Danio rerio

0 known processes

hcn4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4

hcn4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.079
maintenance of location GO:0051235 4 0.047
aging GO:0007568 2 0.046
positive regulation of transport GO:0051050 2 0.040
amine metabolic process GO:0009308 2 0.034
sensory perception of chemical stimulus GO:0007606 3 0.034
phagocytosis GO:0006909 3 0.033
stem cell maintenance GO:0019827 4 0.033
establishment of localization GO:0051234 244 0.033
regulation of biological quality GO:0065008 263 0.031
regulation of synapse assembly GO:0051963 3 0.031
cell part morphogenesis GO:0032990 246 0.031
response to external stimulus GO:0009605 264 0.030
positive regulation of cellular component biogenesis GO:0044089 3 0.029
positive regulation of cell cycle GO:0045787 3 0.029
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.029
ion transmembrane transport GO:0034220 91 0.028
transport GO:0006810 220 0.028
organonitrogen compound metabolic process GO:1901564 74 0.028
cell morphogenesis GO:0000902 289 0.028
system process GO:0003008 185 0.028
transmembrane transport GO:0055085 120 0.028
actin polymerization or depolymerization GO:0008154 2 0.027
neurotransmitter transport GO:0006836 2 0.026
amino acid transport GO:0006865 2 0.026
response to chemical GO:0042221 320 0.026
regulation of cellular amine metabolic process GO:0033238 0 0.025
regulation of reproductive process GO:2000241 4 0.025
single organism localization GO:1902578 225 0.025
cellular amine metabolic process GO:0044106 2 0.025
regulation of synapse organization GO:0050807 3 0.024
hormone transport GO:0009914 2 0.024
regulation of multicellular organismal process GO:0051239 277 0.024
protein localization to nucleus GO:0034504 3 0.024
hormone secretion GO:0046879 2 0.024
cellular response to external stimulus GO:0071496 2 0.024
cell morphogenesis involved in differentiation GO:0000904 195 0.023
muscle structure development GO:0061061 196 0.023
single organism metabolic process GO:0044710 217 0.023
endocrine process GO:0050886 2 0.022
regulation of hormone secretion GO:0046883 2 0.022
cellular component morphogenesis GO:0032989 336 0.022
cognition GO:0050890 1 0.022
regulation of protein transport GO:0051223 3 0.022
head development GO:0060322 303 0.022
cellular macromolecule metabolic process GO:0044260 391 0.022
regulation of establishment of protein localization GO:0070201 4 0.022
oxoacid metabolic process GO:0043436 31 0.022
small molecule metabolic process GO:0044281 77 0.021
regulation of binding GO:0051098 3 0.021
regulation of muscle contraction GO:0006937 3 0.021
neuron differentiation GO:0030182 353 0.021
compound eye development GO:0048749 2 0.021
cellular component movement GO:0006928 335 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
regulation of multicellular organismal development GO:2000026 223 0.021
neuron neuron synaptic transmission GO:0007270 1 0.021
determination of bilateral symmetry GO:0009855 204 0.021
nitrogen compound metabolic process GO:0006807 319 0.021
female gonad development GO:0008585 4 0.021
cell projection morphogenesis GO:0048858 244 0.021
chemosensory behavior GO:0007635 1 0.021
multicellular organism growth GO:0035264 4 0.021
digestive system development GO:0055123 289 0.021
meiotic cell cycle process GO:1903046 3 0.021
regulation of blood pressure GO:0008217 1 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
neuron projection development GO:0031175 180 0.020
central nervous system development GO:0007417 387 0.020
female sex differentiation GO:0046660 4 0.020
sequestering of metal ion GO:0051238 3 0.020
signal transduction GO:0007165 455 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
immune system process GO:0002376 241 0.020
negative regulation of sequestering of calcium ion GO:0051283 4 0.020
positive regulation of biological process GO:0048518 253 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
development of primary female sexual characteristics GO:0046545 4 0.020
single organism transport GO:0044765 206 0.020
cellular nitrogen compound metabolic process GO:0034641 290 0.020
stem cell proliferation GO:0072089 4 0.020
organic acid metabolic process GO:0006082 31 0.019
cytokinesis GO:0000910 3 0.019
negative regulation of protein phosphorylation GO:0001933 4 0.019
positive regulation of cellular catabolic process GO:0031331 3 0.019
eye development GO:0001654 277 0.019
establishment of protein localization to organelle GO:0072594 4 0.019
gastrulation GO:0007369 208 0.019
synaptic growth at neuromuscular junction GO:0051124 2 0.019
regionalization GO:0003002 274 0.019
regulation of response to stimulus GO:0048583 269 0.019
regulation of blood vessel size GO:0050880 2 0.019
organic substance biosynthetic process GO:1901576 289 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
negative regulation of protein kinase activity GO:0006469 4 0.019
regulation of synaptic plasticity GO:0048167 1 0.018
adult behavior GO:0030534 2 0.018
regulation of cytokine production GO:0001817 3 0.018
growth GO:0040007 174 0.018
regulation of endocrine process GO:0044060 2 0.018
regulation of metal ion transport GO:0010959 4 0.018
response to other organism GO:0051707 97 0.018
regulation of protein catabolic process GO:0042176 1 0.018
positive regulation of catabolic process GO:0009896 4 0.018
cellular ketone metabolic process GO:0042180 11 0.018
modification dependent macromolecule catabolic process GO:0043632 3 0.018
sequestering of calcium ion GO:0051208 3 0.018
tube morphogenesis GO:0035239 349 0.018
generation of neurons GO:0048699 385 0.018
gtp metabolic process GO:0046039 4 0.018
locomotion GO:0040011 313 0.018
aromatic compound biosynthetic process GO:0019438 217 0.017
nuclear transport GO:0051169 4 0.017
gtp catabolic process GO:0006184 2 0.017
cell projection organization GO:0030030 284 0.017
phototransduction GO:0007602 2 0.017
striated muscle cell development GO:0055002 108 0.017
synaptic vesicle localization GO:0097479 1 0.017
modification dependent protein catabolic process GO:0019941 3 0.017
cellular biosynthetic process GO:0044249 286 0.017
single organism nuclear import GO:1902593 3 0.017
neurotransmitter secretion GO:0007269 2 0.017
regulation of multicellular organism growth GO:0040014 4 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
biosynthetic process GO:0009058 294 0.017
cellular response to extracellular stimulus GO:0031668 2 0.016
single fertilization GO:0007338 3 0.016
organic cyclic compound biosynthetic process GO:1901362 223 0.016
cellular protein catabolic process GO:0044257 4 0.016
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.016
regulation of ion transmembrane transporter activity GO:0032412 2 0.016
negative regulation of kinase activity GO:0033673 4 0.016
negative regulation of biological process GO:0048519 304 0.016
vasculature development GO:0001944 278 0.016
cellular response to biotic stimulus GO:0071216 3 0.016
regulation of protein complex assembly GO:0043254 3 0.016
regulation of metabolic process GO:0019222 359 0.016
protein import GO:0017038 3 0.016
regulation of cell activation GO:0050865 1 0.016
cellular response to starvation GO:0009267 1 0.016
cell migration GO:0016477 237 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
phagocytosis engulfment GO:0006911 1 0.016
localization of cell GO:0051674 244 0.016
neurological system process GO:0050877 62 0.016
morphogenesis of an epithelium GO:0002009 333 0.016
positive regulation of immune effector process GO:0002699 3 0.016
nuclear import GO:0051170 3 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.016
response to carbohydrate GO:0009743 3 0.016
peptidyl lysine acetylation GO:0018394 2 0.016
regulation of developmental process GO:0050793 247 0.016
cytoplasm organization GO:0007028 4 0.016
regulation of cell communication GO:0010646 232 0.016
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
regulation of tube size GO:0035150 2 0.015
muscle cell development GO:0055001 115 0.015
camera type eye development GO:0043010 222 0.015
cation transmembrane transport GO:0098655 65 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
cellular aromatic compound metabolic process GO:0006725 295 0.015
translational initiation GO:0006413 3 0.015
regulation of circadian rhythm GO:0042752 4 0.015
sensory organ development GO:0007423 393 0.015
ion transport GO:0006811 114 0.015
protein polymerization GO:0051258 4 0.015
regulation of sequestering of calcium ion GO:0051282 4 0.015
rna localization GO:0006403 4 0.015
monovalent inorganic cation transport GO:0015672 42 0.015
nucleic acid templated transcription GO:0097659 181 0.015
peptide transport GO:0015833 1 0.015
regulation of localization GO:0032879 104 0.015
regulation of nitrogen compound metabolic process GO:0051171 251 0.015
regulation of cellular metabolic process GO:0031323 320 0.015
guanosine containing compound catabolic process GO:1901069 2 0.015
heart development GO:0007507 313 0.015
negative regulation of catabolic process GO:0009895 3 0.015
cellular nitrogen compound biosynthetic process GO:0044271 218 0.015
lipid storage GO:0019915 1 0.015
heterocycle metabolic process GO:0046483 290 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
embryonic organ development GO:0048568 381 0.015
regulation of cell shape GO:0008360 1 0.015
protein targeting to nucleus GO:0044744 3 0.015
response to drug GO:0042493 3 0.015
regulation of inflammatory response GO:0050727 2 0.014
cellular response to lipopolysaccharide GO:0071222 3 0.014
golgi vesicle transport GO:0048193 3 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
synaptic vesicle transport GO:0048489 1 0.014
lipid catabolic process GO:0016042 4 0.014
negative regulation of multicellular organismal process GO:0051241 69 0.014
regulation of protein localization to nucleus GO:1900180 2 0.014
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.014
regulation of macromolecule metabolic process GO:0060255 317 0.014
rna metabolic process GO:0016070 219 0.014
establishment of synaptic vesicle localization GO:0097480 1 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
cellular component disassembly GO:0022411 1 0.014
protein homooligomerization GO:0051260 3 0.014
positive regulation of reproductive process GO:2000243 2 0.014
immune system development GO:0002520 191 0.014
angiogenesis GO:0001525 158 0.014
secondary metabolic process GO:0019748 3 0.014
response to stress GO:0006950 263 0.014
olfactory lobe development GO:0021988 4 0.014
blood vessel development GO:0001568 246 0.014
exocytosis GO:0006887 1 0.014
production of molecular mediator of immune response GO:0002440 2 0.014
post embryonic organ development GO:0048569 4 0.014
negative regulation of protein localization to nucleus GO:1900181 2 0.014
positive regulation of cellular process GO:0048522 201 0.014
positive regulation of secretion by cell GO:1903532 1 0.014
sensory perception of smell GO:0007608 2 0.014
regulation of gene expression GO:0010468 265 0.014
rna biosynthetic process GO:0032774 181 0.014
leukocyte proliferation GO:0070661 1 0.014
regulation of transmembrane transporter activity GO:0022898 2 0.014
regulation of primary metabolic process GO:0080090 311 0.014
macromolecular complex disassembly GO:0032984 1 0.014
sensory perception GO:0007600 39 0.014
cellular response to nutrient levels GO:0031669 2 0.014
regulation of sodium ion transport GO:0002028 2 0.014
nucleobase containing compound metabolic process GO:0006139 274 0.013
mononuclear cell proliferation GO:0032943 1 0.013
blood circulation GO:0008015 87 0.013
lens fiber cell morphogenesis GO:0070309 3 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.013
maternal determination of anterior posterior axis embryo GO:0008358 4 0.013
single organism organelle organization GO:1902589 199 0.013
protein complex disassembly GO:0043241 1 0.013
regulation of neurotransmitter secretion GO:0046928 1 0.013
protein import into nucleus GO:0006606 3 0.013
negative regulation of secretion GO:0051048 2 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
meiotic chromosome segregation GO:0045132 3 0.013
response to nutrient GO:0007584 3 0.013
positive regulation of secretion GO:0051047 1 0.013
sleep GO:0030431 1 0.013
membrane invagination GO:0010324 1 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
organic cyclic compound metabolic process GO:1901360 301 0.013
release of sequestered calcium ion into cytosol GO:0051209 3 0.013
protein secretion GO:0009306 1 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
gene expression GO:0010467 252 0.013
muscle organ development GO:0007517 101 0.013
calcium ion transport into cytosol GO:0060402 3 0.013
cellular component biogenesis GO:0044085 178 0.013
regulation of autophagy GO:0010506 3 0.013
b cell activation GO:0042113 2 0.013
anterior posterior pattern specification GO:0009952 152 0.013
homeostatic process GO:0042592 142 0.013
cation transport GO:0006812 81 0.013
regulation of cellular biosynthetic process GO:0031326 245 0.013
actin filament polymerization GO:0030041 2 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
carbohydrate biosynthetic process GO:0016051 1 0.013
protein acylation GO:0043543 3 0.013
cytoskeleton dependent cytokinesis GO:0061640 3 0.013
neuron development GO:0048666 262 0.013
inorganic ion transmembrane transport GO:0098660 57 0.013
positive regulation of cell activation GO:0050867 1 0.013
regulation of neurotransmitter transport GO:0051588 1 0.012
specification of symmetry GO:0009799 204 0.012
regulation of neural precursor cell proliferation GO:2000177 3 0.012
autophagy GO:0006914 4 0.012
negative regulation of cellular process GO:0048523 283 0.012
positive regulation of blood circulation GO:1903524 2 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
cell motility GO:0048870 244 0.012
regulation of systemic arterial blood pressure GO:0003073 1 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
response to external biotic stimulus GO:0043207 97 0.012
response to biotic stimulus GO:0009607 97 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
actin filament based movement GO:0030048 1 0.012
blood vessel morphogenesis GO:0048514 216 0.012
regulation of signaling GO:0023051 235 0.012
internal peptidyl lysine acetylation GO:0018393 2 0.012
regulation of dendrite development GO:0050773 3 0.012
catechol containing compound metabolic process GO:0009712 2 0.012
inorganic cation transmembrane transport GO:0098662 50 0.012
protein stabilization GO:0050821 2 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
intracellular mrna localization GO:0008298 1 0.012
leukocyte mediated cytotoxicity GO:0001909 1 0.012
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.012
neuroblast proliferation GO:0007405 2 0.012
positive regulation of cytokine production GO:0001819 2 0.012
cellular lipid catabolic process GO:0044242 3 0.012
positive regulation of chromatin modification GO:1903310 1 0.012
negative regulation of synapse assembly GO:0051964 2 0.012
cytosolic calcium ion transport GO:0060401 3 0.012
negative regulation of defense response GO:0031348 2 0.012
mitochondrion organization GO:0007005 4 0.012
regulation of cell differentiation GO:0045595 142 0.012
protein localization to plasma membrane GO:0072659 1 0.012
response to organic substance GO:0010033 153 0.012
organelle organization GO:0006996 227 0.012
negative regulation of secretion by cell GO:1903531 2 0.012
stem cell division GO:0017145 1 0.012
lymphocyte proliferation GO:0046651 1 0.012
positive regulation of protein complex assembly GO:0031334 2 0.012
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
protein acetylation GO:0006473 2 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
brain development GO:0007420 293 0.011
small molecule catabolic process GO:0044282 3 0.011
sensory perception of pain GO:0019233 1 0.011
regulation of skeletal muscle tissue development GO:0048641 4 0.011
segmentation GO:0035282 97 0.011
negative regulation of chromosome organization GO:2001251 1 0.011
regulation of signal transduction GO:0009966 225 0.011
positive regulation of chromosome organization GO:2001252 1 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
ovulation cycle GO:0042698 2 0.011
convergent extension GO:0060026 118 0.011
digestive tract morphogenesis GO:0048546 231 0.011
regulation of protein polymerization GO:0032271 2 0.011
regulation of biosynthetic process GO:0009889 250 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
carbohydrate homeostasis GO:0033500 1 0.011
circulatory system process GO:0003013 87 0.011
positive regulation of cell division GO:0051781 2 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
cellular component assembly GO:0022607 170 0.011
positive regulation of histone modification GO:0031058 1 0.011
olfactory bulb development GO:0021772 4 0.011
heterocycle biosynthetic process GO:0018130 215 0.011
hemopoiesis GO:0030097 183 0.011
somitogenesis GO:0001756 87 0.011
regulation of neuronal synaptic plasticity GO:0048168 1 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
dicarboxylic acid transport GO:0006835 1 0.011
digestive tract development GO:0048565 265 0.011
interspecies interaction between organisms GO:0044419 4 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
behavior GO:0007610 74 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
protein metabolic process GO:0019538 183 0.011
regulation of protein complex disassembly GO:0043244 1 0.011
striated muscle tissue development GO:0014706 110 0.011
response to monosaccharide GO:0034284 3 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.011
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
regulation of transporter activity GO:0032409 2 0.011
endocrine hormone secretion GO:0060986 2 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
detection of chemical stimulus GO:0009593 4 0.011
regulation of membrane potential GO:0042391 23 0.011
cellular amide metabolic process GO:0043603 4 0.010
muscle cell differentiation GO:0042692 139 0.010
homeostasis of number of cells GO:0048872 62 0.010
multi organism process GO:0051704 134 0.010
nucleic acid metabolic process GO:0090304 244 0.010
embryonic heart tube development GO:0035050 133 0.010
response to wounding GO:0009611 116 0.010
phosphorus metabolic process GO:0006793 109 0.010
regulation of protein binding GO:0043393 3 0.010
actin filament based process GO:0030029 64 0.010
ventricular cardiac muscle tissue development GO:0003229 3 0.010
heart looping GO:0001947 94 0.010
endosomal transport GO:0016197 2 0.010
regulation of protein import into nucleus GO:0042306 2 0.010
regulation of nucleic acid templated transcription GO:1903506 213 0.010
negative regulation of reproductive process GO:2000242 3 0.010
neuron projection morphogenesis GO:0048812 161 0.010
synaptic target recognition GO:0008039 1 0.010
regulation of rna biosynthetic process GO:2001141 213 0.010
fertilization GO:0009566 3 0.010
membrane hyperpolarization GO:0060081 1 0.010
sodium ion transport GO:0006814 24 0.010
spermatid differentiation GO:0048515 2 0.010
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.010
vacuolar transport GO:0007034 2 0.010
dopamine metabolic process GO:0042417 2 0.010
regulation of translational initiation GO:0006446 1 0.010
regulation of transcription dna templated GO:0006355 213 0.010
rna transport GO:0050658 2 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
negative regulation of protein transport GO:0051224 3 0.010
lens fiber cell development GO:0070307 3 0.010
g protein coupled receptor signaling pathway GO:0007186 74 0.010
skeletal muscle tissue development GO:0007519 67 0.010
taxis GO:0042330 109 0.010
single organism membrane fusion GO:0044801 2 0.010
cellular macromolecule biosynthetic process GO:0034645 224 0.010
spermatid development GO:0007286 2 0.010
membrane fusion GO:0061025 2 0.010
axonogenesis GO:0007409 152 0.010

hcn4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
musculoskeletal system disease DOID:17 0 0.017
nervous system disease DOID:863 0 0.016
disease of metabolism DOID:0014667 0 0.013
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
muscular disease DOID:0080000 0 0.011
organ system cancer DOID:0050686 0 0.010
sensory system disease DOID:0050155 0 0.010
eye and adnexa disease DOID:1492 0 0.010