:0043010 222 0.103
female gamete generation GO:0007292 14 0.103
Fly
negative regulation of cell communication GO:0010648 96 0.103
Fly
endodermal digestive tract morphogenesis GO:0061031 2 0.101
positive regulation of signal transduction GO:0009967 56 0.099
gliogenesis GO:0042063 45 0.099
heart valve morphogenesis GO:0003179 8 0.099
protein import GO:0017038 3 0.098
Mouse
embryonic eye morphogenesis GO:0048048 30 0.097
enzyme linked receptor protein signaling pathway GO:0007167 106 0.096
regulation of transcription dna templated GO:0006355 213 0.094
Mouse
dna templated transcription elongation GO:0006354 3 0.093
actin filament based process GO:0030029 64 0.092
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.091
negative regulation of neurogenesis GO:0050768 20 0.090
embryonic epithelial tube formation GO:0001838 17 0.090
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.089
negative regulation of cell differentiation GO:0045596 46 0.089
Mouse Fly
endodermal cell fate determination GO:0007493 2 0.088
outflow tract morphogenesis GO:0003151 1 0.088
convergent extension GO:0060026 118 0.087
kidney development GO:0001822 92 0.086
Mouse
foregut morphogenesis GO:0007440 4 0.086
nephron tubule morphogenesis GO:0072078 1 0.085
Mouse
response to other organism GO:0051707 97 0.085
transcription dna templated GO:0006351 181 0.085
Mouse
regulation of axonogenesis GO:0050770 32 0.085
negative regulation of transcription elongation from rna polymerase ii promoter GO:0034244 1 0.085
osteoblast differentiation GO:0001649 5 0.084
Mouse Rat
embryonic camera type eye development GO:0031076 29 0.084
negative regulation of wnt signaling pathway involved in heart development GO:0003308 2 0.084
negative regulation of signal transduction GO:0009968 94 0.083
Fly
blastoderm segmentation GO:0007350 6 0.083
Fly
stem cell division GO:0017145 1 0.082
regulation of organ growth GO:0046620 3 0.082
positive regulation of gene expression GO:0010628 71 0.082
Mouse
single organism nuclear import GO:1902593 3 0.081
Mouse
meiotic cell cycle process GO:1903046 3 0.081
system process GO:0003008 185 0.081
organic cyclic compound metabolic process GO:1901360 301 0.080
Mouse
regulation of biosynthetic process GO:0009889 250 0.080
Mouse
positive regulation of transcription dna templated GO:0045893 57 0.079
Mouse
circulatory system process GO:0003013 87 0.078
regulation of cellular component organization GO:0051128 86 0.077
Fly
otic vesicle morphogenesis GO:0071600 34 0.076
wound healing GO:0042060 90 0.076
regulation of smoothened signaling pathway GO:0008589 18 0.075
protein localization to nucleus GO:0034504 3 0.075
Mouse
muscle cell migration GO:0014812 4 0.075
Mouse
cell cycle GO:0007049 93 0.075
Fly
eye morphogenesis GO:0048592 144 0.074
Fly
facial nucleus development GO:0021754 7 0.074
liver development GO:0001889 96 0.074
fin development GO:0033333 77 0.074
developmental growth GO:0048589 166 0.072
Mouse Rat
morphogenesis of a branching epithelium GO:0061138 16 0.071
Mouse
negative regulation of rna metabolic process GO:0051253 48 0.071
Mouse
regulation of establishment of planar polarity GO:0090175 4 0.071
metal ion transport GO:0030001 58 0.070
face morphogenesis GO:0060325 6 0.070
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.070
Mouse
negative regulation of response to stimulus GO:0048585 104 0.070
Fly
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.068
single organism membrane organization GO:0044802 20 0.067
response to biotic stimulus GO:0009607 97 0.066
Human
organic cyclic compound biosynthetic process GO:1901362 223 0.066
Mouse
positive regulation of neuron apoptotic process GO:0043525 1 0.066
positive regulation of muscle organ development GO:0048636 1 0.065
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.065
regulation of glial cell differentiation GO:0045685 4 0.065
retinal rod cell development GO:0046548 4 0.064
regulation of developmental growth GO:0048638 38 0.062
organ formation GO:0048645 17 0.062
bmp signaling pathway involved in determination of left right symmetry GO:0003154 14 0.062
chondroitin sulfate proteoglycan biosynthetic process GO:0050650 7 0.062
negative regulation of cellular metabolic process GO:0031324 77 0.062
Mouse
cardioblast migration to the midline involved in heart rudiment formation GO:0003319 5 0.062
optic nerve formation GO:0021634 6 0.061
nephron morphogenesis GO:0072028 2 0.061
Mouse
specification of organ position GO:0010159 3 0.060
nephron epithelium morphogenesis GO:0072088 1 0.060
Mouse
g1 s transition of mitotic cell cycle GO:0000082 1 0.059
Fly
mitotic cell cycle GO:0000278 64 0.058
Fly
epithelium migration GO:0090132 25 0.058
hepaticobiliary system development GO:0061008 98 0.058
cell fate specification involved in pattern specification GO:0060573 3 0.057
positive regulation of response to stimulus GO:0048584 80 0.057
axial mesoderm development GO:0048318 10 0.056
ear morphogenesis GO:0042471 64 0.055
sensory neuron axon guidance GO:0097374 3 0.054
negative regulation of rna biosynthetic process GO:1902679 45 0.054
Mouse
camera type eye morphogenesis GO:0048593 108 0.054
heparan sulfate proteoglycan biosynthetic process GO:0015012 5 0.052
medial fin development GO:0033338 16 0.052
tube formation GO:0035148 25 0.052
pharyngeal muscle development GO:0043282 4 0.052
cellular protein metabolic process GO:0044267 129 0.051
positive regulation of cellular component biogenesis GO:0044089 3 0.051
appendage development GO:0048736 80 0.050
regulation of heart contraction GO:0008016 32 0.050
embryonic foregut morphogenesis GO:0048617 1 0.050
axis elongation GO:0003401 31 0.050
positive regulation of mesodermal cell fate specification GO:0048337 1 0.050
forebrain dorsal ventral pattern formation GO:0021798 1 0.050
larval development GO:0002164 2 0.050
mitotic cell cycle process GO:1903047 48 0.050
Fly
regulation of collateral sprouting in absence of injury GO:0048696 4 0.050
negative regulation of muscle organ development GO:0048635 5 0.050
negative regulation of nucleic acid templated transcription GO:1903507 45 0.050
Mouse
somatic stem cell maintenance GO:0035019 1 0.050
Fly
intracellular signal transduction GO:0035556 85 0.049
Mouse
cell projection organization GO:0030030 284 0.049
ventral midline development GO:0007418 13 0.049
single organism organelle organization GO:1902589 199 0.049
proteoglycan metabolic process GO:0006029 14 0.049
positive regulation of apoptotic process GO:0043065 29 0.048
protein targeting to nucleus GO:0044744 3 0.048
Mouse
regulation of locomotion GO:0040012 55 0.048
myotube differentiation GO:0014902 45 0.048
neuromuscular junction development GO:0007528 9 0.048
aromatic compound biosynthetic process GO:0019438 217 0.048
Mouse
abducens nucleus development GO:0021742 2 0.048
nephron epithelium development GO:0072009 16 0.048
Mouse
carbohydrate derivative metabolic process GO:1901135 61 0.047
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.047
Mouse
determination of dorsal ventral asymmetry GO:0048262 34 0.047
regulation of cell cycle GO:0051726 52 0.047
Fly
mesoderm development GO:0007498 88 0.046
Mouse
regulation of isoprenoid metabolic process GO:0019747 6 0.046
brain morphogenesis GO:0048854 18 0.046
Mouse
skeletal muscle fiber development GO:0048741 35 0.046
positive regulation of jun kinase activity GO:0043507 2 0.046
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.045
response to organic substance GO:0010033 153 0.045
Mouse Rat
mesenchymal cell differentiation GO:0048762 87 0.045
stem cell fate commitment GO:0048865 1 0.044
tongue morphogenesis GO:0043587 3 0.044
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.044
Mouse
cell death GO:0008219 121 0.044
Mouse Fly
regulation of protein targeting GO:1903533 2 0.044
Mouse
negative regulation of transcription dna templated GO:0045892 45 0.044
Mouse
heart field specification GO:0003128 1 0.044
reciprocal meiotic recombination GO:0007131 1 0.043
regulation of rna metabolic process GO:0051252 224 0.043
Mouse
embryonic heart tube left right pattern formation GO:0060971 5 0.043
regulation of protein transport GO:0051223 3 0.043
Mouse
positive regulation of endothelial cell proliferation GO:0001938 1 0.043
divalent metal ion transport GO:0070838 20 0.042
positive regulation of histone modification GO:0031058 1 0.042
positive regulation of reproductive process GO:2000243 2 0.042
motor neuron axon guidance GO:0008045 23 0.042
muscle tissue development GO:0060537 110 0.042
regulation of cellular response to growth factor stimulus GO:0090287 35 0.042
single organism metabolic process GO:0044710 217 0.042
stem cell development GO:0048864 82 0.041
Mouse Fly
histone deacetylation GO:0016575 2 0.041
cellular response to growth factor stimulus GO:0071363 39 0.041
heart process GO:0003015 71 0.040
regulation of neuron projection development GO:0010975 40 0.040
regulation of mesodermal cell fate specification GO:0042661 9 0.040
cell migration GO:0016477 237 0.040
oligodendrocyte differentiation GO:0048709 23 0.039
chromatin organization GO:0006325 22 0.039
transcription from rna polymerase ii promoter GO:0006366 80 0.039
Mouse
specification of organ identity GO:0010092 2 0.039
programmed cell death GO:0012501 119 0.039
Mouse Fly
otic vesicle development GO:0071599 42 0.039
skeletal muscle organ development GO:0060538 78 0.038
axon extension GO:0048675 45 0.038
Rat
anterior posterior axis specification GO:0009948 20 0.038
hard palate development GO:0060022 4 0.038
regulation of cell death GO:0010941 103 0.038
Mouse Fly
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.037
Mouse
periodic partitioning GO:0007365 1 0.037
regulation of axon extension GO:0030516 24 0.037
heterocycle metabolic process GO:0046483 290 0.036
Mouse
nucleobase containing compound metabolic process GO:0006139 274 0.036
Mouse
post anal tail morphogenesis GO:0036342 19 0.036
regulation of cell proliferation involved in tissue homeostasis GO:0060784 2 0.036
regulation of cell differentiation GO:0045595 142 0.036
Mouse Fly
negative regulation of programmed cell death GO:0043069 58 0.036
Mouse
oogenesis GO:0048477 14 0.036
Fly
cardiac endothelial cell differentiation GO:0003348 5 0.036
pons development GO:0021548 11 0.035
positive regulation of cellular catabolic process GO:0031331 3 0.035
regulation of gene expression GO:0010468 265 0.035
Mouse
positive regulation of stem cell proliferation GO:2000648 1 0.035
Mouse
embryonic neurocranium morphogenesis GO:0048702 15 0.035
skin development GO:0043588 54 0.034
Mouse
regulation of skeletal muscle fiber development GO:0048742 2 0.034
positive regulation of biosynthetic process GO:0009891 68 0.034
Mouse
morphogenesis of a branching structure GO:0001763 21 0.034
Mouse
anal fin morphogenesis GO:0035144 1 0.034
endodermal cell fate specification GO:0001714 17 0.034
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.034
adenohypophysis morphogenesis GO:0048855 4 0.033
macromolecule modification GO:0043412 111 0.033
odontogenesis GO:0042476 9 0.033
Mouse
regulation of receptor internalization GO:0002090 2 0.033
aorta development GO:0035904 4 0.033
regulation of cellular protein catabolic process GO:1903362 1 0.033
habenula development GO:0021986 9 0.033
regulation of binding GO:0051098 3 0.032
Mouse
negative regulation of apoptotic process GO:0043066 55 0.032
Mouse
response to bacterium GO:0009617 58 0.032
exocrine pancreas development GO:0031017 28 0.032
mesoderm formation GO:0001707 43 0.032
gtp catabolic process GO:0006184 2 0.032
regulation of cell cycle phase transition GO:1901987 8 0.032
Fly
pectoral fin development GO:0033339 50 0.032
maturation of ssu rrna GO:0030490 1 0.032
establishment of cell polarity involved in gastrulation cell migration GO:0003379 2 0.032
negative regulation of synapse assembly GO:0051964 2 0.032
response to external biotic stimulus GO:0043207 97 0.031
neurological system process GO:0050877 62 0.031
spinal cord motor neuron differentiation GO:0021522 26 0.031
epithalamus development GO:0021538 10 0.031
negative regulation of striated muscle tissue development GO:0045843 2 0.031
dorsal convergence GO:0060030 14 0.031
mesoderm morphogenesis GO:0048332 51 0.031
head development GO:0060322 303 0.031
regulation of oocyte development GO:0060281 3 0.031
regulation of cellular ketone metabolic process GO:0010565 7 0.030
compound eye development GO:0048749 2 0.030
regulation of mesenchymal cell proliferation GO:0010464 1 0.030
Mouse
regulation of mitotic cell cycle GO:0007346 25 0.030
Fly
forebrain regionalization GO:0021871 4 0.030
regulation of rna biosynthetic process GO:2001141 213 0.029
Mouse
regulation of nucleocytoplasmic transport GO:0046822 2 0.029
Mouse
heparan sulfate proteoglycan metabolic process GO:0030201 6 0.029

smo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system cancer DOID:0060100 0 0.075
cancer DOID:162 0 0.075
disease of cellular proliferation DOID:14566 0 0.075
organ system cancer DOID:0050686 0 0.075