Danio rerio

34 known processes

otx1a

orthodenticle homolog 1a

(Aliases: otx1l,otx3)

otx1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of anatomical structure morphogenesis GO:0022603 130 0.977
Zebrafish Fly
sensory organ development GO:0007423 393 0.969
neuron differentiation GO:0030182 353 0.964
Zebrafish Worm Fly
cellular component morphogenesis GO:0032989 336 0.928
Fly
signal transduction GO:0007165 455 0.919
generation of neurons GO:0048699 385 0.914
Zebrafish Worm Fly
nucleic acid templated transcription GO:0097659 181 0.895
Human Zebrafish Mouse Worm Fly
embryonic organ morphogenesis GO:0048562 274 0.832
Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.829
Fly
negative regulation of cellular process GO:0048523 283 0.808
Zebrafish Fly
neuron projection development GO:0031175 180 0.805
Fly
neuron projection morphogenesis GO:0048812 161 0.788
Fly
heterocycle metabolic process GO:0046483 290 0.781
Human Zebrafish Mouse Worm Fly
transcription dna templated GO:0006351 181 0.777
Human Zebrafish Mouse Worm Fly
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.761
Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.758
Human Zebrafish Mouse Worm Fly
neuron development GO:0048666 262 0.740
Zebrafish Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.710
Human Zebrafish Mouse Worm Fly
camera type eye development GO:0043010 222 0.690
regulation of collateral sprouting of intact axon in response to injury GO:0048683 2 0.676
cell morphogenesis GO:0000902 289 0.645
Fly
negative regulation of collateral sprouting of intact axon in response to injury GO:0048685 2 0.628
central nervous system development GO:0007417 387 0.626
eye development GO:0001654 277 0.622
rna metabolic process GO:0016070 219 0.609
Human Zebrafish Mouse Worm Fly
embryonic organ development GO:0048568 381 0.608
Mouse
cell surface receptor signaling pathway GO:0007166 325 0.605
axonogenesis GO:0007409 152 0.601
gene expression GO:0010467 252 0.584
Human Zebrafish Mouse Worm Fly
regulation of primary metabolic process GO:0080090 311 0.584
Human Zebrafish Mouse Worm Fly
head development GO:0060322 303 0.528
rna biosynthetic process GO:0032774 181 0.496
Human Zebrafish Mouse Worm Fly
axon guidance GO:0007411 86 0.495
cellular aromatic compound metabolic process GO:0006725 295 0.450
Human Zebrafish Mouse Worm Fly
axon development GO:0061564 166 0.448
aromatic compound biosynthetic process GO:0019438 217 0.445
Human Zebrafish Mouse Worm Fly
cellular component movement GO:0006928 335 0.445
organic cyclic compound metabolic process GO:1901360 301 0.442
Human Zebrafish Mouse Worm Fly
cell migration GO:0016477 237 0.429
cellular macromolecule metabolic process GO:0044260 391 0.428
Human Zebrafish Mouse Worm Fly
gliogenesis GO:0042063 45 0.427
nucleic acid metabolic process GO:0090304 244 0.426
Human Zebrafish Mouse Worm Fly
regulation of nervous system development GO:0051960 90 0.425
Fly
heterocycle biosynthetic process GO:0018130 215 0.403
Human Zebrafish Mouse Worm Fly
digestive tract morphogenesis GO:0048546 231 0.392
endoderm development GO:0007492 49 0.383
cellular macromolecule biosynthetic process GO:0034645 224 0.380
Human Zebrafish Mouse Worm Fly
specification of symmetry GO:0009799 204 0.377
regulation of gene expression GO:0010468 265 0.375
Human Zebrafish Mouse Worm Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.363
Human Zebrafish Mouse Worm Fly
regulation of multicellular organismal development GO:2000026 223 0.355
Zebrafish Fly
regulation of reproductive process GO:2000241 4 0.351
negative regulation of neuron projection regeneration GO:0070571 4 0.351
hindbrain development GO:0030902 91 0.349
negative regulation of collateral sprouting GO:0048671 2 0.346
retina development in camera type eye GO:0060041 146 0.340
oligodendrocyte differentiation GO:0048709 23 0.338
cell fate commitment GO:0045165 99 0.330
Worm Fly
diencephalon development GO:0021536 58 0.325
Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.324
Human Zebrafish Mouse Worm Fly
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.321
tube morphogenesis GO:0035239 349 0.315
thalamus development GO:0021794 6 0.313
response to chemical GO:0042221 320 0.301
Zebrafish Worm
peripheral nervous system development GO:0007422 55 0.291
glial cell fate specification GO:0021780 4 0.287
regulation of nitrogen compound metabolic process GO:0051171 251 0.279
Human Zebrafish Mouse Worm Fly
cellular biosynthetic process GO:0044249 286 0.277
Human Zebrafish Mouse Worm Fly
cell projection morphogenesis GO:0048858 244 0.276
Fly
convergent extension GO:0060026 118 0.274
cellular nitrogen compound metabolic process GO:0034641 290 0.271
Human Zebrafish Mouse Worm Fly
eye morphogenesis GO:0048592 144 0.270
Zebrafish Fly
chordate embryonic development GO:0043009 271 0.270
system process GO:0003008 185 0.267
Zebrafish Worm
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.267
Fly
digestive system development GO:0055123 289 0.266
retinal ganglion cell axon guidance GO:0031290 35 0.266
ectodermal placode formation GO:0060788 26 0.260
determination of heart left right asymmetry GO:0061371 117 0.251
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.246
Human Zebrafish Worm Fly
macromolecule biosynthetic process GO:0009059 227 0.242
Human Zebrafish Mouse Worm Fly
regulation of multicellular organismal process GO:0051239 277 0.225
Zebrafish Fly
brain development GO:0007420 293 0.224
cellular nitrogen compound biosynthetic process GO:0044271 218 0.223
Human Zebrafish Mouse Worm Fly
ear development GO:0043583 127 0.221
Mouse
dorsal ventral pattern formation GO:0009953 125 0.219
regulation of macromolecule metabolic process GO:0060255 317 0.211
Human Zebrafish Mouse Worm Fly
regulation of endodermal cell fate specification GO:0042663 15 0.209
axis specification GO:0009798 43 0.208
regulation of inner ear receptor cell differentiation GO:2000980 1 0.198
otic vesicle formation GO:0030916 27 0.195
embryonic camera type eye morphogenesis GO:0048596 19 0.194
regulation of cellular component organization GO:0051128 86 0.194
embryo development ending in birth or egg hatching GO:0009792 271 0.190
regulation of rna metabolic process GO:0051252 224 0.187
Human Zebrafish Mouse Worm Fly
nucleobase containing compound metabolic process GO:0006139 274 0.186
Human Zebrafish Mouse Worm Fly
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.184
cell projection organization GO:0030030 284 0.183
Fly
regulation of rna biosynthetic process GO:2001141 213 0.180
Human Zebrafish Mouse Worm Fly
embryonic heart tube development GO:0035050 133 0.179
gland development GO:0048732 143 0.178
cell motility GO:0048870 244 0.178
nitrogen compound metabolic process GO:0006807 319 0.177
Human Zebrafish Mouse Worm Fly
regulation of developmental process GO:0050793 247 0.176
Zebrafish Fly
regulation of signaling GO:0023051 235 0.174
glial cell development GO:0021782 20 0.172
negative regulation of cell fate specification GO:0009996 11 0.169
camera type eye morphogenesis GO:0048593 108 0.165
determination of bilateral symmetry GO:0009855 204 0.162
inner ear morphogenesis GO:0042472 63 0.162
Mouse
regulation of response to stimulus GO:0048583 269 0.159
embryonic eye morphogenesis GO:0048048 30 0.155
muscle organ development GO:0007517 101 0.154
axial mesodermal cell fate specification GO:0048327 3 0.154
embryonic heart tube morphogenesis GO:0003143 108 0.153
digestive tract development GO:0048565 265 0.151
anterior posterior pattern specification GO:0009952 152 0.150
taxis GO:0042330 109 0.150
collateral sprouting of intact axon in response to injury GO:0048673 2 0.150
positive regulation of neural precursor cell proliferation GO:2000179 1 0.141
cell cell signaling involved in cell fate commitment GO:0045168 12 0.140
regulation of neural precursor cell proliferation GO:2000177 3 0.139
regulation of cell development GO:0060284 100 0.136
Zebrafish Fly
organic substance biosynthetic process GO:1901576 289 0.136
Human Zebrafish Mouse Worm Fly
response to external stimulus GO:0009605 264 0.135
heart morphogenesis GO:0003007 156 0.134
muscle structure development GO:0061061 196 0.134
cell cycle GO:0007049 93 0.133
neurological system process GO:0050877 62 0.130
Zebrafish Worm
otic vesicle development GO:0071599 42 0.129
muscle fiber development GO:0048747 52 0.128
inner ear development GO:0048839 126 0.123
Mouse
ear morphogenesis GO:0042471 64 0.123
Mouse
muscle cell development GO:0055001 115 0.121
heart development GO:0007507 313 0.121
regulation of neurogenesis GO:0050767 87 0.119
Fly
otic placode formation GO:0043049 23 0.118
ectodermal placode development GO:0071696 37 0.116
oligodendrocyte cell fate specification GO:0021778 4 0.116
embryonic camera type eye development GO:0031076 29 0.116
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.115
striated muscle cell differentiation GO:0051146 129 0.114
determination of left right symmetry GO:0007368 179 0.112
regulation of cell growth GO:0001558 29 0.111
neuroblast proliferation GO:0007405 2 0.111
positive regulation of cell communication GO:0010647 56 0.111
floor plate morphogenesis GO:0033505 12 0.110
ectodermal placode morphogenesis GO:0071697 32 0.109
localization of cell GO:0051674 244 0.108
regionalization GO:0003002 274 0.106
endodermal cell fate specification GO:0001714 17 0.105
striated muscle tissue development GO:0014706 110 0.105
regulation of locomotion GO:0040012 55 0.104
negative regulation of axon regeneration GO:0048681 4 0.102
positive regulation of gene expression GO:0010628 71 0.100
Human Zebrafish Worm Fly
morphogenesis of an epithelium GO:0002009 333 0.099
epithelial tube morphogenesis GO:0060562 148 0.099
stem cell proliferation GO:0072089 4 0.099
cell fate specification GO:0001708 68 0.099
Worm
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.098
glial cell differentiation GO:0010001 42 0.098
regulation of axonogenesis GO:0050770 32 0.098
regulation of cell differentiation GO:0045595 142 0.097
Zebrafish Fly
regulation of stem cell proliferation GO:0072091 2 0.097
rhombomere morphogenesis GO:0021593 17 0.096
neuron projection guidance GO:0097485 86 0.095
ameboidal type cell migration GO:0001667 143 0.095
biosynthetic process GO:0009058 294 0.094
Human Zebrafish Mouse Worm Fly
rhombomere formation GO:0021594 12 0.094
locomotion GO:0040011 313 0.094
negative regulation of signaling GO:0023057 96 0.093
cardiac chamber formation GO:0003207 4 0.093
liver development GO:0001889 96 0.088
regulation of cell morphogenesis GO:0022604 42 0.088
facial nucleus development GO:0021754 7 0.088
skin development GO:0043588 54 0.088
regulation of transcription involved in cell fate commitment GO:0060850 1 0.088
larval development GO:0002164 2 0.087
sensory organ morphogenesis GO:0090596 200 0.086
Zebrafish Mouse Fly
regulation of biosynthetic process GO:0009889 250 0.085
Human Zebrafish Mouse Worm Fly
regulation of transcription dna templated GO:0006355 213 0.085
Human Zebrafish Mouse Worm Fly
regulation of cellular metabolic process GO:0031323 320 0.084
Human Zebrafish Mouse Worm Fly
notochord morphogenesis GO:0048570 17 0.083
cell migration involved in gastrulation GO:0042074 79 0.083
negative regulation of nucleic acid templated transcription GO:1903507 45 0.083
Fly
photoreceptor cell differentiation GO:0046530 55 0.083
Zebrafish Fly
regulation of cell communication GO:0010646 232 0.082
neural tube development GO:0021915 62 0.082
cell cell recognition GO:0009988 1 0.082
determination of dorsal ventral asymmetry GO:0048262 34 0.081
positive regulation of macromolecule metabolic process GO:0010604 93 0.080
Human Zebrafish Worm Fly
positive regulation of cellular process GO:0048522 201 0.080
Human Zebrafish Worm Fly
muscle tissue development GO:0060537 110 0.079
regulation of wnt signaling pathway GO:0030111 53 0.078
cell part morphogenesis GO:0032990 246 0.076
Fly
reproduction GO:0000003 40 0.076
odontogenesis of dentin containing tooth GO:0042475 1 0.075
positive regulation of biological process GO:0048518 253 0.073
Human Zebrafish Worm Fly
maintenance of location GO:0051235 4 0.072
rhombomere boundary formation GO:0021654 10 0.072
regulation of neural retina development GO:0061074 2 0.071
neuroblast differentiation GO:0014016 1 0.071
behavior GO:0007610 74 0.071
Worm
developmental growth GO:0048589 166 0.069
forebrain dorsal ventral pattern formation GO:0021798 1 0.069
transcription from rna polymerase ii promoter GO:0006366 80 0.069
Human Mouse Worm Fly
negative regulation of mesodermal cell fate specification GO:0042662 3 0.068
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.068
Human Zebrafish Worm Fly
negative regulation of gastrulation GO:2000542 11 0.068
growth GO:0040007 174 0.068
motor neuron axon guidance GO:0008045 23 0.067
positive regulation of signal transduction GO:0009967 56 0.067
negative regulation of rna metabolic process GO:0051253 48 0.066
Fly
negative regulation of transcription dna templated GO:0045892 45 0.066
Fly
embryonic cranial skeleton morphogenesis GO:0048701 90 0.065
muscle cell differentiation GO:0042692 139 0.065
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.064
Human Zebrafish Mouse Worm Fly
striated muscle cell development GO:0055002 108 0.064
negative regulation of reproductive process GO:2000242 3 0.063
fin morphogenesis GO:0033334 53 0.063
endodermal cell differentiation GO:0035987 19 0.062
positive regulation of rna biosynthetic process GO:1902680 57 0.062
Human Zebrafish Worm Fly
axon extension GO:0048675 45 0.062
pons development GO:0021548 11 0.061
optic placode formation involved in camera type eye formation GO:0046619 3 0.061
primary neural tube formation GO:0014020 1 0.060
heart looping GO:0001947 94 0.060
cell differentiation in spinal cord GO:0021515 40 0.060
neural nucleus development GO:0048857 15 0.059
regulation of axon extension GO:0030516 24 0.057
establishment of localization GO:0051234 244 0.057
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.057
skeletal muscle organ development GO:0060538 78 0.057
mesodermal cell fate specification GO:0007501 12 0.057
organelle localization GO:0051640 49 0.056
negative regulation of nervous system development GO:0051961 22 0.056
determination of left right asymmetry in diencephalon GO:0035462 4 0.055
enzyme linked receptor protein signaling pathway GO:0007167 106 0.055
positive regulation of transcription dna templated GO:0045893 57 0.054
Human Zebrafish Worm Fly
cell cycle process GO:0022402 53 0.054
skeletal system development GO:0001501 181 0.053
regulation of cell proliferation GO:0042127 37 0.053
positive regulation of stem cell proliferation GO:2000648 1 0.053
chemotaxis GO:0006935 104 0.053
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.052
Fly
optic placode formation GO:0001743 4 0.052
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.051
Human Mouse Worm Fly
otic vesicle morphogenesis GO:0071600 34 0.051
regulation of developmental growth GO:0048638 38 0.051
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.051
Human Zebrafish Mouse Worm Fly
sensory perception GO:0007600 39 0.051
Zebrafish Worm
regulation of cardiac chamber morphogenesis GO:1901219 2 0.050
regulation of cell fate commitment GO:0010453 22 0.049
segmentation GO:0035282 97 0.049
Fly
developmental induction GO:0031128 10 0.049
bmp signaling pathway GO:0030509 52 0.049
single organism cellular localization GO:1902580 46 0.049
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.048
Fly
organ formation GO:0048645 17 0.048
embryonic camera type eye formation GO:0060900 10 0.048
regulation of metabolic process GO:0019222 359 0.048
Human Zebrafish Mouse Worm Fly
pharyngeal muscle development GO:0043282 4 0.048
adenohypophysis development GO:0021984 15 0.048
peripheral nervous system neuron development GO:0048935 22 0.048
metencephalon development GO:0022037 27 0.048
Mouse
neural retina development GO:0003407 49 0.048
cell proliferation in forebrain GO:0021846 3 0.047
developmental growth involved in morphogenesis GO:0060560 86 0.046
fin development GO:0033333 77 0.045
compound eye development GO:0048749 2 0.045
Fly
axial mesoderm formation GO:0048320 4 0.045
wnt signaling pathway GO:0016055 80 0.043
regulation of cellular biosynthetic process GO:0031326 245 0.043
Human Zebrafish Mouse Worm Fly
regulation of skeletal muscle tissue development GO:0048641 4 0.043
heart formation GO:0060914 13 0.043
neuron fate specification GO:0048665 20 0.043
Worm
cellular component assembly GO:0022607 170 0.043
notch signaling pathway GO:0007219 35 0.043
hindbrain formation GO:0021576 3 0.042
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.042
Fly
neural plate regionalization GO:0060897 10 0.042
developmental cell growth GO:0048588 52 0.041
mesenchymal cell development GO:0014031 78 0.041
determination of left right asymmetry in nervous system GO:0035545 4 0.041
negative regulation of cell development GO:0010721 26 0.041
Zebrafish
floor plate formation GO:0021508 12 0.041
retina morphogenesis in camera type eye GO:0060042 79 0.041
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.041
eye photoreceptor cell development GO:0042462 30 0.040
Zebrafish Fly
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.040
regulation of multicellular organism growth GO:0040014 4 0.039
cellular localization GO:0051641 97 0.039
somite development GO:0061053 96 0.039
regulation of neuron differentiation GO:0045664 56 0.038
Fly
peripheral nervous system neuron axonogenesis GO:0048936 13 0.038
macromolecule localization GO:0033036 54 0.038
regulation of heart morphogenesis GO:2000826 17 0.038
microtubule based process GO:0007017 60 0.037
negative regulation of endodermal cell fate specification GO:0042664 8 0.037
rhombomere development GO:0021546 19 0.037
regulation of organ growth GO:0046620 3 0.037
phosphorus metabolic process GO:0006793 109 0.037
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.036
positive regulation of catabolic process GO:0009896 4 0.036
bmp signaling pathway involved in heart jogging GO:0003303 14 0.036
positive regulation of cell fate commitment GO:0010455 1 0.036
neural crest cell differentiation GO:0014033 72 0.035
pigmentation GO:0043473 85 0.035
negative regulation of rna biosynthetic process GO:1902679 45 0.035
Fly
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.034
anterior posterior axis specification GO:0009948 20 0.034
regeneration GO:0031099 91 0.034
embryonic skeletal system morphogenesis GO:0048704 93 0.033
nerve development GO:0021675 45 0.032
mesoderm development GO:0007498 88 0.032
negative regulation of endodermal cell differentiation GO:1903225 8 0.032
forebrain regionalization GO:0021871 4 0.032
ventral midline development GO:0007418 13 0.032
myotube differentiation GO:0014902 45 0.031
regulation of cytoplasmic transport GO:1903649 4 0.031
somitogenesis GO:0001756 87 0.030
neural precursor cell proliferation GO:0061351 20 0.030
positive regulation of rna metabolic process GO:0051254 59 0.030
Human Zebrafish Worm Fly
spinal cord oligodendrocyte cell differentiation GO:0021529 5 0.030
cardioblast migration GO:0003260 7 0.030
response to stress GO:0006950 263 0.030
regulation of mechanoreceptor differentiation GO:0045631 1 0.030
pectoral fin development GO:0033339 50 0.029
negative regulation of response to stimulus GO:0048585 104 0.029
negative regulation of biological process GO:0048519 304 0.029
Zebrafish Fly
single organism metabolic process GO:0044710 217 0.029
forebrain anterior posterior pattern specification GO:0021797 3 0.028
mesenchymal cell differentiation GO:0048762 87 0.028
cell fate specification involved in pattern specification GO:0060573 3 0.028
endodermal cell fate determination GO:0007493 2 0.028
neural plate pattern specification GO:0060896 12 0.028
apoptotic process GO:0006915 116 0.028
endodermal cell fate commitment GO:0001711 18 0.028
mesodermal cell fate commitment GO:0001710 14 0.027
epidermis development GO:0008544 48 0.027
phosphate containing compound metabolic process GO:0006796 108 0.027
convergent extension involved in gastrulation GO:0060027 71 0.027
cellular component assembly involved in morphogenesis GO:0010927 107 0.027
regulation of gastrulation GO:0010470 24 0.027
positive regulation of nucleic acid templated transcription GO:1903508 57 0.027
Human Zebrafish Worm Fly
bmp signaling pathway involved in determination of left right symmetry GO:0003154 14 0.027
embryonic digestive tract morphogenesis GO:0048557 3 0.027
protein metabolic process GO:0019538 183 0.027
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.027
gabaergic neuron differentiation GO:0097154 2 0.026
skeletal muscle fiber development GO:0048741 35 0.026
negative regulation of gliogenesis GO:0014014 1 0.026
negative regulation of chromosome organization GO:2001251 1 0.026
mitotic cell cycle process GO:1903047 48 0.026
cranial nerve development GO:0021545 42 0.026
palate development GO:0060021 8 0.025
paraxial mesodermal cell differentiation GO:0048342 2 0.025
neural crest cell development GO:0014032 62 0.025
kupffer s vesicle development GO:0070121 50 0.025
midbrain development GO:0030901 28 0.025
regulation of extent of cell growth GO:0061387 29 0.025
positive regulation of biosynthetic process GO:0009891 68 0.025
Human Zebrafish Worm Fly
skeletal muscle tissue development GO:0007519 67 0.025
heart field specification GO:0003128 1 0.025
negative regulation of embryonic development GO:0045992 11 0.025
organelle organization GO:0006996 227 0.024
Fly
eye photoreceptor cell differentiation GO:0001754 45 0.024
Zebrafish Fly
positive regulation of muscle tissue development GO:1901863 1 0.024
cell cell signaling GO:0007267 52 0.024
notochord development GO:0030903 54 0.024
establishment of mitotic spindle orientation GO:0000132 10 0.024
astrocyte differentiation GO:0048708 1 0.023
stem cell maintenance GO:0019827 4 0.023
connective tissue development GO:0061448 99 0.023
non canonical wnt signaling pathway GO:0035567 13 0.023
regulation of collateral sprouting GO:0048670 7 0.023
negative regulation of metabolic process GO:0009892 86 0.023
Fly
stem cell development GO:0048864 82 0.023
regulation of protein complex assembly GO:0043254 3 0.023
positive regulation of embryonic development GO:0040019 3 0.023
regulation of neuron projection development GO:0010975 40 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.022
Human Zebrafish Worm Fly
camera type eye photoreceptor cell differentiation GO:0060219 19 0.022
negative regulation of muscle cell differentiation GO:0051148 1 0.022
retina layer formation GO:0010842 24 0.022
optic nerve development GO:0021554 15 0.022
angioblast cell migration GO:0035476 9 0.022
response to organic substance GO:0010033 153 0.022
Zebrafish
regulation of cell fate specification GO:0042659 20 0.021
bmp signaling pathway involved in heart development GO:0061312 15 0.021
cell proliferation GO:0008283 80 0.021
regulation of notch signaling pathway GO:0008593 16 0.021
positive regulation of neuron migration GO:2001224 2 0.021
forebrain development GO:0030900 96 0.021
Mouse
regulation of protein transport GO:0051223 3 0.021
cell fate commitment involved in pattern specification GO:0060581 6 0.021
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.020
immune system development GO:0002520 191 0.020
adult behavior GO:0030534 2 0.020
blood vessel morphogenesis GO:0048514 216 0.020
cardiac cell fate commitment GO:0060911 1 0.020
oocyte maturation GO:0001556 4 0.020
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.020
multicellular organism growth GO:0035264 4 0.020
specification of organ identity GO:0010092 2 0.019
regulation of cellular response to growth factor stimulus GO:0090287 35 0.019
neuron projection extension GO:1990138 45 0.019
negative regulation of histone modification GO:0031057 1 0.019
pituitary gland development GO:0021983 16 0.019
glial cell migration GO:0008347 3 0.019
protein import into nucleus GO:0006606 3 0.019
positive regulation of metabolic process GO:0009893 108 0.019
Human Zebrafish Worm Fly
mesenchymal cell proliferation GO:0010463 1 0.019
floor plate development GO:0033504 15 0.018
cellular protein modification process GO:0006464 100 0.018
regulation of cell cycle GO:0051726 52 0.018
regulation of cellular response to drug GO:2001038 1 0.018
positive regulation of cell cycle GO:0045787 3 0.018
gastrulation GO:0007369 208 0.018
negative regulation of cell differentiation GO:0045596 46 0.018
Zebrafish
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.018
cellular protein catabolic process GO:0044257 4 0.018
stem cell fate commitment GO:0048865 1 0.017
single organism organelle organization GO:1902589 199 0.017
protein modification process GO:0036211 100 0.017
morphogenesis of an epithelial sheet GO:0002011 49 0.017
positive regulation of epithelial cell differentiation GO:0030858 2 0.017
cell growth GO:0016049 57 0.017
central nervous system neuron differentiation GO:0021953 74 0.017
extracellular fibril organization GO:0043206 1 0.017
regulation of embryonic development GO:0045995 47 0.017
formation of anatomical boundary GO:0048859 14 0.016
mitotic cell cycle GO:0000278 64 0.016
myotube cell development GO:0014904 35 0.016
female gamete generation GO:0007292 14 0.016
cerebellum formation GO:0021588 2 0.016
cellular response to growth factor stimulus GO:0071363 39 0.016
neural tube patterning GO:0021532 33 0.016
regulation of organelle organization GO:0033043 29 0.016
angiogenesis GO:0001525 158 0.016
negative regulation of cellular metabolic process GO:0031324 77 0.016
Fly
negative regulation of protein complex assembly GO:0031333 1 0.016
regulation of growth GO:0040008 42 0.016
central nervous system neuron axonogenesis GO:0021955 18 0.015
retinal pigment epithelium development GO:0003406 8 0.015
negative regulation of striated muscle cell differentiation GO:0051154 1 0.015
cell proliferation in hindbrain GO:0021534 4 0.015
establishment of protein localization to organelle GO:0072594 4 0.015
endocrine system development GO:0035270 65 0.015
negative regulation of wnt signaling pathway GO:0030178 30 0.015
establishment of organelle localization GO:0051656 45 0.015
cartilage development GO:0051216 96 0.015
endoderm formation GO:0001706 29 0.015
mesenchyme development GO:0060485 127 0.015
lipid storage GO:0019915 1 0.015
positive regulation of cellular metabolic process GO:0031325 94 0.015
Human Zebrafish Worm Fly
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
blood vessel development GO:0001568 246 0.015
regulation of endodermal cell differentiation GO:1903224 15 0.015
photoreceptor cell development GO:0042461 40 0.015
Zebrafish Fly
regulation of mesenchymal cell proliferation GO:0010464 1 0.014
regulation of molecular function GO:0065009 70 0.014
wound healing GO:0042060 90 0.014
anterior commissure morphogenesis GO:0021960 3 0.014
histone h3 k27 methylation GO:0070734 2 0.014
regulation of mesoderm development GO:2000380 11 0.014
peripheral nervous system neuron differentiation GO:0048934 28 0.014
positive regulation of cellular component biogenesis GO:0044089 3 0.014
positive regulation of reproductive process GO:2000243 2 0.014
positive regulation of developmental process GO:0051094 50 0.014
Fly
photoreceptor cell fate commitment GO:0046552 1 0.014
Fly
regulation of organ morphogenesis GO:2000027 35 0.014
Zebrafish Fly
formation of primary germ layer GO:0001704 62 0.014
positive regulation of striated muscle tissue development GO:0045844 1 0.014
water homeostasis GO:0030104 4 0.014
cellular response to decreased oxygen levels GO:0036294 1 0.014
regulation of cellular localization GO:0060341 12 0.014
tube closure GO:0060606 1 0.014
protein localization to nucleus GO:0034504 3 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
cardiac muscle tissue development GO:0048738 48 0.013
renal system development GO:0072001 94 0.013

otx1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.075
bone development disease DOID:0080006 0 0.048
bone disease DOID:0080001 0 0.048
musculoskeletal system disease DOID:17 0 0.048
connective tissue disease DOID:65 0 0.048
epilepsy syndrome DOID:1826 0 0.033
central nervous system disease DOID:331 0 0.033
brain disease DOID:936 0 0.033
electroclinical syndrome DOID:0050701 0 0.033
nervous system disease DOID:863 0 0.033
dysostosis DOID:1934 0 0.025
acrocephalosyndactylia DOID:12960 0 0.020
synostosis DOID:11971 0 0.020
pfeiffer syndrome DOID:14705 0 0.014
osteochondrodysplasia DOID:2256 0 0.014
cleidocranial dysplasia DOID:13994 0 0.014